Tonsilar NK cells restrict B cell transformation by the Epstein-Barr virus via IFN-gamma.

abstract：:Uncovering how natural selection and genetic drift shape the evolutionary dynamics of virus populations within their hosts can pave the way to a better understanding of virus emergence. Mathematical models already play a leading role in these studies and are intended to predict future emergences. Here, using high-thro...

journal_title：PLoS pathogens

authors： Fabre F,Montarry J,Coville J,Senoussi R,Simon V,Moury B

更新日期：2012-01-01 00:00:00

abstract：:Human Papillomavirus (HPV) 16 E7 protein promotes the transformation of HPV infected epithelium to malignancy. Here, we use a murine model in which the E7 protein of HPV16 is expressed as a transgene in epithelium to show that mast cells are recruited to the basal layer of E7-expressing epithelium, and that this recru...

journal_title：PLoS pathogens

authors： Bergot AS,Ford N,Leggatt GR,Wells JW,Frazer IH,Grimbaldeston MA

更新日期：2014-10-23 00:00:00

abstract：:The SUPPRESSOR OF rps4-RLD1 (SRFR1) gene was identified based on enhanced AvrRps4-triggered resistance in the naturally susceptible Arabidopsis accession RLD. No other phenotypic effects were recorded, and the extent of SRFR1 involvement in regulating effector-triggered immunity was unknown. Here we show that mutation...

journal_title：PLoS pathogens

authors： Kim SH,Gao F,Bhattacharjee S,Adiasor JA,Nam JC,Gassmann W

更新日期：2010-11-04 00:00:00

abstract：:A key difference that distinguishes viral infections from protein immunizations is the recognition of viral nucleic acids by cytosolic pattern recognition receptors (PRRs). Insights into the functions of cytosolic PRRs such as the RNA-sensing Rig-I-like receptors (RLRs) in the instruction of adaptive immunity are ther...

journal_title：PLoS pathogens

authors： O'Ketch M,Williams S,Larson C,Uhrlaub JL,Wong R,Hall B,Deshpande NR,Schenten D

更新日期：2020-10-26 00:00:00

abstract：:Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known. We generated replication-competent, FAST protein-deficient pteropine orthoreov...

journal_title：PLoS pathogens

authors： Kanai Y,Kawagishi T,Sakai Y,Nouda R,Shimojima M,Saijo M,Matsuura Y,Kobayashi T

更新日期：2019-04-25 00:00:00

abstract：:Knowledge of the within-host frequencies of resistance-associated amino acid variants (RAVs) is important to the identification of optimal drug combinations for the treatment of hepatitis C virus (HCV) infection. Multiple RAVs may exist in infected individuals, often below detection limits, at any resistance locus, de...

journal_title：PLoS pathogens

authors： Raja R,Pareek A,Newar K,Dixit NM

更新日期：2019-04-01 00:00:00

abstract：:A central question in Leishmania research is why most species cause cutaneous infections but others cause fatal visceral disease. Interestingly, L. donovani causes both visceral and cutaneous leishmaniasis in Sri Lanka. L. donovani clinical isolates were therefore obtained from cutaneous leishmaniasis (CL-SL) and visc...

journal_title：PLoS pathogens

authors： Zhang WW,Ramasamy G,McCall LI,Haydock A,Ranasinghe S,Abeygunasekara P,Sirimanna G,Wickremasinghe R,Myler P,Matlashewski G

更新日期：2014-07-03 00:00:00

abstract：:One of the hallmarks of adaptive immunity is the development of a long-term pathogen specific memory response. While persistent memory T cells certainly impact the immune response during a secondary challenge, their role in unrelated infections is less clear. To address this issue, we utilized lymphocytic choriomening...

journal_title：PLoS pathogens

authors： Crosby EJ,Goldschmidt MH,Wherry EJ,Scott P

更新日期：2014-02-27 00:00:00

abstract：:IFNγ signaling drives dendritic cells (DCs) to promote type I T cell (Th1) immunity. Here, we show that activation of DCs by IFNγ is equally crucial for the differentiation of a population of T-bet+ regulatory T (Treg) cells specialized to inhibit Th1 immune responses. Conditional deletion of IFNγ receptor in DCs but ...

journal_title：PLoS pathogens

authors： Lee HM,Fleige A,Forman R,Cho S,Khan AA,Lin LL,Nguyen DT,O'Hara-Hall A,Yin Z,Hunter CA,Muller W,Lu LF

更新日期：2015-02-06 00:00:00

abstract：:In plants, innate immune responses are initiated by plasma membrane-located pattern recognition receptors (PRRs) upon recognition of elicitors, including exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs). Arabidopsis thaliana produces more than 1000 se...

journal_title：PLoS pathogens

authors： Hou S,Wang X,Chen D,Yang X,Wang M,Turrà D,Di Pietro A,Zhang W

更新日期：2014-09-04 00:00:00

abstract：:The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are well characterized, their crosstalk and dynamics of occurrence during the HIV transcription cycle remain unclear.We examine interactions between two critical modi...

journal_title：PLoS pathogens

authors： Sakane N,Kwon HS,Pagans S,Kaehlcke K,Mizusawa Y,Kamada M,Lassen KG,Chan J,Greene WC,Schnoelzer M,Ott M

更新日期：2011-08-01 00:00:00

abstract：:Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide. Recognition of M. tuberculosis by pattern recognition receptors is crucial for activation of both innate and adaptive immune responses. In the present study, we demonstrate that nucleotide-binding oligomerization domain 2 (NOD2)...

journal_title：PLoS pathogens

authors： Ferwerda G,Girardin SE,Kullberg BJ,Le Bourhis L,de Jong DJ,Langenberg DM,van Crevel R,Adema GJ,Ottenhoff TH,Van der Meer JW,Netea MG

更新日期：2005-11-01 00:00:00

abstract：:Entamoeba histolytica transmembrane kinases (EhTMKs) can be grouped into six distinct families on the basis of motifs and sequences. Analysis of the E. histolytica genome revealed the presence of 35 EhTMKB1 members on the basis of sequence identity (>or=95%). Only six homologs were full length containing an extracellu...

journal_title：PLoS pathogens

authors： Shrimal S,Bhattacharya S,Bhattacharya A

更新日期：2010-06-03 00:00:00

abstract：:Acute resistance to low dose M. tuberculosis (Mtb) infection is not dependent on Toll-like receptor (TLR) 2. However, whether TLR2 contributes to resistance in chronic Mtb infection has remained uncertain. Here we report that, following low dose aerosol infection with Mtb, mice lacking TLR2 (TLR2KO), in comparison wit...

journal_title：PLoS pathogens

authors： McBride A,Konowich J,Salgame P

更新日期：2013-01-01 00:00:00

abstract：:CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts infected with the β-herpesviridae human cytomegalovirus (HCMV) or murine cytomegalovirus (MCMV) express the regulatory cytokine interleukin (IL)-10. IL-10+CD4+ T...

journal_title：PLoS pathogens

authors： Clement M,Marsden M,Stacey MA,Abdul-Karim J,Gimeno Brias S,Costa Bento D,Scurr MJ,Ghazal P,Weaver CT,Carlesso G,Clare S,Jones SA,Godkin A,Jones GW,Humphreys IR

更新日期：2016-12-07 00:00:00

abstract：:Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse). We identified approximately 20 TRIM proteins that, when transiently expressed in HE...

journal_title：PLoS pathogens

authors： Uchil PD,Quinlan BD,Chan WT,Luna JM,Mothes W

更新日期：2008-02-08 00:00:00

abstract：:The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (T4SS) VirB, which is thought to translocate effector proteins that mo...

journal_title：PLoS pathogens

authors： Myeni S,Child R,Ng TW,Kupko JJ 3rd,Wehrly TD,Porcella SF,Knodler LA,Celli J

更新日期：2013-01-01 00:00:00

abstract：:More than half of the world population is at risk of dengue virus (DENV) infection because of the global distribution of its mosquito vectors. DENV is an envelope virus that relies on host lipid membranes for its life-cycle. Here, we characterized how DENV hijacks the mosquito lipidome to identify targets for novel tr...

journal_title：PLoS pathogens

authors： Vial T,Tan WL,Wong Wei Xiang B,Missé D,Deharo E,Marti G,Pompon J

更新日期：2019-12-09 00:00:00

abstract：:Viroporins are small transmembrane proteins with ion channel activities modulating properties of intracellular membranes that have diverse proviral functions. Hepatitis C virus (HCV) encodes a viroporin, p7, acting during assembly, envelopment and secretion of viral particles (VP). HCV p7 is released from the viral po...

journal_title：PLoS pathogens

authors： Denolly S,Mialon C,Bourlet T,Amirache F,Penin F,Lindenbach B,Boson B,Cosset FL

更新日期：2017-12-18 00:00:00

abstract：:Hepatitis B virus (HBV) core protein (HBc) contains an N-terminal domain (NTD, assembly domain) and a C-terminal domain (CTD), which are linked by a flexible linker region. HBc plays multiple essential roles in viral replication, including capsid assembly, packaging of the viral pregenomic RNA (pgRNA) into nucleocapsi...

journal_title：PLoS pathogens

authors： Liu K,Luckenbaugh L,Ning X,Xi J,Hu J

更新日期：2018-05-21 00:00:00

abstract：:The rice blast fungus Magnaporthe oryzae is one of the most significant pathogens affecting global food security. To cause rice blast disease the fungus elaborates a specialised infection structure called an appressorium. Here, we report genome wide transcriptional profile analysis of appressorium development using ne...

journal_title：PLoS pathogens

authors： Soanes DM,Chakrabarti A,Paszkiewicz KH,Dawe AL,Talbot NJ

更新日期：2012-02-01 00:00:00

abstract：:Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in the development of new effective vaccines and in the appropriate use of antimalarial drugs. By performing a full-genome s...

journal_title：PLoS pathogens

authors： Kidgell C,Volkman SK,Daily J,Borevitz JO,Plouffe D,Zhou Y,Johnson JR,Le Roch K,Sarr O,Ndir O,Mboup S,Batalov S,Wirth DF,Winzeler EA

更新日期：2006-06-01 00:00:00

abstract：:Paramount to the success of persistent viral infection is the ability of viruses to navigate hostile environments en route to future targets. In response to such obstacles, many viruses have developed the ability of establishing actin rich-membrane bridges to aid in future infections. Herein through dynamic imaging of...

journal_title：PLoS pathogens

authors： Aggarwal A,Iemma TL,Shih I,Newsome TP,McAllery S,Cunningham AL,Turville SG

更新日期：2012-01-01 00:00:00

abstract：:Streptococcus agalactiae is a common human commensal and a major life-threatening pathogen in neonates. Adherence to host epithelial cells is the first critical step of the infectious process. Pili have been observed on the surface of several gram-positive bacteria including S. agalactiae. We previously characterized ...

journal_title：PLoS pathogens

authors： Konto-Ghiorghi Y,Mairey E,Mallet A,Duménil G,Caliot E,Trieu-Cuot P,Dramsi S

更新日期：2009-05-01 00:00:00

abstract：:We have investigated to what extent natural transformation acting on free DNA substrates can facilitate transfer of mobile elements including transposons, integrons and/or gene cassettes between bacterial species. Naturally transformable cells of Acinetobacter baylyi were exposed to DNA from integron-carrying strains ...

journal_title：PLoS pathogens

authors： Domingues S,Harms K,Fricke WF,Johnsen PJ,da Silva GJ,Nielsen KM

更新日期：2012-01-01 00:00:00

abstract：:Previously, we demonstrated that Pseudomonas aeruginosa ExoT induces potent apoptosis in host epithelial cells in a manner that primarily depends on its ADP-ribosyltransferase domain (ADPRT) activity. However, the mechanism underlying ExoT/ADPRT-induced apoptosis remains undetermined. We now report that ExoT/ADPRT dis...

journal_title：PLoS pathogens

authors： Wood S,Goldufsky J,Shafikhani SH

更新日期：2015-05-28 00:00:00

abstract：:RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap (m(7)GpppAm) of viral RNA genome. Here we reported, for the first time, that flavivirus NS5 has a novel interna...

journal_title：PLoS pathogens

authors： Dong H,Chang DC,Hua MH,Lim SP,Chionh YH,Hia F,Lee YH,Kukkaro P,Lok SM,Dedon PC,Shi PY

更新日期：2012-01-01 00:00:00

abstract：:Autophagy is a cellular process that is highly conserved among eukaryotes and permits the degradation of cellular material. Autophagy is involved in multiple survival-promoting processes. It not only facilitates the maintenance of cell homeostasis by degrading long-lived proteins and damaged organelles, but it also pl...

journal_title：PLoS pathogens

authors： Besteiro S,Brooks CF,Striepen B,Dubremetz JF

更新日期：2011-12-01 00:00:00

abstract：:HIV-1 assembly and release are believed to occur at the plasma membrane in most host cells with the exception of primary macrophages, for which exclusive budding at late endosomes has been reported. Here, we applied a novel ultrastructural approach to assess HIV-1 budding in primary macrophages in an immunomarker-inde...

journal_title：PLoS pathogens

authors： Welsch S,Keppler OT,Habermann A,Allespach I,Krijnse-Locker J,Kräusslich HG

更新日期：2007-03-01 00:00:00

abstract：:Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed circular (RC) DNA capsids can be enveloped and secreted as stable vir...

journal_title：PLoS pathogens

authors： Heger-Stevic J,Zimmermann P,Lecoq L,Böttcher B,Nassal M

更新日期：2018-12-19 00:00:00