Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs.

abstract：:The type III secretion system is an essential component for virulence in many Gram-negative bacteria. Though components of the secretion system apparatus are conserved, its substrates--effector proteins--are not. We have used a novel computational approach to confidently identify new secreted effectors by integrating ...

journal_title：PLoS pathogens

authors： Samudrala R,Heffron F,McDermott JE

更新日期：2009-04-01 00:00:00

abstract：:In human cytomegalovirus (HCMV), tropism to epithelial and endothelial cells is dependent upon a pentameric complex (PC). Given the structure of the placenta, the PC is potentially an important neutralizing antibody target antigen against congenital infection. The guinea pig is the only small animal model for congenit...

journal_title：PLoS pathogens

authors： Coleman S,Choi KY,Root M,McGregor A

更新日期：2016-07-07 00:00:00

abstract：:This study investigated the role of prion infection of the olfactory mucosa in the shedding of prion infectivity into nasal secretions. Prion infection with the HY strain of the transmissible mink encephalopathy (TME) agent resulted in a prominent infection of the olfactory bulb and the olfactory sensory epithelium in...

journal_title：PLoS pathogens

authors： Bessen RA,Shearin H,Martinka S,Boharski R,Lowe D,Wilham JM,Caughey B,Wiley JA

更新日期：2010-04-15 00:00:00

abstract：:The bunyavirus genome comprises a small (S), medium (M), and large (L) RNA segment of negative polarity. Although genome segmentation confers evolutionary advantages by enabling genome reassortment events with related viruses, genome segmentation also complicates genome replication and packaging. Accumulating evidence...

journal_title：PLoS pathogens

authors： Wichgers Schreur PJ,Kortekaas J

更新日期：2016-08-22 00:00:00

abstract：:Unique purine-rich mRNA sequences embedded in the coding sequences of a distinct group of gammaherpesvirus maintenance proteins underlie the ability of the latently infected cell to minimize immune recognition. The Epstein-Barr virus nuclear antigen, EBNA1, a well characterized lymphocryptovirus maintenance protein ha...

journal_title：PLoS pathogens

authors： Tellam JT,Lekieffre L,Zhong J,Lynn DJ,Khanna R

更新日期：2012-12-01 00:00:00

abstract：:Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro. Circulating and antigen-stimulated concentrations of these inflammatory mediators...

journal_title：PLoS pathogens

authors： Coussens AK,Wilkinson RJ,Nikolayevskyy V,Elkington PT,Hanifa Y,Islam K,Timms PM,Bothamley GH,Claxton AP,Packe GE,Darmalingam M,Davidson RN,Milburn HJ,Baker LV,Barker RD,Drobniewski FA,Mein CA,Bhaw-Rosun L,Nuamah RA,

更新日期：2013-01-01 00:00:00

abstract：:Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. We show that the spirochetes can acquire cholesterol from plasma membranes of epithel...

journal_title：PLoS pathogens

authors： Crowley JT,Toledo AM,LaRocca TJ,Coleman JL,London E,Benach JL

更新日期：2013-01-01 00:00:00

abstract：:To ensure their survival, microbial pathogens have evolved diverse strategies to subvert host immune defenses. The human retrovirus HIV-1 has been proposed to hijack the natural endocytic function of dendritic cells (DCs) to infect interacting CD4 T cells in a process termed trans-infection. Although DCs can be direct...

journal_title：PLoS pathogens

authors： Cavrois M,Neidleman J,Greene WC

更新日期：2008-06-27 00:00:00

abstract：:Microbial pathogens often establish infection within particular niches of their host for replication. Determining how infection occurs preferentially in specific host tissues is a key aspect of understanding host-microbe interactions. Here, we describe the discovery of a natural microsporidian parasite of the nematode...

journal_title：PLoS pathogens

authors： Luallen RJ,Reinke AW,Tong L,Botts MR,Félix MA,Troemel ER

更新日期：2016-06-30 00:00:00

abstract：:Malaria starts with the infection of the liver of the host by Plasmodium sporozoites, the parasite form transmitted by infected mosquitoes. Sporozoites migrate through several hepatocytes by breaching their plasma membranes before finally infecting one with the formation of an internalization vacuole. Migration throug...

journal_title：PLoS pathogens

authors： Ono T,Cabrita-Santos L,Leitao R,Bettiol E,Purcell LA,Diaz-Pulido O,Andrews LB,Tadakuma T,Bhanot P,Mota MM,Rodriguez A

更新日期：2008-02-29 00:00:00

abstract：:The herpesvirus life cycle has two distinct phases: latency and lytic replication. The balance between these two phases is critical for viral pathogenesis. It is believed that cellular signals regulate the switch from latency to lytic replication. To systematically evaluate the cellular signals regulating this reactiv...

journal_title：PLoS pathogens

authors： Yu F,Harada JN,Brown HJ,Deng H,Song MJ,Wu TT,Kato-Stankiewicz J,Nelson CG,Vieira J,Tamanoi F,Chanda SK,Sun R

更新日期：2007-03-01 00:00:00

abstract：:HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics remains unclear. In Japan, HIV-1 Reverse Transcriptase codon 135 (RT135) is under strong immune pressure by HLA-B*51:01-restricted and HLA-B*52:01-restricted T ce...

journal_title：PLoS pathogens

authors： Akahoshi T,Gatanaga H,Kuse N,Chikata T,Koyanagi M,Ishizuka N,Brumme CJ,Murakoshi H,Brumme ZL,Oka S,Takiguchi M

更新日期：2020-12-28 00:00:00

abstract：:Rabbit hemorrhagic disease, first described in China in 1984, causes hemorrhagic necrosis of the liver. Its etiological agent, rabbit hemorrhagic disease virus (RHDV), belongs to the Lagovirus genus in the family Caliciviridae. The detailed molecular structure of any lagovirus capsid has yet to be determined. Here, we...

journal_title：PLoS pathogens

authors： Wang X,Xu F,Liu J,Gao B,Liu Y,Zhai Y,Ma J,Zhang K,Baker TS,Schulten K,Zheng D,Pang H,Sun F

更新日期：2013-01-01 00:00:00

abstract：:Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nucleus of coronavirus-infected cells, first, transcriptome dynamics was...

journal_title：PLoS pathogens

authors： Poppe M,Wittig S,Jurida L,Bartkuhn M,Wilhelm J,Müller H,Beuerlein K,Karl N,Bhuju S,Ziebuhr J,Schmitz ML,Kracht M

更新日期：2017-03-29 00:00:00

abstract：:Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus anthracis, disrupts endocytic recycling mediated by the small GTPase Rab11. As a result, cargo proteins such as cadherins fail to reach inter-cellu...

journal_title：PLoS pathogens

authors： Guichard A,Jain P,Moayeri M,Schwartz R,Chin S,Zhu L,Cruz-Moreno B,Liu JZ,Aguilar B,Hollands A,Leppla SH,Nizet V,Bier E

更新日期：2017-09-25 00:00:00

abstract：:Human cytomegalovirus (HCMV) infects about 50% of the US population, is the leading infectious cause of birth defects, and is considered the most important infectious agent in transplant recipients. The virus infects many cell types in vivo and in vitro. While previous studies have identified several cellular proteins...

journal_title：PLoS pathogens

authors： Li Q,Wilkie AR,Weller M,Liu X,Cohen JI

更新日期：2015-07-06 00:00:00

abstract：:The primary role of cytoplasmic viral RNA-dependent RNA polymerase (RdRp) is viral genome replication in the cellular cytoplasm. However, picornaviral RdRp denoted 3D polymerase (3D(pol)) also enters the host nucleus, where its function remains unclear. In this study, we describe a novel mechanism of viral attack in w...

journal_title：PLoS pathogens

authors： Liu YC,Kuo RL,Lin JY,Huang PN,Huang Y,Liu H,Arnold JJ,Chen SJ,Wang RY,Cameron CE,Shih SR

更新日期：2014-06-26 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an RNA virus in the Family Paramyxoviridae. Here, the activities performed by the RSV polymerase when it encounters the viral antigenomic promoter were examined. RSV RNA synthesis was reconstituted in vitro using recombinant, isolated polymerase and an RNA oligonucleotide template ...

journal_title：PLoS pathogens

authors： Noton SL,Deflubé LR,Tremaglio CZ,Fearns R

更新日期：2012-01-01 00:00:00

abstract：:The RNA synthesis machinery of vesicular stomatitis virus (VSV) comprises the genomic RNA encapsidated by the viral nucleocapsid protein (N) and associated with the RNA dependent RNA polymerase, the viral components of which are a large protein (L) and an accessory phosphoprotein (P). The 241 kDa L protein contains al...

journal_title：PLoS pathogens

authors： Tekes G,Rahmeh AA,Whelan SP

更新日期：2011-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a leading cause of liver disease worldwide. The HCV RNA genome is translated into a single polyprotein. Most of the cleavage sites in the non-structural (NS) polyprotein region are processed by the NS3/NS4A serine protease. The vital NS2-NS3 cleavage is catalyzed by the NS2 autopro...

journal_title：PLoS pathogens

authors： Isken O,Langerwisch U,Jirasko V,Rehders D,Redecke L,Ramanathan H,Lindenbach BD,Bartenschlager R,Tautz N

更新日期：2015-03-16 00:00:00

abstract：:Phosphorylated derivatives of phosphatidylinositol (PIPs) are key membrane lipid residues involved in clathrin-mediated endocytosis (CME). CME relies on PIP species PI(4,5)P2 to mark endocytic sites at the plasma membrane (PM) associated to clathrin-coated vesicle (CCV) formation. The highly diverged parasitic protist...

journal_title：PLoS pathogens

authors： Cernikova L,Faso C,Hehl AB

更新日期：2020-02-24 00:00:00

abstract：:The Ras-GAP SH3 domain-binding proteins (G3BP) are essential regulators of the formation of stress granules (SG), cytosolic aggregates of proteins and RNA that are induced upon cellular stress, such as virus infection. Many viruses, including Semliki Forest virus (SFV), block SG induction by targeting G3BP. In this wo...

journal_title：PLoS pathogens

authors： Panas MD,Schulte T,Thaa B,Sandalova T,Kedersha N,Achour A,McInerney GM

更新日期：2015-02-06 00:00:00

abstract：:Salmonella enterica serovar Typhimurium is a Gram-negative bacterial pathogen causing gastroenteritis in humans and a systemic typhoid-like illness in mice. The capacity of Salmonella to cause diseases relies on the establishment of its intracellular replication niche, a membrane-bound compartment named the Salmonella...

journal_title：PLoS pathogens

authors： Schroeder N,Henry T,de Chastellier C,Zhao W,Guilhon AA,Gorvel JP,Méresse S

更新日期：2010-07-15 00:00:00

abstract：:Nuclear factor of activated T cells 5 (NFAT5)/Tonicity enhancer binding protein (TonEBP) is a transcription factor induced by hypertonic stress in the kidney. However, the function of NFAT5 in other organs has rarely been studied, even though it is ubiquitously expressed. Indeed, although NFAT5 was reported to be crit...

journal_title：PLoS pathogens

authors： Qiu Y,Ye X,Zhang HM,Hanson P,Zhao G,Tong L,Xie R,Yang D

更新日期：2017-12-08 00:00:00

abstract：:Gastrointestinal infections caused by enteric yersiniae can become persistent and complicated by relapsing enteritis and severe autoimmune disorders. To establish a persistent infection, the bacteria have to cope with hostile surroundings when they transmigrate through the intestinal epithelium and colonize underlying...

journal_title：PLoS pathogens

authors： Heine W,Beckstette M,Heroven AK,Thiemann S,Heise U,Nuss AM,Pisano F,Strowig T,Dersch P

更新日期：2018-02-01 00:00:00

abstract：:Exosomes can transfer genetic materials between cells. Their roles in viral infections are beginning to be appreciated. Researches have shown that exosomes released from virus-infected cells contain a variety of viral and host cellular factors that are able to modulate recipient's cellular response and result in produ...

journal_title：PLoS pathogens

authors： Fu Y,Zhang L,Zhang F,Tang T,Zhou Q,Feng C,Jin Y,Wu Z

更新日期：2017-09-14 00:00:00

abstract：:The host response to mycobacterial infection depends on host and pathogen genetic factors. Recent studies in human populations suggest a strain specific genetic control of tuberculosis. To test for mycobacterial-strain specific genetic control of susceptibility to infection under highly controlled experimental conditi...

journal_title：PLoS pathogens

authors： Di Pietrantonio T,Hernandez C,Girard M,Verville A,Orlova M,Belley A,Behr MA,Loredo-Osti JC,Schurr E

更新日期：2010-10-28 00:00:00

abstract：:The intrinsic oncotropism and oncosuppressive activities of rodent protoparvoviruses (PVs) are opening new prospects for cancer virotherapy. Virus propagation, cytolytic activity, and spread are tightly connected to activation of the PDK1 signaling cascade, which delays stress-induced cell death and sustains functioni...

journal_title：PLoS pathogens

authors： Bär S,Rommelaere J,Nüesch JP

更新日期：2015-03-05 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) remains a major public health problem, with an effective vaccine continuing to prove elusive. Progress in vaccination strategies has been hampered by a lack of appreciation of the bacterium's response to dynamic changes in the host immune environment. Here, we utilize reporter Mtb stra...

journal_title：PLoS pathogens

authors： Sukumar N,Tan S,Aldridge BB,Russell DG

更新日期：2014-09-18 00:00:00

abstract：:The combination of drug resistance, lack of an effective vaccine, and ongoing conflict and poverty means that malaria remains a major global health crisis. Understanding metabolic pathways at all parasite life stages is important in prioritising and targeting novel anti-parasitic compounds. The unusual heme synthesis ...

journal_title：PLoS pathogens

authors： Rathnapala UL,Goodman CD,McFadden GI

更新日期：2017-06-15 00:00:00