当前位置： SCI文献检索 > PLoS Pathogens期刊下所有文献 > Mannose binding lectin is required for alphavirus-induced arthritis/myositis.

Mannose binding lectin is required for alphavirus-induced arthritis/myositis.

Abstract：

:Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis. The pathology of RRV-induced disease in both humans and mice is associated with induction of the host inflammatory response within the muscle and joints, and prior studies have demonstrated that the host complement system contributes to development of disease. In this study, we have used a mouse model of RRV-induced disease to identify and characterize which complement activation pathways mediate disease progression after infection, and we have identified the mannose binding lectin (MBL) pathway, but not the classical or alternative complement activation pathways, as essential for development of RRV-induced disease. MBL deposition was enhanced in RRV infected muscle tissue from wild type mice and RRV infected MBL deficient mice exhibited reduced disease, tissue damage, and complement deposition compared to wild-type mice. In contrast, mice deficient for key components of the classical or alternative complement activation pathways still developed severe RRV-induced disease. Further characterization of MBL deficient mice demonstrated that similar to C3(-/-) mice, viral replication and inflammatory cell recruitment were equivalent to wild type animals, suggesting that RRV-mediated induction of complement dependent immune pathology is largely MBL dependent. Consistent with these findings, human patients diagnosed with RRV disease had elevated serum MBL levels compared to healthy controls, and MBL levels in the serum and synovial fluid correlated with severity of disease. These findings demonstrate a role for MBL in promoting RRV-induced disease in both mice and humans and suggest that the MBL pathway of complement activation may be an effective target for therapeutic intervention for humans suffering from RRV-induced arthritis and myositis.

journal_name

PLoS Pathog

journal_title

PLoS pathogens

authors

Gunn BM,Morrison TE,Whitmore AC,Blevins LK,Hueston L,Fraser RJ,Herrero LJ,Ramirez R,Smith PN,Mahalingam S,Heise MT

doi

10.1371/journal.ppat.1002586

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

e1002586

issue

eissn

1553-7366

issn

1553-7374

pii

PPATHOGENS-D-11-02232

journal_volume

pub_type

杂志文章

在线工具

Mannose binding lectin is required for alphavirus-induced arthritis/myositis.