Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.

abstract：:In nature, larvae of the fruitfly Drosophila melanogaster are commonly infected by parasitoid wasps, and so have evolved a robust immune response to counter wasp infection. In this response, fly immune cells form a multilayered capsule surrounding the wasp egg, leading to death of the parasite. Many of the molecular m...

journal_title：PLoS pathogens

authors： Mortimer NT,Kacsoh BZ,Keebaugh ES,Schlenke TA

更新日期：2012-01-01 00:00:00

abstract：:Ebola virus (EBOV) is a highly pathogenic filovirus that causes hemorrhagic fever in humans and animals. Currently, how EBOV fuses its envelope membrane within an endosomal membrane to cause infection is poorly understood. We successfully measure cell-cell fusion mediated by the EBOV fusion protein, GP, assayed by the...

journal_title：PLoS pathogens

authors： Markosyan RM,Miao C,Zheng YM,Melikyan GB,Liu SL,Cohen FS

更新日期：2016-01-05 00:00:00

abstract：:The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however, little is known about its relationship to early disease progression. To better understand the relationship between the lung microbiome and early respiratory disease, we characterized the lower airways microbiome using bronchoalv...

journal_title：PLoS pathogens

authors： Muhlebach MS,Zorn BT,Esther CR,Hatch JE,Murray CP,Turkovic L,Ranganathan SC,Boucher RC,Stick SM,Wolfgang MC

更新日期：2018-01-18 00:00:00

abstract：:The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5), sense cytoplasmic viral RNA and initiate innate antiviral responses. How RIG-I and MDA5 are differentially regulated remains enigmatic. In this study, we identified the guanylate-bin...

journal_title：PLoS pathogens

authors： Zhong X,Feng L,Zang R,Lei CQ,Yang Q,Shu HB

更新日期：2020-04-06 00:00:00

abstract：:The recent origin and great evolutionary potential of HIV imply that the virulence of the virus might still be changing, which could greatly affect the future of the pandemic. However, previous studies of time trends of HIV virulence have yielded conflicting results. Here we used an established methodology to assess t...

journal_title：PLoS pathogens

authors： Müller V,Maggiolo F,Suter F,Ladisa N,De Luca A,Antinori A,Sighinolfi L,Quiros-Roldan E,Carosi G,Torti C

更新日期：2009-05-01 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the parental Ankara vaccine virus hundreds of times in chick embryo fibroblast...

journal_title：PLoS pathogens

authors： Peng C,Wyatt LS,Glushakow-Smith SG,Lal-Nag M,Weisberg AS,Moss B

更新日期：2020-08-31 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) latency in sensory ganglia such as trigeminal ganglia (TG) is associated with a persistent immune infiltrate that includes effector memory CD8+ T cells that can influence HSV-1 reactivation. In C57BL/6 mice, HSV-1 induces a highly skewed CD8+ T cell repertoire, in which half of CD8+...

journal_title：PLoS pathogens

authors： Treat BR,Bidula SM,Ramachandran S,St Leger AJ,Hendricks RL,Kinchington PR

更新日期：2017-12-04 00:00:00

abstract：:As with many viruses, rabies virus (RABV) infection induces type I interferon (IFN) production within the infected host cells. However, RABV has evolved mechanisms by which to inhibit IFN production in order to sustain infection. Here we show that RABV infection of dendritic cells (DC) induces potent type I IFN produc...

journal_title：PLoS pathogens

authors： Faul EJ,Wanjalla CN,Suthar MS,Gale M,Wirblich C,Schnell MJ

更新日期：2010-07-22 00:00:00

abstract：:Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nucleus of coronavirus-infected cells, first, transcriptome dynamics was...

journal_title：PLoS pathogens

authors： Poppe M,Wittig S,Jurida L,Bartkuhn M,Wilhelm J,Müller H,Beuerlein K,Karl N,Bhuju S,Ziebuhr J,Schmitz ML,Kracht M

更新日期：2017-03-29 00:00:00

abstract：:The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that s...

journal_title：PLoS pathogens

authors： Anderson A,Laurenson-Schafer H,Partridge FA,Hodgkin J,McMullan R

更新日期：2013-01-01 00:00:00

abstract：:The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood. Recent studies demonstrated that CCR5-tropic HIV-1 efficiently enters tissue-derived memory CD4+ T cells expressin...

journal_title：PLoS pathogens

authors： Hsiao F,Frouard J,Gramatica A,Xie G,Telwatte S,Lee GQ,Roychoudhury P,Schwarzer R,Luo X,Yukl SA,Lee S,Hoh R,Deeks SG,Jones RB,Cavrois M,Greene WC,Roan NR

更新日期：2020-04-30 00:00:00

abstract：:Septic shock caused by Neisseria meningitidis is typically rapidly evolving and often fatal despite antibiotic therapy. Further understanding of the mechanisms underlying the disease is necessary to reduce fatality rates. Postmortem samples from the characteristic purpuric rashes of the infection show bacterial aggreg...

journal_title：PLoS pathogens

authors： Melican K,Michea Veloso P,Martin T,Bruneval P,Duménil G

更新日期：2013-01-01 00:00:00

abstract：:Virions are thought to contain all the essential proteins that govern virus egress from the host cell and initiation of replication in the target cell. It has been known for some time that influenza virions contain nine viral proteins; however, analyses of other enveloped viruses have revealed that proteins from the h...

journal_title：PLoS pathogens

authors： Shaw ML,Stone KL,Colangelo CM,Gulcicek EE,Palese P

更新日期：2008-06-06 00:00:00

abstract：:Isolated influenza A virus nucleoprotein exists in an equilibrium between monomers and trimers. Samples containing only monomers or only trimers can be stabilized by respectively low and high salt. The trimers bind RNA with high affinity but remain trimmers, whereas the monomers polymerise onto RNA forming nucleoprote...

journal_title：PLoS pathogens

authors： Chenavas S,Estrozi LF,Slama-Schwok A,Delmas B,Di Primo C,Baudin F,Li X,Crépin T,Ruigrok RW

更新日期：2013-03-01 00:00:00

abstract：:Candida bloodstream infection, i.e. candidemia, is the most frequently encountered life-threatening fungal infection worldwide, with mortality rates up to almost 50%. In the majority of candidemia cases, Candida albicans is responsible. Worryingly, a global increase in the number of patients who are susceptible to inf...

journal_title：PLoS pathogens

authors： de Vries DH,Matzaraki V,Bakker OB,Brugge H,Westra HJ,Netea MG,Franke L,Kumar V,van der Wijst MGP

更新日期：2020-04-06 00:00:00

abstract：:Root-knot nematodes secrete effectors that manipulate their host plant cells so that the nematode can successfully establish feeding sites and complete its lifecycle. The root-knot nematode feeding structures, their "giant cells," undergo extensive cytoskeletal remodeling. Previous cytological studies have shown the c...

journal_title：PLoS pathogens

authors： Leelarasamee N,Zhang L,Gleason C

更新日期：2018-03-15 00:00:00

abstract：:In HPV-related cancers, the "high-risk" human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in the presence of HPV...

journal_title：PLoS pathogens

authors： Kadaja M,Isok-Paas H,Laos T,Ustav E,Ustav M

更新日期：2009-04-01 00:00:00

abstract：:An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash, polyarthritis, and lethal cases of encephalitis. The basis for chikungunya disease and the tropism of CHIKV remain unkno...

journal_title：PLoS pathogens

authors： Sourisseau M,Schilte C,Casartelli N,Trouillet C,Guivel-Benhassine F,Rudnicka D,Sol-Foulon N,Le Roux K,Prevost MC,Fsihi H,Frenkiel MP,Blanchet F,Afonso PV,Ceccaldi PE,Ozden S,Gessain A,Schuffenecker I,Verhasselt B,Zamb

更新日期：2007-06-01 00:00:00

abstract：:Newcastle Disease Virus (NDV) is a pathogenic strain of avian paramyxovirus (aPMV-1) that is among the most serious of disease threats to the poultry industry worldwide. Viral diversity is high in aPMV-1; eight genotypes are recognized based on phylogenetic reconstruction of gene sequences. Modified live vaccines have...

journal_title：PLoS pathogens

authors： Chong YL,Padhi A,Hudson PJ,Poss M

更新日期：2010-04-22 00:00:00

abstract：:Clostridium difficile is a global health burden and the leading cause of antibiotic-associated diarrhoea worldwide, causing severe gastrointestinal disease and death. Three well characterised toxins are encoded by this bacterium in two genetic loci, specifically, TcdB (toxin B) and TcdA (toxin A) in the Pathogenicity ...

journal_title：PLoS pathogens

authors： Lyon SA,Hutton ML,Rood JI,Cheung JK,Lyras D

更新日期：2016-07-14 00:00:00

abstract：:Rice tungro disease is caused by synergistic interaction of an RNA picorna-like virus Rice tungro spherical virus (RTSV) and a DNA pararetrovirus Rice tungro bacilliform virus (RTBV). It is spread by insects owing to an RTSV-encoded transmission factor. RTBV has evolved a ribosome shunt mechanism to initiate translati...

journal_title：PLoS pathogens

authors： Pooggin MM,Rajeswaran R,Schepetilnikov MV,Ryabova LA

更新日期：2012-01-01 00:00:00

abstract：:B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (TFH) cells. We studied the effects of native heterodimeric IL-15 (hetIL-15) treatmen...

journal_title：PLoS pathogens

authors： Watson DC,Moysi E,Valentin A,Bergamaschi C,Devasundaram S,Fortis SP,Bear J,Chertova E,Bess J Jr,Sowder R,Venzon DJ,Deleage C,Estes JD,Lifson JD,Petrovas C,Felber BK,Pavlakis GN

更新日期：2018-02-23 00:00:00

abstract：:Mycobacterial infection leads to activation of the RIG-I/MAVS/TBK1 RNA sensing pathway in macrophages but the consequences of this activation remains poorly defined. In this study, we determined that activation of this RNA sensing pathway stimulates ICAM-1 expression in M.avium-infected macrophage through the inhibiti...

journal_title：PLoS pathogens

authors： Cheng Y,Kiene NJ,Tatarian A,Eix EF,Schorey JS

更新日期：2020-05-28 00:00:00

abstract：:Altered cell metabolism is inherently connected with pathological conditions including cancer and viral infections. Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS). KS tumour cells display features of lymphatic endothelial differentiation and in their vast majority are ...

journal_title：PLoS pathogens

authors： Yogev O,Lagos D,Enver T,Boshoff C

更新日期：2014-09-25 00:00:00

abstract：:Zika virus (ZIKV) infects pregnant women and causes devastating congenital zika syndrome (CZS). How the virus is vertically transmitted to the fetus and induces neuronal loss remains unclear. We previously reported that Pellino (Peli)1, an E3 ubiquitin ligase, promotes p38MAPK activation in microglia and induction of ...

journal_title：PLoS pathogens

authors： Luo H,Li G,Wang B,Tian B,Gao J,Zou J,Shi S,Zhu S,Peng BH,Adam A,Martinez A,Hein K,Winkelmann ER,Mahmoud Y,Zhou X,Shan C,Rossi S,Weaver S,Barrett ADT,Sun SC,Zhang W,Shi PY,Wu P,Wang T

更新日期：2020-06-16 00:00:00

abstract：:Pseudomonas aeruginosa is one of the leading causes of nosocomial pneumonia and its associated mortality. Moreover, extensively drug-resistant high-risk clones are globally widespread, presenting a major challenge to the healthcare systems. Despite this, no vaccine is available against this high-concerning pathogen. H...

journal_title：PLoS pathogens

authors： Cabral MP,Correia A,Vilanova M,Gärtner F,Moscoso M,García P,Vallejo JA,Pérez A,Francisco-Tomé M,Fuentes-Valverde V,Bou G

更新日期：2020-02-10 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1007696.]. ...

journal_title：PLoS pathogens

authors： Dewan KK,Taylor-Mulneix DL,Campos LL,Skarlupka AL,Wagner SM,Ryman VE,Gestal MC,Ma L,Blas-Machado U,Faddis BT,Harvill ET

更新日期：2019-06-28 00:00:00

abstract：:Viroids are small, non-protein-coding RNAs which can induce disease symptoms in a variety of plant species. Potato (Solanum tuberosum L.) is the natural host of Potato spindle tuber viroid (PSTVd) where infection results in stunting, distortion of leaves and tubers and yield loss. Replication of PSTVd is accompanied b...

journal_title：PLoS pathogens

authors： Bao S,Owens RA,Sun Q,Song H,Liu Y,Eamens AL,Feng H,Tian H,Wang MB,Zhang R

更新日期：2019-12-02 00:00:00

abstract：:Endogenous retroviruses (ERVs), remnants of ancient germline infections, comprise 8% of the human genome. The most recently integrated includes human ERV-K (HERV-K) where several envelope (env) sequences remain intact. Viral pseudotypes decorated with one of those Envs are infectious. Using a recombinant vesicular sto...

journal_title：PLoS pathogens

authors： Robinson-McCarthy LR,McCarthy KR,Raaben M,Piccinotti S,Nieuwenhuis J,Stubbs SH,Bakkers MJG,Whelan SPJ

更新日期：2018-08-06 00:00:00

abstract：:The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB) encoded in the N-t...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Sandalova T,Sun R,Achour A,Masucci MG

更新日期：2019-11-11 00:00:00