Identification of a novel polyomavirus from patients with acute respiratory tract infections.

abstract：:Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells in LN of cART-suppre...

journal_title：PLoS pathogens

authors： Pino M,Paganini S,Deleage C,Padhan K,Harper JL,King CT,Micci L,Cervasi B,Mudd JC,Gill KP,Jean SM,Easley K,Silvestri G,Estes JD,Petrovas C,Lederman MM,Paiardini M

更新日期：2019-10-18 00:00:00

abstract：:Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an amino acid variation of the EHV-1 DNA polymerase (N752/D752) is significantly associated wit...

journal_title：PLoS pathogens

authors： Goodman LB,Loregian A,Perkins GA,Nugent J,Buckles EL,Mercorelli B,Kydd JH,Palù G,Smith KC,Osterrieder N,Davis-Poynter N

更新日期：2007-11-01 00:00:00

abstract：:Respiratory virus infections, such as influenza, typically induce a robust type I (pro-inflammatory cytokine) immune response, however, the production of type 2 cytokines has been observed. Type 2 cytokine production during respiratory virus infection is linked to asthma exacerbation; however, type 2 cytokines may als...

journal_title：PLoS pathogens

authors： Gorski SA,Hahn YS,Braciale TJ

更新日期：2013-09-01 00:00:00

abstract：:Translation initiation is a critical early step in the replication cycle of the positive-sense, single-stranded RNA genome of noroviruses, a major cause of gastroenteritis in humans. Norovirus RNA, which has neither a 5´ m7G cap nor an internal ribosome entry site (IRES), adopts an unusual mechanism to initiate protei...

journal_title：PLoS pathogens

authors： Leen EN,Sorgeloos F,Correia S,Chaudhry Y,Cannac F,Pastore C,Xu Y,Graham SC,Matthews SJ,Goodfellow IG,Curry S

更新日期：2016-01-06 00:00:00

abstract：:Ribonuclease L (RNase L) is an important effector of the innate antiviral response. Mutations or variants that impair function of RNase L, particularly R462Q, have been proposed as susceptibility factors for prostate cancer. Given the role of this gene in viral defense, we sought to explore the possibility that a vira...

journal_title：PLoS pathogens

authors： Urisman A,Molinaro RJ,Fischer N,Plummer SJ,Casey G,Klein EA,Malathi K,Magi-Galluzzi C,Tubbs RR,Ganem D,Silverman RH,DeRisi JL

更新日期：2006-03-01 00:00:00

abstract：:Knowledge of the within-host frequencies of resistance-associated amino acid variants (RAVs) is important to the identification of optimal drug combinations for the treatment of hepatitis C virus (HCV) infection. Multiple RAVs may exist in infected individuals, often below detection limits, at any resistance locus, de...

journal_title：PLoS pathogens

authors： Raja R,Pareek A,Newar K,Dixit NM

更新日期：2019-04-01 00:00:00

abstract：:Vaginal HIV transmission accounts for the majority of new infections worldwide. Currently, multiple efforts to prevent HIV transmission are based on pre-exposure prophylaxis with various antiretroviral drugs. Here, we describe two novel nanoformulations of the reverse transcriptase inhibitor rilpivirine for pericoital...

journal_title：PLoS pathogens

authors： Kovarova M,Council OD,Date AA,Long JM,Nochi T,Belshan M,Shibata A,Vincent H,Baker CE,Thayer WO,Kraus G,Lachaud-Durand S,Williams P,Destache CJ,Garcia JV

更新日期：2015-08-13 00:00:00

abstract：:The NLRP3 inflammasome has emerged as a central immune regulator that senses virulence factors expressed by microbial pathogens for triggering inflammation. Inflammation can be harmful and therefore this response must be tightly controlled. The mechanisms by which immune cells, such as macrophages, discriminate benign...

journal_title：PLoS pathogens

authors： Tucey TM,Verma J,Olivier FAB,Lo TL,Robertson AAB,Naderer T,Traven A

更新日期：2020-08-04 00:00:00

abstract：:All pathogenesis and death associated with Plasmodium falciparum malaria is due to parasite-infected erythrocytes. Invasion of erythrocytes by P. falciparum merozoites requires specific interactions between host receptors and parasite ligands that are localized in apical organelles called micronemes. Here, we identify...

journal_title：PLoS pathogens

authors： Dawn A,Singh S,More KR,Siddiqui FA,Pachikara N,Ramdani G,Langsley G,Chitnis CE

更新日期：2014-12-18 00:00:00

abstract：:Interactions of influenza A virus (IAV) with sialic acid (SIA) receptors determine viral fitness and host tropism. Binding to mucus decoy receptors and receptors on epithelial host cells is determined by a receptor-binding hemagglutinin (HA), a receptor-destroying neuraminidase (NA) and a complex in vivo receptor-repe...

journal_title：PLoS pathogens

authors： Guo H,Rabouw H,Slomp A,Dai M,van der Vegt F,van Lent JWM,McBride R,Paulson JC,de Groot RJ,van Kuppeveld FJM,de Vries E,de Haan CAM

更新日期：2018-08-13 00:00:00

abstract：:Memory T cell inflation is a process in which a subset of cytomegalovirus (CMV) specific CD8 T cells continuously expands mainly during latent infection and establishes a large and stable population of effector memory cells in peripheral tissues. Here we set out to identify in vivo parameters that promote and limit CD...

journal_title：PLoS pathogens

authors： Baumann NS,Welten SPM,Torti N,Pallmer K,Borsa M,Barnstorf I,Oduro JD,Cicin-Sain L,Oxenius A

更新日期：2019-05-13 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1008654.]. ...

journal_title：PLoS pathogens

authors： Ghirardini E,Restelli E,Morini R,Bertani I,Ortolan D,Perrucci F,Pozzi D,Matteoli M,Chiesa R

更新日期：2020-12-22 00:00:00

abstract：:HIV-1 uses a number of means to manipulate the immune system, to avoid recognition and to highjack signaling pathways. HIV-1 infected cells show limited Toll-Like Receptor (TLR) responsiveness via as yet unknown mechanisms. Using biochemical and biophysical approaches, we demonstrate that the trans-membrane domain (TM...

journal_title：PLoS pathogens

authors： Reuven EM,Ali M,Rotem E,Schwarzer R,Gramatica A,Futerman AH,Shai Y

更新日期：2014-08-14 00:00:00

abstract：:Human defensins are at the forefront of the host responses to HIV and other pathogens in mucosal tissues. However, their ability to inactivate HIV in the bloodstream has been questioned due to the antagonistic effect of serum. In this study, we have examined the effect of sub-inhibitory concentrations of human α-defen...

journal_title：PLoS pathogens

authors： Demirkhanyan L,Marin M,Lu W,Melikyan GB

更新日期：2013-01-01 00:00:00

abstract：:Leishmania parasites are transmitted to vertebrate hosts by female phlebotomine sand flies as they bloodfeed by lacerating the upper capillaries of the dermis with their barbed mouthparts. In the sand fly midgut secreted proteophosphoglycans from Leishmania form a biological plug known as the promastigote secretory ge...

journal_title：PLoS pathogens

authors： Giraud E,Lestinova T,Derrick T,Martin O,Dillon RJ,Volf P,Műller I,Bates PA,Rogers ME

更新日期：2018-01-19 00:00:00

abstract：:Zika virus (ZIKV) infects pregnant women and causes devastating congenital zika syndrome (CZS). How the virus is vertically transmitted to the fetus and induces neuronal loss remains unclear. We previously reported that Pellino (Peli)1, an E3 ubiquitin ligase, promotes p38MAPK activation in microglia and induction of ...

journal_title：PLoS pathogens

authors： Luo H,Li G,Wang B,Tian B,Gao J,Zou J,Shi S,Zhu S,Peng BH,Adam A,Martinez A,Hein K,Winkelmann ER,Mahmoud Y,Zhou X,Shan C,Rossi S,Weaver S,Barrett ADT,Sun SC,Zhang W,Shi PY,Wu P,Wang T

更新日期：2020-06-16 00:00:00

abstract：:The E3 ubiquitin ligase COP1 (Constitutive Photomorphogenesis 1) is a well known component of the light-mediated plant development that acts as a repressor of photomorphogenesis. Here we show that COP1 positively regulates defense against turnip crinkle virus (TCV) and avrRPM1 bacteria by contributing to stability of ...

journal_title：PLoS pathogens

authors： Lim GH,Hoey T,Zhu S,Clavel M,Yu K,Navarre D,Kachroo A,Deragon JM,Kachroo P

更新日期：2018-03-07 00:00:00

abstract：:The Vibrio cholerae type VI secretion system (T6SS) assembles as a molecular syringe that injects toxic protein effectors into both eukaryotic and prokaryotic cells. We previously reported that the V. cholerae O37 serogroup strain V52 maintains a constitutively active T6SS to kill other Gram-negative bacteria while be...

journal_title：PLoS pathogens

authors： Miyata ST,Unterweger D,Rudko SP,Pukatzki S

更新日期：2013-01-01 00:00:00

abstract：:Pseudomonas aeruginosa is one of the leading causes of nosocomial pneumonia and its associated mortality. Moreover, extensively drug-resistant high-risk clones are globally widespread, presenting a major challenge to the healthcare systems. Despite this, no vaccine is available against this high-concerning pathogen. H...

journal_title：PLoS pathogens

authors： Cabral MP,Correia A,Vilanova M,Gärtner F,Moscoso M,García P,Vallejo JA,Pérez A,Francisco-Tomé M,Fuentes-Valverde V,Bou G

更新日期：2020-02-10 00:00:00

abstract：:In bacteria, transformation and restriction-modification (R-M) systems play potentially antagonistic roles. While the former, proposed as a form of sexuality, relies on internalized foreign DNA to create genetic diversity, the latter degrade foreign DNA to protect from bacteriophage attack. The human pathogen Streptoc...

journal_title：PLoS pathogens

authors： Johnston C,Martin B,Granadel C,Polard P,Claverys JP

更新日期：2013-02-01 00:00:00

abstract：:Open reading frame (ORF) 45 of Kaposi's sarcoma-associated herpesvirus (KSHV) is a tegument protein. A genetic analysis with a null mutant suggested a possible role for this protein in the events leading to viral egress. In this study, ORF45 was found to interact with KIF3A, a kinesin-2 motor protein that transports c...

journal_title：PLoS pathogens

authors： Sathish N,Zhu FX,Yuan Y

更新日期：2009-03-01 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the parental Ankara vaccine virus hundreds of times in chick embryo fibroblast...

journal_title：PLoS pathogens

authors： Peng C,Wyatt LS,Glushakow-Smith SG,Lal-Nag M,Weisberg AS,Moss B

更新日期：2020-08-31 00:00:00

abstract：:Parasitic nematodes infect over 1 billion people worldwide and cause some of the most common neglected tropical diseases. Despite their prevalence, our understanding of the biology of parasitic nematodes has been limited by the lack of tools for genetic intervention. In particular, it has not yet been possible to gene...

journal_title：PLoS pathogens

authors： Gang SS,Castelletto ML,Bryant AS,Yang E,Mancuso N,Lopez JB,Pellegrini M,Hallem EA

更新日期：2017-10-10 00:00:00

abstract：:Identification of the determinants of pathogen reservoir potential is central to understand disease emergence. It has been proposed that host lifespan is one such determinant: short-lived hosts will invest less in costly defenses against pathogens, so that they will be more susceptible to infection, more competent as ...

journal_title：PLoS pathogens

authors： Hily JM,García A,Moreno A,Plaza M,Wilkinson MD,Fereres A,Fraile A,García-Arenal F

更新日期：2014-11-06 00:00:00

abstract：:The neuraminidase (NA) inhibitor (NAI) oseltamivir (OST) is the most widely used influenza antiviral drug. Several NA amino acid substitutions are reported to reduce viral susceptibility to OST in in vitro assays. However, whether there is a correlation between the level of reduction in susceptibility in vitro and the...

journal_title：PLoS pathogens

authors： Farrukee R,Tai CM,Oh DY,Anderson DE,Gunalan V,Hibberd M,Lau GY,Barr IG,Messling VV,Maurer-Stroh S,Hurt AC

更新日期：2020-06-18 00:00:00

abstract：:RNA silencing is an evolutionarily conserved sequence-specific gene-inactivation system that also functions as an antiviral mechanism in higher plants and insects. To overcome antiviral RNA silencing, viruses express silencing-suppressor proteins. These viral proteins can target one or more key points in the silencing...

journal_title：PLoS pathogens

authors： Giner A,Lakatos L,García-Chapa M,López-Moya JJ,Burgyán J

更新日期：2010-07-15 00:00:00

abstract：:Candida albicans, a clinically important dimorphic fungal pathogen that can evade immune attack by masking its cell wall beta-glucan from immune recognition, mutes protective host responses mediated by the Dectin-1 beta-glucan receptor on innate immune cells. Although the ability of C. albicans to switch between a yea...

journal_title：PLoS pathogens

authors： Wheeler RT,Kombe D,Agarwala SD,Fink GR

更新日期：2008-12-01 00:00:00

abstract：:The cell division cycle of the unicellular eukaryote Trypanosome brucei is tightly regulated despite the paucity of transcriptional control that results from the arrangement of genes in polycistronic units and lack of dynamically regulated transcription factors. To identify the contribution of dynamic phosphorylation ...

journal_title：PLoS pathogens

authors： Benz C,Urbaniak MD

更新日期：2019-12-12 00:00:00

abstract：:The development of next-generation sequencing platforms is set to reveal an unprecedented level of detail on short-term molecular evolutionary processes in bacteria. Here we re-analyse genome-wide single nucleotide polymorphism (SNP) datasets for recently emerged clones of methicillin resistant Staphylococcus aureus (...

journal_title：PLoS pathogens

authors： Castillo-Ramírez S,Harris SR,Holden MT,He M,Parkhill J,Bentley SD,Feil EJ

更新日期：2011-07-01 00:00:00

abstract：:Host cells infected with obligate intracellular bacteria Chlamydia trachomatis are profoundly resistant to diverse apoptotic stimuli. The molecular mechanisms underlying the block in apoptotic signaling of infected cells is not well understood. Here we investigated the molecular mechanism by which apoptosis induced vi...

journal_title：PLoS pathogens

authors： Rajalingam K,Sharma M,Paland N,Hurwitz R,Thieck O,Oswald M,Machuy N,Rudel T

更新日期：2006-10-01 00:00:00