Molecular evolution of a viral non-coding sequence under the selective pressure of amiRNA-mediated silencing.

abstract：:HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics remains unclear. In Japan, HIV-1 Reverse Transcriptase codon 135 (RT135) is under strong immune pressure by HLA-B*51:01-restricted and HLA-B*52:01-restricted T ce...

journal_title：PLoS pathogens

authors： Akahoshi T,Gatanaga H,Kuse N,Chikata T,Koyanagi M,Ishizuka N,Brumme CJ,Murakoshi H,Brumme ZL,Oka S,Takiguchi M

更新日期：2020-12-28 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1005698.]. ...

journal_title：PLoS pathogens

authors： Ersching J,Basso AS,Calich VL,Bortoluci KR,Rodrigues MM

更新日期：2016-07-11 00:00:00

abstract：:Turnip yellow mosaic virus (TYMV)--a member of the alphavirus-like supergroup of viruses--serves as a model system for positive-stranded RNA virus membrane-bound replication. TYMV encodes a precursor replication polyprotein that is processed by the endoproteolytic activity of its internal cysteine proteinase domain (P...

journal_title：PLoS pathogens

authors： Lombardi C,Ayach M,Beaurepaire L,Chenon M,Andreani J,Guerois R,Jupin I,Bressanelli S

更新日期：2013-08-01 00:00:00

abstract：:A key difference that distinguishes viral infections from protein immunizations is the recognition of viral nucleic acids by cytosolic pattern recognition receptors (PRRs). Insights into the functions of cytosolic PRRs such as the RNA-sensing Rig-I-like receptors (RLRs) in the instruction of adaptive immunity are ther...

journal_title：PLoS pathogens

authors： O'Ketch M,Williams S,Larson C,Uhrlaub JL,Wong R,Hall B,Deshpande NR,Schenten D

更新日期：2020-10-26 00:00:00

abstract：:Blocking neurotransmission, botulinum neurotoxin is the most poisonous biological substance known to mankind. Despite its infamy as the scourge of the food industry, the neurotoxin is increasingly used as a pharmaceutical to treat an expanding range of muscle disorders. Whilst neurotoxin expression by the spore-formin...

journal_title：PLoS pathogens

authors： Zhang Z,Korkeala H,Dahlsten E,Sahala E,Heap JT,Minton NP,Lindström M

更新日期：2013-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) suppress the transcriptional and post-transcriptional expression of genes in plants. Several miRNA families target genes encoding nucleotide-binding site-leucine-rich repeat (NB-LRR) plant innate immune receptors. The fungus Fusarium oxysporum f. sp. lycopersici causes vascular wilt disease in tomat...

journal_title：PLoS pathogens

authors： Ouyang S,Park G,Atamian HS,Han CS,Stajich JE,Kaloshian I,Borkovich KA

更新日期：2014-10-16 00:00:00

abstract：:Staphylococcus aureus USA300 strains cause a highly inflammatory necrotizing pneumonia. The virulence of this strain has been attributed to its expression of multiple toxins that have diverse targets including ADAM10, NLRP3 and CD11b. We demonstrate that induction of necroptosis through RIP1/RIP3/MLKL signaling is a m...

journal_title：PLoS pathogens

authors： Kitur K,Parker D,Nieto P,Ahn DS,Cohen TS,Chung S,Wachtel S,Bueno S,Prince A

更新日期：2015-04-16 00:00:00

abstract：:Hospitalization of the elderly for invasive pneumococcal disease is frequently accompanied by the occurrence of an adverse cardiac event; these are primarily new or worsened heart failure and cardiac arrhythmia. Herein, we describe previously unrecognized microscopic lesions (microlesions) formed within the myocardium...

journal_title：PLoS pathogens

authors： Brown AO,Mann B,Gao G,Hankins JS,Humann J,Giardina J,Faverio P,Restrepo MI,Halade GV,Mortensen EM,Lindsey ML,Hanes M,Happel KI,Nelson S,Bagby GJ,Lorent JA,Cardinal P,Granados R,Esteban A,LeSaux CJ,Tuomanen EI,Or

更新日期：2014-09-18 00:00:00

abstract：:The recent emergence of a novel H7N9 influenza A virus (IAV) causing severe human infections in China raises concerns about a possible pandemic. The lack of pre-existing neutralizing antibodies in the broader population highlights the potential protective role of IAV-specific CD8(+) cytotoxic T lymphocyte (CTL) memory...

journal_title：PLoS pathogens

authors： Duan S,Meliopoulos VA,McClaren JL,Guo XZ,Sanders CJ,Smallwood HS,Webby RJ,Schultz-Cherry SL,Doherty PC,Thomas PG

更新日期：2015-02-10 00:00:00

abstract：:Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains unclear. Using a computational approach on HIV gag/pol/nef sequences ...

journal_title：PLoS pathogens

authors： Erdmann N,Du VY,Carlson J,Schaefer M,Jureka A,Sterrett S,Yue L,Dilernia D,Lakhi S,Tang J,Sidney J,Gilmour J,Allen S,Hunter E,Heath S,Bansal A,Goepfert PA

更新日期：2015-08-24 00:00:00

abstract：:Virions are thought to contain all the essential proteins that govern virus egress from the host cell and initiation of replication in the target cell. It has been known for some time that influenza virions contain nine viral proteins; however, analyses of other enveloped viruses have revealed that proteins from the h...

journal_title：PLoS pathogens

authors： Shaw ML,Stone KL,Colangelo CM,Gulcicek EE,Palese P

更新日期：2008-06-06 00:00:00

abstract：:Apolipoprotein E (ApoE) belongs to a class of cellular proteins involved in lipid metabolism. ApoE is a polymorphic protein produced primarily in macrophages and astrocytes. Different isoforms of ApoE have been associated with susceptibility to various diseases including Alzheimer's and cardiovascular diseases. ApoE e...

journal_title：PLoS pathogens

authors： Siddiqui R,Suzu S,Ueno M,Nasser H,Koba R,Bhuyan F,Noyori O,Hamidi S,Sheng G,Yasuda-Inoue M,Hishiki T,Sukegawa S,Miyagi E,Strebel K,Matsushita S,Shimotohno K,Ariumi Y

更新日期：2018-11-29 00:00:00

abstract：:Virus-like particles (VLPs) have not been observed in Caenorhabditis germ cells, although nematode genomes contain low numbers of retrotransposon and retroviral sequences. We used electron microscopy to search for VLPs in various wild strains of Caenorhabditis, and observed very rare candidate VLPs in some strains, in...

journal_title：PLoS pathogens

authors： Dennis S,Sheth U,Feldman JL,English KA,Priess JR

更新日期：2012-01-01 00:00:00

abstract：:Gut dysbiosis associated with intestinal inflammation is characterized by the blooming of particular bacteria such as adherent-invasive E. coli (AIEC). However, the precise mechanisms by which AIEC impact on colitis remain largely unknown. Here we show that antibiotic-induced dysbiosis worsened chemically-induced coli...

journal_title：PLoS pathogens

authors： Ohno M,Hasegawa M,Hayashi A,Caballero-Flores G,Alteri CJ,Lawley TD,Kamada N,Núñez G,Inohara N

更新日期：2020-10-07 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) genome encodes a G protein-coupled receptor (vGPCR). vGPCR is a ligand-independent, constitutively active signaling molecule that promotes cell growth and proliferation; however, it is not clear how vGPCR is negatively regulated. We report here that the KSHV K7 small ...

journal_title：PLoS pathogens

authors： Feng H,Dong X,Negaard A,Feng P

更新日期：2008-09-19 00:00:00

abstract：:Microbial pathogens often establish infection within particular niches of their host for replication. Determining how infection occurs preferentially in specific host tissues is a key aspect of understanding host-microbe interactions. Here, we describe the discovery of a natural microsporidian parasite of the nematode...

journal_title：PLoS pathogens

authors： Luallen RJ,Reinke AW,Tong L,Botts MR,Félix MA,Troemel ER

更新日期：2016-06-30 00:00:00

abstract：:Viroporins are small transmembrane proteins with ion channel activities modulating properties of intracellular membranes that have diverse proviral functions. Hepatitis C virus (HCV) encodes a viroporin, p7, acting during assembly, envelopment and secretion of viral particles (VP). HCV p7 is released from the viral po...

journal_title：PLoS pathogens

authors： Denolly S,Mialon C,Bourlet T,Amirache F,Penin F,Lindenbach B,Boson B,Cosset FL

更新日期：2017-12-18 00:00:00

abstract：:Nematode parasites secrete molecules which regulate the mammalian immune system, but their genetic intractability is a major impediment to identifying and characterising the biological effects of these molecules. We describe here a novel system for heterologous expression of helminth secreted proteins in the natural p...

journal_title：PLoS pathogens

authors： Vaux R,Schnoeller C,Berkachy R,Roberts LB,Hagen J,Gounaris K,Selkirk ME

更新日期：2016-11-01 00:00:00

abstract：:In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neuritogenesis, to prion d...

journal_title：PLoS pathogens

authors： Alleaume-Butaux A,Nicot S,Pietri M,Baudry A,Dakowski C,Tixador P,Ardila-Osorio H,Haeberlé AM,Bailly Y,Peyrin JM,Launay JM,Kellermann O,Schneider B

更新日期：2015-08-04 00:00:00

abstract：:Glycolysis is a metabolic pathway that is central to the assimilation of carbon for either respiration or fermentation and therefore is critical for the growth of all organisms. Consequently, glycolytic transcriptional regulation is important for the metabolic flexibility of pathogens in their attempts to colonize div...

journal_title：PLoS pathogens

authors： Askew C,Sellam A,Epp E,Hogues H,Mullick A,Nantel A,Whiteway M

更新日期：2009-10-01 00:00:00

abstract：:Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens. Colonization by Streptococcus pneumoniae, which is central to the organism's transmission and therefore evolution, is limited by two arms of the immune system: antibody- and T cell- mediated i...

journal_title：PLoS pathogens

authors： Li Y,Gierahn T,Thompson CM,Trzciński K,Ford CB,Croucher N,Gouveia P,Flechtner JB,Malley R,Lipsitch M

更新日期：2012-01-01 00:00:00

abstract：:Intracellular pathogens must withstand nitric oxide (NO.) generated by host phagocytes. Salmonella enterica serovar Typhimurium interferes with intracellular trafficking of inducible nitric oxide synthase (iNOS) and possesses multiple systems to detoxify NO.. Consequently, the level of NO. stress encountered by S. Typ...

journal_title：PLoS pathogens

authors： Richardson AR,Soliven KC,Castor ME,Barnes PD,Libby SJ,Fang FC

更新日期：2009-05-01 00:00:00

abstract：:Magnaporthe oryzae is the causal agent of rice blast disease, a devastating problem worldwide. This fungus has caused breakdown of resistance conferred by newly developed commercial cultivars. To address how the rice blast fungus adapts itself to new resistance genes so quickly, we examined chromosomal locations of AV...

journal_title：PLoS pathogens

authors： Chuma I,Isobe C,Hotta Y,Ibaragi K,Futamata N,Kusaba M,Yoshida K,Terauchi R,Fujita Y,Nakayashiki H,Valent B,Tosa Y

更新日期：2011-07-01 00:00:00

abstract：:The intrinsic oncotropism and oncosuppressive activities of rodent protoparvoviruses (PVs) are opening new prospects for cancer virotherapy. Virus propagation, cytolytic activity, and spread are tightly connected to activation of the PDK1 signaling cascade, which delays stress-induced cell death and sustains functioni...

journal_title：PLoS pathogens

authors： Bär S,Rommelaere J,Nüesch JP

更新日期：2015-03-05 00:00:00

abstract：:Transformation is an important mechanism of microbial evolution through which bacteria have been observed to rapidly adapt in response to clinical interventions; examples include facilitating vaccine evasion and the development of penicillin resistance in the major respiratory pathogen Streptococcus pneumoniae. To cha...

journal_title：PLoS pathogens

authors： Croucher NJ,Harris SR,Barquist L,Parkhill J,Bentley SD

更新日期：2012-01-01 00:00:00

abstract：:Sensing of viral RNA by RIG-I-like receptors initiates innate antiviral response, which is mediated by the central adaptor VISA. How the RIG-I-VISA-mediated antiviral response is terminated at the late phase of infection is enigmatic. Here we identified the protein kinase A catalytic (PKAC) subunits α and β as negativ...

journal_title：PLoS pathogens

authors： Yan BR,Zhou L,Hu MM,Li M,Lin H,Yang Y,Wang YY,Shu HB

更新日期：2017-09-21 00:00:00

abstract：:Nasal colonization by both gram-positive and gram-negative pathogens induces expression of the innate immune protein lipocalin 2 (Lcn2). Lcn2 binds and sequesters the iron-scavenging siderophore enterobactin (Ent), preventing bacterial iron acquisition. In addition, Lcn2 bound to Ent induces release of IL-8 from cultu...

journal_title：PLoS pathogens

authors： Bachman MA,Miller VL,Weiser JN

更新日期：2009-10-01 00:00:00

abstract：:Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel member of this family from Pseudomonas aeruginosa, targets susceptible strains of this species through recognition of the common polysaccharide antigen (CPA) of...

journal_title：PLoS pathogens

authors： McCaughey LC,Grinter R,Josts I,Roszak AW,Waløen KI,Cogdell RJ,Milner J,Evans T,Kelly S,Tucker NP,Byron O,Smith B,Walker D

更新日期：2014-02-06 00:00:00

abstract：:Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutio...

journal_title：PLoS pathogens

authors： Deeg CM,Zimmer MM,George EE,Husnik F,Keeling PJ,Suttle CA

更新日期：2019-05-31 00:00:00

abstract：:Bursaphelenchus xylophilus is the nematode responsible for a devastating epidemic of pine wilt disease in Asia and Europe, and represents a recent, independent origin of plant parasitism in nematodes, ecologically and taxonomically distinct from other nematodes for which genomic data is available. As well as being an ...

journal_title：PLoS pathogens

authors： Kikuchi T,Cotton JA,Dalzell JJ,Hasegawa K,Kanzaki N,McVeigh P,Takanashi T,Tsai IJ,Assefa SA,Cock PJ,Otto TD,Hunt M,Reid AJ,Sanchez-Flores A,Tsuchihara K,Yokoi T,Larsson MC,Miwa J,Maule AG,Sahashi N,Jones JT,Berr

更新日期：2011-09-01 00:00:00