The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.

Abstract:

:DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune system. Mice lacking DDX3X during hematopoiesis showed an altered leukocyte composition in bone marrow and spleen and a striking inability to combat infection with Listeria monocytogenes. Alterations in innate immune responses resulted from decreased effector cell availability and function as well as a sex-dependent impairment of cytokine synthesis. Thus, our data provide further in vivo evidence for an essential contribution of a non-RLR DExD/H RNA helicase to innate immunity and suggest it may contribute to sex-related differences in resistance to microbes and resilience to inflammatory disease.

journal_name

PLoS Pathog

journal_title

PLoS pathogens

authors

Szappanos D,Tschismarov R,Perlot T,Westermayer S,Fischer K,Platanitis E,Kallinger F,Novatchkova M,Lassnig C,Müller M,Sexl V,Bennett KL,Foong-Sobis M,Penninger JM,Decker T

doi

10.1371/journal.ppat.1007397

subject

Has Abstract

pub_date

2018-11-26 00:00:00

pages

e1007397

issue

11

eissn

1553-7366

issn

1553-7374

pii

PPATHOGENS-D-18-00629

journal_volume

14

pub_type

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