Comprehensive analysis of iron utilization by Mycobacterium tuberculosis.

abstract：:Highly phagocytic macrophages line the marginal zone (MZ) of the spleen and the lymph node subcapsular sinus. Although these macrophages have been attributed with a variety of functions, including the uptake and clearance of blood and lymph-borne pathogens, little is known about the effector mechanisms they employ aft...

journal_title：PLoS pathogens

authors： Phillips R,Svensson M,Aziz N,Maroof A,Brown N,Beattie L,Signoret N,Kaye PM

更新日期：2010-03-12 00:00:00

abstract：:Extracellular vesicles (EV) mediate intercellular communication events and alterations in normal vesicle content contribute to function and disease initiation or progression. The ability to package a variety of cargo and transmit molecular information between cells renders EVs important mediators of cell-to-cell cross...

journal_title：PLoS pathogens

authors： Nkosi D,Sun L,Duke LC,Meckes DG Jr

更新日期：2020-12-31 00:00:00

abstract：:Malaria is a global health concern caused by infection with Plasmodium parasites. With rising insecticide and drug resistance, there is a critical need to develop novel control strategies, including strategies to block parasite sporogony in key mosquito vector species. MAPK signaling pathways regulated by extracellula...

journal_title：PLoS pathogens

authors： Souvannaseng L,Hun LV,Baker H,Klyver JM,Wang B,Pakpour N,Bridgewater JM,Napoli E,Giulivi C,Riehle MA,Luckhart S

更新日期：2018-11-29 00:00:00

abstract：:Immunocompromised individuals tend to suffer from influenza longer with more serious complications than otherwise healthy patients. Little is known about the impact of prolonged infection and the efficacy of antiviral therapy in these patients. Among all 189 influenza A virus infected immunocompromised patients admitt...

journal_title：PLoS pathogens

authors： van der Vries E,Stittelaar KJ,van Amerongen G,Veldhuis Kroeze EJ,de Waal L,Fraaij PL,Meesters RJ,Luider TM,van der Nagel B,Koch B,Vulto AG,Schutten M,Osterhaus AD

更新日期：2013-01-01 00:00:00

abstract：:Chlamydia trachomatis remains one of the few major human pathogens for which there is no transformation system. C. trachomatis has a unique obligate intracellular developmental cycle. The extracellular infectious elementary body (EB) is an infectious, electron-dense structure that, following host cell infection, diffe...

journal_title：PLoS pathogens

authors： Wang Y,Kahane S,Cutcliffe LT,Skilton RJ,Lambden PR,Clarke IN

更新日期：2011-09-01 00:00:00

abstract：:In human cytomegalovirus (HCMV), tropism to epithelial and endothelial cells is dependent upon a pentameric complex (PC). Given the structure of the placenta, the PC is potentially an important neutralizing antibody target antigen against congenital infection. The guinea pig is the only small animal model for congenit...

journal_title：PLoS pathogens

authors： Coleman S,Choi KY,Root M,McGregor A

更新日期：2016-07-07 00:00:00

abstract：:The success of Mycobacterium tuberculosis as a pathogen derives from its facile adaptation to the intracellular milieu of human macrophages. To explore this process, we asked whether adaptation also required interference with the metabolic machinery of the host cell. Temporal profiling of the metabolic flux, in cells ...

journal_title：PLoS pathogens

authors： Mehrotra P,Jamwal SV,Saquib N,Sinha N,Siddiqui Z,Manivel V,Chatterjee S,Rao KV

更新日期：2014-07-24 00:00:00

abstract：:The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires thro...

journal_title：PLoS pathogens

authors： Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ

更新日期：2014-01-01 00:00:00

abstract：:Vaccinia virus A33 is an extracellular enveloped virus (EEV)-specific type II membrane glycoprotein that is essential for efficient EEV formation and long-range viral spread within the host. A33 is a target for neutralizing antibody responses against EEV. In this study, we produced seven murine anti-A33 monoclonal ant...

journal_title：PLoS pathogens

authors： Matho MH,Schlossman A,Meng X,Benhnia MR,Kaever T,Buller M,Doronin K,Parker S,Peters B,Crotty S,Xiang Y,Zajonc DM

更新日期：2015-09-01 00:00:00

abstract：:Community acquired-methicillin resistant Staphylococcus aureus (CA-MRSA) is a socially problematic pathogen that infects healthy individuals, causing severe disease. CA-MRSA is more virulent than hospital associated-MRSA (HA-MRSA). The underlying mechanism for the high virulence of CA-MRSA is not known. The transcript...

journal_title：PLoS pathogens

authors： Kaito C,Saito Y,Ikuo M,Omae Y,Mao H,Nagano G,Fujiyuki T,Numata S,Han X,Obata K,Hasegawa S,Yamaguchi H,Inokuchi K,Ito T,Hiramatsu K,Sekimizu K

更新日期：2013-01-01 00:00:00

abstract：:PB1-F2 is a 90 amino acid protein that is expressed from the +1 open reading frame in the PB1 gene of some influenza A viruses and has been shown to contribute to viral pathogenicity. Notably, a serine at position 66 (66S) in PB1-F2 is known to increase virulence compared to an isogenic virus with an asparagine (66N) ...

journal_title：PLoS pathogens

authors： Varga ZT,Ramos I,Hai R,Schmolke M,García-Sastre A,Fernandez-Sesma A,Palese P

更新日期：2011-06-01 00:00:00

abstract：:Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal apparent sequestration in endothelium-lined microvasculature, and pathogenesis thought unrelated to parasite biomass. However, the relationships bet...

journal_title：PLoS pathogens

authors： Barber BE,William T,Grigg MJ,Parameswaran U,Piera KA,Price RN,Yeo TW,Anstey NM

更新日期：2015-01-08 00:00:00

abstract：:Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. We show that the spirochetes can acquire cholesterol from plasma membranes of epithel...

journal_title：PLoS pathogens

authors： Crowley JT,Toledo AM,LaRocca TJ,Coleman JL,London E,Benach JL

更新日期：2013-01-01 00:00:00

abstract：:Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. Sumoylation has roles in the control of protein stability, activity and localization, and is involved in the regulation of transcription, gene expr...

journal_title：PLoS pathogens

authors： Sloan E,Tatham MH,Groslambert M,Glass M,Orr A,Hay RT,Everett RD

更新日期：2015-07-22 00:00:00

abstract：:Dendritic cells (DCs) are specialized phagocytes that internalize exogenous antigens and microbes at peripheral sites, and then migrate to lymphatic organs to display foreign peptides to naïve T cells. There are several examples where DCs have been shown to be more efficient at restricting the intracellular replicatio...

journal_title：PLoS pathogens

authors： Nogueira CV,Lindsten T,Jamieson AM,Case CL,Shin S,Thompson CB,Roy CR

更新日期：2009-06-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006120.]. ...

journal_title：PLoS pathogens

authors： Kinosada H,Yasunaga JI,Shimura K,Miyazato P,Onishi C,Iyoda T,Inaba K,Matsuoka M

更新日期：2017-02-23 00:00:00

abstract：:Microbial pathogens often establish infection within particular niches of their host for replication. Determining how infection occurs preferentially in specific host tissues is a key aspect of understanding host-microbe interactions. Here, we describe the discovery of a natural microsporidian parasite of the nematode...

journal_title：PLoS pathogens

authors： Luallen RJ,Reinke AW,Tong L,Botts MR,Félix MA,Troemel ER

更新日期：2016-06-30 00:00:00

abstract：:Uncovering how natural selection and genetic drift shape the evolutionary dynamics of virus populations within their hosts can pave the way to a better understanding of virus emergence. Mathematical models already play a leading role in these studies and are intended to predict future emergences. Here, using high-thro...

journal_title：PLoS pathogens

authors： Fabre F,Montarry J,Coville J,Senoussi R,Simon V,Moury B

更新日期：2012-01-01 00:00:00

abstract：:Inflammation is critical for controlling pathogens, but also responsible for symptoms of infectious diseases. IL-27 is an important regulator of inflammation and can limit development of IFNγ-producing Tbet+ CD4+ T (Th1) cells. IL-27 is thought to do this by stimulating IL-10 production by CD4+ T cells, but the underl...

journal_title：PLoS pathogens

authors： Montes de Oca M,de Labastida Rivera F,Winterford C,Frame TCM,Ng SS,Amante FH,Edwards CL,Bukali L,Wang Y,Uzonna JE,Kuns RD,Zhang P,Kabat A,Klein Geltink RI,Pearce EJ,Hill GR,Engwerda CR

更新日期：2020-10-13 00:00:00

abstract：:Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large population samples and to the extensive genetic diversity between isolates, the transmission and spread of H. pylori remain poorl...

journal_title：PLoS pathogens

authors： Schwarz S,Morelli G,Kusecek B,Manica A,Balloux F,Owen RJ,Graham DY,van der Merwe S,Achtman M,Suerbaum S

更新日期：2008-10-01 00:00:00

abstract：:Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains unclear. Using a computational approach on HIV gag/pol/nef sequences ...

journal_title：PLoS pathogens

authors： Erdmann N,Du VY,Carlson J,Schaefer M,Jureka A,Sterrett S,Yue L,Dilernia D,Lakhi S,Tang J,Sidney J,Gilmour J,Allen S,Hunter E,Heath S,Bansal A,Goepfert PA

更新日期：2015-08-24 00:00:00

abstract：:As targets of adaptive immunity, influenza viruses are characterized by the fluidity with which they respond to the selective pressure applied by neutralizing antibodies. This mutability of structural determinants of protective immunity is the obstacle in developing universal influenza vaccines. Towards the developmen...

journal_title：PLoS pathogens

authors： Wang TT,Tan GS,Hai R,Pica N,Petersen E,Moran TM,Palese P

更新日期：2010-02-26 00:00:00

abstract：:The Trypanosoma brucei flagellum is a multifunctional organelle with critical roles in motility, cellular morphogenesis, and cell division. Although motility is thought to be important throughout the trypanosome lifecycle, most studies of flagellum structure and function have been restricted to the procyclic lifecycle...

journal_title：PLoS pathogens

authors： Ralston KS,Hill KL

更新日期：2006-09-01 00:00:00

abstract：:Gene expression of DNA viruses requires nuclear import of the viral genome. Human Adenoviruses (Ads), like most DNA viruses, encode factors within early transcription units promoting their own gene expression and counteracting cellular antiviral defense mechanisms. The cellular transcriptional repressor Daxx prevents ...

journal_title：PLoS pathogens

authors： Schreiner S,Martinez R,Groitl P,Rayne F,Vaillant R,Wimmer P,Bossis G,Sternsdorf T,Marcinowski L,Ruzsics Z,Dobner T,Wodrich H

更新日期：2012-02-01 00:00:00

abstract：:The heterosexual risk group has become the largest HIV infected group in the United Kingdom during the last 10 years, but little is known of the network structure and dynamics of viral transmission in this group. The overwhelming majority of UK heterosexual infections are of non-B HIV subtypes, indicating viruses orig...

journal_title：PLoS pathogens

authors： Hughes GJ,Fearnhill E,Dunn D,Lycett SJ,Rambaut A,Leigh Brown AJ,UK HIV Drug Resistance Collaboration.

更新日期：2009-09-01 00:00:00

abstract：:Positive-strand RNA viruses replicate in host cells by forming large viral replication organelles, which harbor numerous membrane-bound viral replicase complexes (VRCs). In spite of its essential role in viral replication, the biogenesis of the VRCs is not fully understood. The authors identified critical roles of cel...

journal_title：PLoS pathogens

authors： Feng Z,Kovalev N,Nagy PD

更新日期：2020-12-28 00:00:00

abstract：:The ability of the tubercle bacillus to arrest phagosome maturation is considered one major mechanism that allows its survival within host macrophages. To identify mycobacterial genes involved in this process, we developed a high throughput phenotypic cell-based assay enabling individual sub-cellular analysis of over ...

journal_title：PLoS pathogens

authors： Brodin P,Poquet Y,Levillain F,Peguillet I,Larrouy-Maumus G,Gilleron M,Ewann F,Christophe T,Fenistein D,Jang J,Jang MS,Park SJ,Rauzier J,Carralot JP,Shrimpton R,Genovesio A,Gonzalo-Asensio JA,Puzo G,Martin C,Brosch R

更新日期：2010-09-09 00:00:00

abstract：:The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle. Although many proteins involved in kDNA replication and segregation are now known, several key steps in the replication...

journal_title：PLoS pathogens

authors： Peña-Diaz P,Vancová M,Resl C,Field MC,Lukeš J

更新日期：2017-04-07 00:00:00

abstract：:The SUPPRESSOR OF rps4-RLD1 (SRFR1) gene was identified based on enhanced AvrRps4-triggered resistance in the naturally susceptible Arabidopsis accession RLD. No other phenotypic effects were recorded, and the extent of SRFR1 involvement in regulating effector-triggered immunity was unknown. Here we show that mutation...

journal_title：PLoS pathogens

authors： Kim SH,Gao F,Bhattacharjee S,Adiasor JA,Nam JC,Gassmann W

更新日期：2010-11-04 00:00:00

abstract：:Dengue is the most common mosquito-borne viral disease in humans. Changes of lipid-related metabolites in endoplasmic reticulum of dengue virus (DENV) infected cells have been associated with replicative complexes formation. Previously, we reported that DENV infection inhibits HMGCR phosphorylation generating a choles...

journal_title：PLoS pathogens

authors： Soto-Acosta R,Bautista-Carbajal P,Cervantes-Salazar M,Angel-Ambrocio AH,Del Angel RM

更新日期：2017-04-06 00:00:00