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Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice.

Abstract：

:The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete understanding of immune correlates of protection represents a major barrier to the design of vaccines and therapeutic approaches to prevent infection or limit disease. This deficit is largely due to the lack of prospectively collected, pre-infection samples from indiviuals that go on to become infected with SARS-CoV-2. Here, we utilized data from genetically diverse Collaborative Cross (CC) mice infected with SARS-CoV to determine whether baseline T cell signatures are associated with a lack of viral control and severe disease upon infection. SARS-CoV infection of CC mice results in a variety of viral load trajectories and disease outcomes. Overall, a dysregulated, pro-inflammatory signature of circulating T cells at baseline was associated with severe disease upon infection. Our study serves as proof of concept that circulating T cell signatures at baseline can predict clinical and virologic outcomes upon SARS-CoV infection. Identification of basal immune predictors in humans could allow for identification of individuals at highest risk of severe clinical and virologic outcomes upon infection, who may thus most benefit from available clinical interventions to restrict infection and disease.

journal_name

PLoS Pathog

journal_title

PLoS pathogens

authors

Graham JB,Swarts JL,Leist SR,Schäfer A,Menachery VD,Gralinski LE,Jeng S,Miller DR,Mooney MA,McWeeney SK,Ferris MT,Pardo-Manuel de Villena F,Heise MT,Baric RS,Lund JM

doi

10.1371/journal.ppat.1009287

subject

Has Abstract

pub_date

2021-01-29 00:00:00

pages

e1009287

issue

1

eissn

1553-7366

issn

1553-7374

pii

PPATHOGENS-D-20-02261

journal_volume

17

pub_type

杂志文章

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