DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling.

abstract：:Production of concatemeric DNA is an essential step during HSV infection, as the packaging machinery must recognize longer-than-unit-length concatemers; however, the mechanism by which they are formed is poorly understood. Although it has been proposed that the viral genome circularizes and rolling circle replication ...

journal_title：PLoS pathogens

authors： Schumacher AJ,Mohni KN,Kan Y,Hendrickson EA,Stark JM,Weller SK

更新日期：2012-01-01 00:00:00

abstract：:Legionella pneumophila translocates multiple bacterial effector proteins into host cells to direct formation of a replication vacuole for the bacterium. The emerging consensus is that formation of this compartment involves recruitment of membrane material that traffics between the endoplasmic reticulum (ER) and Golgi....

journal_title：PLoS pathogens

authors： Dorer MS,Kirton D,Bader JS,Isberg RR

更新日期：2006-04-01 00:00:00

abstract：:The ability of the tubercle bacillus to arrest phagosome maturation is considered one major mechanism that allows its survival within host macrophages. To identify mycobacterial genes involved in this process, we developed a high throughput phenotypic cell-based assay enabling individual sub-cellular analysis of over ...

journal_title：PLoS pathogens

authors： Brodin P,Poquet Y,Levillain F,Peguillet I,Larrouy-Maumus G,Gilleron M,Ewann F,Christophe T,Fenistein D,Jang J,Jang MS,Park SJ,Rauzier J,Carralot JP,Shrimpton R,Genovesio A,Gonzalo-Asensio JA,Puzo G,Martin C,Brosch R

更新日期：2010-09-09 00:00:00

abstract：:Elucidating the mechanism of action of trypanocidal compounds is an important step in the development of more efficient drugs against Trypanosoma brucei. In a screening approach using an RNAi library in T. brucei bloodstream forms, we identified a member of the mitochondrial carrier family, TbMCP14, as a prime candida...

journal_title：PLoS pathogens

authors： de Macêdo JP,Schumann Burkard G,Niemann M,Barrett MP,Vial H,Mäser P,Roditi I,Schneider A,Bütikofer P

更新日期：2015-05-06 00:00:00

abstract：:Kaposi's sarcoma (KS) lesions are complex mixtures of KS-associated herpesvirus (KSHV)-infected spindle and inflammatory cells. In order to survive the host immune responses, KSHV encodes a number of immunomodulatory proteins, including the E3 ubiquitin ligase K5. In exploring the role of this viral protein in monocyt...

journal_title：PLoS pathogens

authors： Karki R,Lang SM,Means RE

更新日期：2011-04-01 00:00:00

abstract：:The envelope glycoprotein (Env) complexes of the human and simian immunodeficiency viruses (HIV and SIV, respectively) mediate viral entry and are a target for neutralizing antibodies. The receptor binding surfaces of Env are in large part sterically occluded or conformationally masked prior to receptor binding. Knowl...

journal_title：PLoS pathogens

authors： Zanetti G,Briggs JA,Grünewald K,Sattentau QJ,Fuller SD

更新日期：2006-08-01 00:00:00

abstract：:Human cytomegalovirus (HCMV), a dsDNA, enveloped virus, is a ubiquitous pathogen that establishes lifelong latent infections and caused disease in persons with compromised immune systems, e.g., organ transplant recipients or AIDS patients. HCMV is also a leading cause of congenital viral infections in newborns. Entry ...

journal_title：PLoS pathogens

authors： Burke HG,Heldwein EE

更新日期：2015-10-20 00:00:00

abstract：:The digestive tract is the first organ affected by the ingestion of foodborne bacteria. While commensal bacteria become resident, opportunistic or virulent bacteria are eliminated from the gut by the local innate immune system. Here we characterize a new mechanism of defense, independent of the immune system, in Droso...

journal_title：PLoS pathogens

authors： Benguettat O,Jneid R,Soltys J,Loudhaief R,Brun-Barale A,Osman D,Gallet A

更新日期：2018-09-04 00:00:00

abstract：:The wide utilization of biocides poses a concern on the impact of these compounds on natural bacterial populations. Furthermore, it has been demonstrated that biocides can select, at least in laboratory experiments, antibiotic resistant bacteria. This situation has raised concerns, not just on scientists and clinician...

journal_title：PLoS pathogens

authors： Hernández A,Ruiz FM,Romero A,Martínez JL

更新日期：2011-06-01 00:00:00

abstract：:Bacterial biofilm is considered as a particular lifestyle helping cells to survive hostile environments triggered by a variety of signals sensed and integrated through adequate regulatory pathways. Pseudomonas aeruginosa, a Gram-negative bacterium causing severe infections in humans, forms biofilms and is a fantastic ...

journal_title：PLoS pathogens

authors： de Bentzmann S,Giraud C,Bernard CS,Calderon V,Ewald F,Plésiat P,Nguyen C,Grunwald D,Attree I,Jeannot K,Fauvarque MO,Bordi C

更新日期：2012-01-01 00:00:00

abstract：:Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely in adults. The mechanisms that determine the age-dependent susceptibility remain largely unclear. Here, we found that the paucity of invariant natural killer T (iNKT) cells together wi...

journal_title：PLoS pathogens

authors： Zhu K,Yang J,Luo K,Yang C,Zhang N,Xu R,Chen J,Jin M,Xu B,Guo N,Wang J,Chen Z,Cui Y,Zhao H,Wang Y,Deng C,Bai L,Ge B,Qin CF,Shen H,Yang CF,Leng Q

更新日期：2015-01-23 00:00:00

abstract：:Despite considerable research efforts, little is yet known about key epidemiological parameters of H5N1 highly pathogenic influenza viruses in their avian hosts. Here we show how these parameters can be estimated using a limited number of birds in experimental transmission studies. Our quantitative estimates, based on...

journal_title：PLoS pathogens

authors： Bouma A,Claassen I,Natih K,Klinkenberg D,Donnelly CA,Koch G,van Boven M

更新日期：2009-01-01 00:00:00

abstract：:Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H. pylori-induced gastritis. H. pylori also induces programmed death lig...

journal_title：PLoS pathogens

authors： Holokai L,Chakrabarti J,Broda T,Chang J,Hawkins JA,Sundaram N,Wroblewski LE,Peek RM Jr,Wang J,Helmrath M,Wells JM,Zavros Y

更新日期：2019-01-31 00:00:00

abstract：:Ebolavirus (EBOV), the causative agent of a severe hemorrhagic fever and a biosafety level 4 pathogen, increases its genome coding capacity by producing multiple transcripts encoding for structural and nonstructural glycoproteins from a single gene. This is achieved through RNA editing, during which non-template adeno...

journal_title：PLoS pathogens

authors： Mehedi M,Hoenen T,Robertson S,Ricklefs S,Dolan MA,Taylor T,Falzarano D,Ebihara H,Porcella SF,Feldmann H

更新日期：2013-01-01 00:00:00

abstract：:Streptococcus gallolyticus subspecies gallolyticus (Sgg) has a strong clinical association with colorectal cancer (CRC) and actively promotes the development of colon tumors. However, the molecular determinants involved in Sgg pathogenicity in the gut are unknown. Bacterial type VII secretion systems (T7SS) mediate pa...

journal_title：PLoS pathogens

authors： Taylor JC,Gao X,Xu J,Holder M,Petrosino J,Kumar R,Liu W,Höök M,Mackenzie C,Hillhouse A,Brashear W,Nunez MP,Xu Y

更新日期：2021-01-06 00:00:00

abstract：:Pathogenic hantaviruses, genus Orthohantaviridae, are maintained in rodent reservoirs with zoonotic transmission to humans occurring through inhalation of rodent excreta. Hantavirus disease in humans is characterized by localized vascular leakage and elevated levels of circulating proinflammatory cytokines. Despite th...

journal_title：PLoS pathogens

authors： Kell AM,Hemann EA,Turnbull JB,Gale M Jr

更新日期：2020-04-24 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) requires the ESX1 specialized protein secretion system for virulence, for triggering cytosolic immune surveillance pathways, and for priming an optimal CD8+ T cell response. This suggests that ESX1 might act primarily by destabilizing the phagosomal membrane that surrounds the bacteriu...

journal_title：PLoS pathogens

authors： Garces A,Atmakuri K,Chase MR,Woodworth JS,Krastins B,Rothchild AC,Ramsdell TL,Lopez MF,Behar SM,Sarracino DA,Fortune SM

更新日期：2010-06-24 00:00:00

abstract：:The highly pathogenic Old World arenavirus Lassa virus (LASV) and the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) use α-dystroglycan as a cellular receptor and enter the host cell by an unusual endocytotic pathway independent of clathrin, caveolin, dynamin, and actin. Upon internalization, the viru...

journal_title：PLoS pathogens

authors： Pasqual G,Rojek JM,Masin M,Chatton JY,Kunz S

更新日期：2011-09-01 00:00:00

abstract：:Idiopathic chronic diarrhea (ICD) is a leading cause of morbidity amongst rhesus monkeys kept in captivity. Here, we show that exposure of affected animals to the whipworm Trichuris trichiura led to clinical improvement in fecal consistency, accompanied by weight gain, in four out of the five treated monkeys. By flow ...

journal_title：PLoS pathogens

authors： Broadhurst MJ,Ardeshir A,Kanwar B,Mirpuri J,Gundra UM,Leung JM,Wiens KE,Vujkovic-Cvijin I,Kim CC,Yarovinsky F,Lerche NW,McCune JM,Loke P

更新日期：2012-01-01 00:00:00

abstract：:We have characterized a novel pleiotropic role for CymR, the master regulator of cysteine metabolism. We show here that CymR plays an important role both in stress response and virulence of Staphylococcus aureus. Genes involved in detoxification processes, including oxidative stress response and metal ion homeostasis,...

journal_title：PLoS pathogens

authors： Soutourina O,Dubrac S,Poupel O,Msadek T,Martin-Verstraete I

更新日期：2010-05-13 00:00:00

abstract：:Malaria is a global health concern caused by infection with Plasmodium parasites. With rising insecticide and drug resistance, there is a critical need to develop novel control strategies, including strategies to block parasite sporogony in key mosquito vector species. MAPK signaling pathways regulated by extracellula...

journal_title：PLoS pathogens

authors： Souvannaseng L,Hun LV,Baker H,Klyver JM,Wang B,Pakpour N,Bridgewater JM,Napoli E,Giulivi C,Riehle MA,Luckhart S

更新日期：2018-11-29 00:00:00

abstract：:Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutio...

journal_title：PLoS pathogens

authors： Deeg CM,Zimmer MM,George EE,Husnik F,Keeling PJ,Suttle CA

更新日期：2019-05-31 00:00:00

abstract：:Bdellovibrio bacteriovorus is a Delta-proteobacterium that oscillates between free-living growth and predation on Gram-negative bacteria including important pathogens of man, animals and plants. After entering the prey periplasm, killing the prey and replicating inside the prey bdelloplast, several motile B. bacteriov...

journal_title：PLoS pathogens

authors： Hobley L,Fung RK,Lambert C,Harris MA,Dabhi JM,King SS,Basford SM,Uchida K,Till R,Ahmad R,Aizawa S,Gomelsky M,Sockett RE

更新日期：2012-02-01 00:00:00

abstract：:Human noroviruses (huNoV) are the most frequent cause of non-bacterial acute gastroenteritis worldwide, particularly genogroup II genotype 4 (GII.4) variants. The viral nonstructural (NS) proteins encoded by the ORF1 polyprotein induce vesical clusters harboring the viral replication sites. Little is known so far abou...

journal_title：PLoS pathogens

authors： Doerflinger SY,Cortese M,Romero-Brey I,Menne Z,Tubiana T,Schenk C,White PA,Bartenschlager R,Bressanelli S,Hansman GS,Lohmann V

更新日期：2017-10-27 00:00:00

abstract：:Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis (Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes siderophores, small molecules with high affinity for iron, and takes up iron-loaded mycobactins (MBT) and carboxymycobactins (cMBT), from the...

journal_title：PLoS pathogens

authors： Zhang L,Hendrickson RC,Meikle V,Lefkowitz EJ,Ioerger TR,Niederweis M

更新日期：2020-02-18 00:00:00

abstract：:Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigotes, by a mechanism that involves reactive oxygen species (ROS) produ...

journal_title：PLoS pathogens

authors： Mittra B,Laranjeira-Silva MF,Perrone Bezerra de Menezes J,Jensen J,Michailowsky V,Andrews NW

更新日期：2016-01-07 00:00:00

abstract：:Negative-sense RNA viruses assemble large ribonucleoprotein (RNP) complexes that direct replication and transcription of the viral genome. Influenza virus RNPs contain the polymerase, genomic RNA and multiple copies of nucleoprotein (NP). During RNP assembly, monomeric NP oligomerizes along the length of the genomic R...

journal_title：PLoS pathogens

authors： Mondal A,Potts GK,Dawson AR,Coon JJ,Mehle A

更新日期：2015-04-13 00:00:00

abstract：:HIV-1 uses a number of means to manipulate the immune system, to avoid recognition and to highjack signaling pathways. HIV-1 infected cells show limited Toll-Like Receptor (TLR) responsiveness via as yet unknown mechanisms. Using biochemical and biophysical approaches, we demonstrate that the trans-membrane domain (TM...

journal_title：PLoS pathogens

authors： Reuven EM,Ali M,Rotem E,Schwarzer R,Gramatica A,Futerman AH,Shai Y

更新日期：2014-08-14 00:00:00

abstract：:Beyond their canonical roles in hemostasis and thrombosis, platelets function in the innate immune response by interacting directly with pathogens and by regulating the recruitment and activation of immune effector cells. Thrombocytopenia often coincides with neutropenia in patients with hematologic malignancies and i...

journal_title：PLoS pathogens

authors： Tischler BY,Tosini NL,Cramer RA,Hohl TM

更新日期：2020-05-14 00:00:00

abstract：:Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nucleus of coronavirus-infected cells, first, transcriptome dynamics was...

journal_title：PLoS pathogens

authors： Poppe M,Wittig S,Jurida L,Bartkuhn M,Wilhelm J,Müller H,Beuerlein K,Karl N,Bhuju S,Ziebuhr J,Schmitz ML,Kracht M

更新日期：2017-03-29 00:00:00