A gatekeeper chaperone complex directs translocator secretion during type three secretion.

abstract：:Many broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1) were shown effective in animal models, and are currently evaluated in clinical trials. However, use of these antibodies in humans is hampered by the rapid emergence of resistant viruses. Here we show that soft-randomizatio...

journal_title：PLoS pathogens

authors： Otsuka Y,Schmitt K,Quinlan BD,Gardner MR,Alfant B,Reich A,Farzan M,Choe H

更新日期：2018-08-20 00:00:00

abstract：:Herpesviruses encode a characteristic serine protease with a unique fold and an active site that comprises the unusual triad Ser-His-His. The protease is essential for viral replication and as such constitutes a promising drug target. In solution, a dynamic equilibrium exists between an inactive monomeric and an activ...

journal_title：PLoS pathogens

authors： Zühlsdorf M,Werten S,Klupp BG,Palm GJ,Mettenleiter TC,Hinrichs W

更新日期：2015-07-10 00:00:00

abstract：:The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires thro...

journal_title：PLoS pathogens

authors： Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ

更新日期：2014-01-01 00:00:00

abstract：:Type VI secretion systems (T6SS) are trans-envelope machines dedicated to the secretion of virulence factors into eukaryotic or prokaryotic cells, therefore required for pathogenesis and/or for competition towards neighboring bacteria. The T6SS apparatus resembles the injection device of bacteriophage T4, and is ancho...

journal_title：PLoS pathogens

authors： Felisberto-Rodrigues C,Durand E,Aschtgen MS,Blangy S,Ortiz-Lombardia M,Douzi B,Cambillau C,Cascales E

更新日期：2011-11-01 00:00:00

abstract：:The ability of pathogens to escape the host's immune response is crucial for the establishment of persistent infections and can influence virulence. Recombination has been observed to contribute to this process by generating novel genetic variants. Although distinctive recombination patterns have been described in man...

journal_title：PLoS pathogens

authors： Simon-Loriere E,Galetto R,Hamoudi M,Archer J,Lefeuvre P,Martin DP,Robertson DL,Negroni M

更新日期：2009-05-01 00:00:00

abstract：:Staphylococcus aureus (SA) is the causative agent of both skin/soft tissue infections as well as invasive bloodstream infections. Though vaccines have been developed to target both humoral and T cell-mediated immune responses against SA, they have largely failed due to lack of protective efficacy. Group 1 CD1-restrict...

journal_title：PLoS pathogens

authors： Visvabharathy L,Genardi S,Cao L,He Y,Alonzo F 3rd,Berdyshev E,Wang CR

更新日期：2020-04-28 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006634.]. ...

journal_title：PLoS pathogens

authors： Walsh D

更新日期：2018-01-04 00:00:00

abstract：:The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to the disassembly of the nuclear lamina. In general, lamina disass...

journal_title：PLoS pathogens

authors： Milbradt J,Hutterer C,Bahsi H,Wagner S,Sonntag E,Horn AH,Kaufer BB,Mori Y,Sticht H,Fossen T,Marschall M

更新日期：2016-08-24 00:00:00

abstract：:More than half of the world population is at risk of dengue virus (DENV) infection because of the global distribution of its mosquito vectors. DENV is an envelope virus that relies on host lipid membranes for its life-cycle. Here, we characterized how DENV hijacks the mosquito lipidome to identify targets for novel tr...

journal_title：PLoS pathogens

authors： Vial T,Tan WL,Wong Wei Xiang B,Missé D,Deharo E,Marti G,Pompon J

更新日期：2019-12-09 00:00:00

abstract：:Amyloidosis describes a group of protein folding diseases in which amyloid proteins are abnormally deposited in organs and/or tissues as fine fibrils. Mouse senile amyloidosis is a disorder in which apolipoprotein A-II (apoA-II) deposits as amyloid fibrils (AApoAII) and can be transmitted from one animal to another bo...

journal_title：PLoS pathogens

authors： Qian J,Yan J,Ge F,Zhang B,Fu X,Tomozawa H,Sawashita J,Mori M,Higuchi K

更新日期：2010-05-20 00:00:00

abstract：:CD8+ T cell responses to Epstein-Barr virus (EBV) lytic cycle expressed antigens display a hierarchy of immunodominance, in which responses to epitopes of immediate-early (IE) and some early (E) antigens are more frequently observed than responses to epitopes of late (L) expressed antigens. It has been proposed that t...

journal_title：PLoS pathogens

authors： Quinn LL,Zuo J,Abbott RJ,Shannon-Lowe C,Tierney RJ,Hislop AD,Rowe M

更新日期：2014-08-21 00:00:00

abstract：:Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined. Here, we report that reduction of HBV transcripts by TGF-β is dependent on AID expression, which significantly decreases both HBV transcripts and viral DNA, resulting in inh...

journal_title：PLoS pathogens

authors： Liang G,Liu G,Kitamura K,Wang Z,Chowdhury S,Monjurul AM,Wakae K,Koura M,Shimadu M,Kinoshita K,Muramatsu M

更新日期：2015-04-02 00:00:00

abstract：:The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The molecular basis and functional consequences of virus conformational dynamics are poorly understood. Here, we identified a single mutation at residue 198 (T198F...

journal_title：PLoS pathogens

authors： Goo L,VanBlargan LA,Dowd KA,Diamond MS,Pierson TC

更新日期：2017-02-16 00:00:00

abstract：:Pathogenic hantaviruses, genus Orthohantaviridae, are maintained in rodent reservoirs with zoonotic transmission to humans occurring through inhalation of rodent excreta. Hantavirus disease in humans is characterized by localized vascular leakage and elevated levels of circulating proinflammatory cytokines. Despite th...

journal_title：PLoS pathogens

authors： Kell AM,Hemann EA,Turnbull JB,Gale M Jr

更新日期：2020-04-24 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear proteins EBNA3A, EBNA3B, and EBNA3C interact with the cell DNA binding protein RBPJ and regulate cell and viral genes. Repression of the CDKN2A tumor suppressor gene products p16(INK4A) and p14(ARF) by EBNA3A and EBNA3C is critical for EBV mediated transformation of resting B lymph...

journal_title：PLoS pathogens

authors： Ohashi M,Holthaus AM,Calderwood MA,Lai CY,Krastins B,Sarracino D,Johannsen E

更新日期：2015-04-09 00:00:00

abstract：:Many viruses express factors that reduce host gene expression through widespread degradation of cellular mRNA. An example of this class of proteins is the mRNA-targeting endoribonuclease SOX from the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV). Previous studies indicated that cleavage of messenger...

journal_title：PLoS pathogens

authors： Gaglia MM,Rycroft CH,Glaunsinger BA

更新日期：2015-12-08 00:00:00

abstract：:Interspecific and intervarietal hybridization may contribute to the biological diversity of fungal populations. Cryptococcus neoformans is a pathogenic yeast and the most common fungal cause of meningitis in patients with AIDS. Most patients are infected with either of the two varieties of C. neoformans, designated as...

journal_title：PLoS pathogens

authors： Litvintseva AP,Lin X,Templeton I,Heitman J,Mitchell TG

更新日期：2007-08-17 00:00:00

abstract：:Mokola virus (MOKV) belongs to the lyssavirus genus. As other genus members-including rabies virus (RABV)-it causes deadly encephalitis in mammals. MOKV entry into host cells is mediated by its transmembrane glycoprotein G. First, G binds cellular receptors, triggering virion endocytosis. Then, in the acidic endosomal...

journal_title：PLoS pathogens

authors： Belot L,Ouldali M,Roche S,Legrand P,Gaudin Y,Albertini AA

更新日期：2020-03-09 00:00:00

abstract：:The Gram-negative bacterium, Legionella pneumophila, is a protozoan parasite and accidental intracellular pathogen of humans. We propose a model in which cycling through multiple protozoan hosts in the environment holds L. pneumophila in a state of evolutionary stasis as a broad host-range pathogen. Using an experimen...

journal_title：PLoS pathogens

authors： Ensminger AW,Yassin Y,Miron A,Isberg RR

更新日期：2012-01-01 00:00:00

abstract：:CD8+ cytotoxic T lymphocytes (CTLs) are critical for clearing many viral infections, and protective CTL memory can be induced by vaccination with attenuated viruses and vectors. Non-replicating vaccines are typically potentiated by the addition of adjuvants that enhance humoral responses, however few are capable of ge...

journal_title：PLoS pathogens

authors： Gasper DJ,Neldner B,Plisch EH,Rustom H,Carrow E,Imai H,Kawaoka Y,Suresh M

更新日期：2016-12-20 00:00:00

abstract：:The COVID-19 pandemic highlights the substantial public health, economic, and societal consequences of virus spillover from a wildlife reservoir. Widespread human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also presents a new set of challenges when considering viral spillover from peo...

journal_title：PLoS pathogens

authors： Olival KJ,Cryan PM,Amman BR,Baric RS,Blehert DS,Brook CE,Calisher CH,Castle KT,Coleman JTH,Daszak P,Epstein JH,Field H,Frick WF,Gilbert AT,Hayman DTS,Ip HS,Karesh WB,Johnson CK,Kading RC,Kingston T,Lorch JM,Mend

更新日期：2020-09-03 00:00:00

abstract：:Nosocomial infections are increasingly being recognised as a major patient safety issue. The modern hospital environment and associated health care practices have provided a niche for the rapid evolution of microbial pathogens that are well adapted to surviving and proliferating in this setting, after which they can i...

journal_title：PLoS pathogens

authors： Carter GP,Douce GR,Govind R,Howarth PM,Mackin KE,Spencer J,Buckley AM,Antunes A,Kotsanas D,Jenkin GA,Dupuy B,Rood JI,Lyras D

更新日期：2011-10-01 00:00:00

abstract：:A global increase in invasive infections due to group A Streptococcus (S. pyogenes or GAS) has been observed since the 1980s, associated with emergence of a clonal group of strains of the M1T1 serotype. Among other virulence attributes, the M1T1 clone secretes NAD+-glycohydrolase (NADase). When GAS binds to epithelial...

journal_title：PLoS pathogens

authors： Sharma O,O'Seaghdha M,Velarde JJ,Wessels MR

更新日期：2016-03-03 00:00:00

abstract：:The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after import have not been studied. To elucidate these essential HIV-1 post-entry events, we labeled viral complexes with two fluorescently tagged virion-incorporated proteins (APOBEC3F or integrase), and analyzed the HIV-1 dynamics of ...

journal_title：PLoS pathogens

authors： Burdick RC,Delviks-Frankenberry KA,Chen J,Janaka SK,Sastri J,Hu WS,Pathak VK

更新日期：2017-08-21 00:00:00

abstract：TRIAL REGISTRATION:ClinicalTrials.gov Clinical Trial NCT00594880. ...

journal_title：PLoS pathogens

authors： Chitre AS,Kattah MG,Rosli YY,Pao M,Deswal M,Deeks SG,Hunt PW,Abdel-Mohsen M,Montaner LJ,Kim CC,Ma A,Somsouk M,McCune JM

更新日期：2018-03-05 00:00:00

abstract：:Poliomyelitis has nearly been eradicated through the efforts of the World Health Organization's Global Eradication Initiative raising questions on containment of the virus after it has been eliminated in the wild. Most manufacture of inactivated polio vaccines currently requires the growth of large amounts of highly v...

journal_title：PLoS pathogens

authors： Knowlson S,Burlison J,Giles E,Fox H,Macadam AJ,Minor PD

更新日期：2015-12-31 00:00:00

abstract：:Reverse transcriptase (RT) is the target for the majority of anti-HIV-1 drugs. As with all anti-AIDS treatments, continued success of RT inhibitors is persistently disrupted by the occurrence of resistance mutations. To explore latent resistance mechanisms potentially accessible to therapeutically challenged HIV-1 vir...

journal_title：PLoS pathogens

authors： Galilee M,Alian A

更新日期：2018-01-24 00:00:00

abstract：:The genus Henipavirus in the family Paramyxoviridae contains two viruses, Hendra virus (HeV) and Nipah virus (NiV) for which pteropid bats act as the main natural reservoir. Each virus also causes serious and commonly lethal infection of people as well as various species of domestic animals, however little is known ab...

journal_title：PLoS pathogens

authors： Marsh GA,de Jong C,Barr JA,Tachedjian M,Smith C,Middleton D,Yu M,Todd S,Foord AJ,Haring V,Payne J,Robinson R,Broz I,Crameri G,Field HE,Wang LF

更新日期：2012-01-01 00:00:00

abstract：:We have identified from the mutualistic grass endophyte Epichloë festucae a non-ribosomal peptide synthetase gene (sidN) encoding a siderophore synthetase. The enzymatic product of SidN is shown to be a novel extracellular siderophore designated as epichloënin A, related to ferrirubin from the ferrichrome family. Targ...

journal_title：PLoS pathogens

authors： Johnson LJ,Koulman A,Christensen M,Lane GA,Fraser K,Forester N,Johnson RD,Bryan GT,Rasmussen S

更新日期：2013-01-01 00:00:00

abstract：:Although invasive cytomegalovirus (CMV) disease is uncommon in the era of antiretroviral therapy (ART), asymptomatic CMV coinfection is nearly ubiquitous in HIV infected individuals. While microbial translocation and gut epithelial barrier dysfunction may promote persistent immune activation in treated HIV infection, ...

journal_title：PLoS pathogens

authors： Maidji E,Somsouk M,Rivera JM,Hunt PW,Stoddart CA

更新日期：2017-02-27 00:00:00