Sustained autophagy contributes to measles virus infectivity.

abstract：:All pathogenesis and death associated with Plasmodium falciparum malaria is due to parasite-infected erythrocytes. Invasion of erythrocytes by P. falciparum merozoites requires specific interactions between host receptors and parasite ligands that are localized in apical organelles called micronemes. Here, we identify...

journal_title：PLoS pathogens

authors： Dawn A,Singh S,More KR,Siddiqui FA,Pachikara N,Ramdani G,Langsley G,Chitnis CE

更新日期：2014-12-18 00:00:00

abstract：:Highly pathogenic avian H5N1 influenza A viruses have spread throughout Asia, Europe, and Africa, raising serious worldwide concern about their pandemic potential. Although more than 250 people have been infected with these viruses, with a consequent high rate of mortality, the molecular mechanisms responsible for the...

journal_title：PLoS pathogens

authors： Hatta M,Hatta Y,Kim JH,Watanabe S,Shinya K,Nguyen T,Lien PS,Le QM,Kawaoka Y

更新日期：2007-10-05 00:00:00

abstract：:As a canonical adaptor for the Toll-like receptor (TLR) family, myeloid differentiation primary response protein 88 (MyD88) has crucial roles in host defense against infection by microbial pathogens, and its dysregulation might induce autoimmune diseases. Here, we demonstrate that the chicken Cullin 3-based ubiquitin ...

journal_title：PLoS pathogens

authors： Li Q,Wang F,Wang Q,Zhang N,Zheng J,Zheng M,Liu R,Cui H,Wen J,Zhao G

更新日期：2020-05-04 00:00:00

abstract：:Pili of pathogenic Neisseria are major virulence factors associated with adhesion, twitching motility, auto-aggregation, and DNA transformation. Pili of N. meningitidis are subject to several different post-translational modifications. Among these pilin modifications, the presence of phosphorylcholine (ChoP) and a gly...

journal_title：PLoS pathogens

authors： Jen FE,Warren MJ,Schulz BL,Power PM,Swords WE,Weiser JN,Apicella MA,Edwards JL,Jennings MP

更新日期：2013-01-01 00:00:00

abstract：:Infection of host tissues by Staphylococcus aureus and S. epidermidis requires an unusual family of staphylococcal adhesive proteins that contain long stretches of serine-aspartate dipeptide-repeats (SDR). The prototype member of this family is clumping factor A (ClfA), a key virulence factor that mediates adhesion to...

journal_title：PLoS pathogens

authors： Hazenbos WL,Kajihara KK,Vandlen R,Morisaki JH,Lehar SM,Kwakkenbos MJ,Beaumont T,Bakker AQ,Phung Q,Swem LR,Ramakrishnan S,Kim J,Xu M,Shah IM,Diep BA,Sai T,Sebrell A,Khalfin Y,Oh A,Koth C,Lin SJ,Lee BC,Strandh M

更新日期：2013-01-01 00:00:00

abstract：:Inactivation of host Rho GTPases is a widespread strategy employed by bacterial pathogens to manipulate mammalian cellular functions and avoid immune defenses. Some bacterial toxins mimic eukaryotic Rho GTPase-activating proteins (GAPs) to inactivate mammalian GTPases, probably as a result of evolutionary convergence....

journal_title：PLoS pathogens

authors： Colinet D,Schmitz A,Depoix D,Crochard D,Poirié M

更新日期：2007-12-28 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1005822.]. ...

journal_title：PLoS pathogens

authors： Abdelrahman Y,Ouellette SP,Belland RJ,Cox JV

更新日期：2016-08-30 00:00:00

abstract：:To further its pathogenesis, S. Typhimurium delivers effector proteins into host cells, including the novel E3 ubiquitin ligase (NEL) effector SspH2. Using model systems in a cross-kingdom approach we gained further insight into the molecular function of this effector. Here, we show that SspH2 modulates innate immunit...

journal_title：PLoS pathogens

authors： Bhavsar AP,Brown NF,Stoepel J,Wiermer M,Martin DD,Hsu KJ,Imami K,Ross CJ,Hayden MR,Foster LJ,Li X,Hieter P,Finlay BB

更新日期：2013-01-01 00:00:00

abstract：:Migrating cells are guided in complex environments mainly by chemotaxis or structural cues presented by the surrounding tissue. During transmission of malaria, parasite motility in the skin is important for Plasmodium sporozoites to reach the blood circulation. Here we show that sporozoite migration varies in differen...

journal_title：PLoS pathogens

authors： Hellmann JK,Münter S,Kudryashev M,Schulz S,Heiss K,Müller AK,Matuschewski K,Spatz JP,Schwarz US,Frischknecht F

更新日期：2011-06-01 00:00:00

abstract：:Tissue samples from Australian carpet pythons (Morelia spilota) with neurological disease were screened for viruses using next-generation sequencing. Coding complete genomes of two bornaviruses were identified with the gene order 3'-N-X-P-G-M-L, representing a transposition of the G and M genes compared to other borna...

journal_title：PLoS pathogens

authors： Hyndman TH,Shilton CM,Stenglein MD,Wellehan JFX Jr

更新日期：2018-02-20 00:00:00

abstract：:Many bacterial pathogens and symbionts use type III secretion machines to interact with their hosts by injecting bacterial effector proteins into host target cells. A central component of this complex machine is the cytoplasmic sorting platform, which orchestrates the engagement and preparation of type III secreted pr...

journal_title：PLoS pathogens

authors： Lara-Tejero M,Qin Z,Hu B,Butan C,Liu J,Galán JE

更新日期：2019-01-22 00:00:00

abstract：:Successful replication and transmission of large DNA viruses such as the cytomegaloviruses (CMV) family of viruses depends on the ability to interfere with multiple aspects of the host immune response. Apoptosis functions as a host innate defence mechanism against viral infection, and the capacity to interfere with th...

journal_title：PLoS pathogens

authors： Fleming P,Kvansakul M,Voigt V,Kile BT,Kluck RM,Huang DC,Degli-Esposti MA,Andoniou CE

更新日期：2013-02-01 00:00:00

abstract：:Caspase-dependent cleavage of antigens associated with apoptotic cells plays a prominent role in the generation of CD8⁺ T cell responses in various infectious diseases. We found that the emergence of a large population of autoreactive CD8⁺ T effector cells specific for apoptotic T cell-associated self-epitopes exceeds...

journal_title：PLoS pathogens

authors： Franceschini D,Del Porto P,Piconese S,Trella E,Accapezzato D,Paroli M,Morrone S,Piccolella E,Spada E,Mele A,Sidney J,Sette A,Barnaba V

更新日期：2012-01-01 00:00:00

abstract：:The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete loss of virulence i...

journal_title：PLoS pathogens

authors： Chung D,Barker BM,Carey CC,Merriman B,Werner ER,Lechner BE,Dhingra S,Cheng C,Xu W,Blosser SJ,Morohashi K,Mazurie A,Mitchell TK,Haas H,Mitchell AP,Cramer RA

更新日期：2014-11-06 00:00:00

abstract：:Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutio...

journal_title：PLoS pathogens

authors： Deeg CM,Zimmer MM,George EE,Husnik F,Keeling PJ,Suttle CA

更新日期：2019-05-31 00:00:00

abstract：:Since the advent of genome-wide small interfering RNA screening, large numbers of cellular cofactors important for viral infection have been discovered at a rapid pace, but the viral targets and the mechanism of action for many of these cofactors remain undefined. One such cofactor is cyclophilin A (CyPA), upon which ...

journal_title：PLoS pathogens

authors： Yang F,Robotham JM,Grise H,Frausto S,Madan V,Zayas M,Bartenschlager R,Robinson M,Greenstein AE,Nag A,Logan TM,Bienkiewicz E,Tang H

更新日期：2010-09-23 00:00:00

abstract：:Infection of the vascular system by Pseudomonas aeruginosa (Pa) occurs during bacterial dissemination in the body or in blood-borne infections. Type 3 secretion system (T3SS) toxins from Pa induce a massive retraction when injected into endothelial cells. Here, we addressed the role of type 2 secretion system (T2SS) e...

journal_title：PLoS pathogens

authors： Golovkine G,Faudry E,Bouillot S,Voulhoux R,Attrée I,Huber P

更新日期：2014-03-13 00:00:00

abstract：:MicroRNAs (miRNAs) are 19 to 23 nucleotide-long RNAs that post-transcriptionally regulate gene expression. Human cells express several hundred miRNAs which regulate important biological pathways such as development, proliferation, and apoptosis. Recently, 12 miRNA genes have been identified within the genome of Kaposi...

journal_title：PLoS pathogens

authors： Samols MA,Skalsky RL,Maldonado AM,Riva A,Lopez MC,Baker HV,Renne R

更新日期：2007-05-11 00:00:00

abstract：:Rice tungro disease is caused by synergistic interaction of an RNA picorna-like virus Rice tungro spherical virus (RTSV) and a DNA pararetrovirus Rice tungro bacilliform virus (RTBV). It is spread by insects owing to an RTSV-encoded transmission factor. RTBV has evolved a ribosome shunt mechanism to initiate translati...

journal_title：PLoS pathogens

authors： Pooggin MM,Rajeswaran R,Schepetilnikov MV,Ryabova LA

更新日期：2012-01-01 00:00:00

abstract：:The metabolic events associated with maintaining redox homeostasis in Mycobacterium tuberculosis (Mtb) during infection are poorly understood. Here, we discovered a novel redox switching mechanism by which Mtb WhiB3 under defined oxidizing and reducing conditions differentially modulates the assimilation of propionate...

journal_title：PLoS pathogens

authors： Singh A,Crossman DK,Mai D,Guidry L,Voskuil MI,Renfrow MB,Steyn AJ

更新日期：2009-08-01 00:00:00

abstract：:Nematode parasites secrete molecules which regulate the mammalian immune system, but their genetic intractability is a major impediment to identifying and characterising the biological effects of these molecules. We describe here a novel system for heterologous expression of helminth secreted proteins in the natural p...

journal_title：PLoS pathogens

authors： Vaux R,Schnoeller C,Berkachy R,Roberts LB,Hagen J,Gounaris K,Selkirk ME

更新日期：2016-11-01 00:00:00

abstract：:Endogenous retroviruses (ERVs) arise from retroviruses chromosomally integrated in the host germline. ERVs are common in vertebrate genomes and provide a valuable fossil record of past retroviral infections to investigate the biology and evolution of retroviruses over a deep time scale, including cross-species transmi...

journal_title：PLoS pathogens

authors： Zhuo X,Feschotte C

更新日期：2015-11-12 00:00:00

abstract：:Antibody-dependent enhancement (ADE) of Ebola virus (EBOV) infection has been demonstrated in vitro, raising concerns about the detrimental potential of some anti-EBOV antibodies. ADE has been described for many viruses and mostly depends on the cross-linking of virus-antibody complexes to cell surface Fc receptors, l...

journal_title：PLoS pathogens

authors： Furuyama W,Marzi A,Carmody AB,Maruyama J,Kuroda M,Miyamoto H,Nanbo A,Manzoor R,Yoshida R,Igarashi M,Feldmann H,Takada A

更新日期：2016-12-30 00:00:00

abstract：:The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle. Although many proteins involved in kDNA replication and segregation are now known, several key steps in the replication...

journal_title：PLoS pathogens

authors： Peña-Diaz P,Vancová M,Resl C,Field MC,Lukeš J

更新日期：2017-04-07 00:00:00

abstract：:During immature capsid assembly, HIV-1 genome packaging is initiated when Gag first associates with unspliced HIV-1 RNA by a poorly understood process. Previously, we defined a pathway of sequential intracellular HIV-1 capsid assembly intermediates; here we sought to identify the intermediate in which HIV-1 Gag first ...

journal_title：PLoS pathogens

authors： Barajas BC,Tanaka M,Robinson BA,Phuong DJ,Chutiraka K,Reed JC,Lingappa JR

更新日期：2018-04-17 00:00:00

abstract：:Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies. While natural killer (NK) cells can directly contribute to the control of viral replication, whet...

journal_title：PLoS pathogens

authors： Robbins SH,Bessou G,Cornillon A,Zucchini N,Rupp B,Ruzsics Z,Sacher T,Tomasello E,Vivier E,Koszinowski UH,Dalod M

更新日期：2007-08-24 00:00:00

abstract：:MicroRNAs play an important role in the interplay between bacterial pathogens and host cells, participating as host defense mechanisms, as well as exploited by bacteria to subvert host cellular functions. Here, we show that microRNAs modulate infection by Shigella flexneri, a major causative agent of bacillary dysente...

journal_title：PLoS pathogens

authors： Sunkavalli U,Aguilar C,Silva RJ,Sharan M,Cruz AR,Tawk C,Maudet C,Mano M,Eulalio A

更新日期：2017-04-10 00:00:00

abstract：:Surface recognition and penetration are critical steps in the infection cycle of many plant pathogenic fungi. In Magnaporthe oryzae, cAMP signaling is involved in surface recognition and pathogenesis. Deletion of the MAC1 adenylate cyclase gene affected appressorium formation and plant infection. In this study, we use...

journal_title：PLoS pathogens

authors： Zhou X,Zhang H,Li G,Shaw B,Xu JR

更新日期：2012-09-01 00:00:00

abstract：:Human cytomegalovirus (HCMV), a dsDNA, enveloped virus, is a ubiquitous pathogen that establishes lifelong latent infections and caused disease in persons with compromised immune systems, e.g., organ transplant recipients or AIDS patients. HCMV is also a leading cause of congenital viral infections in newborns. Entry ...

journal_title：PLoS pathogens

authors： Burke HG,Heldwein EE

更新日期：2015-10-20 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006120.]. ...

journal_title：PLoS pathogens

authors： Kinosada H,Yasunaga JI,Shimura K,Miyazato P,Onishi C,Iyoda T,Inaba K,Matsuoka M

更新日期：2017-02-23 00:00:00