当前位置： SCI文献检索 > PLoS Pathogens期刊下所有文献 > Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.

Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.

Abstract：

:Ribonuclease L (RNase L) is an important effector of the innate antiviral response. Mutations or variants that impair function of RNase L, particularly R462Q, have been proposed as susceptibility factors for prostate cancer. Given the role of this gene in viral defense, we sought to explore the possibility that a viral infection might contribute to prostate cancer in individuals harboring the R462Q variant. A viral detection DNA microarray composed of oligonucleotides corresponding to the most conserved sequences of all known viruses identified the presence of gammaretroviral sequences in cDNA samples from seven of 11 R462Q-homozygous (QQ) cases, and in one of eight heterozygous (RQ) and homozygous wild-type (RR) cases. An expanded survey of 86 tumors by specific RT-PCR detected the virus in eight of 20 QQ cases (40%), compared with only one sample (1.5%) among 66 RQ and RR cases. The full-length viral genome was cloned and sequenced independently from three positive QQ cases. The virus, named XMRV, is closely related to xenotropic murine leukemia viruses (MuLVs), but its sequence is clearly distinct from all known members of this group. Comparison of gag and pol sequences from different tumor isolates suggested infection with the same virus in all cases, yet sequence variation was consistent with the infections being independently acquired. Analysis of prostate tissues from XMRV-positive cases by in situ hybridization and immunohistochemistry showed that XMRV nucleic acid and protein can be detected in about 1% of stromal cells, predominantly fibroblasts and hematopoietic elements in regions adjacent to the carcinoma. These data provide to our knowledge the first demonstration that xenotropic MuLV-related viruses can produce an authentic human infection, and strongly implicate RNase L activity in the prevention or clearance of infection in vivo. These findings also raise questions about the possible relationship between exogenous infection and cancer development in genetically susceptible individuals.

journal_name

PLoS Pathog

journal_title

PLoS pathogens

authors

Urisman A,Molinaro RJ,Fischer N,Plummer SJ,Casey G,Klein EA,Malathi K,Magi-Galluzzi C,Tubbs RR,Ganem D,Silverman RH,DeRisi JL

doi

10.1371/journal.ppat.0020025

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

e25

issue

3

eissn

1553-7366

issn

1553-7374

journal_volume

2

pub_type

杂志文章,多中心研究,收录出版

相关文献

PLoS Pathogens文献大全
  • PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves.

    abstract：:Mycobacterium leprae, an obligate intracellular bacillus, infects Schwann cells (SCs), leading to peripheral nerve damage, the most severe leprosy symptom. In the present study, we revisited the involvement of phenolic glycolipid I (PGL I), an abundant, private, surface M. leprae molecule, in M. leprae-SC interaction ...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1007151

    authors： Díaz Acosta CC,Dias AA,Rosa TLSA,Batista-Silva LR,Rosa PS,Toledo-Pinto TG,Costa FDMR,Lara FA,Rodrigues LS,Mattos KA,Sarno EN,Bozza PT,Guilhot C,de Berrêdo-Pinho M,Pessolani MCV

    更新日期：2018-07-06 00:00:00

  • Measles skin rash: Infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to the epidermis.

    abstract：:Measles is characterized by fever and a maculopapular skin rash, which is accompanied by immune clearance of measles virus (MV)-infected cells. Histopathological analyses of skin biopsies from humans and non-human primates (NHPs) with measles rash have identified MV-infected keratinocytes and mononuclear cells in the ...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1008253

    authors： Laksono BM,Fortugno P,Nijmeijer BM,de Vries RD,Cordisco S,Kuiken T,Geijtenbeek TBH,Duprex WP,Brancati F,de Swart RL

    更新日期：2020-10-08 00:00:00

  • Peli1 signaling blockade attenuates congenital zika syndrome.

    abstract：:Zika virus (ZIKV) infects pregnant women and causes devastating congenital zika syndrome (CZS). How the virus is vertically transmitted to the fetus and induces neuronal loss remains unclear. We previously reported that Pellino (Peli)1, an E3 ubiquitin ligase, promotes p38MAPK activation in microglia and induction of ...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1008538

    authors： Luo H,Li G,Wang B,Tian B,Gao J,Zou J,Shi S,Zhu S,Peng BH,Adam A,Martinez A,Hein K,Winkelmann ER,Mahmoud Y,Zhou X,Shan C,Rossi S,Weaver S,Barrett ADT,Sun SC,Zhang W,Shi PY,Wu P,Wang T

    更新日期：2020-06-16 00:00:00

  • The AraC Negative Regulator family modulates the activity of histone-like proteins in pathogenic bacteria.

    abstract：:The AraC Negative Regulators (ANR) comprise a large family of virulence regulators distributed among diverse clinically important Gram-negative pathogens, including Vibrio spp., Salmonella spp., Shigella spp., Yersinia spp., Citrobacter spp., and pathogenic E. coli strains. We have previously reported broad effects of...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1006545

    authors： Santiago AE,Yan MB,Hazen TH,Sauder B,Meza-Segura M,Rasko DA,Kendall MM,Ruiz-Perez F,Nataro JP

    更新日期：2017-08-14 00:00:00

  • Many globally isolated AD hybrid strains of Cryptococcus neoformans originated in Africa.

    abstract：:Interspecific and intervarietal hybridization may contribute to the biological diversity of fungal populations. Cryptococcus neoformans is a pathogenic yeast and the most common fungal cause of meningitis in patients with AIDS. Most patients are infected with either of the two varieties of C. neoformans, designated as...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.0030114

    authors： Litvintseva AP,Lin X,Templeton I,Heitman J,Mitchell TG

    更新日期：2007-08-17 00:00:00

  • Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.

    abstract：:Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Wester...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1000212

    authors： Towner JS,Sealy TK,Khristova ML,Albariño CG,Conlan S,Reeder SA,Quan PL,Lipkin WI,Downing R,Tappero JW,Okware S,Lutwama J,Bakamutumaho B,Kayiwa J,Comer JA,Rollin PE,Ksiazek TG,Nichol ST

    更新日期：2008-11-01 00:00:00

  • Non-human primate model of Kaposi's sarcoma-associated herpesvirus infection.

    abstract：:Since Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) was first identified in Kaposi's sarcoma (KS) lesions of HIV-infected individuals with AIDS, the basic biological understanding of KSHV has progressed remarkably. However, the absence of a proper animal model for KSHV continues to impede direc...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1000606

    authors： Chang H,Wachtman LM,Pearson CB,Lee JS,Lee HR,Lee SH,Vieira J,Mansfield KG,Jung JU

    更新日期：2009-10-01 00:00:00

  • Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies.

    abstract：:Many broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1) were shown effective in animal models, and are currently evaluated in clinical trials. However, use of these antibodies in humans is hampered by the rapid emergence of resistant viruses. Here we show that soft-randomizatio...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1007238

    authors： Otsuka Y,Schmitt K,Quinlan BD,Gardner MR,Alfant B,Reich A,Farzan M,Choe H

    更新日期：2018-08-20 00:00:00

  • Timelines of infection and transmission dynamics of H1N1pdm09 in swine.

    abstract：:Influenza is a major cause of mortality and morbidity worldwide. Despite numerous studies of the pathogenesis of influenza in humans and animal models the dynamics of infection and transmission in individual hosts remain poorly characterized. In this study, we experimentally modelled transmission using the H1N1pdm09 i...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1008628

    authors： Canini L,Holzer B,Morgan S,Dinie Hemmink J,Clark B,sLoLa Dynamics Consortium.,Woolhouse MEJ,Tchilian E,Charleston B

    更新日期：2020-07-24 00:00:00

  • Novel escape mutants suggest an extensive TRIM5α binding site spanning the entire outer surface of the murine leukemia virus capsid protein.

    abstract：:After entry into target cells, retroviruses encounter the host restriction factors such as Fv1 and TRIM5α. While it is clear that these factors target retrovirus capsid proteins (CA), recognition remains poorly defined in the absence of structural information. To better understand the binding interaction between TRIM5...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1002011

    authors： Ohkura S,Goldstone DC,Yap MW,Holden-Dye K,Taylor IA,Stoye JP

    更新日期：2011-03-01 00:00:00

  • Parallel epigenomic and transcriptomic responses to viral infection in honey bees (Apis mellifera).

    abstract：:Populations of honey bees are declining throughout the world, with US beekeepers losing 30% of their colonies each winter. Though multiple factors are driving these colony losses, it is increasingly clear that viruses play a major role. However, information about the molecular mechanisms mediating antiviral immunity i...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1004713

    authors： Galbraith DA,Yang X,Niño EL,Yi S,Grozinger C

    更新日期：2015-03-26 00:00:00

  • Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection.

    abstract：:The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood. Recent studies demonstrated that CCR5-tropic HIV-1 efficiently enters tissue-derived memory CD4+ T cells expressin...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1008450

    authors： Hsiao F,Frouard J,Gramatica A,Xie G,Telwatte S,Lee GQ,Roychoudhury P,Schwarzer R,Luo X,Yukl SA,Lee S,Hoh R,Deeks SG,Jones RB,Cavrois M,Greene WC,Roan NR

    更新日期：2020-04-30 00:00:00

  • Genomic insights into the origin of parasitism in the emerging plant pathogen Bursaphelenchus xylophilus.

    abstract：:Bursaphelenchus xylophilus is the nematode responsible for a devastating epidemic of pine wilt disease in Asia and Europe, and represents a recent, independent origin of plant parasitism in nematodes, ecologically and taxonomically distinct from other nematodes for which genomic data is available. As well as being an ...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1002219

    authors： Kikuchi T,Cotton JA,Dalzell JJ,Hasegawa K,Kanzaki N,McVeigh P,Takanashi T,Tsai IJ,Assefa SA,Cock PJ,Otto TD,Hunt M,Reid AJ,Sanchez-Flores A,Tsuchihara K,Yokoi T,Larsson MC,Miwa J,Maule AG,Sahashi N,Jones JT,Berr

    更新日期：2011-09-01 00:00:00

  • The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells.

    abstract：:Human respiratory syncytial virus (RSV) is the leading viral cause of acute pediatric lower respiratory tract infections worldwide, with no available vaccine or effective antiviral drug. To gain insight into virus-host interactions, we performed a genome-wide siRNA screen. The expression of over 20,000 cellular genes ...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1007963

    authors： Lingemann M,McCarty T,Liu X,Buchholz UJ,Surman S,Martin SE,Collins PL,Munir S

    更新日期：2019-08-05 00:00:00

  • Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.

    abstract：:Herpesviruses persist indefinitely in their host through complex and poorly defined interactions that mediate latent, chronic or productive states of infection. Human cytomegalovirus (CMV or HCMV), a ubiquitous β-herpesvirus, coordinates the expression of two viral genes, UL135 and UL138, which have opposing roles in ...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1005655

    authors： Buehler J,Zeltzer S,Reitsma J,Petrucelli A,Umashankar M,Rak M,Zagallo P,Schroeder J,Terhune S,Goodrum F

    更新日期：2016-05-24 00:00:00

  • Genome-wide transcriptional profiling of appressorium development by the rice blast fungus Magnaporthe oryzae.

    abstract：:The rice blast fungus Magnaporthe oryzae is one of the most significant pathogens affecting global food security. To cause rice blast disease the fungus elaborates a specialised infection structure called an appressorium. Here, we report genome wide transcriptional profile analysis of appressorium development using ne...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1002514

    authors： Soanes DM,Chakrabarti A,Paszkiewicz KH,Dawe AL,Talbot NJ

    更新日期：2012-02-01 00:00:00

  • Cell-cell fusion induced by reovirus FAST proteins enhances replication and pathogenicity of non-enveloped dsRNA viruses.

    abstract：:Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known. We generated replication-competent, FAST protein-deficient pteropine orthoreov...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1007675

    authors： Kanai Y,Kawagishi T,Sakai Y,Nouda R,Shimojima M,Saijo M,Matsuura Y,Kobayashi T

    更新日期：2019-04-25 00:00:00

  • PKCη/Rdx-driven phosphorylation of PDK1: a novel mechanism promoting cancer cell survival and permissiveness for parvovirus-induced lysis.

    abstract：:The intrinsic oncotropism and oncosuppressive activities of rodent protoparvoviruses (PVs) are opening new prospects for cancer virotherapy. Virus propagation, cytolytic activity, and spread are tightly connected to activation of the PDK1 signaling cascade, which delays stress-induced cell death and sustains functioni...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1004703

    authors： Bär S,Rommelaere J,Nüesch JP

    更新日期：2015-03-05 00:00:00

  • Vector-borne transmission imposes a severe bottleneck on an RNA virus population.

    abstract：:RNA viruses typically occur in genetically diverse populations due to their error-prone genome replication. Genetic diversity is thought to be important in allowing RNA viruses to explore sequence space, facilitating adaptation to changing environments and hosts. Some arboviruses that infect both a mosquito vector and...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1002897

    authors： Forrester NL,Guerbois M,Seymour RL,Spratt H,Weaver SC

    更新日期：2012-09-01 00:00:00

  • The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits.

    abstract：:Parasitic nematodes are of medical and veterinary importance, adversely affecting human health and animal welfare. Ascaris suum is a gastrointestinal parasite of pigs; in addition to its veterinary significance it is a good model of the human parasite Ascaris lumbricoides, estimated to infect approximately 1.4 billion...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1000517

    authors： Williamson SM,Robertson AP,Brown L,Williams T,Woods DJ,Martin RJ,Sattelle DB,Wolstenholme AJ

    更新日期：2009-07-01 00:00:00

  • Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.

    abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that persists lifelong in the host. In ∼4% of infected people, HTLV-1 causes a chronic disabling neuroinflammatory disease known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The pathogenesis of HAM/TSP is unknown and treatment remain...

    journal_title：PLoS pathogens

    pub_type： 临床试验,杂志文章

    doi：10.1371/journal.ppat.1002480

    authors： Tattermusch S,Skinner JA,Chaussabel D,Banchereau J,Berry MP,McNab FW,O'Garra A,Taylor GP,Bangham CR

    更新日期：2012-01-01 00:00:00

  • Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.

    abstract：:Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly regulating anti-micro...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1004549

    authors： Tay HL,Kaiko GE,Plank M,Li J,Maltby S,Essilfie AT,Jarnicki A,Yang M,Mattes J,Hansbro PM,Foster PS

    更新日期：2015-04-20 00:00:00

  • Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector.

    abstract：:Chlamydia trachomatis remains one of the few major human pathogens for which there is no transformation system. C. trachomatis has a unique obligate intracellular developmental cycle. The extracellular infectious elementary body (EB) is an infectious, electron-dense structure that, following host cell infection, diffe...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1002258

    authors： Wang Y,Kahane S,Cutcliffe LT,Skilton RJ,Lambden PR,Clarke IN

    更新日期：2011-09-01 00:00:00

  • Secretory proteins are delivered to the septin-organized penetration interface during root infection by Verticillium dahliae.

    abstract：:Successful infection of the host requires secretion of effector proteins to evade or suppress plant immunity. Secretion of effectors in root-infecting fungal pathogens, however, remains unexplored. We previously reported that Verticillium dahliae, a root-infecting phytopathogenic fungus, develops a penetration peg fro...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1006275

    authors： Zhou TT,Zhao YL,Guo HS

    更新日期：2017-03-10 00:00:00

  • Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection.

    abstract：:Yersinia suppress neutrophil responses by using a type 3 secretion system (T3SS) to inject 6-7 Yersinia effector proteins (Yops) effectors into their cytoplasm. YopH is a tyrosine phosphatase that causes dephosphorylation of the adaptor protein SKAP2, among other targets in neutrophils. SKAP2 functions in reactive oxy...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1008576

    authors： Shaban L,Nguyen GT,Mecsas-Faxon BD,Swanson KD,Tan S,Mecsas J

    更新日期：2020-05-11 00:00:00

  • The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth.

    abstract：:The Epstein-Barr virus (EBV) nuclear proteins EBNA3A, EBNA3B, and EBNA3C interact with the cell DNA binding protein RBPJ and regulate cell and viral genes. Repression of the CDKN2A tumor suppressor gene products p16(INK4A) and p14(ARF) by EBNA3A and EBNA3C is critical for EBV mediated transformation of resting B lymph...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1004822

    authors： Ohashi M,Holthaus AM,Calderwood MA,Lai CY,Krastins B,Sarracino D,Johannsen E

    更新日期：2015-04-09 00:00:00

  • Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics.

    abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1007920

    authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

    更新日期：2019-07-15 00:00:00

  • Protective vaccination against papillomavirus-induced skin tumors under immunocompetent and immunosuppressive conditions: a preclinical study using a natural outbred animal model.

    abstract：:Certain cutaneous human papillomaviruses (HPVs), which are ubiquitous and acquired early during childhood, can cause a variety of skin tumors and are likely involved in the development of non-melanoma skin cancer, especially in immunosuppressed patients. Hence, the burden of these clinical manifestations demands for a...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1003924

    authors： Vinzón SE,Braspenning-Wesch I,Müller M,Geissler EK,Nindl I,Gröne HJ,Schäfer K,Rösl F

    更新日期：2014-02-20 00:00:00

  • RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication.

    abstract：:Pathogenic hantaviruses, genus Orthohantaviridae, are maintained in rodent reservoirs with zoonotic transmission to humans occurring through inhalation of rodent excreta. Hantavirus disease in humans is characterized by localized vascular leakage and elevated levels of circulating proinflammatory cytokines. Despite th...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1008483

    authors： Kell AM,Hemann EA,Turnbull JB,Gale M Jr

    更新日期：2020-04-24 00:00:00

  • A communal bacterial adhesin anchors biofilm and bystander cells to surfaces.

    abstract：:While the exopolysaccharide component of the biofilm matrix has been intensively studied, much less is known about matrix-associated proteins. To better understand the role of these proteins, we undertook a proteomic analysis of the V. cholerae biofilm matrix. Here we show that the two matrix-associated proteins, Bap1...

    journal_title：PLoS pathogens

    pub_type： 杂志文章

    doi：10.1371/journal.ppat.1002210

    authors： Absalon C,Van Dellen K,Watnick PI

    更新日期：2011-08-01 00:00:00