Abstract:
:Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs, which directly target SKN-1, a gene downstream of PMK-1. These findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/PMK-1 MAP kinase pathway.
journal_name
PLoS Pathogjournal_title
PLoS pathogensauthors
Liu F,He CX,Luo LJ,Zou QL,Zhao YX,Saini R,Han SF,Knölker HJ,Wang LS,Ge BXdoi
10.1371/journal.ppat.1003545subject
Has Abstractpub_date
2013-01-01 00:00:00pages
e1003545issue
8eissn
1553-7366issn
1553-7374pii
PPATHOGENS-D-13-00126journal_volume
9pub_type
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