The hallmarks of COVID-19 disease.

abstract：:The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratory adapted DENV2 particles changed from smooth to "bumpy" surfaced morphology when the temperature is switched from 29°C at 37°...

journal_title：PLoS pathogens

authors： Lim XN,Shan C,Marzinek JK,Dong H,Ng TS,Ooi JSG,Fibriansah G,Wang J,Verma CS,Bond PJ,Shi PY,Lok SM

更新日期：2019-09-19 00:00:00

abstract：:Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence of both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs are rarely mentioned as capable of regulating tumor metabolism and tumor angiogenesis. Here, we reporte...

journal_title：PLoS pathogens

authors： Lyu X,Wang J,Guo X,Wu G,Jiao Y,Faleti OD,Liu P,Liu T,Long Y,Chong T,Yang X,Huang J,He M,Tsang CM,Tsao SW,Wang Q,Jiang Q,Li X

更新日期：2018-12-17 00:00:00

abstract：:Several naked virus species, including members of the Picornaviridae family, have recently been described to escape their host cells and spread infection via enclosure in extracellular vesicles (EV). EV are 50-300 nm sized lipid membrane-enclosed particles produced by all cells that are broadly recognized for playing ...

journal_title：PLoS pathogens

authors： van der Grein SG,Defourny KAY,Rabouw HH,Galiveti CR,Langereis MA,Wauben MHM,Arkesteijn GJA,van Kuppeveld FJM,Nolte-'t Hoen ENM

更新日期：2019-02-19 00:00:00

abstract：:Memory T cell inflation is a process in which a subset of cytomegalovirus (CMV) specific CD8 T cells continuously expands mainly during latent infection and establishes a large and stable population of effector memory cells in peripheral tissues. Here we set out to identify in vivo parameters that promote and limit CD...

journal_title：PLoS pathogens

authors： Baumann NS,Welten SPM,Torti N,Pallmer K,Borsa M,Barnstorf I,Oduro JD,Cicin-Sain L,Oxenius A

更新日期：2019-05-13 00:00:00

abstract：:Human T Lymphotropic virus (HTLV) infection can persist in individuals resulting, at least in part, from viral escape of the innate immunity, including inhibition of type I interferon response in infected T-cells. Plasmacytoid dendritic cells (pDCs) are known to bypass viral escape by their robust type I interferon pr...

journal_title：PLoS pathogens

authors： Assil S,Futsch N,Décembre E,Alais S,Gessain A,Cosset FL,Mahieux R,Dreux M,Dutartre H

更新日期：2019-02-28 00:00:00

abstract：:B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (TFH) cells. We studied the effects of native heterodimeric IL-15 (hetIL-15) treatmen...

journal_title：PLoS pathogens

authors： Watson DC,Moysi E,Valentin A,Bergamaschi C,Devasundaram S,Fortis SP,Bear J,Chertova E,Bess J Jr,Sowder R,Venzon DJ,Deleage C,Estes JD,Lifson JD,Petrovas C,Felber BK,Pavlakis GN

更新日期：2018-02-23 00:00:00

abstract：:Streptococcus equi subspecies equi (S. equi) is a clonal, equine host-adapted pathogen of global importance that causes a suppurative lymphodendopathy of the head and neck, more commonly known as Strangles. The disease is highly prevalent, can be severe and is highly contagious. Antibiotic treatment is usually ineffec...

journal_title：PLoS pathogens

authors： Guss B,Flock M,Frykberg L,Waller AS,Robinson C,Smith KC,Flock JI

更新日期：2009-09-01 00:00:00

abstract：:SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been proposed recently. Here, w...

journal_title：PLoS pathogens

authors： Arnold LH,Groom HC,Kunzelmann S,Schwefel D,Caswell SJ,Ordonez P,Mann MC,Rueschenbaum S,Goldstone DC,Pennell S,Howell SA,Stoye JP,Webb M,Taylor IA,Bishop KN

更新日期：2015-10-02 00:00:00

abstract：:The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB) encoded in the N-t...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Sandalova T,Sun R,Achour A,Masucci MG

更新日期：2019-11-11 00:00:00

abstract：:The progression of a natural bacterial infection is a dynamic process influenced by the physiological characteristics of the target organ. Recent developments in live animal imaging allow for the study of the dynamic microbe-host interplay in real-time as the infection progresses within an organ of a live host. Here w...

journal_title：PLoS pathogens

authors： Melican K,Sandoval RM,Kader A,Josefsson L,Tanner GA,Molitoris BA,Richter-Dahlfors A

更新日期：2011-02-01 00:00:00

abstract：:Two-component, self-assembling nanoparticles represent a versatile platform for multivalent presentation of viral antigens. Computational design of protein nanoparticles with differing sizes and geometries enables combination with antigens of choice to test novel multimerization concepts in immunization strategies whe...

journal_title：PLoS pathogens

authors： Antanasijevic A,Ueda G,Brouwer PJM,Copps J,Huang D,Allen JD,Cottrell CA,Yasmeen A,Sewall LM,Bontjer I,Ketas TJ,Turner HL,Berndsen ZT,Montefiori DC,Klasse PJ,Crispin M,Nemazee D,Moore JP,Sanders RW,King NP,Baker D

更新日期：2020-08-11 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein hijacks the host ubiquitin machinery to activate IκB kinases (IKKs) and NF-κB and promote cell survival; however, the key ubiquitinated factors downstream of Tax involved in cell transformation are unknown. Using mass spectrometry, we undertook an unbiased pr...

journal_title：PLoS pathogens

authors： Choi YB,Harhaj EW

更新日期：2014-10-23 00:00:00

abstract：:Serine protease cascades regulate important insect immune responses namely melanization and Toll pathway activation. An important component of these cascades are clip-domain serine protease homologs (cSPHs), which are non-catalytic, but essential for activating the enzyme prophenoloxidase (PPO) in the melanization res...

journal_title：PLoS pathogens

authors： El Moussawi L,Nakhleh J,Kamareddine L,Osta MA

更新日期：2019-11-25 00:00:00

abstract：:HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein between capsid p24 capsid (CA) and spacer peptide 1 (SP1), leading to the production of infectious virus. BMS-955176 is a second generation MI with improved antiviral activity toward polymorphic Gag ...

journal_title：PLoS pathogens

authors： Lin Z,Cantone J,Lu H,Nowicka-Sans B,Protack T,Yuan T,Yang H,Liu Z,Drexler D,Regueiro-Ren A,Meanwell NA,Cockett M,Krystal M,Lataillade M,Dicker IB

更新日期：2016-11-28 00:00:00

abstract：:Eradication of tuberculosis (TB), the world's leading cause of death due to infectious disease, requires a highly efficacious TB vaccine. Many TB vaccine candidates are in pre-clinical and clinical development but only a few can be advanced to large-scale efficacy trials due to limited global resources. We aimed to pe...

journal_title：PLoS pathogens

authors： Rodo MJ,Rozot V,Nemes E,Dintwe O,Hatherill M,Little F,Scriba TJ

更新日期：2019-03-04 00:00:00

abstract：:Ebolaviruses, highly lethal zoonotic pathogens, possess longer genomes than most other non-segmented negative-strand RNA viruses due in part to long 5' and 3' untranslated regions (UTRs) present in the seven viral transcriptional units. To date, specific functions have not been assigned to these UTRs. With reporter as...

journal_title：PLoS pathogens

authors： Shabman RS,Hoenen T,Groseth A,Jabado O,Binning JM,Amarasinghe GK,Feldmann H,Basler CF

更新日期：2013-01-01 00:00:00

abstract：:Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to specific receptors on the same or neighbouring cells to activate the expression of hundreds of IFN stimulated genes (ISGs) with antiviral function. Type I IFN has bee...

journal_title：PLoS pathogens

authors： Crotta S,Davidson S,Mahlakoiv T,Desmet CJ,Buckwalter MR,Albert ML,Staeheli P,Wack A

更新日期：2013-01-01 00:00:00

abstract：:Malaria is a global health concern caused by infection with Plasmodium parasites. With rising insecticide and drug resistance, there is a critical need to develop novel control strategies, including strategies to block parasite sporogony in key mosquito vector species. MAPK signaling pathways regulated by extracellula...

journal_title：PLoS pathogens

authors： Souvannaseng L,Hun LV,Baker H,Klyver JM,Wang B,Pakpour N,Bridgewater JM,Napoli E,Giulivi C,Riehle MA,Luckhart S

更新日期：2018-11-29 00:00:00

abstract：:Bacterial cell division predominantly occurs by a highly conserved process, termed binary fission, that requires the bacterial homologue of tubulin, FtsZ. Other mechanisms of bacterial cell division that are independent of FtsZ are rare. Although the obligate intracellular human pathogen Chlamydia trachomatis, the lea...

journal_title：PLoS pathogens

authors： Abdelrahman Y,Ouellette SP,Belland RJ,Cox JV

更新日期：2016-08-09 00:00:00

abstract：:Bacille Calmette-Guérin (BCG) is currently the only approved vaccine against tuberculosis (TB) and is administered in over 150 countries worldwide. Despite its widespread use, the vaccine has a variable protective efficacy of 0-80%, with the lowest efficacy rates in tropical regions where TB is most prevalent. This va...

journal_title：PLoS pathogens

authors： Price DN,Kusewitt DF,Lino CA,McBride AA,Muttil P

更新日期：2016-05-06 00:00:00

abstract：:Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8(+) T cell responses in a context of chronic inflammation and antigen persistence, since it is characterized by chronic infection in the spleen and CD8(+) T cells are required for the development of protective immunity. However, antigen...

journal_title：PLoS pathogens

authors： Joshi T,Rodriguez S,Perovic V,Cockburn IA,Stäger S

更新日期：2009-05-01 00:00:00

abstract：:The structure of the infectious prion protein (PrPSc), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate. PrPSc replicates by converting the non-infectious, cellular prion protei...

journal_title：PLoS pathogens

authors： Vázquez-Fernández E,Vos MR,Afanasyev P,Cebey L,Sevillano AM,Vidal E,Rosa I,Renault L,Ramos A,Peters PJ,Fernández JJ,van Heel M,Young HS,Requena JR,Wille H

更新日期：2016-09-08 00:00:00

abstract：:The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires thro...

journal_title：PLoS pathogens

authors： Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ

更新日期：2014-01-01 00:00:00

abstract：:Plants possess active defense systems and can protect themselves from pathogenic invasion by secretion of a variety of small antimicrobial or antifungal proteins such as thionins. The antibacterial and antifungal properties of thionins are derived from their ability to induce open pore formation on cell membranes of p...

journal_title：PLoS pathogens

authors： Asano T,Miwa A,Maeda K,Kimura M,Nishiuchi T

更新日期：2013-01-01 00:00:00

abstract：:The tremendous success of S. aureus as a human pathogen has been explained primarily by its array of virulence factors that enable the organism to evade host immunity. Perhaps equally important, but less well understood, is the importance of the intensity of the host response in determining the extent of pathology ind...

journal_title：PLoS pathogens

authors： Parker D,Planet PJ,Soong G,Narechania A,Prince A

更新日期：2014-02-20 00:00:00

abstract：:The survival and persistence of Mycobacterium tuberculosis depends on its capacity to manipulate multiple host defense pathways, including the ability to actively inhibit the death by apoptosis of infected host cells. The genetic basis for this anti-apoptotic activity and its implication for mycobacterial virulence ha...

journal_title：PLoS pathogens

authors： Velmurugan K,Chen B,Miller JL,Azogue S,Gurses S,Hsu T,Glickman M,Jacobs WR Jr,Porcelli SA,Briken V

更新日期：2007-07-01 00:00:00

abstract：:Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts. PB1-F2 is an alternative translation product of the viral PB1 segment that was initially characterized as a pro-apoptotic mitochondrial viral pathog...

journal_title：PLoS pathogens

authors： Schmolke M,Manicassamy B,Pena L,Sutton T,Hai R,Varga ZT,Hale BG,Steel J,Pérez DR,García-Sastre A

更新日期：2011-08-01 00:00:00

abstract：:Glycolysis is a metabolic pathway that is central to the assimilation of carbon for either respiration or fermentation and therefore is critical for the growth of all organisms. Consequently, glycolytic transcriptional regulation is important for the metabolic flexibility of pathogens in their attempts to colonize div...

journal_title：PLoS pathogens

authors： Askew C,Sellam A,Epp E,Hogues H,Mullick A,Nantel A,Whiteway M

更新日期：2009-10-01 00:00:00

abstract：:Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative transcription factors in a machine-anno...

journal_title：PLoS pathogens

authors： Cho Y,Srivastava A,Ohm RA,Lawrence CB,Wang KH,Grigoriev IV,Marahatta SP

更新日期：2012-01-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that persists lifelong in the host. In ∼4% of infected people, HTLV-1 causes a chronic disabling neuroinflammatory disease known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The pathogenesis of HAM/TSP is unknown and treatment remain...

journal_title：PLoS pathogens

authors： Tattermusch S,Skinner JA,Chaussabel D,Banchereau J,Berry MP,McNab FW,O'Garra A,Taylor GP,Bangham CR

更新日期：2012-01-01 00:00:00