Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction.

abstract：:In HPV-related cancers, the "high-risk" human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in the presence of HPV...

journal_title：PLoS pathogens

authors： Kadaja M,Isok-Paas H,Laos T,Ustav E,Ustav M

更新日期：2009-04-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear proteins EBNA3A, EBNA3B, and EBNA3C interact with the cell DNA binding protein RBPJ and regulate cell and viral genes. Repression of the CDKN2A tumor suppressor gene products p16(INK4A) and p14(ARF) by EBNA3A and EBNA3C is critical for EBV mediated transformation of resting B lymph...

journal_title：PLoS pathogens

authors： Ohashi M,Holthaus AM,Calderwood MA,Lai CY,Krastins B,Sarracino D,Johannsen E

更新日期：2015-04-09 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1007696.]. ...

journal_title：PLoS pathogens

authors： Dewan KK,Taylor-Mulneix DL,Campos LL,Skarlupka AL,Wagner SM,Ryman VE,Gestal MC,Ma L,Blas-Machado U,Faddis BT,Harvill ET

更新日期：2019-06-28 00:00:00

abstract：:The heterosexual risk group has become the largest HIV infected group in the United Kingdom during the last 10 years, but little is known of the network structure and dynamics of viral transmission in this group. The overwhelming majority of UK heterosexual infections are of non-B HIV subtypes, indicating viruses orig...

journal_title：PLoS pathogens

authors： Hughes GJ,Fearnhill E,Dunn D,Lycett SJ,Rambaut A,Leigh Brown AJ,UK HIV Drug Resistance Collaboration.

更新日期：2009-09-01 00:00:00

abstract：:The diversity of a highly variable RNA plant virus was considered to determine the range of virulence substitutions, the evolutionary pathways to virulence, and whether intraspecific diversity modulates virulence pathways and propensity. In all, 114 isolates representative of the genetic and geographic diversity of Ri...

journal_title：PLoS pathogens

authors： Pinel-Galzi A,Rakotomalala M,Sangu E,Sorho F,Kanyeka Z,Traoré O,Sérémé D,Poulicard N,Rabenantoandro Y,Séré Y,Konaté G,Ghesquière A,Hébrard E,Fargette D

更新日期：2007-11-01 00:00:00

abstract：:Ebolavirus (EBOV), the causative agent of a severe hemorrhagic fever and a biosafety level 4 pathogen, increases its genome coding capacity by producing multiple transcripts encoding for structural and nonstructural glycoproteins from a single gene. This is achieved through RNA editing, during which non-template adeno...

journal_title：PLoS pathogens

authors： Mehedi M,Hoenen T,Robertson S,Ricklefs S,Dolan MA,Taylor T,Falzarano D,Ebihara H,Porcella SF,Feldmann H

更新日期：2013-01-01 00:00:00

abstract：:CD4(+) T cell loss is central to HIV pathogenesis. In the initial weeks post-infection, the great majority of dying cells are uninfected CD4(+) T cells. We previously showed that the 3S motif of HIV-1 gp41 induces surface expression of NKp44L, a cellular ligand for an activating NK receptor, on uninfected bystander CD...

journal_title：PLoS pathogens

authors： Fausther-Bovendo H,Vieillard V,Sagan S,Bismuth G,Debré P

更新日期：2010-07-01 00:00:00

abstract：:Unlike the pandemic form of HIV-1 (group M), group O viruses are endemic in west central Africa, especially in Cameroon. However, little is known about group O's genetic evolution, and why this highly divergent lineage has not become pandemic. Using a unique and large set of group O sequences from samples collected fr...

journal_title：PLoS pathogens

authors： Leoz M,Feyertag F,Kfutwah A,Mauclère P,Lachenal G,Damond F,De Oliveira F,Lemée V,Simon F,Robertson DL,Plantier JC

更新日期：2015-08-04 00:00:00

abstract：:SIV(mac239) infection of rhesus macaques (RMs) results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL) response, possibly due to the emergence of viral escape mutants that prevent recognition of infected cells by CTLs. To determine the anatomic origin of these SIV mutants, we longitud...

journal_title：PLoS pathogens

authors： Vanderford TH,Bleckwehl C,Engram JC,Dunham RM,Klatt NR,Feinberg MB,Garber DA,Betts MR,Silvestri G

更新日期：2011-05-01 00:00:00

abstract：:For many viruses, one or two proteins allow cell attachment and entry, which occurs through the plasma membrane or following endocytosis at low pH. In contrast, vaccinia virus (VACV) enters cells by both neutral and low pH routes; four proteins mediate cell attachment and twelve that are associated in a membrane compl...

journal_title：PLoS pathogens

authors： Laliberte JP,Weisberg AS,Moss B

更新日期：2011-12-01 00:00:00

abstract：:Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely in adults. The mechanisms that determine the age-dependent susceptibility remain largely unclear. Here, we found that the paucity of invariant natural killer T (iNKT) cells together wi...

journal_title：PLoS pathogens

authors： Zhu K,Yang J,Luo K,Yang C,Zhang N,Xu R,Chen J,Jin M,Xu B,Guo N,Wang J,Chen Z,Cui Y,Zhao H,Wang Y,Deng C,Bai L,Ge B,Qin CF,Shen H,Yang CF,Leng Q

更新日期：2015-01-23 00:00:00

abstract：:The flagellum organelle is an intricate multiprotein assembly best known for its rotational propulsion of bacteria. However, recent studies have expanded our knowledge of other functions in pathogenic contexts, particularly adherence and immune modulation, e.g., for Salmonella enterica, Campylobacter jejuni, Pseudomon...

journal_title：PLoS pathogens

authors： Rossez Y,Wolfson EB,Holmes A,Gally DL,Holden NJ

更新日期：2015-01-15 00:00:00

abstract：:The ability of the tubercle bacillus to arrest phagosome maturation is considered one major mechanism that allows its survival within host macrophages. To identify mycobacterial genes involved in this process, we developed a high throughput phenotypic cell-based assay enabling individual sub-cellular analysis of over ...

journal_title：PLoS pathogens

authors： Brodin P,Poquet Y,Levillain F,Peguillet I,Larrouy-Maumus G,Gilleron M,Ewann F,Christophe T,Fenistein D,Jang J,Jang MS,Park SJ,Rauzier J,Carralot JP,Shrimpton R,Genovesio A,Gonzalo-Asensio JA,Puzo G,Martin C,Brosch R

更新日期：2010-09-09 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that persists lifelong in the host. In ∼4% of infected people, HTLV-1 causes a chronic disabling neuroinflammatory disease known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The pathogenesis of HAM/TSP is unknown and treatment remain...

journal_title：PLoS pathogens

authors： Tattermusch S,Skinner JA,Chaussabel D,Banchereau J,Berry MP,McNab FW,O'Garra A,Taylor GP,Bangham CR

更新日期：2012-01-01 00:00:00

abstract：:The envelope glycoprotein (Env) complexes of the human and simian immunodeficiency viruses (HIV and SIV, respectively) mediate viral entry and are a target for neutralizing antibodies. The receptor binding surfaces of Env are in large part sterically occluded or conformationally masked prior to receptor binding. Knowl...

journal_title：PLoS pathogens

authors： Zanetti G,Briggs JA,Grünewald K,Sattentau QJ,Fuller SD

更新日期：2006-08-01 00:00:00

abstract：:The opportunistic human fungal pathogen, Candida albicans, undergoes morphological and transcriptional adaptation in the switch from commensalism to pathogenicity. Although previous gene-knockout studies have identified many factors involved in this transformation, it remains unclear how these factors are regulated to...

journal_title：PLoS pathogens

authors： Greig JA,Sudbery IM,Richardson JP,Naglik JR,Wang Y,Sudbery PE

更新日期：2015-01-24 00:00:00

abstract：:To guide control policies, it is important that the determinants of influenza transmission are fully characterized. Such assessment is complex because the risk of influenza infection is multifaceted and depends both on immunity acquired naturally or via vaccination and on the individual level of exposure to influenza ...

journal_title：PLoS pathogens

authors： Cauchemez S,Ferguson NM,Fox A,Mai le Q,Thanh le T,Thai PQ,Thoang DD,Duong TN,Minh Hoa le N,Tran Hien N,Horby P

更新日期：2014-08-21 00:00:00

abstract：:Sensing of viral RNA by RIG-I-like receptors initiates innate antiviral response, which is mediated by the central adaptor VISA. How the RIG-I-VISA-mediated antiviral response is terminated at the late phase of infection is enigmatic. Here we identified the protein kinase A catalytic (PKAC) subunits α and β as negativ...

journal_title：PLoS pathogens

authors： Yan BR,Zhou L,Hu MM,Li M,Lin H,Yang Y,Wang YY,Shu HB

更新日期：2017-09-21 00:00:00

abstract：:Type I interferons (T1-IFN) are critical in the innate immune response, acting upon infected and uninfected cells to initiate an antiviral state by expressing genes that inhibit multiple stages of the lifecycle of many viruses. T1-IFN triggers the production of Interferon-Stimulated Genes (ISGs), activating an antivir...

journal_title：PLoS pathogens

authors： Parekh NJ,Krouse TE,Reider IE,Hobbs RP,Ward BM,Norbury CC

更新日期：2019-10-11 00:00:00

abstract：:Apicomplexans are obligate intracellular parasites that actively penetrate their host cells to create an intracellular niche for replication. Commitment to invasion is thought to be mediated by the rhoptries, specialized apical secretory organelles that inject a protein complex into the host cell to form a tight-junct...

journal_title：PLoS pathogens

authors： Beck JR,Fung C,Straub KW,Coppens I,Vashisht AA,Wohlschlegel JA,Bradley PJ

更新日期：2013-02-01 00:00:00

abstract：:The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after import have not been studied. To elucidate these essential HIV-1 post-entry events, we labeled viral complexes with two fluorescently tagged virion-incorporated proteins (APOBEC3F or integrase), and analyzed the HIV-1 dynamics of ...

journal_title：PLoS pathogens

authors： Burdick RC,Delviks-Frankenberry KA,Chen J,Janaka SK,Sastri J,Hu WS,Pathak VK

更新日期：2017-08-21 00:00:00

abstract：:Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant strains continue to emerge, underscoring the need for additional novel mechanism inhibitors that will offer expanded therapeutic options in the clinic. We report a new class of small molecule antiretroviral compounds that di...

journal_title：PLoS pathogens

authors： Blair WS,Pickford C,Irving SL,Brown DG,Anderson M,Bazin R,Cao J,Ciaramella G,Isaacson J,Jackson L,Hunt R,Kjerrstrom A,Nieman JA,Patick AK,Perros M,Scott AD,Whitby K,Wu H,Butler SL

更新日期：2010-12-09 00:00:00

abstract：:The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression. These viruses have evolved countermeasures to disperse PML-NBs,...

journal_title：PLoS pathogens

authors： Reichelt M,Wang L,Sommer M,Perrino J,Nour AM,Sen N,Baiker A,Zerboni L,Arvin AM

更新日期：2011-02-03 00:00:00

abstract：:Extracellular signaling is a mechanism that higher eukaryotes have evolved to facilitate organismal homeostasis. Recent years have seen an emerging interest in the role of secreted microvesicles, termed extracellular vesicles (EV) or exosomes in this signaling network. EV contents can be modified by the cell in respon...

journal_title：PLoS pathogens

authors： McNamara RP,Chugh PE,Bailey A,Costantini LM,Ma Z,Bigi R,Cheves A,Eason AB,Landis JT,Host KM,Xiong J,Griffith JD,Damania B,Dittmer DP

更新日期：2019-02-04 00:00:00

abstract：:Competence stimulating peptide (CSP) is a 17-amino acid peptide pheromone secreted by Streptococcus pneumoniae. Upon binding of CSP to its membrane-associated receptor kinase ComD, a cascade of signaling events is initiated, leading to activation of the competence regulon by the response regulator ComE. Genes encoding...

journal_title：PLoS pathogens

authors： Zhu L,Lau GW

更新日期：2011-09-01 00:00:00

abstract：:Mycoplasma pneumoniae, a human pathogenic bacterium, glides on host cell surfaces by a unique and unknown mechanism. It forms an attachment organelle at a cell pole as a membrane protrusion composed of surface and internal structures, with a highly organized architecture. In the present study, we succeeded in isolatin...

journal_title：PLoS pathogens

authors： Nakane D,Kenri T,Matsuo L,Miyata M

更新日期：2015-12-03 00:00:00

abstract：:Caspase-dependent cleavage of antigens associated with apoptotic cells plays a prominent role in the generation of CD8⁺ T cell responses in various infectious diseases. We found that the emergence of a large population of autoreactive CD8⁺ T effector cells specific for apoptotic T cell-associated self-epitopes exceeds...

journal_title：PLoS pathogens

authors： Franceschini D,Del Porto P,Piconese S,Trella E,Accapezzato D,Paroli M,Morrone S,Piccolella E,Spada E,Mele A,Sidney J,Sette A,Barnaba V

更新日期：2012-01-01 00:00:00

abstract：:Positive-strand RNA viruses replicate in host cells by forming large viral replication organelles, which harbor numerous membrane-bound viral replicase complexes (VRCs). In spite of its essential role in viral replication, the biogenesis of the VRCs is not fully understood. The authors identified critical roles of cel...

journal_title：PLoS pathogens

authors： Feng Z,Kovalev N,Nagy PD

更新日期：2020-12-28 00:00:00

abstract：:Influenza viruses continue to pose a major public health threat worldwide and options for antiviral therapy are limited by the emergence of drug-resistant virus strains. The antiviral cytokine, interferon (IFN) is an essential mediator of the innate immune response and influenza viruses, like many viruses, have evolve...

journal_title：PLoS pathogens

authors： Ortigoza MB,Dibben O,Maamary J,Martinez-Gil L,Leyva-Grado VH,Abreu P Jr,Ayllon J,Palese P,Shaw ML

更新日期：2012-01-01 00:00:00

abstract：:In host-pathogen interactions, the struggle for iron may have major consequences on the outcome of the disease. To overcome the low solubility and bio-availability of iron, bacteria have evolved multiple systems to acquire iron from various sources such as heme, hemoglobin and ferritin. The molecular basis of iron acq...

journal_title：PLoS pathogens

authors： Segond D,Abi Khalil E,Buisson C,Daou N,Kallassy M,Lereclus D,Arosio P,Bou-Abdallah F,Nielsen Le Roux C

更新日期：2014-02-13 00:00:00