Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor.

abstract：:The flagellum organelle is an intricate multiprotein assembly best known for its rotational propulsion of bacteria. However, recent studies have expanded our knowledge of other functions in pathogenic contexts, particularly adherence and immune modulation, e.g., for Salmonella enterica, Campylobacter jejuni, Pseudomon...

journal_title：PLoS pathogens

authors： Rossez Y,Wolfson EB,Holmes A,Gally DL,Holden NJ

更新日期：2015-01-15 00:00:00

abstract：:The factors determining the functional avidity and its relationship with the broad heterogeneity of antiviral T cell responses remain partially understood. We investigated HIV-specific CD8 T cell responses in 85 patients with primary HIV infection (PHI) or chronic (progressive and non-progressive) infection. The funct...

journal_title：PLoS pathogens

authors： Viganò S,Bellutti Enders F,Miconnet I,Cellerai C,Savoye AL,Rozot V,Perreau M,Faouzi M,Ohmiti K,Cavassini M,Bart PA,Pantaleo G,Harari A

更新日期：2013-01-01 00:00:00

abstract：:In an effort to suppress microbial outgrowth, the host sequesters essential nutrients in a process termed nutritional immunity. However, inflammatory responses to bacterial insult can restore nutritional resources. Given that nutrient availability modulates virulence factor production and biofilm formation by other ba...

journal_title：PLoS pathogens

authors： Szelestey BR,Heimlich DR,Raffel FK,Justice SS,Mason KM

更新日期：2013-01-01 00:00:00

abstract：:Viruses have evolved several strategies to modify cellular processes and evade the immune response in order to successfully infect, replicate, and persist in the host. By utilizing in-silico testing of a transmembrane sequence library derived from virus protein sequences, we have pin-pointed a nine amino-acid motif sh...

journal_title：PLoS pathogens

authors： Cohen T,Cohen SJ,Antonovsky N,Cohen IR,Shai Y

更新日期：2010-09-02 00:00:00

abstract：:While immunological memory has long been considered the province of T- and B-lymphocytes, it has recently been reported that innate cell populations are capable of mediating memory responses. We now show that an innate memory immune response is generated in mice following infection with vaccinia virus, a poxvirus for ...

journal_title：PLoS pathogens

authors： Gillard GO,Bivas-Benita M,Hovav AH,Grandpre LE,Panas MW,Seaman MS,Haynes BF,Letvin NL

更新日期：2011-08-01 00:00:00

abstract：:Viroporins are small transmembrane proteins with ion channel activities modulating properties of intracellular membranes that have diverse proviral functions. Hepatitis C virus (HCV) encodes a viroporin, p7, acting during assembly, envelopment and secretion of viral particles (VP). HCV p7 is released from the viral po...

journal_title：PLoS pathogens

authors： Denolly S,Mialon C,Bourlet T,Amirache F,Penin F,Lindenbach B,Boson B,Cosset FL

更新日期：2017-12-18 00:00:00

abstract：:Lytic herpes simplex virus 1 (HSV-1) infection triggers disruption of transcription termination (DoTT) of most cellular genes, resulting in extensive intergenic transcription. Similarly, cellular stress responses lead to gene-specific transcription downstream of genes (DoG). In this study, we performed a detailed comp...

journal_title：PLoS pathogens

authors： Hennig T,Michalski M,Rutkowski AJ,Djakovic L,Whisnant AW,Friedl MS,Jha BA,Baptista MAP,L'Hernault A,Erhard F,Dölken L,Friedel CC

更新日期：2018-03-26 00:00:00

abstract：:Accurate calculation of mutation rates for viruses and viroids is necessary for evolutionary studies and to evaluate adaptation potential. However, estimation of in vivo mutation rates is complicated by selection, which leads to loss or proliferation of certain mutations. To minimize this concern, lethal mutations, in...

journal_title：PLoS pathogens

authors： Wu J,Bisaro DM

更新日期：2020-12-22 00:00:00

abstract：:Bacteria of the Burkholderia cepacia complex (Bcc) can cause devastating pulmonary infections in cystic fibrosis (CF) patients, yet the precise mechanisms underlying inflammation, recurrent exacerbations and transition from chronic stages to acute infection and septicemia are not known. Bcc bacteria are generally beli...

journal_title：PLoS pathogens

authors： Mesureur J,Feliciano JR,Wagner N,Gomes MC,Zhang L,Blanco-Gonzalez M,van der Vaart M,O'Callaghan D,Meijer AH,Vergunst AC

更新日期：2017-06-26 00:00:00

abstract：:RNA interference (RNAi) pathways are widespread in metaozoans but the genes required show variable occurrence or activity in eukaryotic microbes, including many pathogens. While some Leishmania lack RNAi activity and Argonaute or Dicer genes, we show that Leishmania braziliensis and other species within the Leishmania...

journal_title：PLoS pathogens

authors： Lye LF,Owens K,Shi H,Murta SM,Vieira AC,Turco SJ,Tschudi C,Ullu E,Beverley SM

更新日期：2010-10-28 00:00:00

abstract：:A global increase in invasive infections due to group A Streptococcus (S. pyogenes or GAS) has been observed since the 1980s, associated with emergence of a clonal group of strains of the M1T1 serotype. Among other virulence attributes, the M1T1 clone secretes NAD+-glycohydrolase (NADase). When GAS binds to epithelial...

journal_title：PLoS pathogens

authors： Sharma O,O'Seaghdha M,Velarde JJ,Wessels MR

更新日期：2016-03-03 00:00:00

abstract：:We have identified from the mutualistic grass endophyte Epichloë festucae a non-ribosomal peptide synthetase gene (sidN) encoding a siderophore synthetase. The enzymatic product of SidN is shown to be a novel extracellular siderophore designated as epichloënin A, related to ferrirubin from the ferrichrome family. Targ...

journal_title：PLoS pathogens

authors： Johnson LJ,Koulman A,Christensen M,Lane GA,Fraser K,Forester N,Johnson RD,Bryan GT,Rasmussen S

更新日期：2013-01-01 00:00:00

abstract：:The AraC Negative Regulators (ANR) comprise a large family of virulence regulators distributed among diverse clinically important Gram-negative pathogens, including Vibrio spp., Salmonella spp., Shigella spp., Yersinia spp., Citrobacter spp., and pathogenic E. coli strains. We have previously reported broad effects of...

journal_title：PLoS pathogens

authors： Santiago AE,Yan MB,Hazen TH,Sauder B,Meza-Segura M,Rasko DA,Kendall MM,Ruiz-Perez F,Nataro JP

更新日期：2017-08-14 00:00:00

abstract：:The Adeno-associated virus (AAV) gene delivery system is ushering in a new and exciting era in the United States; following the first approved gene therapy (Glybera) in Europe, the FDA has approved a second therapy, Luxturna [1]. However, challenges to this system remain. In viral gene therapy, the surface of the caps...

journal_title：PLoS pathogens

authors： Smith JK,Agbandje-McKenna M

更新日期：2018-05-03 00:00:00

abstract：:Replication of viroids, small non-protein-coding plant pathogenic RNAs, entails reiterative transcription of their incoming single-stranded circular genomes, to which the (+) polarity is arbitrarily assigned, cleavage of the oligomeric strands of one or both polarities to unit-length, and ligation to circular RNAs. Wh...

journal_title：PLoS pathogens

authors： Gas ME,Hernández C,Flores R,Daròs JA

更新日期：2007-11-01 00:00:00

abstract：:The COVID-19 pandemic highlights the substantial public health, economic, and societal consequences of virus spillover from a wildlife reservoir. Widespread human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also presents a new set of challenges when considering viral spillover from peo...

journal_title：PLoS pathogens

authors： Olival KJ,Cryan PM,Amman BR,Baric RS,Blehert DS,Brook CE,Calisher CH,Castle KT,Coleman JTH,Daszak P,Epstein JH,Field H,Frick WF,Gilbert AT,Hayman DTS,Ip HS,Karesh WB,Johnson CK,Kading RC,Kingston T,Lorch JM,Mend

更新日期：2020-09-03 00:00:00

abstract：:Elucidating virus-host interactions responsible for HIV-1 transmission is important for advancing HIV-1 prevention strategies. To this end, single genome amplification (SGA) and sequencing of HIV-1 within the context of a model of random virus evolution has made possible for the first time an unambiguous identificatio...

journal_title：PLoS pathogens

authors： Li H,Bar KJ,Wang S,Decker JM,Chen Y,Sun C,Salazar-Gonzalez JF,Salazar MG,Learn GH,Morgan CJ,Schumacher JE,Hraber P,Giorgi EE,Bhattacharya T,Korber BT,Perelson AS,Eron JJ,Cohen MS,Hicks CB,Haynes BF,Markowitz M,K

更新日期：2010-05-13 00:00:00

abstract：TRIAL REGISTRATION:ClinicalTrials.gov Clinical Trial NCT00594880. ...

journal_title：PLoS pathogens

authors： Chitre AS,Kattah MG,Rosli YY,Pao M,Deswal M,Deeks SG,Hunt PW,Abdel-Mohsen M,Montaner LJ,Kim CC,Ma A,Somsouk M,McCune JM

更新日期：2018-03-05 00:00:00

abstract：:Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional cure for HIV-infected patients appears to be a more reachable short-term goal. We identified 14 HIV patients (post-treatment controllers [P...

journal_title：PLoS pathogens

authors： Sáez-Cirión A,Bacchus C,Hocqueloux L,Avettand-Fenoel V,Girault I,Lecuroux C,Potard V,Versmisse P,Melard A,Prazuck T,Descours B,Guergnon J,Viard JP,Boufassa F,Lambotte O,Goujard C,Meyer L,Costagliola D,Venet A,Pancin

更新日期：2013-03-01 00:00:00

abstract：:Mycoplasma pneumoniae, a human pathogenic bacterium, glides on host cell surfaces by a unique and unknown mechanism. It forms an attachment organelle at a cell pole as a membrane protrusion composed of surface and internal structures, with a highly organized architecture. In the present study, we succeeded in isolatin...

journal_title：PLoS pathogens

authors： Nakane D,Kenri T,Matsuo L,Miyata M

更新日期：2015-12-03 00:00:00

abstract：:Enterovirus 71 (EV71) is one of the most virulent enteroviruses, but the specific molecular features that enhance its ability to disseminate in humans remain unknown. We analyzed the genomic features of EV71 in an immunocompromised host with disseminated disease according to the different sites of infection. Compariso...

journal_title：PLoS pathogens

authors： Cordey S,Petty TJ,Schibler M,Martinez Y,Gerlach D,van Belle S,Turin L,Zdobnov E,Kaiser L,Tapparel C

更新日期：2012-01-01 00:00:00

abstract：:The microbiome and the phage meta-genome within the human gut are influenced by antibiotic treatments. Identifying a novel mechanism, here we demonstrate that bacteria use the universal communication molecule AI-2 to induce virulence genes and transfer them via phage release. High concentrations (i.e. 100 μM) of AI-2 ...

journal_title：PLoS pathogens

authors： Rossmann FS,Racek T,Wobser D,Puchalka J,Rabener EM,Reiger M,Hendrickx AP,Diederich AK,Jung K,Klein C,Huebner J

更新日期：2015-02-23 00:00:00

abstract：:Plants are constantly exposed to a large and diverse array of microbes; however, most plants are immune to the majority of potential invaders and susceptible to only a small subset of pathogens. The cytoskeleton comprises a dynamic intracellular framework that responds rapidly to biotic stresses and supports numerous ...

journal_title：PLoS pathogens

authors： Henty-Ridilla JL,Shimono M,Li J,Chang JH,Day B,Staiger CJ

更新日期：2013-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) induces interferon (IFN) stimulated genes in the liver despite of distinct innate immune evasion mechanisms, suggesting that beyond HCV infected cells other cell types contribute to innate immune activation. Upon coculture with HCV replicating cells, human CD141+ myeloid dendritic cells (DC) pr...

journal_title：PLoS pathogens

authors： Pfaender S,Grabski E,Detje CN,Riebesehl N,Lienenklaus S,Steinmann E,Kalinke U,Pietschmann T

更新日期：2016-07-06 00:00:00

abstract：:Bacterial bloodstream infections (BSI) are a major health concern and can cause up to 40% mortality. Pseudomonas aeruginosa BSI is often of nosocomial origin and is associated with a particularly poor prognosis. The mechanism of bacterial persistence in blood is still largely unknown. Here, we analyzed the behavior of...

journal_title：PLoS pathogens

authors： Pont S,Fraikin N,Caspar Y,Van Melderen L,Attrée I,Cretin F

更新日期：2020-12-16 00:00:00

abstract：:Recognition of peptidoglycan (PGN) is paramount for insect antibacterial defenses. In the fruit fly Drosophila melanogaster, the transmembrane PGN Recognition Protein LC (PGRP-LC) is a receptor of the Imd signaling pathway that is activated after infection with bacteria, mainly Gram-negative (Gram-). Here we demonstra...

journal_title：PLoS pathogens

authors： Meister S,Agianian B,Turlure F,Relógio A,Morlais I,Kafatos FC,Christophides GK

更新日期：2009-08-01 00:00:00

abstract：:Acute resistance to low dose M. tuberculosis (Mtb) infection is not dependent on Toll-like receptor (TLR) 2. However, whether TLR2 contributes to resistance in chronic Mtb infection has remained uncertain. Here we report that, following low dose aerosol infection with Mtb, mice lacking TLR2 (TLR2KO), in comparison wit...

journal_title：PLoS pathogens

authors： McBride A,Konowich J,Salgame P

更新日期：2013-01-01 00:00:00

abstract：:The host response to mycobacterial infection depends on host and pathogen genetic factors. Recent studies in human populations suggest a strain specific genetic control of tuberculosis. To test for mycobacterial-strain specific genetic control of susceptibility to infection under highly controlled experimental conditi...

journal_title：PLoS pathogens

authors： Di Pietrantonio T,Hernandez C,Girard M,Verville A,Orlova M,Belley A,Behr MA,Loredo-Osti JC,Schurr E

更新日期：2010-10-28 00:00:00

abstract：:Cells of the innate immune system act in synergy to provide a first line of defense against pathogens. Here we describe that dendritic cells (DCs), matured with viral products or mimics thereof, including Epstein-Barr virus (EBV), activated natural killer (NK) cells more efficiently than other mature DC preparations. ...

journal_title：PLoS pathogens

authors： Strowig T,Brilot F,Arrey F,Bougras G,Thomas D,Muller WA,Münz C

更新日期：2008-02-08 00:00:00

abstract：:For many viruses, one or two proteins allow cell attachment and entry, which occurs through the plasma membrane or following endocytosis at low pH. In contrast, vaccinia virus (VACV) enters cells by both neutral and low pH routes; four proteins mediate cell attachment and twelve that are associated in a membrane compl...

journal_title：PLoS pathogens

authors： Laliberte JP,Weisberg AS,Moss B

更新日期：2011-12-01 00:00:00