MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner.

abstract：:The cytidine deaminases APOBEC3G and APOBEC3F exert anti-HIV-1 activity that is countered by the HIV-1 vif protein. Based on potential transcription factor binding sites in their putative promoters, we hypothesized that expression of APOBEC3G and APOBEC3F would vary with T helper lymphocyte differentiation. Naive CD4+...

journal_title：PLoS pathogens

authors： Vetter ML,Johnson ME,Antons AK,Unutmaz D,D'Aquila RT

更新日期：2009-02-01 00:00:00

abstract：:Nasal colonization by both gram-positive and gram-negative pathogens induces expression of the innate immune protein lipocalin 2 (Lcn2). Lcn2 binds and sequesters the iron-scavenging siderophore enterobactin (Ent), preventing bacterial iron acquisition. In addition, Lcn2 bound to Ent induces release of IL-8 from cultu...

journal_title：PLoS pathogens

authors： Bachman MA,Miller VL,Weiser JN

更新日期：2009-10-01 00:00:00

abstract：:Herpesviruses encode a characteristic serine protease with a unique fold and an active site that comprises the unusual triad Ser-His-His. The protease is essential for viral replication and as such constitutes a promising drug target. In solution, a dynamic equilibrium exists between an inactive monomeric and an activ...

journal_title：PLoS pathogens

authors： Zühlsdorf M,Werten S,Klupp BG,Palm GJ,Mettenleiter TC,Hinrichs W

更新日期：2015-07-10 00:00:00

abstract：:African trypanosomes of the Trypanosoma brucei species are extra-cellular parasites that cause human African trypanosomiasis (HAT) as well as infections in game animals and livestock. Trypanosomes are known to evade the immune response of their mammalian host by continuous antigenic variation of their surface coat. He...

journal_title：PLoS pathogens

authors： Radwanska M,Guirnalda P,De Trez C,Ryffel B,Black S,Magez S

更新日期：2008-05-30 00:00:00

abstract：:Type III secretion systems (T3SS) are nano-syringes used by a wide range of Gram-negative pathogens to promote infection by directly injecting effector proteins into targeted host cells. Translocation of effectors is triggered by host-cell contact and requires assembly of a pore in the host-cell plasma membrane, which...

journal_title：PLoS pathogens

authors： Armentrout EI,Rietsch A

更新日期：2016-03-29 00:00:00

abstract：:Abilities of bacterial pathogens to adapt to the iron limitation present in hosts is critical to their virulence. Bacterial pathogens have evolved diverse strategies to coordinately regulate iron metabolism and virulence associated functions to maintain iron homeostasis in response to changing iron availability in the...

journal_title：PLoS pathogens

authors： Pandey SS,Patnana PK,Lomada SK,Tomar A,Chatterjee S

更新日期：2016-11-30 00:00:00

abstract：:In HPV-related cancers, the "high-risk" human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in the presence of HPV...

journal_title：PLoS pathogens

authors： Kadaja M,Isok-Paas H,Laos T,Ustav E,Ustav M

更新日期：2009-04-01 00:00:00

abstract：:Septic shock caused by Neisseria meningitidis is typically rapidly evolving and often fatal despite antibiotic therapy. Further understanding of the mechanisms underlying the disease is necessary to reduce fatality rates. Postmortem samples from the characteristic purpuric rashes of the infection show bacterial aggreg...

journal_title：PLoS pathogens

authors： Melican K,Michea Veloso P,Martin T,Bruneval P,Duménil G

更新日期：2013-01-01 00:00:00

abstract：:Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation characterized by the influx of myeloid cells and production of proinflammatory cytokines including interferons (IFNs). It is unclear, however, how the immune system clears the virus without causing lethal immunopathology. Here,...

journal_title：PLoS pathogens

authors： Stifter SA,Bhattacharyya N,Pillay R,Flórido M,Triccas JA,Britton WJ,Feng CG

更新日期：2016-01-05 00:00:00

abstract：:The prevalence of antibiotic resistance genes in pathogenic bacteria is a major challenge to treating many infectious diseases. The spread of these genes is driven by the strong selection imposed by the use of antibacterial drugs. However, in the absence of drug selection, antibiotic resistance genes impose a fitness ...

journal_title：PLoS pathogens

authors： Albarracín Orio AG,Piñas GE,Cortes PR,Cian MB,Echenique J

更新日期：2011-02-01 00:00:00

abstract：:Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely in adults. The mechanisms that determine the age-dependent susceptibility remain largely unclear. Here, we found that the paucity of invariant natural killer T (iNKT) cells together wi...

journal_title：PLoS pathogens

authors： Zhu K,Yang J,Luo K,Yang C,Zhang N,Xu R,Chen J,Jin M,Xu B,Guo N,Wang J,Chen Z,Cui Y,Zhao H,Wang Y,Deng C,Bai L,Ge B,Qin CF,Shen H,Yang CF,Leng Q

更新日期：2015-01-23 00:00:00

abstract：:Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress granules to limit the use of energy and nutrients. Because this threatens viral gene expression,...

journal_title：PLoS pathogens

authors： Brocard M,Iadevaia V,Klein P,Hall B,Lewis G,Lu J,Burke J,Willcocks MM,Parker R,Goodfellow IG,Ruggieri A,Locker N

更新日期：2020-01-06 00:00:00

abstract：:Cholera, the pandemic diarrheal disease caused by the gram-negative bacterium Vibrio cholerae, continues to be a major public health challenge in the developing world. Cholera toxin, which is responsible for the voluminous stools of cholera, causes constitutive activation of adenylyl cyclase, resulting in the export o...

journal_title：PLoS pathogens

authors： Blow NS,Salomon RN,Garrity K,Reveillaud I,Kopin A,Jackson FR,Watnick PI

更新日期：2005-09-01 00:00:00

abstract：:In human cytomegalovirus (HCMV), tropism to epithelial and endothelial cells is dependent upon a pentameric complex (PC). Given the structure of the placenta, the PC is potentially an important neutralizing antibody target antigen against congenital infection. The guinea pig is the only small animal model for congenit...

journal_title：PLoS pathogens

authors： Coleman S,Choi KY,Root M,McGregor A

更新日期：2016-07-07 00:00:00

abstract：:Modern agriculture favours the selection and spread of novel plant diseases. Furthermore, crop genetic resistance against pathogens is often rendered ineffective within a few years of its commercial deployment. Leptosphaeria maculans, the cause of phoma stem canker of oilseed rape, develops gene-for-gene interactions ...

journal_title：PLoS pathogens

authors： Daverdin G,Rouxel T,Gout L,Aubertot JN,Fudal I,Meyer M,Parlange F,Carpezat J,Balesdent MH

更新日期：2012-01-01 00:00:00

abstract：:The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade of HSV gene transcription is initiated by the multifunctional vi...

journal_title：PLoS pathogens

authors： Thompson RL,Preston CM,Sawtell NM

更新日期：2009-03-01 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, invades and replicates within macrophages and protozoan cells inside a vacuole. The type IVB Icm/Dot secretion system is necessary for the translocation of effector proteins that modulate vesicle trafficking pathways in the host cell, thus avoiding ...

journal_title：PLoS pathogens

authors： Franco IS,Shohdy N,Shuman HA

更新日期：2012-02-01 00:00:00

abstract：:Plant microRNAs (miRNA) guide cleavage of target mRNAs by DICER-like proteins, thereby reducing mRNA abundance. Native precursor miRNAs can be redesigned to target RNAs of interest, and one application of such artificial microRNA (amiRNA) technology is to generate plants resistant to pathogenic viruses. Transgenic Ara...

journal_title：PLoS pathogens

authors： Lin SS,Wu HW,Elena SF,Chen KC,Niu QW,Yeh SD,Chen CC,Chua NH

更新日期：2009-02-01 00:00:00

abstract：:Many viruses subvert the host cell's ability to mount and complete various DNA damage responses (DDRs) after infection. HCMV infection of permissive fibroblasts activates host DDRs at the time of viral deposition and during replication, but the DDRs remain uncompleted without arrest or apoptosis. We believe this was i...

journal_title：PLoS pathogens

authors： O'Dowd JM,Zavala AG,Brown CJ,Mori T,Fortunato EA

更新日期：2012-01-01 00:00:00

abstract：:Streptococcus agalactiae is a common human commensal and a major life-threatening pathogen in neonates. Adherence to host epithelial cells is the first critical step of the infectious process. Pili have been observed on the surface of several gram-positive bacteria including S. agalactiae. We previously characterized ...

journal_title：PLoS pathogens

authors： Konto-Ghiorghi Y,Mairey E,Mallet A,Duménil G,Caliot E,Trieu-Cuot P,Dramsi S

更新日期：2009-05-01 00:00:00

abstract：:For many viruses, one or two proteins allow cell attachment and entry, which occurs through the plasma membrane or following endocytosis at low pH. In contrast, vaccinia virus (VACV) enters cells by both neutral and low pH routes; four proteins mediate cell attachment and twelve that are associated in a membrane compl...

journal_title：PLoS pathogens

authors： Laliberte JP,Weisberg AS,Moss B

更新日期：2011-12-01 00:00:00

abstract：:Gut microbiota facilitate many aspects of human health and development, but dysbiotic microbiota can promote hyperplasia and inflammation and contribute to human diseases such as cancer. Human patients infected with the gastric cancer-causing bacterium Helicobacter pylori have altered microbiota; however, whether dysb...

journal_title：PLoS pathogens

authors： Jones TA,Hernandez DZ,Wong ZC,Wandler AM,Guillemin K

更新日期：2017-10-19 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1005698.]. ...

journal_title：PLoS pathogens

authors： Ersching J,Basso AS,Calich VL,Bortoluci KR,Rodrigues MM

更新日期：2016-07-11 00:00:00

abstract：:Influenza A virus (IAV) infection can be severe or even lethal in toddlers, the elderly and patients with certain medical conditions. Infection of apparently healthy individuals nonetheless accounts for many severe disease cases and deaths, suggesting that viruses with increased pathogenicity co-circulate with pandemi...

journal_title：PLoS pathogens

authors： Vasilijevic J,Zamarreño N,Oliveros JC,Rodriguez-Frandsen A,Gómez G,Rodriguez G,Pérez-Ruiz M,Rey S,Barba I,Pozo F,Casas I,Nieto A,Falcón A

更新日期：2017-10-12 00:00:00

abstract：:Flavivirus nonstructural protein 5 (NS5) consists of methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains, which catalyze 5'-RNA capping/methylation and RNA synthesis, respectively, during viral genome replication. Although the crystal structure of flavivirus NS5 is known, no data about the quater...

journal_title：PLoS pathogens

authors： Klema VJ,Ye M,Hindupur A,Teramoto T,Gottipati K,Padmanabhan R,Choi KH

更新日期：2016-02-19 00:00:00

abstract：:Hepatitis B virus (HBV) core protein (HBc) contains an N-terminal domain (NTD, assembly domain) and a C-terminal domain (CTD), which are linked by a flexible linker region. HBc plays multiple essential roles in viral replication, including capsid assembly, packaging of the viral pregenomic RNA (pgRNA) into nucleocapsi...

journal_title：PLoS pathogens

authors： Liu K,Luckenbaugh L,Ning X,Xi J,Hu J

更新日期：2018-05-21 00:00:00

abstract：:The emergence of ceftriaxone-resistant strains of Neisseria gonorrhoeae may herald an era of untreatable gonorrhea. Vaccines against this infection are urgently needed. The 2C7 epitope is a conserved oligosaccharide (OS) structure, a part of lipooligosaccharide (LOS) on N gonorrhoeae. The epitope is expressed by 94% o...

journal_title：PLoS pathogens

authors： Gulati S,Zheng B,Reed GW,Su X,Cox AD,St Michael F,Stupak J,Lewis LA,Ram S,Rice PA

更新日期：2013-01-01 00:00:00

abstract：:Little is known about the role of viral genes in modulating host cytokine responses. Here we report a new functional role of the viral encoded IE1 protein of the murine cytomegalovirus in sculpting the inflammatory response in an acute infection. In time course experiments of infected primary macrophages (MΦs) measuri...

journal_title：PLoS pathogens

authors： Rodríguez-Martín S,Kropp KA,Wilhelmi V,Lisnic VJ,Hsieh WY,Blanc M,Livingston A,Busche A,Tekotte H,Messerle M,Auer M,Fraser I,Jonjic S,Angulo A,Reddehase MJ,Ghazal P

更新日期：2012-01-01 00:00:00

abstract：:Our appreciation for the extent of Epstein Barr virus (EBV) transcriptome complexity continues to grow through findings of EBV encoded microRNAs, new long non-coding RNAs as well as the more recent discovery of over a hundred new polyadenylated lytic transcripts. Here we report an additional layer to the EBV transcrip...

journal_title：PLoS pathogens

authors： Ungerleider N,Concha M,Lin Z,Roberts C,Wang X,Cao S,Baddoo M,Moss WN,Yu Y,Seddon M,Lehman T,Tibbetts S,Renne R,Dong Y,Flemington EK

更新日期：2018-08-06 00:00:00

abstract：:While immunological memory has long been considered the province of T- and B-lymphocytes, it has recently been reported that innate cell populations are capable of mediating memory responses. We now show that an innate memory immune response is generated in mice following infection with vaccinia virus, a poxvirus for ...

journal_title：PLoS pathogens

authors： Gillard GO,Bivas-Benita M,Hovav AH,Grandpre LE,Panas MW,Seaman MS,Haynes BF,Letvin NL

更新日期：2011-08-01 00:00:00