Quantitative models of the dose-response and time course of inhalational anthrax in humans.

abstract：:Targeting of permissive entry sites is crucial for bacterial infection. The targeting mechanisms are incompletely understood. We have analyzed target-site selection by S. Typhimurium. This enteropathogenic bacterium employs adhesins (e.g. fim) and the type III secretion system 1 (TTSS-1) for host cell binding, the tri...

journal_title：PLoS pathogens

authors： Misselwitz B,Barrett N,Kreibich S,Vonaesch P,Andritschke D,Rout S,Weidner K,Sormaz M,Songhet P,Horvath P,Chabria M,Vogel V,Spori DM,Jenny P,Hardt WD

更新日期：2012-01-01 00:00:00

abstract：:Many animal and plant viruses rely on vectors for their transmission from host to host. Grapevine fanleaf virus (GFLV), a picorna-like virus from plants, is transmitted specifically by the ectoparasitic nematode Xiphinema index. The icosahedral capsid of GFLV, which consists of 60 identical coat protein subunits (CP),...

journal_title：PLoS pathogens

authors： Schellenberger P,Sauter C,Lorber B,Bron P,Trapani S,Bergdoll M,Marmonier A,Schmitt-Keichinger C,Lemaire O,Demangeat G,Ritzenthaler C

更新日期：2011-05-01 00:00:00

abstract：:Many bacterial pathogens and symbionts use type III secretion machines to interact with their hosts by injecting bacterial effector proteins into host target cells. A central component of this complex machine is the cytoplasmic sorting platform, which orchestrates the engagement and preparation of type III secreted pr...

journal_title：PLoS pathogens

authors： Lara-Tejero M,Qin Z,Hu B,Butan C,Liu J,Galán JE

更新日期：2019-01-22 00:00:00

abstract：:Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus anthracis, disrupts endocytic recycling mediated by the small GTPase Rab11. As a result, cargo proteins such as cadherins fail to reach inter-cellu...

journal_title：PLoS pathogens

authors： Guichard A,Jain P,Moayeri M,Schwartz R,Chin S,Zhu L,Cruz-Moreno B,Liu JZ,Aguilar B,Hollands A,Leppla SH,Nizet V,Bier E

更新日期：2017-09-25 00:00:00

abstract：:Ebola virus disease afflicts both human and animal populations and is caused by four ebolaviruses. These different ebolaviruses may have distinct reservoir hosts and ecological contexts that determine how, where, and when different ebolavirus spillover events occur. Understanding these virus-specific relationships is ...

journal_title：PLoS pathogens

authors： Judson SD,Fischer R,Judson A,Munster VJ

更新日期：2016-08-05 00:00:00

abstract：:Hendra and Nipah viruses (family Paramyxoviridae, genus Henipavirus) are bat-borne viruses that cause fatal disease in humans and a range of other mammalian species. Gaining a deeper understanding of host pathways exploited by henipaviruses for infection may identify targets for new anti-viral therapies. Here we have ...

journal_title：PLoS pathogens

authors： Foo CH,Rootes CL,Cowley K,Marsh GA,Gould CM,Deffrasnes C,Cowled CJ,Klein R,Riddell SJ,Middleton D,Simpson KJ,Wang LF,Bean AG,Stewart CR

更新日期：2016-10-26 00:00:00

abstract：:To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma and on host cells by plasma complement regulator factor H (FH). ...

journal_title：PLoS pathogens

authors： Meri T,Amdahl H,Lehtinen MJ,Hyvärinen S,McDowell JV,Bhattacharjee A,Meri S,Marconi R,Goldman A,Jokiranta TS

更新日期：2013-01-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) remains a major public health problem, with an effective vaccine continuing to prove elusive. Progress in vaccination strategies has been hampered by a lack of appreciation of the bacterium's response to dynamic changes in the host immune environment. Here, we utilize reporter Mtb stra...

journal_title：PLoS pathogens

authors： Sukumar N,Tan S,Aldridge BB,Russell DG

更新日期：2014-09-18 00:00:00

abstract：:The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single round of APOBEC3G-dependent mutagenesis can be catastrophic, but evidence suggests that sublethal levels contribute to viral genetic diversity a...

journal_title：PLoS pathogens

authors： Refsland EW,Hultquist JF,Harris RS

更新日期：2012-01-01 00:00:00

abstract：:To further its pathogenesis, S. Typhimurium delivers effector proteins into host cells, including the novel E3 ubiquitin ligase (NEL) effector SspH2. Using model systems in a cross-kingdom approach we gained further insight into the molecular function of this effector. Here, we show that SspH2 modulates innate immunit...

journal_title：PLoS pathogens

authors： Bhavsar AP,Brown NF,Stoepel J,Wiermer M,Martin DD,Hsu KJ,Imami K,Ross CJ,Hayden MR,Foster LJ,Li X,Hieter P,Finlay BB

更新日期：2013-01-01 00:00:00

abstract：:The ubiquitin-like modifier ISG15 is one of the most predominant proteins induced by type I interferons (IFN). In this study, murine embryo fibroblast (MEFs) and mice lacking the gene were used to demonstrate a novel role of ISG15 as a host defense molecule against vaccinia virus (VACV) infection. In MEFs, the growth ...

journal_title：PLoS pathogens

authors： Guerra S,Cáceres A,Knobeloch KP,Horak I,Esteban M

更新日期：2008-07-04 00:00:00

abstract：:Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I degradation. A systematic proteomic study using Plasma Membrane ...

journal_title：PLoS pathogens

authors： Hsu JL,van den Boomen DJ,Tomasec P,Weekes MP,Antrobus R,Stanton RJ,Ruckova E,Sugrue D,Wilkie GS,Davison AJ,Wilkinson GW,Lehner PJ

更新日期：2015-04-14 00:00:00

abstract：:One of the hallmarks of adaptive immunity is the development of a long-term pathogen specific memory response. While persistent memory T cells certainly impact the immune response during a secondary challenge, their role in unrelated infections is less clear. To address this issue, we utilized lymphocytic choriomening...

journal_title：PLoS pathogens

authors： Crosby EJ,Goldschmidt MH,Wherry EJ,Scott P

更新日期：2014-02-27 00:00:00

abstract：:Streptococcus gallolyticus subspecies gallolyticus (Sgg) has a strong clinical association with colorectal cancer (CRC) and actively promotes the development of colon tumors. However, the molecular determinants involved in Sgg pathogenicity in the gut are unknown. Bacterial type VII secretion systems (T7SS) mediate pa...

journal_title：PLoS pathogens

authors： Taylor JC,Gao X,Xu J,Holder M,Petrosino J,Kumar R,Liu W,Höök M,Mackenzie C,Hillhouse A,Brashear W,Nunez MP,Xu Y

更新日期：2021-01-06 00:00:00

abstract：:Septic shock caused by Neisseria meningitidis is typically rapidly evolving and often fatal despite antibiotic therapy. Further understanding of the mechanisms underlying the disease is necessary to reduce fatality rates. Postmortem samples from the characteristic purpuric rashes of the infection show bacterial aggreg...

journal_title：PLoS pathogens

authors： Melican K,Michea Veloso P,Martin T,Bruneval P,Duménil G

更新日期：2013-01-01 00:00:00

abstract：:Plasmodium falciparum malaria kills over 500,000 children every year and has been a scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum parasites, the human genome is imprinted with polymorphisms that not only confer innate resistance to falciparum malaria, but also cause hemoglobino...

journal_title：PLoS pathogens

authors： Taylor SM,Cerami C,Fairhurst RM

更新日期：2013-01-01 00:00:00

abstract：:MicroRNAs play an important role in the interplay between bacterial pathogens and host cells, participating as host defense mechanisms, as well as exploited by bacteria to subvert host cellular functions. Here, we show that microRNAs modulate infection by Shigella flexneri, a major causative agent of bacillary dysente...

journal_title：PLoS pathogens

authors： Sunkavalli U,Aguilar C,Silva RJ,Sharan M,Cruz AR,Tawk C,Maudet C,Mano M,Eulalio A

更新日期：2017-04-10 00:00:00

abstract：:The role of regulatory T cells (Tregs) in vaccination has been poorly investigated. We have reported that vaccination with ex vivo-generated dendritic-cells (DC) loaded with HIV-lipopeptides (LIPO-5-DC vaccine) in HIV-infected patients was well tolerated and highly immunogenic. These responses and their relation to vi...

journal_title：PLoS pathogens

authors： Brezar V,Ruffin N,Richert L,Surenaud M,Lacabaratz C,Palucka K,Thiébaut R,Banchereau J,Levy Y,Seddiki N

更新日期：2015-03-27 00:00:00

abstract：:The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or in...

journal_title：PLoS pathogens

authors： Hovius JW,Bijlsma MF,van der Windt GJ,Wiersinga WJ,Boukens BJ,Coumou J,Oei A,de Beer R,de Vos AF,van 't Veer C,van Dam AP,Wang P,Fikrig E,Levi MM,Roelofs JJ,van der Poll T

更新日期：2009-05-01 00:00:00

abstract：:Intracellular pathogens have evolved diverse strategies to invade and survive within host cells. Among the most studied facultative intracellular pathogens, Listeria monocytogenes is known to express two invasins-InlA and InlB-that induce bacterial internalization into nonphagocytic cells. The pore-forming toxin liste...

journal_title：PLoS pathogens

authors： Vadia S,Arnett E,Haghighat AC,Wilson-Kubalek EM,Tweten RK,Seveau S

更新日期：2011-11-01 00:00:00

abstract：:Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related ...

journal_title：PLoS pathogens

authors： Cotter PD,Draper LA,Lawton EM,Daly KM,Groeger DS,Casey PG,Ross RP,Hill C

更新日期：2008-09-12 00:00:00

abstract：:Poxviruses subvert the host immune response by producing immunomodulatory proteins, including a complement regulatory protein. Ectromelia virus provides a mouse model for smallpox where the virus and the host's immune response have co-evolved. Using this model, our study investigated the role of the complement system ...

journal_title：PLoS pathogens

authors： Moulton EA,Atkinson JP,Buller RM

更新日期：2008-12-01 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC), particularly serotype O157:H7, causes hemorrhagic colitis, hemolytic uremic syndrome, and even death. In vitro studies showed that Shiga toxin 2 (Stx2), the primary virulence factor expressed by EDL933 (an O157:H7 strain), is encoded by the 933W prophage. And the bacterial su...

journal_title：PLoS pathogens

authors： Tyler JS,Beeri K,Reynolds JL,Alteri CJ,Skinner KG,Friedman JH,Eaton KA,Friedman DI

更新日期：2013-03-01 00:00:00

abstract：:The two-component system (TCS) KdpD/KdpE, extensively studied for its regulatory role in potassium (K(+)) transport, has more recently been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria, including Staphylococcus aureus, entero-haemorrhagic Escherichia c...

journal_title：PLoS pathogens

authors： Freeman ZN,Dorus S,Waterfield NR

更新日期：2013-03-01 00:00:00

abstract：:Botulinum neurotoxin serotype C (BoNT/C) is a neuroparalytic toxin associated with outbreaks of animal botulism, particularly in birds, and is the only BoNT known to cleave two different SNARE proteins, SNAP-25 and syntaxin. BoNT/C was shown to be a good substitute for BoNT/A1 in human dystonia therapy because of its ...

journal_title：PLoS pathogens

authors： Zanetti G,Sikorra S,Rummel A,Krez N,Duregotti E,Negro S,Henke T,Rossetto O,Binz T,Pirazzini M

更新日期：2017-08-11 00:00:00

abstract：:Phytopathogenic ascomycete fungi possess huge effector repertoires that are dominated by hundreds of sequence-unrelated small secreted proteins. The molecular function of these effectors and the evolutionary mechanisms that generate this tremendous number of singleton genes are largely unknown. To get a deeper underst...

journal_title：PLoS pathogens

authors： de Guillen K,Ortiz-Vallejo D,Gracy J,Fournier E,Kroj T,Padilla A

更新日期：2015-10-27 00:00:00

abstract：:The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete loss of virulence i...

journal_title：PLoS pathogens

authors： Chung D,Barker BM,Carey CC,Merriman B,Werner ER,Lechner BE,Dhingra S,Cheng C,Xu W,Blosser SJ,Morohashi K,Mazurie A,Mitchell TK,Haas H,Mitchell AP,Cramer RA

更新日期：2014-11-06 00:00:00

abstract：:Apolipoprotein E (ApoE) belongs to a class of cellular proteins involved in lipid metabolism. ApoE is a polymorphic protein produced primarily in macrophages and astrocytes. Different isoforms of ApoE have been associated with susceptibility to various diseases including Alzheimer's and cardiovascular diseases. ApoE e...

journal_title：PLoS pathogens

authors： Siddiqui R,Suzu S,Ueno M,Nasser H,Koba R,Bhuyan F,Noyori O,Hamidi S,Sheng G,Yasuda-Inoue M,Hishiki T,Sukegawa S,Miyagi E,Strebel K,Matsushita S,Shimotohno K,Ariumi Y

更新日期：2018-11-29 00:00:00

abstract：:The porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to swine health worldwide and is considered the most significant viral disease in the swine industry today. In past years, studies on the entry of the virus into its host cell have led to the identification of a number of essential virus...

journal_title：PLoS pathogens

authors： Van Breedam W,Van Gorp H,Zhang JQ,Crocker PR,Delputte PL,Nauwynck HJ

更新日期：2010-01-15 00:00:00

abstract：:Human defensins are at the forefront of the host responses to HIV and other pathogens in mucosal tissues. However, their ability to inactivate HIV in the bloodstream has been questioned due to the antagonistic effect of serum. In this study, we have examined the effect of sub-inhibitory concentrations of human α-defen...

journal_title：PLoS pathogens

authors： Demirkhanyan L,Marin M,Lu W,Melikyan GB

更新日期：2013-01-01 00:00:00