Abstract:
:A fatal human case of Duvenhage virus (DUVV) infection in a Dutch traveller who had returned from Kenya was reported in 2007. She exhibited classical symptoms of rabies encephalitis with distinct pathological findings. In the present study we describe the isolation and characterization of DUVV in vitro and its passage in BALB/c mice. The virus proved to be neuroinvasive in both juvenile and adult mice, resulting in about 50% lethality upon peripheral infection. Clinical signs in infected mice were those of classical rabies. However, the distribution of viral antigen expression in the brain differed from that of classical rabies virus infection and neither inclusion bodies nor neuronal necrosis were observed. This is the first study to describe the in vitro and in vivo isolation and characterization of DUVV.
journal_name
PLoS Pathogjournal_title
PLoS pathogensauthors
Koraka P,Martina BE,Roose JM,van Thiel PP,van Amerongen G,Kuiken T,Osterhaus ADdoi
10.1371/journal.ppat.1002682subject
Has Abstractpub_date
2012-01-01 00:00:00pages
e1002682issue
5eissn
1553-7366issn
1553-7374pii
PPATHOGENS-D-11-02462journal_volume
8pub_type
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