Hepatitis C Virus Stimulates Murine CD8α-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner.

abstract：:The clinical course of prion diseases is accurately predictable despite long latency periods, suggesting that prion pathogenesis is driven by precisely timed molecular events. We constructed a searchable genome-wide atlas of mRNA abundance and splicing alterations during the course of disease in prion-inoculated mice....

journal_title：PLoS pathogens

authors： Sorce S,Nuvolone M,Russo G,Chincisan A,Heinzer D,Avar M,Pfammatter M,Schwarz P,Delic M,Müller M,Hornemann S,Sanoudou D,Scheckel C,Aguzzi A

更新日期：2020-06-29 00:00:00

abstract：:Lyme disease in humans is caused by several genospecies of the Borrelia burgdorferi sensu lato (s.l.) complex of spirochetal bacteria, including B. burgdorferi, B. afzelii and B. garinii. These bacteria exist in nature as obligate parasites in an enzootic cycle between small vertebrate hosts and Ixodid tick vectors, w...

journal_title：PLoS pathogens

authors： Bhatia B,Hillman C,Carracoi V,Cheff BN,Tilly K,Rosa PA

更新日期：2018-04-05 00:00:00

abstract：:The ~9.5 kilobase HIV-1 genome contains RNA sequences and structures that control many aspects of viral replication, including transcription, splicing, nuclear export, translation, packaging and reverse transcription. Nonetheless, chemical probing and other approaches suggest that the HIV-1 genome may contain many mor...

journal_title：PLoS pathogens

authors： Takata MA,Soll SJ,Emery A,Blanco-Melo D,Swanstrom R,Bieniasz PD

更新日期：2018-01-29 00:00:00

abstract：:KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded miRNAs are readily detectable in all KSHV-associated tumors suggests a potential role in viral pathogenesis and tumorigenesis. MiRNA-mediated regula...

journal_title：PLoS pathogens

authors： Haecker I,Gay LA,Yang Y,Hu J,Morse AM,McIntyre LM,Renne R

更新日期：2012-01-01 00:00:00

abstract：:The N-terminal domains of the herpesvirus large tegument proteins encode a conserved cysteine protease with ubiquitin- and NEDD8-specific deconjugase activity. The proteins are expressed during the productive virus cycle and are incorporated into infectious virus particles, being delivered to the target cells upon pri...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Callegari S,Tsai MH,Delecluse HJ,Masucci MG

更新日期：2018-01-22 00:00:00

abstract：:HIV-1 assembly and release are believed to occur at the plasma membrane in most host cells with the exception of primary macrophages, for which exclusive budding at late endosomes has been reported. Here, we applied a novel ultrastructural approach to assess HIV-1 budding in primary macrophages in an immunomarker-inde...

journal_title：PLoS pathogens

authors： Welsch S,Keppler OT,Habermann A,Allespach I,Krijnse-Locker J,Kräusslich HG

更新日期：2007-03-01 00:00:00

abstract：:Monepantel is a member of the recently identified class of anthelmintics known as the amino-acetonitrile derivatives (AADs). Monepantel controls all major gastro-intestinal nematodes in sheep including those that are resistant to the classical anthelmintics. Previous studies have shown that the Caenorhabditis elegans ...

journal_title：PLoS pathogens

authors： Rufener L,Bedoni N,Baur R,Rey S,Glauser DA,Bouvier J,Beech R,Sigel E,Puoti A

更新日期：2013-01-01 00:00:00

abstract：:The disease phenotype of bovine spongiform encephalopathy (BSE) and the molecular/ biological properties of its prion strain, including the host range and the characteristics of BSE-related disorders, have been extensively studied since its discovery in 1986. In recent years, systematic testing of the brains of cattle...

journal_title：PLoS pathogens

authors： Lombardi G,Casalone C,D' Angelo A,Gelmetti D,Torcoli G,Barbieri I,Corona C,Fasoli E,Farinazzo A,Fiorini M,Gelati M,Iulini B,Tagliavini F,Ferrari S,Caramelli M,Monaco S,Capucci L,Zanusso G

更新日期：2008-05-23 00:00:00

abstract：:The human T cell leukemia virus HTLV-1 establishes a persistent infection in vivo in which the viral sense-strand transcription is usually silent at a given time in each cell. However, cellular stress responses trigger the reactivation of HTLV-1, enabling the virus to transmit to a new host cell. Using single-molecule...

journal_title：PLoS pathogens

authors： Miura M,Dey S,Ramanayake S,Singh A,Rueda DS,Bangham CRM

更新日期：2019-11-18 00:00:00

abstract：:Pathogens often follow more than one transmission route during outbreaks-from needle sharing plus sexual transmission of HIV to small droplet aerosol plus fomite transmission of influenza. Thus, controlling an infectious disease outbreak often requires characterizing the risk associated with multiple mechanisms of tra...

journal_title：PLoS pathogens

authors： Allard A,Althouse BM,Hébert-Dufresne L,Scarpino SV

更新日期：2017-09-21 00:00:00

abstract：:Magnaporthe oryzae is the causal agent of rice blast disease, a devastating problem worldwide. This fungus has caused breakdown of resistance conferred by newly developed commercial cultivars. To address how the rice blast fungus adapts itself to new resistance genes so quickly, we examined chromosomal locations of AV...

journal_title：PLoS pathogens

authors： Chuma I,Isobe C,Hotta Y,Ibaragi K,Futamata N,Kusaba M,Yoshida K,Terauchi R,Fujita Y,Nakayashiki H,Valent B,Tosa Y

更新日期：2011-07-01 00:00:00

abstract：:Vibrio cholerae is a bacterial pathogen that colonizes the chitinous exoskeleton of zooplankton as well as the human gastrointestinal tract. Colonization of these different niches involves an N-acetylglucosamine binding protein (GbpA) that has been reported to mediate bacterial attachment to both marine chitin and mam...

journal_title：PLoS pathogens

authors： Wong E,Vaaje-Kolstad G,Ghosh A,Hurtado-Guerrero R,Konarev PV,Ibrahim AF,Svergun DI,Eijsink VG,Chatterjee NS,van Aalten DM

更新日期：2012-01-01 00:00:00

abstract：:SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been proposed recently. Here, w...

journal_title：PLoS pathogens

authors： Arnold LH,Groom HC,Kunzelmann S,Schwefel D,Caswell SJ,Ordonez P,Mann MC,Rueschenbaum S,Goldstone DC,Pennell S,Howell SA,Stoye JP,Webb M,Taylor IA,Bishop KN

更新日期：2015-10-02 00:00:00

abstract：:The bunyavirus genome comprises a small (S), medium (M), and large (L) RNA segment of negative polarity. Although genome segmentation confers evolutionary advantages by enabling genome reassortment events with related viruses, genome segmentation also complicates genome replication and packaging. Accumulating evidence...

journal_title：PLoS pathogens

authors： Wichgers Schreur PJ,Kortekaas J

更新日期：2016-08-22 00:00:00

abstract：:Recognition of peptidoglycan (PGN) is paramount for insect antibacterial defenses. In the fruit fly Drosophila melanogaster, the transmembrane PGN Recognition Protein LC (PGRP-LC) is a receptor of the Imd signaling pathway that is activated after infection with bacteria, mainly Gram-negative (Gram-). Here we demonstra...

journal_title：PLoS pathogens

authors： Meister S,Agianian B,Turlure F,Relógio A,Morlais I,Kafatos FC,Christophides GK

更新日期：2009-08-01 00:00:00

abstract：:The cytidine deaminases APOBEC3G and APOBEC3F exert anti-HIV-1 activity that is countered by the HIV-1 vif protein. Based on potential transcription factor binding sites in their putative promoters, we hypothesized that expression of APOBEC3G and APOBEC3F would vary with T helper lymphocyte differentiation. Naive CD4+...

journal_title：PLoS pathogens

authors： Vetter ML,Johnson ME,Antons AK,Unutmaz D,D'Aquila RT

更新日期：2009-02-01 00:00:00

abstract：:Hospitalization of the elderly for invasive pneumococcal disease is frequently accompanied by the occurrence of an adverse cardiac event; these are primarily new or worsened heart failure and cardiac arrhythmia. Herein, we describe previously unrecognized microscopic lesions (microlesions) formed within the myocardium...

journal_title：PLoS pathogens

authors： Brown AO,Mann B,Gao G,Hankins JS,Humann J,Giardina J,Faverio P,Restrepo MI,Halade GV,Mortensen EM,Lindsey ML,Hanes M,Happel KI,Nelson S,Bagby GJ,Lorent JA,Cardinal P,Granados R,Esteban A,LeSaux CJ,Tuomanen EI,Or

更新日期：2014-09-18 00:00:00

abstract：:The root knot nematode, Meloidogyne incognita, is an obligate parasite that causes significant damage to a broad range of host plants. Infection is associated with secretion of proteins surrounded by proliferating cells. Many parasites are known to secrete effectors that interfere with plant innate immunity, enabling ...

journal_title：PLoS pathogens

authors： Bellafiore S,Shen Z,Rosso MN,Abad P,Shih P,Briggs SP

更新日期：2008-10-01 00:00:00

abstract：:Future HIV vaccines are expected to induce effective Th1 cell-mediated and Env-specific antibody responses that are necessary to offer protective immunity to HIV infection. However, HIV infections are highly prevalent in helminth endemic areas. Helminth infections induce polarised Th2 responses that may impair HIV vac...

journal_title：PLoS pathogens

authors： Dzhivhuho GA,Rehrl SA,Ndlovu H,Horsnell WGC,Brombacher F,Williamson AL,Chege GK

更新日期：2018-07-26 00:00:00

abstract：:The progression of a natural bacterial infection is a dynamic process influenced by the physiological characteristics of the target organ. Recent developments in live animal imaging allow for the study of the dynamic microbe-host interplay in real-time as the infection progresses within an organ of a live host. Here w...

journal_title：PLoS pathogens

authors： Melican K,Sandoval RM,Kader A,Josefsson L,Tanner GA,Molitoris BA,Richter-Dahlfors A

更新日期：2011-02-01 00:00:00

abstract：:Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative transcription factors in a machine-anno...

journal_title：PLoS pathogens

authors： Cho Y,Srivastava A,Ohm RA,Lawrence CB,Wang KH,Grigoriev IV,Marahatta SP

更新日期：2012-01-01 00:00:00

abstract：:Glycolysis is a metabolic pathway that is central to the assimilation of carbon for either respiration or fermentation and therefore is critical for the growth of all organisms. Consequently, glycolytic transcriptional regulation is important for the metabolic flexibility of pathogens in their attempts to colonize div...

journal_title：PLoS pathogens

authors： Askew C,Sellam A,Epp E,Hogues H,Mullick A,Nantel A,Whiteway M

更新日期：2009-10-01 00:00:00

abstract：:Malaria parasites must undergo a round of sexual reproduction in the blood meal of a mosquito vector to be transmitted between hosts. Developing a transmission-blocking intervention to prevent parasites from mating is a major goal of biomedicine, but its effectiveness could be compromised if parasites can compensate b...

journal_title：PLoS pathogens

authors： Ramiro RS,Alpedrinha J,Carter L,Gardner A,Reece SE

更新日期：2011-03-01 00:00:00

abstract：:Phylogenetic analyses have provided strong evidence that amino acid changes in spike (S) protein of animal and human SARS coronaviruses (SARS-CoVs) during and between two zoonotic transfers (2002/03 and 2003/04) are the result of positive selection. While several studies support that some amino acid changes between an...

journal_title：PLoS pathogens

authors： Sui J,Aird DR,Tamin A,Murakami A,Yan M,Yammanuru A,Jing H,Kan B,Liu X,Zhu Q,Yuan QA,Adams GP,Bellini WJ,Xu J,Anderson LJ,Marasco WA

更新日期：2008-11-01 00:00:00

abstract：:All pathogenesis and death associated with Plasmodium falciparum malaria is due to parasite-infected erythrocytes. Invasion of erythrocytes by P. falciparum merozoites requires specific interactions between host receptors and parasite ligands that are localized in apical organelles called micronemes. Here, we identify...

journal_title：PLoS pathogens

authors： Dawn A,Singh S,More KR,Siddiqui FA,Pachikara N,Ramdani G,Langsley G,Chitnis CE

更新日期：2014-12-18 00:00:00

abstract：:Mouse polyomavirus (MPyV) lytically infects mouse cells, transforms rat cells in culture, and is highly oncogenic in rodents. We have used deep sequencing to follow MPyV infection of mouse NIH3T6 cells at various times after infection and analyzed both the viral and cellular transcriptomes. Alignment of sequencing rea...

journal_title：PLoS pathogens

authors： Garren SB,Kondaveeti Y,Duff MO,Carmichael GG

更新日期：2015-09-25 00:00:00

abstract：:Adjunctive vitamin D treatment for pulmonary tuberculosis enhances resolution of inflammation but has modest effects on bacterial clearance. Sodium 4-phenylbutyrate (PBA) is in clinical use for a range of conditions and has been shown to synergise with vitamin D metabolites to upregulate cathelicidin antimicrobial pep...

journal_title：PLoS pathogens

authors： Coussens AK,Wilkinson RJ,Martineau AR

更新日期：2015-07-02 00:00:00

abstract：:Herpes simplex virus (HSV)--and herpesviruses in general--encode for a multipartite entry/fusion apparatus. In HSV it consists of the HSV-specific glycoprotein D (gD), and three additional glycoproteins, gH/gL and gB, conserved across the Herpesviridae family and responsible for the execution of fusion. According to t...

journal_title：PLoS pathogens

authors： Gianni T,Salvioli S,Chesnokova LS,Hutt-Fletcher LM,Campadelli-Fiume G

更新日期：2013-01-01 00:00:00

abstract：:Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little is known about its possible wider regulatory role in this organism...

journal_title：PLoS pathogens

authors： De Majumdar S,Yu J,Fookes M,McAteer SP,Llobet E,Finn S,Spence S,Monahan A,Monaghan A,Kissenpfennig A,Ingram RJ,Bengoechea J,Gally DL,Fanning S,Elborn JS,Schneiders T

更新日期：2015-01-29 00:00:00

abstract：:In an effort to suppress microbial outgrowth, the host sequesters essential nutrients in a process termed nutritional immunity. However, inflammatory responses to bacterial insult can restore nutritional resources. Given that nutrient availability modulates virulence factor production and biofilm formation by other ba...

journal_title：PLoS pathogens

authors： Szelestey BR,Heimlich DR,Raffel FK,Justice SS,Mason KM

更新日期：2013-01-01 00:00:00