Crystal Structures of a Piscine Betanodavirus: Mechanisms of Capsid Assembly and Viral Infection.

abstract：:MicroRNAs play an important role in the interplay between bacterial pathogens and host cells, participating as host defense mechanisms, as well as exploited by bacteria to subvert host cellular functions. Here, we show that microRNAs modulate infection by Shigella flexneri, a major causative agent of bacillary dysente...

journal_title：PLoS pathogens

authors： Sunkavalli U,Aguilar C,Silva RJ,Sharan M,Cruz AR,Tawk C,Maudet C,Mano M,Eulalio A

更新日期：2017-04-10 00:00:00

abstract：:RNA silencing is an evolutionarily conserved sequence-specific gene-inactivation system that also functions as an antiviral mechanism in higher plants and insects. To overcome antiviral RNA silencing, viruses express silencing-suppressor proteins. These viral proteins can target one or more key points in the silencing...

journal_title：PLoS pathogens

authors： Giner A,Lakatos L,García-Chapa M,López-Moya JJ,Burgyán J

更新日期：2010-07-15 00:00:00

abstract：:Ebola virus disease afflicts both human and animal populations and is caused by four ebolaviruses. These different ebolaviruses may have distinct reservoir hosts and ecological contexts that determine how, where, and when different ebolavirus spillover events occur. Understanding these virus-specific relationships is ...

journal_title：PLoS pathogens

authors： Judson SD,Fischer R,Judson A,Munster VJ

更新日期：2016-08-05 00:00:00

abstract：:B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (TFH) cells. We studied the effects of native heterodimeric IL-15 (hetIL-15) treatmen...

journal_title：PLoS pathogens

authors： Watson DC,Moysi E,Valentin A,Bergamaschi C,Devasundaram S,Fortis SP,Bear J,Chertova E,Bess J Jr,Sowder R,Venzon DJ,Deleage C,Estes JD,Lifson JD,Petrovas C,Felber BK,Pavlakis GN

更新日期：2018-02-23 00:00:00

abstract：:Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription template, which plays a pivotal role in viral infection and persistence. Upon infection, the non-replicative cccDNA is converted from the incoming and de novo synthesized viral genomic relaxed circular (rc) DNA, presumably through e...

journal_title：PLoS pathogens

authors： Long Q,Yan R,Hu J,Cai D,Mitra B,Kim ES,Marchetti A,Zhang H,Wang S,Liu Y,Huang A,Guo H

更新日期：2017-12-29 00:00:00

abstract：:Viroporins are small transmembrane proteins with ion channel activities modulating properties of intracellular membranes that have diverse proviral functions. Hepatitis C virus (HCV) encodes a viroporin, p7, acting during assembly, envelopment and secretion of viral particles (VP). HCV p7 is released from the viral po...

journal_title：PLoS pathogens

authors： Denolly S,Mialon C,Bourlet T,Amirache F,Penin F,Lindenbach B,Boson B,Cosset FL

更新日期：2017-12-18 00:00:00

abstract：:Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. We show that the spirochetes can acquire cholesterol from plasma membranes of epithel...

journal_title：PLoS pathogens

authors： Crowley JT,Toledo AM,LaRocca TJ,Coleman JL,London E,Benach JL

更新日期：2013-01-01 00:00:00

abstract：:Accurate calculation of mutation rates for viruses and viroids is necessary for evolutionary studies and to evaluate adaptation potential. However, estimation of in vivo mutation rates is complicated by selection, which leads to loss or proliferation of certain mutations. To minimize this concern, lethal mutations, in...

journal_title：PLoS pathogens

authors： Wu J,Bisaro DM

更新日期：2020-12-22 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) are at the forefront of host-microbe interactions. Molecular and cell-based studies suggest that HSPG-pathogen interactions promote pathogenesis by facilitating microbial attachment and invasion of host cells. However, the specific identity of HSPGs, precise mechanisms by which HS...

journal_title：PLoS pathogens

authors： Aquino RS,Hayashida A,Park PW

更新日期：2020-05-26 00:00:00

abstract：:Many Gram-negative bacteria use Type Three Secretion Systems (T3SS) to deliver effector proteins into host cells. These protein delivery machines are composed of cytosolic components that recognize substrates and generate the force needed for translocation, the secretion conduit, formed by a needle complex and associa...

journal_title：PLoS pathogens

authors： Archuleta TL,Spiller BW

更新日期：2014-11-06 00:00:00

abstract：:Malaria, caused by the apicomplexan parasite Plasmodium, still represents a major threat to human health and welfare and leads to about one million human deaths annually. Plasmodium is a rapidly multiplying unicellular organism undergoing a complex developmental cycle in man and mosquito - a life style that requires r...

journal_title：PLoS pathogens

authors： Kehr S,Sturm N,Rahlfs S,Przyborski JM,Becker K

更新日期：2010-12-23 00:00:00

abstract：:Retroviruses encode cis-acting RNA nuclear export elements that override nuclear retention of intron-containing viral mRNAs including the full-length, unspliced genomic RNAs (gRNAs) packaged into assembling virions. The HIV-1 Rev-response element (RRE) recruits the cellular nuclear export receptor CRM1 (also known as ...

journal_title：PLoS pathogens

authors： Pocock GM,Becker JT,Swanson CM,Ahlquist P,Sherer NM

更新日期：2016-04-12 00:00:00

abstract：:In an effort to suppress microbial outgrowth, the host sequesters essential nutrients in a process termed nutritional immunity. However, inflammatory responses to bacterial insult can restore nutritional resources. Given that nutrient availability modulates virulence factor production and biofilm formation by other ba...

journal_title：PLoS pathogens

authors： Szelestey BR,Heimlich DR,Raffel FK,Justice SS,Mason KM

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006750.]. ...

journal_title：PLoS pathogens

authors： Patterson Ross Z,Klunk J,Fornaciari G,Giuffra V,Duchêne S,Duggan AT,Poinar D,Douglas MW,Eden JS,Holmes EC,Poinar HN

更新日期：2018-02-09 00:00:00

abstract：:The emergence of multi-drug (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB) is a major threat to the global management of tuberculosis (TB) worldwide. New chemical entities are of need to treat drug-resistant TB. In this study, the mode of action of new, potent quinazoline derivatives was investigated ag...

journal_title：PLoS pathogens

authors： Lupien A,Foo CS,Savina S,Vocat A,Piton J,Monakhova N,Benjak A,Lamprecht DA,Steyn AJC,Pethe K,Makarov VA,Cole ST

更新日期：2020-01-23 00:00:00

abstract：:Endogenous retroviruses (ERVs), remnants of ancient germline infections, comprise 8% of the human genome. The most recently integrated includes human ERV-K (HERV-K) where several envelope (env) sequences remain intact. Viral pseudotypes decorated with one of those Envs are infectious. Using a recombinant vesicular sto...

journal_title：PLoS pathogens

authors： Robinson-McCarthy LR,McCarthy KR,Raaben M,Piccinotti S,Nieuwenhuis J,Stubbs SH,Bakkers MJG,Whelan SPJ

更新日期：2018-08-06 00:00:00

abstract：:Community acquired-methicillin resistant Staphylococcus aureus (CA-MRSA) is a socially problematic pathogen that infects healthy individuals, causing severe disease. CA-MRSA is more virulent than hospital associated-MRSA (HA-MRSA). The underlying mechanism for the high virulence of CA-MRSA is not known. The transcript...

journal_title：PLoS pathogens

authors： Kaito C,Saito Y,Ikuo M,Omae Y,Mao H,Nagano G,Fujiyuki T,Numata S,Han X,Obata K,Hasegawa S,Yamaguchi H,Inokuchi K,Ito T,Hiramatsu K,Sekimizu K

更新日期：2013-01-01 00:00:00

abstract：:The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade of HSV gene transcription is initiated by the multifunctional vi...

journal_title：PLoS pathogens

authors： Thompson RL,Preston CM,Sawtell NM

更新日期：2009-03-01 00:00:00

abstract：:The flagellum organelle is an intricate multiprotein assembly best known for its rotational propulsion of bacteria. However, recent studies have expanded our knowledge of other functions in pathogenic contexts, particularly adherence and immune modulation, e.g., for Salmonella enterica, Campylobacter jejuni, Pseudomon...

journal_title：PLoS pathogens

authors： Rossez Y,Wolfson EB,Holmes A,Gally DL,Holden NJ

更新日期：2015-01-15 00:00:00

abstract：:The RNA synthesis machinery of vesicular stomatitis virus (VSV) comprises the genomic RNA encapsidated by the viral nucleocapsid protein (N) and associated with the RNA dependent RNA polymerase, the viral components of which are a large protein (L) and an accessory phosphoprotein (P). The 241 kDa L protein contains al...

journal_title：PLoS pathogens

authors： Tekes G,Rahmeh AA,Whelan SP

更新日期：2011-06-01 00:00:00

abstract：:The human parvovirus Adeno-Associated Virus (AAV) type 2 can only replicate in cells co-infected with a helper virus, such as Adenovirus or Herpes Simplex Virus type 1 (HSV-1); whereas, in the absence of a helper virus, it establishes a latent infection. Previous studies demonstrated that the ternary HSV-1 helicase/pr...

journal_title：PLoS pathogens

authors： Alazard-Dany N,Nicolas A,Ploquin A,Strasser R,Greco A,Epstein AL,Fraefel C,Salvetti A

更新日期：2009-03-01 00:00:00

abstract：:Prions are pathogens formed from abnormal conformers (PrPSc) of the host-encoded cellular prion protein (PrPC). PrPSc conformation to disease phenotype relationships extensively vary among prion strains. In particular, prions exhibit a strain-dependent tropism for lymphoid tissues. Prions can be composed of several su...

journal_title：PLoS pathogens

authors： Béringue V,Tixador P,Andréoletti O,Reine F,Castille J,Laï TL,Le Dur A,Laisné A,Herzog L,Passet B,Rezaei H,Vilotte JL,Laude H

更新日期：2020-07-23 00:00:00

abstract：:The viral replication proteins of plus-stranded RNA viruses orchestrate the biogenesis of the large viral replication compartments, including the numerous viral replicase complexes, which represent the sites of viral RNA replication. The formation and operation of these virus-driven structures require subversion of nu...

journal_title：PLoS pathogens

authors： Lin W,Liu Y,Molho M,Zhang S,Wang L,Xie L,Nagy PD

更新日期：2019-10-24 00:00:00

abstract：:Interspecific and intervarietal hybridization may contribute to the biological diversity of fungal populations. Cryptococcus neoformans is a pathogenic yeast and the most common fungal cause of meningitis in patients with AIDS. Most patients are infected with either of the two varieties of C. neoformans, designated as...

journal_title：PLoS pathogens

authors： Litvintseva AP,Lin X,Templeton I,Heitman J,Mitchell TG

更新日期：2007-08-17 00:00:00

abstract：:Poxviruses subvert the host immune response by producing immunomodulatory proteins, including a complement regulatory protein. Ectromelia virus provides a mouse model for smallpox where the virus and the host's immune response have co-evolved. Using this model, our study investigated the role of the complement system ...

journal_title：PLoS pathogens

authors： Moulton EA,Atkinson JP,Buller RM

更新日期：2008-12-01 00:00:00

abstract：:The simultaneous targeting of host and pathogen processes represents an untapped approach for the treatment of intracellular infections. Hypoxia-inducible factor-1 (HIF-1) is a host cell transcription factor that is activated by and required for the growth of the intracellular protozoan parasite Toxoplasma gondii at p...

journal_title：PLoS pathogens

authors： Brown KM,Suvorova E,Farrell A,McLain A,Dittmar A,Wiley GB,Marth G,Gaffney PM,Gubbels MJ,White M,Blader IJ

更新日期：2014-06-12 00:00:00

abstract：:The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB) encoded in the N-t...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Sandalova T,Sun R,Achour A,Masucci MG

更新日期：2019-11-11 00:00:00

abstract：:The cell division cycle of the unicellular eukaryote Trypanosome brucei is tightly regulated despite the paucity of transcriptional control that results from the arrangement of genes in polycistronic units and lack of dynamically regulated transcription factors. To identify the contribution of dynamic phosphorylation ...

journal_title：PLoS pathogens

authors： Benz C,Urbaniak MD

更新日期：2019-12-12 00:00:00

abstract：:Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related ...

journal_title：PLoS pathogens

authors： Cotter PD,Draper LA,Lawton EM,Daly KM,Groeger DS,Casey PG,Ross RP,Hill C

更新日期：2008-09-12 00:00:00

abstract：:Chlamydia trachomatis remains one of the few major human pathogens for which there is no transformation system. C. trachomatis has a unique obligate intracellular developmental cycle. The extracellular infectious elementary body (EB) is an infectious, electron-dense structure that, following host cell infection, diffe...

journal_title：PLoS pathogens

authors： Wang Y,Kahane S,Cutcliffe LT,Skilton RJ,Lambden PR,Clarke IN

更新日期：2011-09-01 00:00:00