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Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes.

Abstract：

:While immunological memory has long been considered the province of T- and B-lymphocytes, it has recently been reported that innate cell populations are capable of mediating memory responses. We now show that an innate memory immune response is generated in mice following infection with vaccinia virus, a poxvirus for which no cognate germline-encoded receptor has been identified. This immune response results in viral clearance in the absence of classical adaptive T and B lymphocyte populations, and is mediated by a Thy1(+) subset of natural killer (NK) cells. We demonstrate that immune protection against infection from a lethal dose of virus can be adoptively transferred with memory hepatic Thy1(+) NK cells that were primed with live virus. Our results also indicate that, like classical immunological memory, stronger innate memory responses form in response to priming with live virus than a highly attenuated vector. These results demonstrate that a defined innate memory cell population alone can provide host protection against a lethal systemic infection through viral clearance.

journal_name

PLoS Pathog

journal_title

PLoS pathogens

authors

Gillard GO,Bivas-Benita M,Hovav AH,Grandpre LE,Panas MW,Seaman MS,Haynes BF,Letvin NL

doi

10.1371/journal.ppat.1002141

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

e1002141

issue

8

eissn

1553-7366

issn

1553-7374

pii

PPATHOGENS-D-10-00573

journal_volume

7

pub_type

杂志文章

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