Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread.

abstract：:Streptococcus equi subspecies equi (S. equi) is a clonal, equine host-adapted pathogen of global importance that causes a suppurative lymphodendopathy of the head and neck, more commonly known as Strangles. The disease is highly prevalent, can be severe and is highly contagious. Antibiotic treatment is usually ineffec...

journal_title：PLoS pathogens

authors： Guss B,Flock M,Frykberg L,Waller AS,Robinson C,Smith KC,Flock JI

更新日期：2009-09-01 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC), particularly serotype O157:H7, causes hemorrhagic colitis, hemolytic uremic syndrome, and even death. In vitro studies showed that Shiga toxin 2 (Stx2), the primary virulence factor expressed by EDL933 (an O157:H7 strain), is encoded by the 933W prophage. And the bacterial su...

journal_title：PLoS pathogens

authors： Tyler JS,Beeri K,Reynolds JL,Alteri CJ,Skinner KG,Friedman JH,Eaton KA,Friedman DI

更新日期：2013-03-01 00:00:00

abstract：:Rice tungro disease is caused by synergistic interaction of an RNA picorna-like virus Rice tungro spherical virus (RTSV) and a DNA pararetrovirus Rice tungro bacilliform virus (RTBV). It is spread by insects owing to an RTSV-encoded transmission factor. RTBV has evolved a ribosome shunt mechanism to initiate translati...

journal_title：PLoS pathogens

authors： Pooggin MM,Rajeswaran R,Schepetilnikov MV,Ryabova LA

更新日期：2012-01-01 00:00:00

abstract：:Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory CD8 T cells in providing protection against respiratory syncytial virus (RSV) infection is currently unclear. To address this knowledge gap, we utilized a prime-bo...

journal_title：PLoS pathogens

authors： Schmidt ME,Knudson CJ,Hartwig SM,Pewe LL,Meyerholz DK,Langlois RA,Harty JT,Varga SM

更新日期：2018-01-02 00:00:00

abstract：:Trichothecenes are a family of terpenoid toxins produced by multiple genera of fungi, including plant and insect pathogens. Some trichothecenes produced by the fungus Fusarium are among the mycotoxins of greatest concern to food and feed safety because of their toxicity and frequent occurrence in cereal crops, and tri...

journal_title：PLoS pathogens

authors： Proctor RH,McCormick SP,Kim HS,Cardoza RE,Stanley AM,Lindo L,Kelly A,Brown DW,Lee T,Vaughan MM,Alexander NJ,Busman M,Gutiérrez S

更新日期：2018-04-12 00:00:00

abstract：:Epidemiological studies have identified a correlation between maternal helminth infections and reduced immunity to some early childhood vaccinations, but the cellular basis for this is poorly understood. Here, we investigated the effects of maternal Schistosoma mansoni infection on steady-state offspring immunity, as ...

journal_title：PLoS pathogens

authors： Cortés-Selva D,Gibbs L,Ready A,Ekiz HA,O'Connell R,Rajwa B,Fairfax KC

更新日期：2021-02-01 00:00:00

abstract：:Intracellular bacteria have evolved mechanisms that promote survival within hostile host environments, often resulting in functional dysregulation and disease. Using the Anaplasma phagocytophilum-infected granulocyte model, we establish a link between host chromatin modifications, defense gene transcription and intrac...

journal_title：PLoS pathogens

authors： Garcia-Garcia JC,Barat NC,Trembley SJ,Dumler JS

更新日期：2009-06-01 00:00:00

abstract：:To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma and on host cells by plasma complement regulator factor H (FH). ...

journal_title：PLoS pathogens

authors： Meri T,Amdahl H,Lehtinen MJ,Hyvärinen S,McDowell JV,Bhattacharjee A,Meri S,Marconi R,Goldman A,Jokiranta TS

更新日期：2013-01-01 00:00:00

abstract：:Betanodaviruses cause massive mortality in marine fish species with viral nervous necrosis. The structure of a T = 3 Grouper nervous necrosis virus-like particle (GNNV-LP) is determined by the ab initio method with non-crystallographic symmetry averaging at 3.6 Å resolution. Each capsid protein (CP) shows three major ...

journal_title：PLoS pathogens

authors： Chen NC,Yoshimura M,Guan HH,Wang TY,Misumi Y,Lin CC,Chuankhayan P,Nakagawa A,Chan SI,Tsukihara T,Chen TY,Chen CJ

更新日期：2015-10-22 00:00:00

abstract：:The factors that govern the development of tuberculosis disease are incompletely understood. We hypothesized that some strains of Mycobacterium tuberculosis (M. tuberculosis) are more capable of causing disseminated disease than others and may be associated with polymorphisms in host genes responsible for the innate i...

journal_title：PLoS pathogens

authors： Caws M,Thwaites G,Dunstan S,Hawn TR,Lan NT,Thuong NT,Stepniewska K,Huyen MN,Bang ND,Loc TH,Gagneux S,van Soolingen D,Kremer K,van der Sande M,Small P,Anh PT,Chinh NT,Quy HT,Duyen NT,Tho DQ,Hieu NT,Torok E,Hien

更新日期：2008-03-28 00:00:00

abstract：:In an effort to suppress microbial outgrowth, the host sequesters essential nutrients in a process termed nutritional immunity. However, inflammatory responses to bacterial insult can restore nutritional resources. Given that nutrient availability modulates virulence factor production and biofilm formation by other ba...

journal_title：PLoS pathogens

authors： Szelestey BR,Heimlich DR,Raffel FK,Justice SS,Mason KM

更新日期：2013-01-01 00:00:00

abstract：:RNA viruses typically occur in genetically diverse populations due to their error-prone genome replication. Genetic diversity is thought to be important in allowing RNA viruses to explore sequence space, facilitating adaptation to changing environments and hosts. Some arboviruses that infect both a mosquito vector and...

journal_title：PLoS pathogens

authors： Forrester NL,Guerbois M,Seymour RL,Spratt H,Weaver SC

更新日期：2012-09-01 00:00:00

abstract：:Phosphorylated derivatives of phosphatidylinositol (PIPs) are key membrane lipid residues involved in clathrin-mediated endocytosis (CME). CME relies on PIP species PI(4,5)P2 to mark endocytic sites at the plasma membrane (PM) associated to clathrin-coated vesicle (CCV) formation. The highly diverged parasitic protist...

journal_title：PLoS pathogens

authors： Cernikova L,Faso C,Hehl AB

更新日期：2020-02-24 00:00:00

abstract：:Pomalidomide (Pom) is an immunomodulatory drug that has efficacy against Kaposi's sarcoma, a tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Pom also induces direct cytotoxicity in primary effusion lymphoma (PEL), a B-cell malignancy caused by KSHV, in part through downregulation of IRF4, cMyc, and CK1...

journal_title：PLoS pathogens

authors： Shrestha P,Davis DA,Jaeger HK,Stream A,Aisabor AI,Yarchoan R

更新日期：2021-01-07 00:00:00

abstract：:Whereas the majority of pathogenic Salmonella serovars are capable of infecting many different animal species, typically producing a self-limited gastroenteritis, serovars with narrow host-specificity exhibit increased virulence and their infections frequently result in fatal systemic diseases. In our study, a genetic...

journal_title：PLoS pathogens

authors： Kisiela DI,Chattopadhyay S,Libby SJ,Karlinsey JE,Fang FC,Tchesnokova V,Kramer JJ,Beskhlebnaya V,Samadpour M,Grzymajlo K,Ugorski M,Lankau EW,Mackie RI,Clegg S,Sokurenko EV

更新日期：2012-01-01 00:00:00

abstract：:The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at extraordinarily high rates. Blocking VSG synthesis triggers a pre...

journal_title：PLoS pathogens

authors： Cheung JL,Wand NV,Ooi CP,Ridewood S,Wheeler RJ,Rudenko G

更新日期：2016-11-28 00:00:00

abstract：:Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injection into host cells is facilitated by a so-called injectisome. Its small hydrop...

journal_title：PLoS pathogens

authors： Dietsche T,Tesfazgi Mebrhatu M,Brunner MJ,Abrusci P,Yan J,Franz-Wachtel M,Schärfe C,Zilkenat S,Grin I,Galán JE,Kohlbacher O,Lea S,Macek B,Marlovits TC,Robinson CV,Wagner S

更新日期：2016-12-15 00:00:00

abstract：:Streptococcus agalactiae is a common human commensal and a major life-threatening pathogen in neonates. Adherence to host epithelial cells is the first critical step of the infectious process. Pili have been observed on the surface of several gram-positive bacteria including S. agalactiae. We previously characterized ...

journal_title：PLoS pathogens

authors： Konto-Ghiorghi Y,Mairey E,Mallet A,Duménil G,Caliot E,Trieu-Cuot P,Dramsi S

更新日期：2009-05-01 00:00:00

abstract：:HIV and other lentiviruses can productively infect nondividing cells, whereas most other retroviruses, such as murine leukemia virus, require cell division for efficient infection. However, the determinants for this phenotype have been controversial. Here, we show that HIV-1 capsid (CA) is involved in facilitating HIV...

journal_title：PLoS pathogens

authors： Yamashita M,Perez O,Hope TJ,Emerman M

更新日期：2007-10-26 00:00:00

abstract：:Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis. The pathology of RRV-induced disease in both humans and mice is associated with induction of the host inflammatory response within th...

journal_title：PLoS pathogens

authors： Gunn BM,Morrison TE,Whitmore AC,Blevins LK,Hueston L,Fraser RJ,Herrero LJ,Ramirez R,Smith PN,Mahalingam S,Heise MT

更新日期：2012-01-01 00:00:00

abstract：:Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigotes, by a mechanism that involves reactive oxygen species (ROS) produ...

journal_title：PLoS pathogens

authors： Mittra B,Laranjeira-Silva MF,Perrone Bezerra de Menezes J,Jensen J,Michailowsky V,Andrews NW

更新日期：2016-01-07 00:00:00

abstract：:Trypanosoma cruzi is the most important parasitic infection in Latin America and is also genetically highly diverse, with at least six discrete typing units (DTUs) reported: Tc I, IIa, IIb, IIc, IId, and IIe. However, the current six-genotype classification is likely to be a poor reflection of the total genetic divers...

journal_title：PLoS pathogens

authors： Llewellyn MS,Miles MA,Carrasco HJ,Lewis MD,Yeo M,Vargas J,Torrico F,Diosque P,Valente V,Valente SA,Gaunt MW

更新日期：2009-05-01 00:00:00

abstract：:Malaria parasites must undergo a round of sexual reproduction in the blood meal of a mosquito vector to be transmitted between hosts. Developing a transmission-blocking intervention to prevent parasites from mating is a major goal of biomedicine, but its effectiveness could be compromised if parasites can compensate b...

journal_title：PLoS pathogens

authors： Ramiro RS,Alpedrinha J,Carter L,Gardner A,Reece SE

更新日期：2011-03-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1004331.]. ...

journal_title：PLoS pathogens

authors： PLOS Pathogens Staff.

更新日期：2015-02-19 00:00:00

abstract：:Yersinia utilizes a sophisticated type III secretion system to enhance its chances of survival and to overcome the host immune system. SmpB (small protein B) and SsrA (small stable RNA A) are components of a unique bacterial translational control system that help maintain the bacterial translational machinery in a ful...

journal_title：PLoS pathogens

authors： Okan NA,Bliska JB,Karzai AW

更新日期：2006-01-01 00:00:00

abstract：:As a canonical adaptor for the Toll-like receptor (TLR) family, myeloid differentiation primary response protein 88 (MyD88) has crucial roles in host defense against infection by microbial pathogens, and its dysregulation might induce autoimmune diseases. Here, we demonstrate that the chicken Cullin 3-based ubiquitin ...

journal_title：PLoS pathogens

authors： Li Q,Wang F,Wang Q,Zhang N,Zheng J,Zheng M,Liu R,Cui H,Wen J,Zhao G

更新日期：2020-05-04 00:00:00

abstract：:Helicobacter pylori (Hp) injects the CagA effector protein into host epithelial cells and induces growth factor-like signaling, perturbs cell-cell junctions, and alters host cell polarity. This enables Hp to grow as microcolonies adhered to the host cell surface even in conditions that do not support growth of free-sw...

journal_title：PLoS pathogens

authors： Tan S,Noto JM,Romero-Gallo J,Peek RM Jr,Amieva MR

更新日期：2011-05-01 00:00:00

abstract：:The recent origin and great evolutionary potential of HIV imply that the virulence of the virus might still be changing, which could greatly affect the future of the pandemic. However, previous studies of time trends of HIV virulence have yielded conflicting results. Here we used an established methodology to assess t...

journal_title：PLoS pathogens

authors： Müller V,Maggiolo F,Suter F,Ladisa N,De Luca A,Antinori A,Sighinolfi L,Quiros-Roldan E,Carosi G,Torti C

更新日期：2009-05-01 00:00:00

abstract：:Beyond their canonical roles in hemostasis and thrombosis, platelets function in the innate immune response by interacting directly with pathogens and by regulating the recruitment and activation of immune effector cells. Thrombocytopenia often coincides with neutropenia in patients with hematologic malignancies and i...

journal_title：PLoS pathogens

authors： Tischler BY,Tosini NL,Cramer RA,Hohl TM

更新日期：2020-05-14 00:00:00

abstract：:Both iron starvation and excess are detrimental to cellular life, especially for animal and plant pathogens since they always live in iron-limited environments produced by host immune responses. However, how organisms sense and respond to iron is incompletely understood. Herein, we reveal that in the phytopathogenic b...

journal_title：PLoS pathogens

authors： Wang L,Pan Y,Yuan ZH,Zhang H,Peng BY,Wang FF,Qian W

更新日期：2016-12-30 00:00:00