Abstract:
:Increasing evidence suggests important roles for long noncoding RNAs (lncRNAs) as new gene modulators involved in various biological processes. However, the function roles of lncRNAs in lower vertebrates are still unknown. Here, we firstly identify a lncRNA, named MAVS antiviral-related lncRNA (MARL), as a key regulator for antiviral immunity in teleost fish. The results indicate that fish MAVS play essential roles in host antiviral responses and inhibition of Siniperca chuatsi rhabdovirus (SCRV) replication. miR-122 reduces MAVS expression and suppress MAVS-mediated antiviral responses, which may help viruses evade host antiviral responses. Further, MARL functions as a competing endogenous RNA (ceRNA) for miR-122 to control protein abundance of MAVS, thereby inhibiting SCRV replication and promoting antiviral responses. Our data not only shed new light on understanding the function role of lncRNA in biological processes in lower vertebrates, but confirmed the hypothesis that ceRNA regulatory networks exist widely in vertebrates.
journal_name
PLoS Pathogjournal_title
PLoS pathogensauthors
Chu Q,Xu T,Zheng W,Chang R,Zhang Ldoi
10.1371/journal.ppat.1008670subject
Has Abstractpub_date
2020-07-17 00:00:00pages
e1008670issue
7eissn
1553-7366issn
1553-7374pii
PPATHOGENS-D-20-00669journal_volume
16pub_type
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