Mobile genetic element SCCmec-encoded psm-mec RNA suppresses translation of agrA and attenuates MRSA virulence.

abstract：:The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> 10 μm and up to 100 μm). We found and optimized in vitro conditions that produce titan cells in order to identify the ancestry of titan c...

journal_title：PLoS pathogens

authors： Hommel B,Mukaremera L,Cordero RJB,Coelho C,Desjardins CA,Sturny-Leclère A,Janbon G,Perfect JR,Fraser JA,Casadevall A,Cuomo CA,Dromer F,Nielsen K,Alanio A

更新日期：2018-05-18 00:00:00

abstract：:The bank vole is a rodent susceptible to different prion strains from humans and various animal species. We analyzed the transmission features of different prions in a panel of seven rodent species which showed various degrees of phylogenetic affinity and specific prion protein (PrP) sequence divergences in order to i...

journal_title：PLoS pathogens

authors： Agrimi U,Nonno R,Dell'Omo G,Di Bari MA,Conte M,Chiappini B,Esposito E,Di Guardo G,Windl O,Vaccari G,Lipp HP

更新日期：2008-07-25 00:00:00

abstract：:Plants are constantly exposed to a large and diverse array of microbes; however, most plants are immune to the majority of potential invaders and susceptible to only a small subset of pathogens. The cytoskeleton comprises a dynamic intracellular framework that responds rapidly to biotic stresses and supports numerous ...

journal_title：PLoS pathogens

authors： Henty-Ridilla JL,Shimono M,Li J,Chang JH,Day B,Staiger CJ

更新日期：2013-01-01 00:00:00

abstract：:Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in the development of new effective vaccines and in the appropriate use of antimalarial drugs. By performing a full-genome s...

journal_title：PLoS pathogens

authors： Kidgell C,Volkman SK,Daily J,Borevitz JO,Plouffe D,Zhou Y,Johnson JR,Le Roch K,Sarr O,Ndir O,Mboup S,Batalov S,Wirth DF,Winzeler EA

更新日期：2006-06-01 00:00:00

abstract：:HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics remains unclear. In Japan, HIV-1 Reverse Transcriptase codon 135 (RT135) is under strong immune pressure by HLA-B*51:01-restricted and HLA-B*52:01-restricted T ce...

journal_title：PLoS pathogens

authors： Akahoshi T,Gatanaga H,Kuse N,Chikata T,Koyanagi M,Ishizuka N,Brumme CJ,Murakoshi H,Brumme ZL,Oka S,Takiguchi M

更新日期：2020-12-28 00:00:00

abstract：:Plants have evolved pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) to protect themselves from infection by diverse pathogens. Avirulence (Avr) effectors that trigger plant ETI as a result of recognition by plant resistance (R) gene products have been identif...

journal_title：PLoS pathogens

authors： Dong S,Yin W,Kong G,Yang X,Qutob D,Chen Q,Kale SD,Sui Y,Zhang Z,Dou D,Zheng X,Gijzen M,Tyler BM,Wang Y

更新日期：2011-11-01 00:00:00

abstract：:Competence stimulating peptide (CSP) is a 17-amino acid peptide pheromone secreted by Streptococcus pneumoniae. Upon binding of CSP to its membrane-associated receptor kinase ComD, a cascade of signaling events is initiated, leading to activation of the competence regulon by the response regulator ComE. Genes encoding...

journal_title：PLoS pathogens

authors： Zhu L,Lau GW

更新日期：2011-09-01 00:00:00

abstract：:Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related ...

journal_title：PLoS pathogens

authors： Cotter PD,Draper LA,Lawton EM,Daly KM,Groeger DS,Casey PG,Ross RP,Hill C

更新日期：2008-09-12 00:00:00

abstract：:Since Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) was first identified in Kaposi's sarcoma (KS) lesions of HIV-infected individuals with AIDS, the basic biological understanding of KSHV has progressed remarkably. However, the absence of a proper animal model for KSHV continues to impede direc...

journal_title：PLoS pathogens

authors： Chang H,Wachtman LM,Pearson CB,Lee JS,Lee HR,Lee SH,Vieira J,Mansfield KG,Jung JU

更新日期：2009-10-01 00:00:00

abstract：:Knowledge of the within-host frequencies of resistance-associated amino acid variants (RAVs) is important to the identification of optimal drug combinations for the treatment of hepatitis C virus (HCV) infection. Multiple RAVs may exist in infected individuals, often below detection limits, at any resistance locus, de...

journal_title：PLoS pathogens

authors： Raja R,Pareek A,Newar K,Dixit NM

更新日期：2019-04-01 00:00:00

abstract：:Eradication of tuberculosis (TB), the world's leading cause of death due to infectious disease, requires a highly efficacious TB vaccine. Many TB vaccine candidates are in pre-clinical and clinical development but only a few can be advanced to large-scale efficacy trials due to limited global resources. We aimed to pe...

journal_title：PLoS pathogens

authors： Rodo MJ,Rozot V,Nemes E,Dintwe O,Hatherill M,Little F,Scriba TJ

更新日期：2019-03-04 00:00:00

abstract：:The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB) encoded in the N-t...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Sandalova T,Sun R,Achour A,Masucci MG

更新日期：2019-11-11 00:00:00

abstract：:Plants and animals mediate early steps of the innate immune response through pathogen recognition receptors (PRRs). PRRs commonly associate with or contain members of a monophyletic group of kinases called the interleukin-1 receptor-associated kinase (IRAK) family that include Drosophila Pelle, human IRAKs, rice XA21 ...

journal_title：PLoS pathogens

authors： Dardick C,Ronald P

更新日期：2006-01-01 00:00:00

abstract：:The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell-mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number of important features of the immune system that relate directly to the...

journal_title：PLoS pathogens

authors： Chen CY,Huang D,Wang RC,Shen L,Zeng G,Yao S,Shen Y,Halliday L,Fortman J,McAllister M,Estep J,Hunt R,Vasconcelos D,Du G,Porcelli SA,Larsen MH,Jacobs WR Jr,Haynes BF,Letvin NL,Chen ZW

更新日期：2009-04-01 00:00:00

abstract：:Transmission of prions between species is limited by the "species barrier," which hampers a full characterization of human prion strains in the mouse model. We report that the efficiency of primary transmission of prions from Creutzfeldt-Jakob disease patients to a wild rodent species, the bank vole (Clethrionomys gla...

journal_title：PLoS pathogens

authors： Nonno R,Di Bari MA,Cardone F,Vaccari G,Fazzi P,Dell'Omo G,Cartoni C,Ingrosso L,Boyle A,Galeno R,Sbriccoli M,Lipp HP,Bruce M,Pocchiari M,Agrimi U

更新日期：2006-02-01 00:00:00

abstract：:The two-component system (TCS) KdpD/KdpE, extensively studied for its regulatory role in potassium (K(+)) transport, has more recently been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria, including Staphylococcus aureus, entero-haemorrhagic Escherichia c...

journal_title：PLoS pathogens

authors： Freeman ZN,Dorus S,Waterfield NR

更新日期：2013-03-01 00:00:00

abstract：:Recognition of intracellular pathogenic bacteria by members of the nucleotide-binding domain and leucine-rich repeat containing (NLR) family triggers immune responses against bacterial infection. A major response induced by several Gram-negative bacteria is the activation of caspase-1 via the Nlrc4 inflammasome. Upon ...

journal_title：PLoS pathogens

authors： Suzuki S,Franchi L,He Y,Muñoz-Planillo R,Mimuro H,Suzuki T,Sasakawa C,Núñez G

更新日期：2014-02-06 00:00:00

abstract：:Hepatitis B virus infection (HBV) is a major risk factor for the development of hepatocellular carcinoma. HBV replicates from a covalently closed circular DNA (cccDNA) that remains as an episome within the nucleus of infected cells and serves as a template for the transcription of HBV RNAs. The regulatory protein HBx ...

journal_title：PLoS pathogens

authors： Ducroux A,Benhenda S,Rivière L,Semmes OJ,Benkirane M,Neuveut C

更新日期：2014-09-11 00:00:00

abstract：:Apicomplexans are obligate intracellular parasites that actively penetrate their host cells to create an intracellular niche for replication. Commitment to invasion is thought to be mediated by the rhoptries, specialized apical secretory organelles that inject a protein complex into the host cell to form a tight-junct...

journal_title：PLoS pathogens

authors： Beck JR,Fung C,Straub KW,Coppens I,Vashisht AA,Wohlschlegel JA,Bradley PJ

更新日期：2013-02-01 00:00:00

abstract：:Pili of pathogenic Neisseria are major virulence factors associated with adhesion, twitching motility, auto-aggregation, and DNA transformation. Pili of N. meningitidis are subject to several different post-translational modifications. Among these pilin modifications, the presence of phosphorylcholine (ChoP) and a gly...

journal_title：PLoS pathogens

authors： Jen FE,Warren MJ,Schulz BL,Power PM,Swords WE,Weiser JN,Apicella MA,Edwards JL,Jennings MP

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006634.]. ...

journal_title：PLoS pathogens

authors： Walsh D

更新日期：2018-01-04 00:00:00

abstract：:Toxoplasma gondii possesses an armada of secreted virulent factors that enable parasite invasion and survival into host cells. These factors are contained in specific secretory organelles, the rhoptries, micronemes and dense granules that release their content upon host cell recognition. Dense granules are secreted in...

journal_title：PLoS pathogens

authors： Venugopal K,Chehade S,Werkmeister E,Barois N,Periz J,Lafont F,Tardieux I,Khalife J,Langsley G,Meissner M,Marion S

更新日期：2020-05-28 00:00:00

abstract：:The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood. Recent studies demonstrated that CCR5-tropic HIV-1 efficiently enters tissue-derived memory CD4+ T cells expressin...

journal_title：PLoS pathogens

authors： Hsiao F,Frouard J,Gramatica A,Xie G,Telwatte S,Lee GQ,Roychoudhury P,Schwarzer R,Luo X,Yukl SA,Lee S,Hoh R,Deeks SG,Jones RB,Cavrois M,Greene WC,Roan NR

更新日期：2020-04-30 00:00:00

abstract：:Type I interferons (IFN) are important for antiviral responses. Melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-induced gene I (RIG-I) proteins detect cytosolic double-stranded RNA (dsRNA) or 5'-triphosphate (5'-ppp) RNA and mediate IFN production. Cytosolic 5'-ppp RNA and dsRNA are generated duri...

journal_title：PLoS pathogens

authors： Nikonov A,Mölder T,Sikut R,Kiiver K,Männik A,Toots U,Lulla A,Lulla V,Utt A,Merits A,Ustav M

更新日期：2013-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a global public health burden for which no licensed vaccine exists. To aid vaccine development via increased understanding of the protective antibody response to RSV prefusion glycoprotein F (PreF), we performed structural and functional studies using the human neutralizing antibod...

journal_title：PLoS pathogens

authors： Harshbarger W,Tian S,Wahome N,Balsaraf A,Bhattacharya D,Jiang D,Pandey R,Tungare K,Friedrich K,Mehzabeen N,Biancucci M,Chinchilla-Olszar D,Mallett CP,Huang Y,Wang Z,Bottomley MJ,Malito E,Chandramouli S

更新日期：2020-11-02 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein hijacks the host ubiquitin machinery to activate IκB kinases (IKKs) and NF-κB and promote cell survival; however, the key ubiquitinated factors downstream of Tax involved in cell transformation are unknown. Using mass spectrometry, we undertook an unbiased pr...

journal_title：PLoS pathogens

authors： Choi YB,Harhaj EW

更新日期：2014-10-23 00:00:00

abstract：:Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in the Plasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated a pepc null mutant (D10(Δpepc) ), which was only achievable when malate, a reduction product o...

journal_title：PLoS pathogens

authors： Storm J,Sethia S,Blackburn GJ,Chokkathukalam A,Watson DG,Breitling R,Coombs GH,Müller S

更新日期：2014-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I degradation. A systematic proteomic study using Plasma Membrane ...

journal_title：PLoS pathogens

authors： Hsu JL,van den Boomen DJ,Tomasec P,Weekes MP,Antrobus R,Stanton RJ,Ruckova E,Sugrue D,Wilkie GS,Davison AJ,Wilkinson GW,Lehner PJ

更新日期：2015-04-14 00:00:00

abstract：:Since mucosal surfaces may be simultaneously colonized by multiple species, the success of an organism may be determined by its ability to compete with co-inhabitants of its niche. To explore the contribution of host factors to polymicrobial competition, a murine model was used to study the initiation of colonization ...

journal_title：PLoS pathogens

authors： Lysenko ES,Ratner AJ,Nelson AL,Weiser JN

更新日期：2005-09-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1007696.]. ...

journal_title：PLoS pathogens

authors： Dewan KK,Taylor-Mulneix DL,Campos LL,Skarlupka AL,Wagner SM,Ryman VE,Gestal MC,Ma L,Blas-Machado U,Faddis BT,Harvill ET

更新日期：2019-06-28 00:00:00