Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis.

abstract：:Gastrointestinal infections caused by enteric yersiniae can become persistent and complicated by relapsing enteritis and severe autoimmune disorders. To establish a persistent infection, the bacteria have to cope with hostile surroundings when they transmigrate through the intestinal epithelium and colonize underlying...

journal_title：PLoS pathogens

authors： Heine W,Beckstette M,Heroven AK,Thiemann S,Heise U,Nuss AM,Pisano F,Strowig T,Dersch P

更新日期：2018-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection is a chronic condition, where viral DNA integrates into the genome. Latently infected cells form a persistent, heterogeneous reservoir that at any time can reactivate the integrated HIV-1. Here we confirmed that latently infected cells from HIV-1 positive study par...

journal_title：PLoS pathogens

authors： Lindqvist B,Svensson Akusjärvi S,Sönnerborg A,Dimitriou M,Svensson JP

更新日期：2020-01-30 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that persists lifelong in the host. In ∼4% of infected people, HTLV-1 causes a chronic disabling neuroinflammatory disease known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The pathogenesis of HAM/TSP is unknown and treatment remain...

journal_title：PLoS pathogens

authors： Tattermusch S,Skinner JA,Chaussabel D,Banchereau J,Berry MP,McNab FW,O'Garra A,Taylor GP,Bangham CR

更新日期：2012-01-01 00:00:00

abstract：:RNA silencing is an evolutionarily conserved sequence-specific gene-inactivation system that also functions as an antiviral mechanism in higher plants and insects. To overcome antiviral RNA silencing, viruses express silencing-suppressor proteins. These viral proteins can target one or more key points in the silencing...

journal_title：PLoS pathogens

authors： Giner A,Lakatos L,García-Chapa M,López-Moya JJ,Burgyán J

更新日期：2010-07-15 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a leading cause of liver disease worldwide. The HCV RNA genome is translated into a single polyprotein. Most of the cleavage sites in the non-structural (NS) polyprotein region are processed by the NS3/NS4A serine protease. The vital NS2-NS3 cleavage is catalyzed by the NS2 autopro...

journal_title：PLoS pathogens

authors： Isken O,Langerwisch U,Jirasko V,Rehders D,Redecke L,Ramanathan H,Lindenbach BD,Bartenschlager R,Tautz N

更新日期：2015-03-16 00:00:00

abstract：:Regulated protein secretion is required for malaria parasite life cycle progression and transmission between the mammalian host and mosquito vector. During transmission from the host to the vector, exocytosis of highly specialised secretory vesicles, such as osmiophilic bodies, is key to the dissolution of the red blo...

journal_title：PLoS pathogens

authors： Kehrer J,Singer M,Lemgruber L,Silva PA,Frischknecht F,Mair GR

更新日期：2016-07-18 00:00:00

abstract：:The Venus kinase receptor (VKR) is a single transmembrane molecule composed of an intracellular tyrosine kinase domain close to that of insulin receptor and an extracellular Venus Flytrap (VFT) structure similar to the ligand binding domain of many class C G protein coupled receptors. This receptor tyrosine kinase (RT...

journal_title：PLoS pathogens

authors： Vanderstraete M,Gouignard N,Cailliau K,Morel M,Hahnel S,Leutner S,Beckmann S,Grevelding CG,Dissous C

更新日期：2014-05-29 00:00:00

abstract：:The mechanisms involved in the persistence of activated CD4+ T lymphocytes following primary human T leukemia/lymphoma virus type 1 (HTLV-1) infection remain unclear. Here, we demonstrate that the HTLV-1 Tax oncoprotein modulates phosphorylation and transcriptional activity of the FOXO3a transcription factor, via upst...

journal_title：PLoS pathogens

authors： Olagnier D,Sze A,Bel Hadj S,Chiang C,Steel C,Han X,Routy JP,Lin R,Hiscott J,van Grevenynghe J

更新日期：2014-12-18 00:00:00

abstract：:Shoot apical meristems (SAM) are resistant to most plant viruses due to RNA silencing, which is restrained by viral suppressors of RNA silencing (VSRs) to facilitate transient viral invasion of the SAM. In many cases chronic symptoms and long-term virus recovery occur, but the underlying mechanisms are poorly understo...

journal_title：PLoS pathogens

authors： Zhang XP,Liu DS,Yan T,Fang XD,Dong K,Xu J,Wang Y,Yu JL,Wang XB

更新日期：2017-07-20 00:00:00

abstract：:A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. Here, we combined an experimental model with the transcriptional profi...

journal_title：PLoS pathogens

authors： Sacramento LA,Benevides L,Maruyama SR,Tavares L,Fukutani KF,Francozo M,Sparwasser T,Cunha FQ,Almeida RP,da Silva JS,Carregaro V

更新日期：2020-03-25 00:00:00

abstract：:Two-component signal transduction systems (TCS) are used by bacteria to sense and respond to their environment. TCS are typically composed of a sensor histidine kinase (HK) and a response regulator (RR). The Vibrio cholerae genome encodes 52 RR, but the role of these RRs in V. cholerae pathogenesis is largely unknown....

journal_title：PLoS pathogens

authors： Cheng AT,Ottemann KM,Yildiz FH

更新日期：2015-05-22 00:00:00

abstract：:Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse). We identified approximately 20 TRIM proteins that, when transiently expressed in HE...

journal_title：PLoS pathogens

authors： Uchil PD,Quinlan BD,Chan WT,Luna JM,Mothes W

更新日期：2008-02-08 00:00:00

abstract：:Dendritic cells (DCs) are specialized phagocytes that internalize exogenous antigens and microbes at peripheral sites, and then migrate to lymphatic organs to display foreign peptides to naïve T cells. There are several examples where DCs have been shown to be more efficient at restricting the intracellular replicatio...

journal_title：PLoS pathogens

authors： Nogueira CV,Lindsten T,Jamieson AM,Case CL,Shin S,Thompson CB,Roy CR

更新日期：2009-06-01 00:00:00

abstract：:Toll-like receptor (TLR) ligands are being considered as adjuvants for the induction of antigen-specific immune responses, as in the design of vaccines. Polyriboinosinic-polyribocytoidylic acid (poly I:C), a synthetic double-stranded RNA (dsRNA), is recognized by TLR3 and other intracellular receptors. Poly ICLC is a ...

journal_title：PLoS pathogens

authors： Stahl-Hennig C,Eisenblätter M,Jasny E,Rzehak T,Tenner-Racz K,Trumpfheller C,Salazar AM,Uberla K,Nieto K,Kleinschmidt J,Schulte R,Gissmann L,Müller M,Sacher A,Racz P,Steinman RM,Uguccioni M,Ignatius R

更新日期：2009-04-01 00:00:00

abstract：:We assessed the role of myeloid dendritic cells (mDCs) in the outcome of SIV infection by comparing and contrasting their frequency, mobilization, phenotype, cytokine production and apoptosis in pathogenic (pigtailed macaques, PTMs), nonpathogenic (African green monkeys, AGMs) and controlled (rhesus macaques, RMs) SIV...

journal_title：PLoS pathogens

authors： Wijewardana V,Kristoff J,Xu C,Ma D,Haret-Richter G,Stock JL,Policicchio BB,Mobley AD,Nusbaum R,Aamer H,Trichel A,Ribeiro RM,Apetrei C,Pandrea I

更新日期：2013-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) and human pegivirus (HPgV), formerly GBV-C, are the only known human viruses in the Hepacivirus and Pegivirus genera, respectively, of the family Flaviviridae. We present the discovery of a second pegivirus, provisionally designated human pegivirus 2 (HPgV-2), by next-generation sequencing of p...

journal_title：PLoS pathogens

authors： Berg MG,Lee D,Coller K,Frankel M,Aronsohn A,Cheng K,Forberg K,Marcinkus M,Naccache SN,Dawson G,Brennan C,Jensen DM,Hackett J Jr,Chiu CY

更新日期：2015-12-11 00:00:00

abstract：:In the United States, the introduction of the heptavalent pneumococcal conjugate vaccine (PCV) largely eliminated vaccine serotypes (VT); non-vaccine serotypes (NVT) subsequently increased in carriage and disease. Vaccination also disrupts the composition of the pneumococcal pangenome, which includes mobile genetic el...

journal_title：PLoS pathogens

authors： Azarian T,Grant LR,Arnold BJ,Hammitt LL,Reid R,Santosham M,Weatherholtz R,Goklish N,Thompson CM,Bentley SD,O'Brien KL,Hanage WP,Lipsitch M

更新日期：2018-04-04 00:00:00

abstract：:Among the several new antimalarials discovered over the past decade are at least three clinical candidate drugs, each with a distinct chemical structure, that disrupt Na+ homeostasis resulting in a rapid increase in intracellular Na+ concentration ([Na+]i) within the erythrocytic stages of Plasmodium falciparum. At pr...

journal_title：PLoS pathogens

authors： Das S,Bhatanagar S,Morrisey JM,Daly TM,Burns JM Jr,Coppens I,Vaidya AB

更新日期：2016-05-26 00:00:00

abstract：:More than half of the world population is at risk of dengue virus (DENV) infection because of the global distribution of its mosquito vectors. DENV is an envelope virus that relies on host lipid membranes for its life-cycle. Here, we characterized how DENV hijacks the mosquito lipidome to identify targets for novel tr...

journal_title：PLoS pathogens

authors： Vial T,Tan WL,Wong Wei Xiang B,Missé D,Deharo E,Marti G,Pompon J

更新日期：2019-12-09 00:00:00

abstract：:Gut dysbiosis associated with intestinal inflammation is characterized by the blooming of particular bacteria such as adherent-invasive E. coli (AIEC). However, the precise mechanisms by which AIEC impact on colitis remain largely unknown. Here we show that antibiotic-induced dysbiosis worsened chemically-induced coli...

journal_title：PLoS pathogens

authors： Ohno M,Hasegawa M,Hayashi A,Caballero-Flores G,Alteri CJ,Lawley TD,Kamada N,Núñez G,Inohara N

更新日期：2020-10-07 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

journal_title：PLoS pathogens

authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

更新日期：2019-07-15 00:00:00

abstract：:Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc. Prion diseases are invariably fatal and currently incurable, but oral drugs that can prolong incubation times in prion-infected mice have been developed. Here, we test...

journal_title：PLoS pathogens

authors： Burke CM,Mark KMK,Kun J,Beauchemin KS,Supattapone S

更新日期：2020-05-18 00:00:00

abstract：:HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We report that effector CD8+ T cells during HIV infection in blood and SIV i...

journal_title：PLoS pathogens

authors： Chew GM,Fujita T,Webb GM,Burwitz BJ,Wu HL,Reed JS,Hammond KB,Clayton KL,Ishii N,Abdel-Mohsen M,Liegler T,Mitchell BI,Hecht FM,Ostrowski M,Shikuma CM,Hansen SG,Maurer M,Korman AJ,Deeks SG,Sacha JB,Ndhlovu LC

更新日期：2016-01-07 00:00:00

abstract：:Many viral pathogens are persistently transmitted by insect vectors and cause agricultural or health problems. Generally, an insect vector can use autophagy as an intrinsic antiviral defense mechanism against viral infection. Whether viruses can evolve to exploit autophagy to promote their transmission by insect vecto...

journal_title：PLoS pathogens

authors： Chen Y,Chen Q,Li M,Mao Q,Chen H,Wu W,Jia D,Wei T

更新日期：2017-11-10 00:00:00

abstract：:The bunyavirus genome comprises a small (S), medium (M), and large (L) RNA segment of negative polarity. Although genome segmentation confers evolutionary advantages by enabling genome reassortment events with related viruses, genome segmentation also complicates genome replication and packaging. Accumulating evidence...

journal_title：PLoS pathogens

authors： Wichgers Schreur PJ,Kortekaas J

更新日期：2016-08-22 00:00:00

abstract：:The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to the disassembly of the nuclear lamina. In general, lamina disass...

journal_title：PLoS pathogens

authors： Milbradt J,Hutterer C,Bahsi H,Wagner S,Sonntag E,Horn AH,Kaufer BB,Mori Y,Sticht H,Fossen T,Marschall M

更新日期：2016-08-24 00:00:00

abstract：:Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation characterized by the influx of myeloid cells and production of proinflammatory cytokines including interferons (IFNs). It is unclear, however, how the immune system clears the virus without causing lethal immunopathology. Here,...

journal_title：PLoS pathogens

authors： Stifter SA,Bhattacharyya N,Pillay R,Flórido M,Triccas JA,Britton WJ,Feng CG

更新日期：2016-01-05 00:00:00

abstract：:MicroRNAs play an important role in the interplay between bacterial pathogens and host cells, participating as host defense mechanisms, as well as exploited by bacteria to subvert host cellular functions. Here, we show that microRNAs modulate infection by Shigella flexneri, a major causative agent of bacillary dysente...

journal_title：PLoS pathogens

authors： Sunkavalli U,Aguilar C,Silva RJ,Sharan M,Cruz AR,Tawk C,Maudet C,Mano M,Eulalio A

更新日期：2017-04-10 00:00:00

abstract：:In many bacteria, inhibition of cell wall synthesis leads to cell death and lysis. The pathways and enzymes that mediate cell lysis after exposure to cell wall-acting antibiotics (e.g. beta lactams) are incompletely understood, but the activities of enzymes that degrade the cell wall ('autolysins') are thought to be c...

journal_title：PLoS pathogens

authors： Dörr T,Davis BM,Waldor MK

更新日期：2015-04-17 00:00:00

abstract：:RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap (m(7)GpppAm) of viral RNA genome. Here we reported, for the first time, that flavivirus NS5 has a novel interna...

journal_title：PLoS pathogens

authors： Dong H,Chang DC,Hua MH,Lim SP,Chionh YH,Hia F,Lee YH,Kukkaro P,Lok SM,Dedon PC,Shi PY

更新日期：2012-01-01 00:00:00