CAGE-seq analysis of Epstein-Barr virus lytic gene transcription: 3 kinetic classes from 2 mechanisms.

abstract：:In this study, we investigated the significance of a conserved five-amino acid motif 'AELPR' in the C-terminal region of helper component-proteinase (HCPro) for potato virus A (PVA; genus Potyvirus) infection. This motif is a putative interaction site for WD40 domain-containing proteins, including VARICOSE (VCS). We a...

journal_title：PLoS pathogens

authors： De S,Pollari M,Varjosalo M,Mäkinen K

更新日期：2020-10-12 00:00:00

abstract：:Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both in vitro and in vivo during influenza virus infec...

journal_title：PLoS pathogens

authors： Wei F,Jiang Z,Sun H,Pu J,Sun Y,Wang M,Tong Q,Bi Y,Ma X,Gao GF,Liu J

更新日期：2019-10-04 00:00:00

abstract：:Whereas the majority of pathogenic Salmonella serovars are capable of infecting many different animal species, typically producing a self-limited gastroenteritis, serovars with narrow host-specificity exhibit increased virulence and their infections frequently result in fatal systemic diseases. In our study, a genetic...

journal_title：PLoS pathogens

authors： Kisiela DI,Chattopadhyay S,Libby SJ,Karlinsey JE,Fang FC,Tchesnokova V,Kramer JJ,Beskhlebnaya V,Samadpour M,Grzymajlo K,Ugorski M,Lankau EW,Mackie RI,Clegg S,Sokurenko EV

更新日期：2012-01-01 00:00:00

abstract：:Microfold (M) cell host-pathogen interaction studies would benefit from the visual analysis of dynamic cellular and microbial interplays. We adapted a human in vitro M cell model to physiological bacterial infections, expression of fluorescent localization reporters and long-term three-dimensional time-lapse microscop...

journal_title：PLoS pathogens

authors： Rey C,Chang YY,Latour-Lambert P,Varet H,Proux C,Legendre R,Coppée JY,Enninga J

更新日期：2020-04-13 00:00:00

abstract：:Unlike for other retroviruses, only a few host cell factors that aid the replication of foamy viruses (FVs) via interaction with viral structural components are known. Using a yeast-two-hybrid (Y2H) screen with prototype FV (PFV) Gag protein as bait we identified human polo-like kinase 2 (hPLK2), a member of cell cycl...

journal_title：PLoS pathogens

authors： Zurnic I,Hütter S,Rzeha U,Stanke N,Reh J,Müllers E,Hamann MV,Kern T,Gerresheim GK,Lindel F,Serrao E,Lesbats P,Engelman AN,Cherepanov P,Lindemann D

更新日期：2016-08-31 00:00:00

abstract：:IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in transcriptional regulation, also functions as an innate immune response DNA sensor and induces the IL-1β and antiviral type-1 interferon-β (IFN-β) cytokines. We have shown that IFI16, in association with BRCA1, functions as a se...

journal_title：PLoS pathogens

authors： Iqbal J,Ansari MA,Kumar B,Dutta D,Roy A,Chikoti L,Pisano G,Dutta S,Vahedi S,Veettil MV,Chandran B

更新日期：2016-10-20 00:00:00

abstract：:Knowledge of the within-host frequencies of resistance-associated amino acid variants (RAVs) is important to the identification of optimal drug combinations for the treatment of hepatitis C virus (HCV) infection. Multiple RAVs may exist in infected individuals, often below detection limits, at any resistance locus, de...

journal_title：PLoS pathogens

authors： Raja R,Pareek A,Newar K,Dixit NM

更新日期：2019-04-01 00:00:00

abstract：:Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis (Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes siderophores, small molecules with high affinity for iron, and takes up iron-loaded mycobactins (MBT) and carboxymycobactins (cMBT), from the...

journal_title：PLoS pathogens

authors： Zhang L,Hendrickson RC,Meikle V,Lefkowitz EJ,Ioerger TR,Niederweis M

更新日期：2020-02-18 00:00:00

abstract：:Mitochondrial antiviral-signaling protein (MAVS) transmits signals from RIG-I-like receptors after RNA virus infections. However, the mechanism by which MAVS activates downstream components, such as TBK1 and IKKα/β, is unclear, although previous work suggests the involvement of NEMO or TBK1-binding proteins TANK, NAP1...

journal_title：PLoS pathogens

authors： Fang R,Jiang Q,Zhou X,Wang C,Guan Y,Tao J,Xi J,Feng JM,Jiang Z

更新日期：2017-11-10 00:00:00

abstract：:The neuraminidase (NA) inhibitor (NAI) oseltamivir (OST) is the most widely used influenza antiviral drug. Several NA amino acid substitutions are reported to reduce viral susceptibility to OST in in vitro assays. However, whether there is a correlation between the level of reduction in susceptibility in vitro and the...

journal_title：PLoS pathogens

authors： Farrukee R,Tai CM,Oh DY,Anderson DE,Gunalan V,Hibberd M,Lau GY,Barr IG,Messling VV,Maurer-Stroh S,Hurt AC

更新日期：2020-06-18 00:00:00

abstract：:The interplay between autophagy and intracellular pathogens is intricate as autophagy is an essential cellular response to fight against infections, whereas numerous microbes have developed strategies to escape this process or even exploit it to their own benefit. The fine tuned timing and/or selective molecular pathw...

journal_title：PLoS pathogens

authors： Richetta C,Grégoire IP,Verlhac P,Azocar O,Baguet J,Flacher M,Tangy F,Rabourdin-Combe C,Faure M

更新日期：2013-01-01 00:00:00

abstract：:The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however, little is known about its relationship to early disease progression. To better understand the relationship between the lung microbiome and early respiratory disease, we characterized the lower airways microbiome using bronchoalv...

journal_title：PLoS pathogens

authors： Muhlebach MS,Zorn BT,Esther CR,Hatch JE,Murray CP,Turkovic L,Ranganathan SC,Boucher RC,Stick SM,Wolfgang MC

更新日期：2018-01-18 00:00:00

abstract：:The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression. These viruses have evolved countermeasures to disperse PML-NBs,...

journal_title：PLoS pathogens

authors： Reichelt M,Wang L,Sommer M,Perrino J,Nour AM,Sen N,Baiker A,Zerboni L,Arvin AM

更新日期：2011-02-03 00:00:00

abstract：:HIV-1 assembly and release are believed to occur at the plasma membrane in most host cells with the exception of primary macrophages, for which exclusive budding at late endosomes has been reported. Here, we applied a novel ultrastructural approach to assess HIV-1 budding in primary macrophages in an immunomarker-inde...

journal_title：PLoS pathogens

authors： Welsch S,Keppler OT,Habermann A,Allespach I,Krijnse-Locker J,Kräusslich HG

更新日期：2007-03-01 00:00:00

abstract：:Ebola virus (EBOV) is a highly pathogenic filovirus that causes hemorrhagic fever in humans and animals. Currently, how EBOV fuses its envelope membrane within an endosomal membrane to cause infection is poorly understood. We successfully measure cell-cell fusion mediated by the EBOV fusion protein, GP, assayed by the...

journal_title：PLoS pathogens

authors： Markosyan RM,Miao C,Zheng YM,Melikyan GB,Liu SL,Cohen FS

更新日期：2016-01-05 00:00:00

abstract：:The control of mosquito populations with insecticide treated bed nets and indoor residual sprays remains the cornerstone of malaria reduction and elimination programs. In light of widespread insecticide resistance in mosquitoes, however, alternative strategies for reducing transmission by the mosquito vector are urgen...

journal_title：PLoS pathogens

authors： Childs LM,Cai FY,Kakani EG,Mitchell SN,Paton D,Gabrieli P,Buckee CO,Catteruccia F

更新日期：2016-12-15 00:00:00

abstract：:We performed a quantitative analysis of the HLA restriction, antigen and epitope specificity of human pathogen specific responses in healthy individuals infected with M. tuberculosis (Mtb), in a South African cohort as a test case. The results estimate the breadth of T cell responses for the first time in the context ...

journal_title：PLoS pathogens

authors： Lindestam Arlehamn CS,McKinney DM,Carpenter C,Paul S,Rozot V,Makgotlho E,Gregg Y,van Rooyen M,Ernst JD,Hatherill M,Hanekom WA,Peters B,Scriba TJ,Sette A

更新日期：2016-07-13 00:00:00

abstract：:Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc. Prion diseases are invariably fatal and currently incurable, but oral drugs that can prolong incubation times in prion-infected mice have been developed. Here, we test...

journal_title：PLoS pathogens

authors： Burke CM,Mark KMK,Kun J,Beauchemin KS,Supattapone S

更新日期：2020-05-18 00:00:00

abstract：:The innate immune system is the first line of host defense against invading organisms. Thus, pathogens have developed virulence mechanisms to evade the innate immune system. Here, we report a novel means for inhibition of neutrophil recruitment by Group A Streptococcus (GAS). Deletion of the secreted esterase gene (de...

journal_title：PLoS pathogens

authors： Liu M,Zhu H,Li J,Garcia CC,Feng W,Kirpotina LN,Hilmer J,Tavares LP,Layton AW,Quinn MT,Bothner B,Teixeira MM,Lei B

更新日期：2012-01-01 00:00:00

abstract：:Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. Sumoylation has roles in the control of protein stability, activity and localization, and is involved in the regulation of transcription, gene expr...

journal_title：PLoS pathogens

authors： Sloan E,Tatham MH,Groslambert M,Glass M,Orr A,Hay RT,Everett RD

更新日期：2015-07-22 00:00:00

abstract：:Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative transcription factors in a machine-anno...

journal_title：PLoS pathogens

authors： Cho Y,Srivastava A,Ohm RA,Lawrence CB,Wang KH,Grigoriev IV,Marahatta SP

更新日期：2012-01-01 00:00:00

abstract：:RANTES (CCL5) is a chemokine expressed by many hematopoietic and non-hematopoietic cell types that plays an important role in homing and migration of effector and memory T cells during acute infections. The RANTES receptor, CCR5, is a major target of anti-HIV drugs based on blocking viral entry. However, defects in RA...

journal_title：PLoS pathogens

authors： Crawford A,Angelosanto JM,Nadwodny KL,Blackburn SD,Wherry EJ

更新日期：2011-07-01 00:00:00

abstract：:Epstein-Barr virus (EBV), a ubiquitous human herpesvirus, can latently infect the human population. EBV is associated with several types of malignancies originating from lymphoid and epithelial cell types. EBV latent antigen 3C (EBNA3C) is essential for EBV-induced immortalization of B-cells. The Moloney murine leukem...

journal_title：PLoS pathogens

authors： Banerjee S,Lu J,Cai Q,Sun Z,Jha HC,Robertson ES

更新日期：2014-08-14 00:00:00

abstract：:The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09 vaccination correlated with in-vivo antibody affinity maturation...

journal_title：PLoS pathogens

authors： Khurana S,Frasca D,Blomberg B,Golding H

更新日期：2012-09-01 00:00:00

abstract：:It is poorly understood how progressive brain swelling in experimental cerebral malaria (ECM) evolves in space and over time, and whether mechanisms of inflammation or microvascular sequestration/obstruction dominate the underlying pathophysiology. We therefore monitored in the Plasmodium berghei ANKA-C57BL/6 murine E...

journal_title：PLoS pathogens

authors： Hoffmann A,Pfeil J,Alfonso J,Kurz FT,Sahm F,Heiland S,Monyer H,Bendszus M,Mueller AK,Helluy X,Pham M

更新日期：2016-03-10 00:00:00

abstract：:Many viral pathogens are persistently transmitted by insect vectors and cause agricultural or health problems. Generally, an insect vector can use autophagy as an intrinsic antiviral defense mechanism against viral infection. Whether viruses can evolve to exploit autophagy to promote their transmission by insect vecto...

journal_title：PLoS pathogens

authors： Chen Y,Chen Q,Li M,Mao Q,Chen H,Wu W,Jia D,Wei T

更新日期：2017-11-10 00:00:00

abstract：:Acute resistance to low dose M. tuberculosis (Mtb) infection is not dependent on Toll-like receptor (TLR) 2. However, whether TLR2 contributes to resistance in chronic Mtb infection has remained uncertain. Here we report that, following low dose aerosol infection with Mtb, mice lacking TLR2 (TLR2KO), in comparison wit...

journal_title：PLoS pathogens

authors： McBride A,Konowich J,Salgame P

更新日期：2013-01-01 00:00:00

abstract：:Plants are constantly exposed to a large and diverse array of microbes; however, most plants are immune to the majority of potential invaders and susceptible to only a small subset of pathogens. The cytoskeleton comprises a dynamic intracellular framework that responds rapidly to biotic stresses and supports numerous ...

journal_title：PLoS pathogens

authors： Henty-Ridilla JL,Shimono M,Li J,Chang JH,Day B,Staiger CJ

更新日期：2013-01-01 00:00:00

abstract：:Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2'3'-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUMO-specific protease...

journal_title：PLoS pathogens

authors： Cui Y,Yu H,Zheng X,Peng R,Wang Q,Zhou Y,Wang R,Wang J,Qu B,Shen N,Guo Q,Liu X,Wang C

更新日期：2017-01-17 00:00:00

abstract：:Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigotes, by a mechanism that involves reactive oxygen species (ROS) produ...

journal_title：PLoS pathogens

authors： Mittra B,Laranjeira-Silva MF,Perrone Bezerra de Menezes J,Jensen J,Michailowsky V,Andrews NW

更新日期：2016-01-07 00:00:00