A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.

abstract：:Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage, but also for infectious virus production. To identify cellular factors that interact with NS2 and are important for HCV propagation, we screened a human liver cDNA library by sp...

journal_title：PLoS pathogens

authors： Suzuki R,Matsuda M,Watashi K,Aizaki H,Matsuura Y,Wakita T,Suzuki T

更新日期：2013-01-01 00:00:00

abstract：:Leishmania parasites are transmitted to vertebrate hosts by female phlebotomine sand flies as they bloodfeed by lacerating the upper capillaries of the dermis with their barbed mouthparts. In the sand fly midgut secreted proteophosphoglycans from Leishmania form a biological plug known as the promastigote secretory ge...

journal_title：PLoS pathogens

authors： Giraud E,Lestinova T,Derrick T,Martin O,Dillon RJ,Volf P,Műller I,Bates PA,Rogers ME

更新日期：2018-01-19 00:00:00

abstract：:Autophagy is a cellular process that is highly conserved among eukaryotes and permits the degradation of cellular material. Autophagy is involved in multiple survival-promoting processes. It not only facilitates the maintenance of cell homeostasis by degrading long-lived proteins and damaged organelles, but it also pl...

journal_title：PLoS pathogens

authors： Besteiro S,Brooks CF,Striepen B,Dubremetz JF

更新日期：2011-12-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1005698.]. ...

journal_title：PLoS pathogens

authors： Ersching J,Basso AS,Calich VL,Bortoluci KR,Rodrigues MM

更新日期：2016-07-11 00:00:00

abstract：:KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded miRNAs are readily detectable in all KSHV-associated tumors suggests a potential role in viral pathogenesis and tumorigenesis. MiRNA-mediated regula...

journal_title：PLoS pathogens

authors： Haecker I,Gay LA,Yang Y,Hu J,Morse AM,McIntyre LM,Renne R

更新日期：2012-01-01 00:00:00

abstract：:B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (TFH) cells. We studied the effects of native heterodimeric IL-15 (hetIL-15) treatmen...

journal_title：PLoS pathogens

authors： Watson DC,Moysi E,Valentin A,Bergamaschi C,Devasundaram S,Fortis SP,Bear J,Chertova E,Bess J Jr,Sowder R,Venzon DJ,Deleage C,Estes JD,Lifson JD,Petrovas C,Felber BK,Pavlakis GN

更新日期：2018-02-23 00:00:00

abstract：:Babesia bovis is an apicomplexan tick-transmitted pathogen of cattle imposing a global risk and severe constraints to livestock health and economic development. The complete genome sequence was undertaken to facilitate vaccine antigen discovery, and to allow for comparative analysis with the related apicomplexan hemop...

journal_title：PLoS pathogens

authors： Brayton KA,Lau AO,Herndon DR,Hannick L,Kappmeyer LS,Berens SJ,Bidwell SL,Brown WC,Crabtree J,Fadrosh D,Feldblum T,Forberger HA,Haas BJ,Howell JM,Khouri H,Koo H,Mann DJ,Norimine J,Paulsen IT,Radune D,Ren Q,Smith

更新日期：2007-10-19 00:00:00

abstract：:RNA helicases and chaperones are the two major classes of RNA remodeling proteins, which function to remodel RNA structures and/or RNA-protein interactions, and are required for all aspects of RNA metabolism. Although some virus-encoded RNA helicases/chaperones have been predicted or identified, their RNA remodeling a...

journal_title：PLoS pathogens

authors： Xia H,Wang P,Wang GC,Yang J,Sun X,Wu W,Qiu Y,Shu T,Zhao X,Yin L,Qin CF,Hu Y,Zhou X

更新日期：2015-07-28 00:00:00

abstract：:Since the advent of genome-wide small interfering RNA screening, large numbers of cellular cofactors important for viral infection have been discovered at a rapid pace, but the viral targets and the mechanism of action for many of these cofactors remain undefined. One such cofactor is cyclophilin A (CyPA), upon which ...

journal_title：PLoS pathogens

authors： Yang F,Robotham JM,Grise H,Frausto S,Madan V,Zayas M,Bartenschlager R,Robinson M,Greenstein AE,Nag A,Logan TM,Bienkiewicz E,Tang H

更新日期：2010-09-23 00:00:00

abstract：:Certain cutaneous human papillomaviruses (HPVs), which are ubiquitous and acquired early during childhood, can cause a variety of skin tumors and are likely involved in the development of non-melanoma skin cancer, especially in immunosuppressed patients. Hence, the burden of these clinical manifestations demands for a...

journal_title：PLoS pathogens

authors： Vinzón SE,Braspenning-Wesch I,Müller M,Geissler EK,Nindl I,Gröne HJ,Schäfer K,Rösl F

更新日期：2014-02-20 00:00:00

abstract：:Bovine tuberculosis (bTB) is a chronic disease of cattle caused by Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex group of bacteria. Vaccination of cattle might offer a long-term solution for controlling the disease and priority has been given to the development of a cattle vaccine against bTB...

journal_title：PLoS pathogens

authors： Bhuju S,Aranday-Cortes E,Villarreal-Ramos B,Xing Z,Singh M,Vordermeier HM

更新日期：2012-12-01 00:00:00

abstract：:Necrotrophic plant pathogens acquire nutrients from dead plant cells, which requires the disintegration of the plant cell wall and tissue structures by the pathogen. Infected plants lose tissue integrity and functional immunity as a result, exposing the nutrient rich, decayed tissues to the environment. One challenge ...

journal_title：PLoS pathogens

authors： Cui Z,Yang CH,Kharadi RR,Yuan X,Sundin GW,Triplett LR,Wang J,Zeng Q

更新日期：2019-08-05 00:00:00

abstract：:PML (Promyelocytic Leukemia protein), also known as TRIM19, belongs to the family of tripartite motif (TRIM) proteins. PML is mainly expressed in the nucleus, where it forms dynamic structures known as PML nuclear bodies that recruit many other proteins, such as Sp100 and Daxx. While the role of PML/TRIM19 in antivira...

journal_title：PLoS pathogens

authors： Dutrieux J,Maarifi G,Portilho DM,Arhel NJ,Chelbi-Alix MK,Nisole S

更新日期：2015-11-13 00:00:00

abstract：:The African sleeping sickness parasite Trypanosoma brucei evades the host immune system through antigenic variation of its variant surface glycoprotein (VSG) coat. Although the T. brucei genome contains ∼1500 VSGs, only one VSG is expressed at a time from one of about 15 subtelomeric VSG expression sites (ESs). For an...

journal_title：PLoS pathogens

authors： Povelones ML,Gluenz E,Dembek M,Gull K,Rudenko G

更新日期：2012-01-01 00:00:00

abstract：:Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for aspergillosis, have been widely disseminated across the globe. To eluc...

journal_title：PLoS pathogens

authors： Hagiwara D,Miura D,Shimizu K,Paul S,Ohba A,Gonoi T,Watanabe A,Kamei K,Shintani T,Moye-Rowley WS,Kawamoto S,Gomi K

更新日期：2017-01-04 00:00:00

abstract：:HIV Nef acts as an anti-autophagic maturation factor through interaction with beclin-1 (BECN1). We report that exposure of macrophages to infectious or non-infectious purified HIV induces toll-like receptor 8 (TLR8) and BECN1 dependent dephosphorylation and nuclear translocation of TFEB and that this correlates with a...

journal_title：PLoS pathogens

authors： Campbell GR,Rawat P,Bruckman RS,Spector SA

更新日期：2015-06-26 00:00:00

abstract：:The high environmental adaptability of bacteria is contingent upon their ability to sense changes in their surroundings. Bacterial pathogen entry into host poses an abrupt and dramatic environmental change, during which successful pathogens gauge multiple parameters that signal host localization. The facultative human...

journal_title：PLoS pathogens

authors： Haber A,Friedman S,Lobel L,Burg-Golani T,Sigal N,Rose J,Livnat-Levanon N,Lewinson O,Herskovits AA

更新日期：2017-01-23 00:00:00

abstract：:The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during HIV-1 entry. Here we present the crystal structure of the HK20 Fab in complex with a gp41 mimetic 5-Helix at 2.3 Å resolut...

journal_title：PLoS pathogens

authors： Sabin C,Corti D,Buzon V,Seaman MS,Lutje Hulsik D,Hinz A,Vanzetta F,Agatic G,Silacci C,Mainetti L,Scarlatti G,Sallusto F,Weiss R,Lanzavecchia A,Weissenhorn W

更新日期：2010-11-18 00:00:00

abstract：:The host's immune system plays a key role in modulating growth of pathogens and the intestinal microbiota in the gut. In particular, inflammatory bowel disorders and pathogen infections induce shifts of the resident commensal microbiota which can result in overgrowth of Enterobacteriaceae ("inflammation-inflicted bloo...

journal_title：PLoS pathogens

authors： Nedialkova LP,Denzler R,Koeppel MB,Diehl M,Ring D,Wille T,Gerlach RG,Stecher B

更新日期：2014-01-01 00:00:00

abstract：:Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) is a negative-stranded RNA virus with a tripartite genome. RVFV is transmitted by mosquitoes and causes fever and severe hemorrhagic illness among humans, and fever and high rates of abortions in livestock. A nonstructural RVFV NSs protein inhibit...

journal_title：PLoS pathogens

authors： Ikegami T,Narayanan K,Won S,Kamitani W,Peters CJ,Makino S

更新日期：2009-02-01 00:00:00

abstract：:For Hepatitis C virus (HCV), initiation of translation is cap-independently mediated by its internal ribosome entry site (IRES). Unlike other IRES-containing viruses that shut off host cap-dependent translation, translation of HCV coexists with that of the host. How HCV IRES-mediated translation is regulated in the in...

journal_title：PLoS pathogens

authors： Huang JY,Su WC,Jeng KS,Chang TH,Lai MM

更新日期：2012-06-01 00:00:00

abstract：:A recently characterized calmodulin-like protein is an endogenous RNA silencing suppressor that suppresses sense-RNA induced post-transcriptional gene silencing (S-PTGS) and enhances virus infection, but the mechanism underlying calmodulin-like protein-mediated S-PTGS suppression is obscure. Here, we show that a calmo...

journal_title：PLoS pathogens

authors： Li F,Zhao N,Li Z,Xu X,Wang Y,Yang X,Liu SS,Wang A,Zhou X

更新日期：2017-02-17 00:00:00

abstract：:Many viral pathogens are persistently transmitted by insect vectors and cause agricultural or health problems. Generally, an insect vector can use autophagy as an intrinsic antiviral defense mechanism against viral infection. Whether viruses can evolve to exploit autophagy to promote their transmission by insect vecto...

journal_title：PLoS pathogens

authors： Chen Y,Chen Q,Li M,Mao Q,Chen H,Wu W,Jia D,Wei T

更新日期：2017-11-10 00:00:00

abstract：:The diversity of a highly variable RNA plant virus was considered to determine the range of virulence substitutions, the evolutionary pathways to virulence, and whether intraspecific diversity modulates virulence pathways and propensity. In all, 114 isolates representative of the genetic and geographic diversity of Ri...

journal_title：PLoS pathogens

authors： Pinel-Galzi A,Rakotomalala M,Sangu E,Sorho F,Kanyeka Z,Traoré O,Sérémé D,Poulicard N,Rabenantoandro Y,Séré Y,Konaté G,Ghesquière A,Hébrard E,Fargette D

更新日期：2007-11-01 00:00:00

abstract：:Gastrointestinal infections caused by enteric yersiniae can become persistent and complicated by relapsing enteritis and severe autoimmune disorders. To establish a persistent infection, the bacteria have to cope with hostile surroundings when they transmigrate through the intestinal epithelium and colonize underlying...

journal_title：PLoS pathogens

authors： Heine W,Beckstette M,Heroven AK,Thiemann S,Heise U,Nuss AM,Pisano F,Strowig T,Dersch P

更新日期：2018-02-01 00:00:00

abstract：:It has been proposed that in wild ecosystems viruses are often plant mutualists, whereas agroecosystems favour pathogenicity. We seek evidence for virus pathogenicity in wild ecosystems through the analysis of plant-virus coevolution, which requires a negative effect of infection on the host fitness. We focus on the i...

journal_title：PLoS pathogens

authors： Montes N,Alonso-Blanco C,García-Arenal F

更新日期：2019-05-28 00:00:00

abstract：:Gut microbiota facilitate many aspects of human health and development, but dysbiotic microbiota can promote hyperplasia and inflammation and contribute to human diseases such as cancer. Human patients infected with the gastric cancer-causing bacterium Helicobacter pylori have altered microbiota; however, whether dysb...

journal_title：PLoS pathogens

authors： Jones TA,Hernandez DZ,Wong ZC,Wandler AM,Guillemin K

更新日期：2017-10-19 00:00:00

abstract：:The Spumaretrovirinae, or foamy viruses (FVs) are complex retroviruses that infect many species of monkey and ape. Despite little sequence homology, FV and orthoretroviral Gag proteins perform equivalent functions, including genome packaging, virion assembly, trafficking and membrane targeting. However, there is a pau...

journal_title：PLoS pathogens

authors： Ball NJ,Nicastro G,Dutta M,Pollard DJ,Goldstone DC,Sanz-Ramos M,Ramos A,Müllers E,Stirnnagel K,Stanke N,Lindemann D,Stoye JP,Taylor WR,Rosenthal PB,Taylor IA

更新日期：2016-11-09 00:00:00

abstract：:A key difference that distinguishes viral infections from protein immunizations is the recognition of viral nucleic acids by cytosolic pattern recognition receptors (PRRs). Insights into the functions of cytosolic PRRs such as the RNA-sensing Rig-I-like receptors (RLRs) in the instruction of adaptive immunity are ther...

journal_title：PLoS pathogens

authors： O'Ketch M,Williams S,Larson C,Uhrlaub JL,Wong R,Hall B,Deshpande NR,Schenten D

更新日期：2020-10-26 00:00:00

abstract：:Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs. Unusually potent nAb titers developed in 2 of 8 rabbits immunized with virus-like particles (VLPs) expressing trimers (trimer...

journal_title：PLoS pathogens

authors： Crooks ET,Tong T,Chakrabarti B,Narayan K,Georgiev IS,Menis S,Huang X,Kulp D,Osawa K,Muranaka J,Stewart-Jones G,Destefano J,O'Dell S,LaBranche C,Robinson JE,Montefiori DC,McKee K,Du SX,Doria-Rose N,Kwong PD,Mascola

更新日期：2015-05-29 00:00:00