Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics.

abstract：:Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant strains continue to emerge, underscoring the need for additional novel mechanism inhibitors that will offer expanded therapeutic options in the clinic. We report a new class of small molecule antiretroviral compounds that di...

journal_title：PLoS pathogens

authors： Blair WS,Pickford C,Irving SL,Brown DG,Anderson M,Bazin R,Cao J,Ciaramella G,Isaacson J,Jackson L,Hunt R,Kjerrstrom A,Nieman JA,Patick AK,Perros M,Scott AD,Whitby K,Wu H,Butler SL

更新日期：2010-12-09 00:00:00

abstract：:Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely in adults. The mechanisms that determine the age-dependent susceptibility remain largely unclear. Here, we found that the paucity of invariant natural killer T (iNKT) cells together wi...

journal_title：PLoS pathogens

authors： Zhu K,Yang J,Luo K,Yang C,Zhang N,Xu R,Chen J,Jin M,Xu B,Guo N,Wang J,Chen Z,Cui Y,Zhao H,Wang Y,Deng C,Bai L,Ge B,Qin CF,Shen H,Yang CF,Leng Q

更新日期：2015-01-23 00:00:00

abstract：:The ability to switch between yeast and filamentous forms is central to Candida albicans biology. The yeast-hyphal transition is implicated in adherence, tissue invasion, biofilm formation, phagocyte escape, and pathogenesis. A second form of morphological plasticity in C. albicans involves epigenetic switching betwee...

journal_title：PLoS pathogens

authors： Si H,Hernday AD,Hirakawa MP,Johnson AD,Bennett RJ

更新日期：2013-03-01 00:00:00

abstract：:The widespread use of antibiotics is selecting for a variety of resistance mechanisms that seriously challenge our ability to treat bacterial infections. Resistant bacteria can be selected at the high concentrations of antibiotics used therapeutically, but what role the much lower antibiotic concentrations present in ...

journal_title：PLoS pathogens

authors： Gullberg E,Cao S,Berg OG,Ilbäck C,Sandegren L,Hughes D,Andersson DI

更新日期：2011-07-01 00:00:00

abstract：:A defect in the PKA1 gene encoding the catalytic subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase A (PKA) is known to reduce capsule size and attenuate virulence in the fungal pathogen Cryptococcus neoformans. Conversely, loss of the PKA regulatory subunit encoded by pkr1 results in overpro...

journal_title：PLoS pathogens

authors： Hu G,Steen BR,Lian T,Sham AP,Tam N,Tangen KL,Kronstad JW

更新日期：2007-03-01 00:00:00

abstract：:The MHC class I D(k) molecule supplies vital host resistance during murine cytomegalovirus (MCMV) infection. Natural killer (NK) cells expressing the Ly49G2 inhibitory receptor, which specifically binds D(k), are required to control viral spread. The extent of D(k)-dependent host resistance, however, differs significa...

journal_title：PLoS pathogens

authors： Gillespie AL,Teoh J,Lee H,Prince J,Stadnisky MD,Anderson M,Nash W,Rival C,Wei H,Gamache A,Farber CR,Tung K,Brown MG

更新日期：2016-02-04 00:00:00

abstract：:Newcastle Disease Virus (NDV) is a pathogenic strain of avian paramyxovirus (aPMV-1) that is among the most serious of disease threats to the poultry industry worldwide. Viral diversity is high in aPMV-1; eight genotypes are recognized based on phylogenetic reconstruction of gene sequences. Modified live vaccines have...

journal_title：PLoS pathogens

authors： Chong YL,Padhi A,Hudson PJ,Poss M

更新日期：2010-04-22 00:00:00

abstract：:The control of mosquito populations with insecticide treated bed nets and indoor residual sprays remains the cornerstone of malaria reduction and elimination programs. In light of widespread insecticide resistance in mosquitoes, however, alternative strategies for reducing transmission by the mosquito vector are urgen...

journal_title：PLoS pathogens

authors： Childs LM,Cai FY,Kakani EG,Mitchell SN,Paton D,Gabrieli P,Buckee CO,Catteruccia F

更新日期：2016-12-15 00:00:00

abstract：:Prions are pathogens formed from abnormal conformers (PrPSc) of the host-encoded cellular prion protein (PrPC). PrPSc conformation to disease phenotype relationships extensively vary among prion strains. In particular, prions exhibit a strain-dependent tropism for lymphoid tissues. Prions can be composed of several su...

journal_title：PLoS pathogens

authors： Béringue V,Tixador P,Andréoletti O,Reine F,Castille J,Laï TL,Le Dur A,Laisné A,Herzog L,Passet B,Rezaei H,Vilotte JL,Laude H

更新日期：2020-07-23 00:00:00

abstract：:DNA methylation is a fundamental epigenetic modification that regulates gene expression and represses endogenous transposons and invading DNA viruses. As a counter-defense, the geminiviruses encode proteins that inhibit methylation and transcriptional gene silencing (TGS). Some geminiviruses have acquired a betasatell...

journal_title：PLoS pathogens

authors： Yang X,Xie Y,Raja P,Li S,Wolf JN,Shen Q,Bisaro DM,Zhou X

更新日期：2011-10-01 00:00:00

abstract：:For many viruses, one or two proteins allow cell attachment and entry, which occurs through the plasma membrane or following endocytosis at low pH. In contrast, vaccinia virus (VACV) enters cells by both neutral and low pH routes; four proteins mediate cell attachment and twelve that are associated in a membrane compl...

journal_title：PLoS pathogens

authors： Laliberte JP,Weisberg AS,Moss B

更新日期：2011-12-01 00:00:00

abstract：:Human herpesviruses are antigenically rich agents that induce strong CD8+T cell responses in primary infection yet persist for life, continually challenging T cell memory through recurrent lytic replication and potentially influencing the spectrum of antigen-specific responses. Here we describe the first lytic proteom...

journal_title：PLoS pathogens

authors： Forrest C,Hislop AD,Rickinson AB,Zuo J

更新日期：2018-09-24 00:00:00

abstract：:Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription template, which plays a pivotal role in viral infection and persistence. Upon infection, the non-replicative cccDNA is converted from the incoming and de novo synthesized viral genomic relaxed circular (rc) DNA, presumably through e...

journal_title：PLoS pathogens

authors： Long Q,Yan R,Hu J,Cai D,Mitra B,Kim ES,Marchetti A,Zhang H,Wang S,Liu Y,Huang A,Guo H

更新日期：2017-12-29 00:00:00

abstract：:Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for aspergillosis, have been widely disseminated across the globe. To eluc...

journal_title：PLoS pathogens

authors： Hagiwara D,Miura D,Shimizu K,Paul S,Ohba A,Gonoi T,Watanabe A,Kamei K,Shintani T,Moye-Rowley WS,Kawamoto S,Gomi K

更新日期：2017-01-04 00:00:00

abstract：:The rice blast fungus Magnaporthe oryzae is one of the most significant pathogens affecting global food security. To cause rice blast disease the fungus elaborates a specialised infection structure called an appressorium. Here, we report genome wide transcriptional profile analysis of appressorium development using ne...

journal_title：PLoS pathogens

authors： Soanes DM,Chakrabarti A,Paszkiewicz KH,Dawe AL,Talbot NJ

更新日期：2012-02-01 00:00:00

abstract：:The N-terminal domains of the herpesvirus large tegument proteins encode a conserved cysteine protease with ubiquitin- and NEDD8-specific deconjugase activity. The proteins are expressed during the productive virus cycle and are incorporated into infectious virus particles, being delivered to the target cells upon pri...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Callegari S,Tsai MH,Delecluse HJ,Masucci MG

更新日期：2018-01-22 00:00:00

abstract：:Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely unexplored. Using a primary human lymphatic endothelial cell model, we found that HIV-1 envelo...

journal_title：PLoS pathogens

authors： Zhang X,Yu J,Kuzontkoski PM,Zhu W,Li DY,Groopman JE

更新日期：2012-01-01 00:00:00

abstract：:HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein between capsid p24 capsid (CA) and spacer peptide 1 (SP1), leading to the production of infectious virus. BMS-955176 is a second generation MI with improved antiviral activity toward polymorphic Gag ...

journal_title：PLoS pathogens

authors： Lin Z,Cantone J,Lu H,Nowicka-Sans B,Protack T,Yuan T,Yang H,Liu Z,Drexler D,Regueiro-Ren A,Meanwell NA,Cockett M,Krystal M,Lataillade M,Dicker IB

更新日期：2016-11-28 00:00:00

abstract：:HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contain an incomplete spherical shell where Gag is arranged with the N-term...

journal_title：PLoS pathogens

authors： de Marco A,Müller B,Glass B,Riches JD,Kräusslich HG,Briggs JA

更新日期：2010-11-24 00:00:00

abstract：:The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little is known about this interaction. We used isothermal titration calorimetry, X-ray crystallography and mutagenesis-validated modeling to...

journal_title：PLoS pathogens

authors： Fisher CR,Sutton HJ,Kaczmarski JA,McNamara HA,Clifton B,Mitchell J,Cai Y,Dups JN,D'Arcy NJ,Singh M,Chuah A,Peat TS,Jackson CJ,Cockburn IA

更新日期：2017-07-31 00:00:00

abstract：:Human Papillomavirus (HPV) 16 E7 protein promotes the transformation of HPV infected epithelium to malignancy. Here, we use a murine model in which the E7 protein of HPV16 is expressed as a transgene in epithelium to show that mast cells are recruited to the basal layer of E7-expressing epithelium, and that this recru...

journal_title：PLoS pathogens

authors： Bergot AS,Ford N,Leggatt GR,Wells JW,Frazer IH,Grimbaldeston MA

更新日期：2014-10-23 00:00:00

abstract：:A global increase in invasive infections due to group A Streptococcus (S. pyogenes or GAS) has been observed since the 1980s, associated with emergence of a clonal group of strains of the M1T1 serotype. Among other virulence attributes, the M1T1 clone secretes NAD+-glycohydrolase (NADase). When GAS binds to epithelial...

journal_title：PLoS pathogens

authors： Sharma O,O'Seaghdha M,Velarde JJ,Wessels MR

更新日期：2016-03-03 00:00:00

abstract：:Viruses have evolved several strategies to modify cellular processes and evade the immune response in order to successfully infect, replicate, and persist in the host. By utilizing in-silico testing of a transmembrane sequence library derived from virus protein sequences, we have pin-pointed a nine amino-acid motif sh...

journal_title：PLoS pathogens

authors： Cohen T,Cohen SJ,Antonovsky N,Cohen IR,Shai Y

更新日期：2010-09-02 00:00:00

abstract：:The envelope glycoprotein (Env) of the Human Immunodeficiency Virus Type-1 (HIV-1) is a critical determinant of viral infectivity, tropism and is the main target for humoral immunity; however, little is known about the cellular machinery that directs Env trafficking and its incorporation into nascent virions. Here we ...

journal_title：PLoS pathogens

authors： Groppelli E,Len AC,Granger LA,Jolly C

更新日期：2014-11-13 00:00:00

abstract：:The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered. Streptococcus equi subspecies equi (S. equi) is a host-restricted pathogen of horses that has evolved from the zoonotic p...

journal_title：PLoS pathogens

authors： Holden MT,Heather Z,Paillot R,Steward KF,Webb K,Ainslie F,Jourdan T,Bason NC,Holroyd NE,Mungall K,Quail MA,Sanders M,Simmonds M,Willey D,Brooks K,Aanensen DM,Spratt BG,Jolley KA,Maiden MC,Kehoe M,Chanter N,Bentl

更新日期：2009-03-01 00:00:00

abstract：:The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after import have not been studied. To elucidate these essential HIV-1 post-entry events, we labeled viral complexes with two fluorescently tagged virion-incorporated proteins (APOBEC3F or integrase), and analyzed the HIV-1 dynamics of ...

journal_title：PLoS pathogens

authors： Burdick RC,Delviks-Frankenberry KA,Chen J,Janaka SK,Sastri J,Hu WS,Pathak VK

更新日期：2017-08-21 00:00:00

abstract：:Mouse polyomavirus (MPyV) lytically infects mouse cells, transforms rat cells in culture, and is highly oncogenic in rodents. We have used deep sequencing to follow MPyV infection of mouse NIH3T6 cells at various times after infection and analyzed both the viral and cellular transcriptomes. Alignment of sequencing rea...

journal_title：PLoS pathogens

authors： Garren SB,Kondaveeti Y,Duff MO,Carmichael GG

更新日期：2015-09-25 00:00:00

abstract：:Plant microRNAs (miRNA) guide cleavage of target mRNAs by DICER-like proteins, thereby reducing mRNA abundance. Native precursor miRNAs can be redesigned to target RNAs of interest, and one application of such artificial microRNA (amiRNA) technology is to generate plants resistant to pathogenic viruses. Transgenic Ara...

journal_title：PLoS pathogens

authors： Lin SS,Wu HW,Elena SF,Chen KC,Niu QW,Yeh SD,Chen CC,Chua NH

更新日期：2009-02-01 00:00:00

abstract：:Clostridium difficile is a global health burden and the leading cause of antibiotic-associated diarrhoea worldwide, causing severe gastrointestinal disease and death. Three well characterised toxins are encoded by this bacterium in two genetic loci, specifically, TcdB (toxin B) and TcdA (toxin A) in the Pathogenicity ...

journal_title：PLoS pathogens

authors： Lyon SA,Hutton ML,Rood JI,Cheung JK,Lyras D

更新日期：2016-07-14 00:00:00

abstract：:HIV-1 replicative capacity (RC) provides a measure of within-host fitness and is determined in the context of phenotypic drug resistance testing. However it is unclear how these in-vitro measurements relate to in-vivo processes. Here we assess RCs in a clinical setting by combining a previously published machine-learn...

journal_title：PLoS pathogens

authors： Kouyos RD,von Wyl V,Hinkley T,Petropoulos CJ,Haddad M,Whitcomb JM,Böni J,Yerly S,Cellerai C,Klimkait T,Günthard HF,Bonhoeffer S,Swiss HIV Cohort Study.

更新日期：2011-11-01 00:00:00