Abstract:
:Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both in vitro and in vivo during influenza virus infection. Using a PGRN knockdown assay and PGRN-deficient mice model, we demonstrated that influenza virus-inducing PGRN negatively regulated type I IFNs production by inhibiting the activation of NF-κB and IRF3 signaling. Furthermore, we showed that PGRN directly interacted with NF-κB essential modulator (NEMO) via its Grn CDE domains. We also verified that PGRN recruited A20 to deubiquitinate K63-linked polyubiquitin chains on NEMO at K264. In addition, we found that macrophage played a major source of PGRN during influenza virus infection, and PGRN neutralizing antibodies could protect against influenza virus-induced lethality in mice. Our data identify a PGRN-mediated IFN evasion pathway exploited by influenza virus with implication in antiviral applications. These findings also provide insights into the functions and crosstalk of PGRN in innate immunity.
journal_name
PLoS Pathogjournal_title
PLoS pathogensauthors
Wei F,Jiang Z,Sun H,Pu J,Sun Y,Wang M,Tong Q,Bi Y,Ma X,Gao GF,Liu Jdoi
10.1371/journal.ppat.1008062subject
Has Abstractpub_date
2019-10-04 00:00:00pages
e1008062issue
10eissn
1553-7366issn
1553-7374pii
PPATHOGENS-D-18-02446journal_volume
15pub_type
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