Differences in APOBEC3G expression in CD4+ T helper lymphocyte subtypes modulate HIV-1 infectivity.

abstract：:Bacteria of the Burkholderia cepacia complex (Bcc) can cause devastating pulmonary infections in cystic fibrosis (CF) patients, yet the precise mechanisms underlying inflammation, recurrent exacerbations and transition from chronic stages to acute infection and septicemia are not known. Bcc bacteria are generally beli...

journal_title：PLoS pathogens

authors： Mesureur J,Feliciano JR,Wagner N,Gomes MC,Zhang L,Blanco-Gonzalez M,van der Vaart M,O'Callaghan D,Meijer AH,Vergunst AC

更新日期：2017-06-26 00:00:00

abstract：:Bacterial bloodstream infections (BSI) are a major health concern and can cause up to 40% mortality. Pseudomonas aeruginosa BSI is often of nosocomial origin and is associated with a particularly poor prognosis. The mechanism of bacterial persistence in blood is still largely unknown. Here, we analyzed the behavior of...

journal_title：PLoS pathogens

authors： Pont S,Fraikin N,Caspar Y,Van Melderen L,Attrée I,Cretin F

更新日期：2020-12-16 00:00:00

abstract：:Unlike the pandemic form of HIV-1 (group M), group O viruses are endemic in west central Africa, especially in Cameroon. However, little is known about group O's genetic evolution, and why this highly divergent lineage has not become pandemic. Using a unique and large set of group O sequences from samples collected fr...

journal_title：PLoS pathogens

authors： Leoz M,Feyertag F,Kfutwah A,Mauclère P,Lachenal G,Damond F,De Oliveira F,Lemée V,Simon F,Robertson DL,Plantier JC

更新日期：2015-08-04 00:00:00

abstract：:Open reading frame (ORF) 45 of Kaposi's sarcoma-associated herpesvirus (KSHV) is a tegument protein. A genetic analysis with a null mutant suggested a possible role for this protein in the events leading to viral egress. In this study, ORF45 was found to interact with KIF3A, a kinesin-2 motor protein that transports c...

journal_title：PLoS pathogens

authors： Sathish N,Zhu FX,Yuan Y

更新日期：2009-03-01 00:00:00

abstract：:Toll-like receptor (TLR) ligands are being considered as adjuvants for the induction of antigen-specific immune responses, as in the design of vaccines. Polyriboinosinic-polyribocytoidylic acid (poly I:C), a synthetic double-stranded RNA (dsRNA), is recognized by TLR3 and other intracellular receptors. Poly ICLC is a ...

journal_title：PLoS pathogens

authors： Stahl-Hennig C,Eisenblätter M,Jasny E,Rzehak T,Tenner-Racz K,Trumpfheller C,Salazar AM,Uberla K,Nieto K,Kleinschmidt J,Schulte R,Gissmann L,Müller M,Sacher A,Racz P,Steinman RM,Uguccioni M,Ignatius R

更新日期：2009-04-01 00:00:00

abstract：:As well as their importance to nutrition, fatty acids (FA) represent a unique group of quorum sensing chemicals that modulate the behavior of bacterial population in virulence. However, the way in which full-length, membrane-bound receptors biochemically detect FA remains unclear. Here, we provide genetic, enzymologic...

journal_title：PLoS pathogens

authors： Cai Z,Yuan ZH,Zhang H,Pan Y,Wu Y,Tian XQ,Wang FF,Wang L,Qian W

更新日期：2017-04-03 00:00:00

abstract：:Epstein-Barr virus (EBV), a ubiquitous human herpesvirus, can latently infect the human population. EBV is associated with several types of malignancies originating from lymphoid and epithelial cell types. EBV latent antigen 3C (EBNA3C) is essential for EBV-induced immortalization of B-cells. The Moloney murine leukem...

journal_title：PLoS pathogens

authors： Banerjee S,Lu J,Cai Q,Sun Z,Jha HC,Robertson ES

更新日期：2014-08-14 00:00:00

abstract：:Dengue is the most common mosquito-borne viral disease in humans. Changes of lipid-related metabolites in endoplasmic reticulum of dengue virus (DENV) infected cells have been associated with replicative complexes formation. Previously, we reported that DENV infection inhibits HMGCR phosphorylation generating a choles...

journal_title：PLoS pathogens

authors： Soto-Acosta R,Bautista-Carbajal P,Cervantes-Salazar M,Angel-Ambrocio AH,Del Angel RM

更新日期：2017-04-06 00:00:00

abstract：:Mycobacterium tuberculosis is sensitive to nitric oxide generated by inducible nitric oxide synthase (iNOS). Consequently, to ensure its survival in macrophages, M. tuberculosis inhibits iNOS recruitment to its phagosome by an unknown mechanism. Here we report the mechanism underlying this process, whereby mycobacteri...

journal_title：PLoS pathogens

authors： Davis AS,Vergne I,Master SS,Kyei GB,Chua J,Deretic V

更新日期：2007-12-01 00:00:00

abstract：:The highly pathogenic Old World arenavirus Lassa virus (LASV) and the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) use α-dystroglycan as a cellular receptor and enter the host cell by an unusual endocytotic pathway independent of clathrin, caveolin, dynamin, and actin. Upon internalization, the viru...

journal_title：PLoS pathogens

authors： Pasqual G,Rojek JM,Masin M,Chatton JY,Kunz S

更新日期：2011-09-01 00:00:00

abstract：:Human bocavirus 1 (HBoV1) belongs to the genus Bocaparvovirus of the Parvoviridae family, and is an emerging human pathogenic respiratory virus. In vitro, HBoV1 infects well-differentiated/polarized primary human airway epithelium (HAE) cultured at an air-liquid interface (HAE-ALI). Although it is well known that auto...

journal_title：PLoS pathogens

authors： Deng X,Yan Z,Cheng F,Engelhardt JF,Qiu J

更新日期：2016-01-14 00:00:00

abstract：:Exposure to Plasmodium falciparum is associated with circulating "atypical" memory B cells (atMBCs), which appear similar to dysfunctional B cells found in HIV-infected individuals. Functional analysis of atMBCs has been limited, with one report suggesting these cells are not dysfunctional but produce protective antib...

journal_title：PLoS pathogens

authors： Sullivan RT,Kim CC,Fontana MF,Feeney ME,Jagannathan P,Boyle MJ,Drakeley CJ,Ssewanyana I,Nankya F,Mayanja-Kizza H,Dorsey G,Greenhouse B

更新日期：2015-05-19 00:00:00

abstract：:Gastrointestinal infections caused by enteric yersiniae can become persistent and complicated by relapsing enteritis and severe autoimmune disorders. To establish a persistent infection, the bacteria have to cope with hostile surroundings when they transmigrate through the intestinal epithelium and colonize underlying...

journal_title：PLoS pathogens

authors： Heine W,Beckstette M,Heroven AK,Thiemann S,Heise U,Nuss AM,Pisano F,Strowig T,Dersch P

更新日期：2018-02-01 00:00:00

abstract：:Bacterial cell division predominantly occurs by a highly conserved process, termed binary fission, that requires the bacterial homologue of tubulin, FtsZ. Other mechanisms of bacterial cell division that are independent of FtsZ are rare. Although the obligate intracellular human pathogen Chlamydia trachomatis, the lea...

journal_title：PLoS pathogens

authors： Abdelrahman Y,Ouellette SP,Belland RJ,Cox JV

更新日期：2016-08-09 00:00:00

abstract：:The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are well characterized, their crosstalk and dynamics of occurrence during the HIV transcription cycle remain unclear.We examine interactions between two critical modi...

journal_title：PLoS pathogens

authors： Sakane N,Kwon HS,Pagans S,Kaehlcke K,Mizusawa Y,Kamada M,Lassen KG,Chan J,Greene WC,Schnoelzer M,Ott M

更新日期：2011-08-01 00:00:00

abstract：:The life cycle of the mammalian pathogen Trypanosoma brucei involves commuting between two markedly different environments: the homeothermic mammalian host and the poikilothermic invertebrate vector. The ability to resist temperature and other stresses is essential for trypanosome survival. Trypanosome gene expression...

journal_title：PLoS pathogens

authors： Minia I,Clayton C

更新日期：2016-03-22 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) composed of the receptor binding domain gp120 and the fusion protein subunit gp41 catalyzes virus entry and is a major target for therapeutic intervention and for neutralizing antibodies. Env interactions with cellular receptors trigger refolding of gp41, which induces close appos...

journal_title：PLoS pathogens

authors： Buzon V,Natrajan G,Schibli D,Campelo F,Kozlov MM,Weissenhorn W

更新日期：2010-05-06 00:00:00

abstract：:Plasmodium falciparum malaria kills over 500,000 children every year and has been a scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum parasites, the human genome is imprinted with polymorphisms that not only confer innate resistance to falciparum malaria, but also cause hemoglobino...

journal_title：PLoS pathogens

authors： Taylor SM,Cerami C,Fairhurst RM

更新日期：2013-01-01 00:00:00

abstract：:HIV and other lentiviruses can productively infect nondividing cells, whereas most other retroviruses, such as murine leukemia virus, require cell division for efficient infection. However, the determinants for this phenotype have been controversial. Here, we show that HIV-1 capsid (CA) is involved in facilitating HIV...

journal_title：PLoS pathogens

authors： Yamashita M,Perez O,Hope TJ,Emerman M

更新日期：2007-10-26 00:00:00

abstract：:The shape and form of the flagellated eukaryotic parasite Leishmania is sculpted to its ecological niches and needs to be transmitted to each generation with great fidelity. The shape of the Leishmania cell is defined by the sub-pellicular microtubule array and the positioning of the nucleus, kinetoplast and the flage...

journal_title：PLoS pathogens

authors： Halliday C,Yanase R,Catta-Preta CMC,Moreira-Leite F,Myskova J,Pruzinova K,Volf P,Mottram JC,Sunter JD

更新日期：2020-10-22 00:00:00

abstract：:After entry into target cells, retroviruses encounter the host restriction factors such as Fv1 and TRIM5α. While it is clear that these factors target retrovirus capsid proteins (CA), recognition remains poorly defined in the absence of structural information. To better understand the binding interaction between TRIM5...

journal_title：PLoS pathogens

authors： Ohkura S,Goldstone DC,Yap MW,Holden-Dye K,Taylor IA,Stoye JP

更新日期：2011-03-01 00:00:00

abstract：:Beyond their canonical roles in hemostasis and thrombosis, platelets function in the innate immune response by interacting directly with pathogens and by regulating the recruitment and activation of immune effector cells. Thrombocytopenia often coincides with neutropenia in patients with hematologic malignancies and i...

journal_title：PLoS pathogens

authors： Tischler BY,Tosini NL,Cramer RA,Hohl TM

更新日期：2020-05-14 00:00:00

abstract：:Serine protease cascades regulate important insect immune responses namely melanization and Toll pathway activation. An important component of these cascades are clip-domain serine protease homologs (cSPHs), which are non-catalytic, but essential for activating the enzyme prophenoloxidase (PPO) in the melanization res...

journal_title：PLoS pathogens

authors： El Moussawi L,Nakhleh J,Kamareddine L,Osta MA

更新日期：2019-11-25 00:00:00

abstract：:While the exopolysaccharide component of the biofilm matrix has been intensively studied, much less is known about matrix-associated proteins. To better understand the role of these proteins, we undertook a proteomic analysis of the V. cholerae biofilm matrix. Here we show that the two matrix-associated proteins, Bap1...

journal_title：PLoS pathogens

authors： Absalon C,Van Dellen K,Watnick PI

更新日期：2011-08-01 00:00:00

abstract：:In bacteria, transformation and restriction-modification (R-M) systems play potentially antagonistic roles. While the former, proposed as a form of sexuality, relies on internalized foreign DNA to create genetic diversity, the latter degrade foreign DNA to protect from bacteriophage attack. The human pathogen Streptoc...

journal_title：PLoS pathogens

authors： Johnston C,Martin B,Granadel C,Polard P,Claverys JP

更新日期：2013-02-01 00:00:00

abstract：:Tsetse flies are vectors of the protozoan parasite African trypanosomes, which cause sleeping sickness disease in humans and nagana in livestock. Although there are no effective vaccines and efficacious drugs against this parasite, vector reduction methods have been successful in curbing the disease, especially for na...

journal_title：PLoS pathogens

authors： Alam U,Medlock J,Brelsfoard C,Pais R,Lohs C,Balmand S,Carnogursky J,Heddi A,Takac P,Galvani A,Aksoy S

更新日期：2011-12-01 00:00:00

abstract：:Many viral pathogens are persistently transmitted by insect vectors and cause agricultural or health problems. Generally, an insect vector can use autophagy as an intrinsic antiviral defense mechanism against viral infection. Whether viruses can evolve to exploit autophagy to promote their transmission by insect vecto...

journal_title：PLoS pathogens

authors： Chen Y,Chen Q,Li M,Mao Q,Chen H,Wu W,Jia D,Wei T

更新日期：2017-11-10 00:00:00

abstract：:Cerebrovascular dysfunction plays a key role in the pathogenesis of cerebral malaria. In experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA, cerebrovascular dysfunction characterized by vascular constriction, occlusion and damage results in impaired perfusion and reduced cerebral blood flow and oxy...

journal_title：PLoS pathogens

authors： Ong PK,Melchior B,Martins YC,Hofer A,Orjuela-Sánchez P,Cabrales P,Zanini GM,Frangos JA,Carvalho LJ

更新日期：2013-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) and related lymphocryptoviruses (LCV) from non-human primates infect B cells, transform their growth to facilitate life-long viral persistence in the host, and contribute to B cell oncogenesis. Co-evolution of LCV with their primate hosts has led to species-specificity so that LCVs preferentia...

journal_title：PLoS pathogens

authors： Mühe J,Wang F

更新日期：2017-12-20 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a leading cause of liver disease worldwide. The HCV RNA genome is translated into a single polyprotein. Most of the cleavage sites in the non-structural (NS) polyprotein region are processed by the NS3/NS4A serine protease. The vital NS2-NS3 cleavage is catalyzed by the NS2 autopro...

journal_title：PLoS pathogens

authors： Isken O,Langerwisch U,Jirasko V,Rehders D,Redecke L,Ramanathan H,Lindenbach BD,Bartenschlager R,Tautz N

更新日期：2015-03-16 00:00:00