The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis.

abstract：:The survival and persistence of Mycobacterium tuberculosis depends on its capacity to manipulate multiple host defense pathways, including the ability to actively inhibit the death by apoptosis of infected host cells. The genetic basis for this anti-apoptotic activity and its implication for mycobacterial virulence ha...

journal_title：PLoS pathogens

authors： Velmurugan K,Chen B,Miller JL,Azogue S,Gurses S,Hsu T,Glickman M,Jacobs WR Jr,Porcelli SA,Briken V

更新日期：2007-07-01 00:00:00

abstract：:Vaccinia virus A33 is an extracellular enveloped virus (EEV)-specific type II membrane glycoprotein that is essential for efficient EEV formation and long-range viral spread within the host. A33 is a target for neutralizing antibody responses against EEV. In this study, we produced seven murine anti-A33 monoclonal ant...

journal_title：PLoS pathogens

authors： Matho MH,Schlossman A,Meng X,Benhnia MR,Kaever T,Buller M,Doronin K,Parker S,Peters B,Crotty S,Xiang Y,Zajonc DM

更新日期：2015-09-01 00:00:00

abstract：:Francisella tularensis (Ft) causes a frequently fatal, acute necrotic pneumonia in humans and animals. Following lethal Ft infection in mice, infiltration of the lungs by predominantly immature myeloid cells and subsequent myeloid cell death drive pathogenesis and host mortality. However, following sub-lethal Ft chall...

journal_title：PLoS pathogens

authors： Periasamy S,Le HT,Duffy EB,Chin H,Harton JA

更新日期：2016-12-07 00:00:00

abstract：:The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (T4SS) VirB, which is thought to translocate effector proteins that mo...

journal_title：PLoS pathogens

authors： Myeni S,Child R,Ng TW,Kupko JJ 3rd,Wehrly TD,Porcella SF,Knodler LA,Celli J

更新日期：2013-01-01 00:00:00

abstract：:Leishmania donovani causes visceral leishmaniasis (VL), which is typically fatal without treatment. There is substantial variation between individuals in rates of disease progression, response to treatment and incidence of post-treatment sequelae, specifically post-kala-azar dermal leishmaniasis (PKDL). Nevertheless, ...

journal_title：PLoS pathogens

authors： Lewis MD,Paun A,Romano A,Langston H,Langner CA,Moore IN,Bock KW,Francisco AF,Brenchley JM,Sacks DL

更新日期：2020-04-13 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006120.]. ...

journal_title：PLoS pathogens

authors： Kinosada H,Yasunaga JI,Shimura K,Miyazato P,Onishi C,Iyoda T,Inaba K,Matsuoka M

更新日期：2017-02-23 00:00:00

abstract：:The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09 vaccination correlated with in-vivo antibody affinity maturation...

journal_title：PLoS pathogens

authors： Khurana S,Frasca D,Blomberg B,Golding H

更新日期：2012-09-01 00:00:00

abstract：:Beyond their canonical roles in hemostasis and thrombosis, platelets function in the innate immune response by interacting directly with pathogens and by regulating the recruitment and activation of immune effector cells. Thrombocytopenia often coincides with neutropenia in patients with hematologic malignancies and i...

journal_title：PLoS pathogens

authors： Tischler BY,Tosini NL,Cramer RA,Hohl TM

更新日期：2020-05-14 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006551.]. ...

journal_title：PLoS pathogens

authors： Gidon A,Åsberg SE,Louet C,Ryan L,Haug M,Flo TH

更新日期：2017-11-07 00:00:00

abstract：:During blood stage Plasmodium falciparum infection, merozoites invade uninfected erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand binding events. Understanding each element in this process increases the potential to block the parasite's life cycle via drugs or vaccines. To i...

journal_title：PLoS pathogens

authors： Weiss GE,Gilson PR,Taechalertpaisarn T,Tham WH,de Jong NW,Harvey KL,Fowkes FJ,Barlow PN,Rayner JC,Wright GJ,Cowman AF,Crabb BS

更新日期：2015-02-27 00:00:00

abstract：:We report the identification of a novel polyomavirus present in respiratory secretions from human patients with symptoms of acute respiratory tract infection. The virus was initially detected in a nasopharyngeal aspirate from a 3-year-old child from Australia diagnosed with pneumonia. A random library was generated fr...

journal_title：PLoS pathogens

authors： Gaynor AM,Nissen MD,Whiley DM,Mackay IM,Lambert SB,Wu G,Brennan DC,Storch GA,Sloots TP,Wang D

更新日期：2007-05-04 00:00:00

abstract：:It has been proposed that in wild ecosystems viruses are often plant mutualists, whereas agroecosystems favour pathogenicity. We seek evidence for virus pathogenicity in wild ecosystems through the analysis of plant-virus coevolution, which requires a negative effect of infection on the host fitness. We focus on the i...

journal_title：PLoS pathogens

authors： Montes N,Alonso-Blanco C,García-Arenal F

更新日期：2019-05-28 00:00:00

abstract：:RANTES (CCL5) is a chemokine expressed by many hematopoietic and non-hematopoietic cell types that plays an important role in homing and migration of effector and memory T cells during acute infections. The RANTES receptor, CCR5, is a major target of anti-HIV drugs based on blocking viral entry. However, defects in RA...

journal_title：PLoS pathogens

authors： Crawford A,Angelosanto JM,Nadwodny KL,Blackburn SD,Wherry EJ

更新日期：2011-07-01 00:00:00

abstract：:The high environmental adaptability of bacteria is contingent upon their ability to sense changes in their surroundings. Bacterial pathogen entry into host poses an abrupt and dramatic environmental change, during which successful pathogens gauge multiple parameters that signal host localization. The facultative human...

journal_title：PLoS pathogens

authors： Haber A,Friedman S,Lobel L,Burg-Golani T,Sigal N,Rose J,Livnat-Levanon N,Lewinson O,Herskovits AA

更新日期：2017-01-23 00:00:00

abstract：:A key difference that distinguishes viral infections from protein immunizations is the recognition of viral nucleic acids by cytosolic pattern recognition receptors (PRRs). Insights into the functions of cytosolic PRRs such as the RNA-sensing Rig-I-like receptors (RLRs) in the instruction of adaptive immunity are ther...

journal_title：PLoS pathogens

authors： O'Ketch M,Williams S,Larson C,Uhrlaub JL,Wong R,Hall B,Deshpande NR,Schenten D

更新日期：2020-10-26 00:00:00

abstract：:Vibrio parahaemolyticus is an emerging bacterial pathogen which colonizes the gastrointestinal tract and can cause severe enteritis and bacteraemia. During infection, V. parahaemolyticus primarily attaches to the small intestine, where it causes extensive tissue damage and compromises epithelial barrier integrity. We ...

journal_title：PLoS pathogens

authors： Lim J,Stones DH,Hawley CA,Watson CA,Krachler AM

更新日期：2014-09-25 00:00:00

abstract：:Serine protease cascades regulate important insect immune responses namely melanization and Toll pathway activation. An important component of these cascades are clip-domain serine protease homologs (cSPHs), which are non-catalytic, but essential for activating the enzyme prophenoloxidase (PPO) in the melanization res...

journal_title：PLoS pathogens

authors： El Moussawi L,Nakhleh J,Kamareddine L,Osta MA

更新日期：2019-11-25 00:00:00

abstract：:Innate immune cells shape the host response to microbial pathogens. Here we elucidate critical differences in the molecular response of macrophages vs. dendritic cells (DCs) to Histoplasma capsulatum, an intracellular fungal pathogen of humans. It has long been known that macrophages are permissive for Histoplasma gro...

journal_title：PLoS pathogens

authors： Van Prooyen N,Henderson CA,Hocking Murray D,Sil A

更新日期：2016-07-26 00:00:00

abstract：:Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for aspergillosis, have been widely disseminated across the globe. To eluc...

journal_title：PLoS pathogens

authors： Hagiwara D,Miura D,Shimizu K,Paul S,Ohba A,Gonoi T,Watanabe A,Kamei K,Shintani T,Moye-Rowley WS,Kawamoto S,Gomi K

更新日期：2017-01-04 00:00:00

abstract：:A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. Here, we combined an experimental model with the transcriptional profi...

journal_title：PLoS pathogens

authors： Sacramento LA,Benevides L,Maruyama SR,Tavares L,Fukutani KF,Francozo M,Sparwasser T,Cunha FQ,Almeida RP,da Silva JS,Carregaro V

更新日期：2020-03-25 00:00:00

abstract：:Zika virus (ZIKV) infects pregnant women and causes devastating congenital zika syndrome (CZS). How the virus is vertically transmitted to the fetus and induces neuronal loss remains unclear. We previously reported that Pellino (Peli)1, an E3 ubiquitin ligase, promotes p38MAPK activation in microglia and induction of ...

journal_title：PLoS pathogens

authors： Luo H,Li G,Wang B,Tian B,Gao J,Zou J,Shi S,Zhu S,Peng BH,Adam A,Martinez A,Hein K,Winkelmann ER,Mahmoud Y,Zhou X,Shan C,Rossi S,Weaver S,Barrett ADT,Sun SC,Zhang W,Shi PY,Wu P,Wang T

更新日期：2020-06-16 00:00:00

abstract：:Flavivirus nonstructural protein 5 (NS5) consists of methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains, which catalyze 5'-RNA capping/methylation and RNA synthesis, respectively, during viral genome replication. Although the crystal structure of flavivirus NS5 is known, no data about the quater...

journal_title：PLoS pathogens

authors： Klema VJ,Ye M,Hindupur A,Teramoto T,Gottipati K,Padmanabhan R,Choi KH

更新日期：2016-02-19 00:00:00

abstract：:Uncovering how natural selection and genetic drift shape the evolutionary dynamics of virus populations within their hosts can pave the way to a better understanding of virus emergence. Mathematical models already play a leading role in these studies and are intended to predict future emergences. Here, using high-thro...

journal_title：PLoS pathogens

authors： Fabre F,Montarry J,Coville J,Senoussi R,Simon V,Moury B

更新日期：2012-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infects about 50% of the US population, is the leading infectious cause of birth defects, and is considered the most important infectious agent in transplant recipients. The virus infects many cell types in vivo and in vitro. While previous studies have identified several cellular proteins...

journal_title：PLoS pathogens

authors： Li Q,Wilkie AR,Weller M,Liu X,Cohen JI

更新日期：2015-07-06 00:00:00

abstract：:All gammaherpesviruses encode a major glycoprotein homologous to the Epstein-Barr virus gp350. These glycoproteins are often involved in cell binding, and some provide neutralization targets. However, the capacity of gammaherpesviruses for long-term transmission from immune hosts implies that in vivo neutralization is...

journal_title：PLoS pathogens

authors： Machiels B,Lété C,Guillaume A,Mast J,Stevenson PG,Vanderplasschen A,Gillet L

更新日期：2011-11-01 00:00:00

abstract：:Yersinia suppress neutrophil responses by using a type 3 secretion system (T3SS) to inject 6-7 Yersinia effector proteins (Yops) effectors into their cytoplasm. YopH is a tyrosine phosphatase that causes dephosphorylation of the adaptor protein SKAP2, among other targets in neutrophils. SKAP2 functions in reactive oxy...

journal_title：PLoS pathogens

authors： Shaban L,Nguyen GT,Mecsas-Faxon BD,Swanson KD,Tan S,Mecsas J

更新日期：2020-05-11 00:00:00

abstract：:Several naked virus species, including members of the Picornaviridae family, have recently been described to escape their host cells and spread infection via enclosure in extracellular vesicles (EV). EV are 50-300 nm sized lipid membrane-enclosed particles produced by all cells that are broadly recognized for playing ...

journal_title：PLoS pathogens

authors： van der Grein SG,Defourny KAY,Rabouw HH,Galiveti CR,Langereis MA,Wauben MHM,Arkesteijn GJA,van Kuppeveld FJM,Nolte-'t Hoen ENM

更新日期：2019-02-19 00:00:00

abstract：:Understanding the roles of neutrophils and macrophages in fighting bacterial infections is a critical issue in human pathologies. Although phagocytic killing has been extensively studied, little is known about how bacteria are eliminated extracellularly in live vertebrates. We have recently developed an infection mode...

journal_title：PLoS pathogens

authors： Phan QT,Sipka T,Gonzalez C,Levraud JP,Lutfalla G,Nguyen-Chi M

更新日期：2018-07-17 00:00:00

abstract：:The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during HIV-1 entry. Here we present the crystal structure of the HK20 Fab in complex with a gp41 mimetic 5-Helix at 2.3 Å resolut...

journal_title：PLoS pathogens

authors： Sabin C,Corti D,Buzon V,Seaman MS,Lutje Hulsik D,Hinz A,Vanzetta F,Agatic G,Silacci C,Mainetti L,Scarlatti G,Sallusto F,Weiss R,Lanzavecchia A,Weissenhorn W

更新日期：2010-11-18 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006634.]. ...

journal_title：PLoS pathogens

authors： Walsh D

更新日期：2018-01-04 00:00:00