MicroRNA antagonism of the picornaviral life cycle: alternative mechanisms of interference.

abstract：:Epitopes that are conserved among SARS-like coronaviruses are attractive targets for design of cross-reactive vaccines and therapeutics. CR3022 is a SARS-CoV neutralizing antibody to a highly conserved epitope on the receptor binding domain (RBD) on the spike protein that is able to cross-react with SARS-CoV-2, but wi...

journal_title：PLoS pathogens

authors： Wu NC,Yuan M,Bangaru S,Huang D,Zhu X,Lee CD,Turner HL,Peng L,Yang L,Burton DR,Nemazee D,Ward AB,Wilson IA

更新日期：2020-12-04 00:00:00

abstract：:In host-pathogen interactions, the struggle for iron may have major consequences on the outcome of the disease. To overcome the low solubility and bio-availability of iron, bacteria have evolved multiple systems to acquire iron from various sources such as heme, hemoglobin and ferritin. The molecular basis of iron acq...

journal_title：PLoS pathogens

authors： Segond D,Abi Khalil E,Buisson C,Daou N,Kallassy M,Lereclus D,Arosio P,Bou-Abdallah F,Nielsen Le Roux C

更新日期：2014-02-13 00:00:00

abstract：:Respiratory virus infections, such as influenza, typically induce a robust type I (pro-inflammatory cytokine) immune response, however, the production of type 2 cytokines has been observed. Type 2 cytokine production during respiratory virus infection is linked to asthma exacerbation; however, type 2 cytokines may als...

journal_title：PLoS pathogens

authors： Gorski SA,Hahn YS,Braciale TJ

更新日期：2013-09-01 00:00:00

abstract：:Candida albicans is the most frequent cause of oral fungal infections. However, the exact pathogenicity mechanisms that this fungus employs are largely unknown and many of the genes expressed during oral infection are uncharacterized. In this study we sought to functionally characterize 12 previously unknown function ...

journal_title：PLoS pathogens

authors： Mayer FL,Wilson D,Jacobsen ID,Miramón P,Große K,Hube B

更新日期：2012-01-01 00:00:00

abstract：:Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly regulating anti-micro...

journal_title：PLoS pathogens

authors： Tay HL,Kaiko GE,Plank M,Li J,Maltby S,Essilfie AT,Jarnicki A,Yang M,Mattes J,Hansbro PM,Foster PS

更新日期：2015-04-20 00:00:00

abstract：:Bursaphelenchus xylophilus is the nematode responsible for a devastating epidemic of pine wilt disease in Asia and Europe, and represents a recent, independent origin of plant parasitism in nematodes, ecologically and taxonomically distinct from other nematodes for which genomic data is available. As well as being an ...

journal_title：PLoS pathogens

authors： Kikuchi T,Cotton JA,Dalzell JJ,Hasegawa K,Kanzaki N,McVeigh P,Takanashi T,Tsai IJ,Assefa SA,Cock PJ,Otto TD,Hunt M,Reid AJ,Sanchez-Flores A,Tsuchihara K,Yokoi T,Larsson MC,Miwa J,Maule AG,Sahashi N,Jones JT,Berr

更新日期：2011-09-01 00:00:00

abstract：:A subset of high-risk Human Papillomaviruses (HPVs) are the causative agents of a large number of human cancers, of which cervical is the most common. Two viral oncoproteins, E6 and E7, contribute directly towards the development and maintenance of malignancy. A characteristic feature of the E6 oncoproteins from cance...

journal_title：PLoS pathogens

authors： Ganti K,Massimi P,Manzo-Merino J,Tomaić V,Pim D,Playford MP,Lizano M,Roberts S,Kranjec C,Doorbar J,Banks L

更新日期：2016-09-20 00:00:00

abstract：:The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered. Streptococcus equi subspecies equi (S. equi) is a host-restricted pathogen of horses that has evolved from the zoonotic p...

journal_title：PLoS pathogens

authors： Holden MT,Heather Z,Paillot R,Steward KF,Webb K,Ainslie F,Jourdan T,Bason NC,Holroyd NE,Mungall K,Quail MA,Sanders M,Simmonds M,Willey D,Brooks K,Aanensen DM,Spratt BG,Jolley KA,Maiden MC,Kehoe M,Chanter N,Bentl

更新日期：2009-03-01 00:00:00

abstract：:Enteropathogenic E. coli (EPEC) is a human pathogen that causes acute and chronic pediatric diarrhea. The hallmark of EPEC infection is the formation of attaching and effacing (A/E) lesions in the intestinal epithelium. Formation of A/E lesions is mediated by genes located on the pathogenicity island locus of enterocy...

journal_title：PLoS pathogens

authors： Cepeda-Molero M,Berger CN,Walsham ADS,Ellis SJ,Wemyss-Holden S,Schüller S,Frankel G,Fernández LÁ

更新日期：2017-10-30 00:00:00

abstract：:The intestine is a common site for invasion by intracellular pathogens, but little is known about how pathogens restructure and exit intestinal cells in vivo. The natural microsporidian parasite N. parisii invades intestinal cells of the nematode C. elegans, progresses through its life cycle, and then exits cells in a...

journal_title：PLoS pathogens

authors： Estes KA,Szumowski SC,Troemel ER

更新日期：2011-09-01 00:00:00

abstract：:Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal apparent sequestration in endothelium-lined microvasculature, and pathogenesis thought unrelated to parasite biomass. However, the relationships bet...

journal_title：PLoS pathogens

authors： Barber BE,William T,Grigg MJ,Parameswaran U,Piera KA,Price RN,Yeo TW,Anstey NM

更新日期：2015-01-08 00:00:00

abstract：:Type I interferons (T1-IFN) are critical in the innate immune response, acting upon infected and uninfected cells to initiate an antiviral state by expressing genes that inhibit multiple stages of the lifecycle of many viruses. T1-IFN triggers the production of Interferon-Stimulated Genes (ISGs), activating an antivir...

journal_title：PLoS pathogens

authors： Parekh NJ,Krouse TE,Reider IE,Hobbs RP,Ward BM,Norbury CC

更新日期：2019-10-11 00:00:00

abstract：:Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and propagating the eukaryotic innate immune signaling cascade. Here, we investigate TirS, a Staphylococcus aureus TIR mimic that is part of a novel bacterial invasion mechanism. Its ectopic expression in eukaryotic cells inh...

journal_title：PLoS pathogens

authors： Patot S,Imbert PR,Baude J,Martins Simões P,Campergue JB,Louche A,Nijland R,Bès M,Tristan A,Laurent F,Fischer A,Schrenzel J,Vandenesch F,Salcedo SP,François P,Lina G

更新日期：2017-01-06 00:00:00

abstract：:Epstein-Barr virus (EBV) and related lymphocryptoviruses (LCV) from non-human primates infect B cells, transform their growth to facilitate life-long viral persistence in the host, and contribute to B cell oncogenesis. Co-evolution of LCV with their primate hosts has led to species-specificity so that LCVs preferentia...

journal_title：PLoS pathogens

authors： Mühe J,Wang F

更新日期：2017-12-20 00:00:00

abstract：:The interplay between autophagy and intracellular pathogens is intricate as autophagy is an essential cellular response to fight against infections, whereas numerous microbes have developed strategies to escape this process or even exploit it to their own benefit. The fine tuned timing and/or selective molecular pathw...

journal_title：PLoS pathogens

authors： Richetta C,Grégoire IP,Verlhac P,Azocar O,Baguet J,Flacher M,Tangy F,Rabourdin-Combe C,Faure M

更新日期：2013-01-01 00:00:00

abstract：:Plants possess active defense systems and can protect themselves from pathogenic invasion by secretion of a variety of small antimicrobial or antifungal proteins such as thionins. The antibacterial and antifungal properties of thionins are derived from their ability to induce open pore formation on cell membranes of p...

journal_title：PLoS pathogens

authors： Asano T,Miwa A,Maeda K,Kimura M,Nishiuchi T

更新日期：2013-01-01 00:00:00

abstract：:DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune system. Mice lacking DDX3X during hematopoiesis showed an altered leuk...

journal_title：PLoS pathogens

authors： Szappanos D,Tschismarov R,Perlot T,Westermayer S,Fischer K,Platanitis E,Kallinger F,Novatchkova M,Lassnig C,Müller M,Sexl V,Bennett KL,Foong-Sobis M,Penninger JM,Decker T

更新日期：2018-11-26 00:00:00

abstract：:Reverse transcriptase (RT) is the target for the majority of anti-HIV-1 drugs. As with all anti-AIDS treatments, continued success of RT inhibitors is persistently disrupted by the occurrence of resistance mutations. To explore latent resistance mechanisms potentially accessible to therapeutically challenged HIV-1 vir...

journal_title：PLoS pathogens

authors： Galilee M,Alian A

更新日期：2018-01-24 00:00:00

abstract：:Expression of genes of the locus of enterocyte effacement (LEE) is essential for adherence of enterohemorrhagic Escherichia coli (EHEC) to intestinal epithelial cells. Gut factors that may modulate LEE gene expression may therefore influence the outcome of the infection. Because nitric oxide (NO) is a critical effecto...

journal_title：PLoS pathogens

authors： Branchu P,Matrat S,Vareille M,Garrivier A,Durand A,Crépin S,Harel J,Jubelin G,Gobert AP

更新日期：2014-01-01 00:00:00

abstract：:More than half of the world population is at risk of dengue virus (DENV) infection because of the global distribution of its mosquito vectors. DENV is an envelope virus that relies on host lipid membranes for its life-cycle. Here, we characterized how DENV hijacks the mosquito lipidome to identify targets for novel tr...

journal_title：PLoS pathogens

authors： Vial T,Tan WL,Wong Wei Xiang B,Missé D,Deharo E,Marti G,Pompon J

更新日期：2019-12-09 00:00:00

abstract：:HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contain an incomplete spherical shell where Gag is arranged with the N-term...

journal_title：PLoS pathogens

authors： de Marco A,Müller B,Glass B,Riches JD,Kräusslich HG,Briggs JA

更新日期：2010-11-24 00:00:00

abstract：:APE1 is a multifunctional protein with a DNA base excision repair function in its C-terminal domain and a redox activity in its N-terminal domain. The redox function of APE1 converts certain transcription factors from inactive oxidized to active reduced forms. Given that among the APE1-regulated transcription factors ...

journal_title：PLoS pathogens

authors： Zhong C,Xu M,Wang Y,Xu J,Yuan Y

更新日期：2017-04-05 00:00:00

abstract：:The hemolytic phospholipase C (PlcHR) expressed by Pseudomonas aeruginosa is the original member of a Phosphoesterase Superfamily, which includes phosphorylcholine-specific phospholipases C (PC-PLC) produced by frank and opportunistic pathogens. PlcHR, but not all its family members, is also a potent sphingomyelinase ...

journal_title：PLoS pathogens

authors： Vasil ML,Stonehouse MJ,Vasil AI,Wadsworth SJ,Goldfine H,Bolcome RE 3rd,Chan J

更新日期：2009-05-01 00:00:00

abstract：:The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood. Recent studies demonstrated that CCR5-tropic HIV-1 efficiently enters tissue-derived memory CD4+ T cells expressin...

journal_title：PLoS pathogens

authors： Hsiao F,Frouard J,Gramatica A,Xie G,Telwatte S,Lee GQ,Roychoudhury P,Schwarzer R,Luo X,Yukl SA,Lee S,Hoh R,Deeks SG,Jones RB,Cavrois M,Greene WC,Roan NR

更新日期：2020-04-30 00:00:00

abstract：:Accurate calculation of mutation rates for viruses and viroids is necessary for evolutionary studies and to evaluate adaptation potential. However, estimation of in vivo mutation rates is complicated by selection, which leads to loss or proliferation of certain mutations. To minimize this concern, lethal mutations, in...

journal_title：PLoS pathogens

authors： Wu J,Bisaro DM

更新日期：2020-12-22 00:00:00

abstract：:A facile and efficient method for the precise editing of large viral genomes is required for the selection of attenuated vaccine strains and the construction of gene therapy vectors. The type II prokaryotic CRISPR-Cas (clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)) RNA-guided nucl...

journal_title：PLoS pathogens

authors： Bi Y,Sun L,Gao D,Ding C,Li Z,Li Y,Cun W,Li Q

更新日期：2014-05-01 00:00:00

abstract：:Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility. While the role of mTORC1 in viral infection has been studied, the mechanisms that induce mTORC1 activation and the substrates regulated by mTORC1 during infl...

journal_title：PLoS pathogens

authors： Kuss-Duerkop SK,Wang J,Mena I,White K,Metreveli G,Sakthivel R,Mata MA,Muñoz-Moreno R,Chen X,Krammer F,Diamond MS,Chen ZJ,García-Sastre A,Fontoura BMA

更新日期：2017-09-27 00:00:00

abstract：:Toxoplasma gondii and Hammondia hammondi are closely-related coccidian intracellular parasites that differ in their ability to cause disease in animal and (likely) humans. The role of the host response in these phenotypic differences is not known and to address this we performed a transcriptomic analysis of a monocyte...

journal_title：PLoS pathogens

authors： Wong ZS,Sokol-Borrelli SL,Olias P,Dubey JP,Boyle JP

更新日期：2020-06-23 00:00:00

abstract：:The type III secretion system is an essential component for virulence in many Gram-negative bacteria. Though components of the secretion system apparatus are conserved, its substrates--effector proteins--are not. We have used a novel computational approach to confidently identify new secreted effectors by integrating ...

journal_title：PLoS pathogens

authors： Samudrala R,Heffron F,McDermott JE

更新日期：2009-04-01 00:00:00

abstract：:Many thousands of endoparasitic wasp species are known to inject polydnavirus (PDV) particles into their caterpillar host during oviposition, causing immune and developmental dysfunctions that benefit the wasp larva. PDVs associated with braconid and ichneumonid wasps, bracoviruses and ichnoviruses respectively, both ...

journal_title：PLoS pathogens

authors： Volkoff AN,Jouan V,Urbach S,Samain S,Bergoin M,Wincker P,Demettre E,Cousserans F,Provost B,Coulibaly F,Legeai F,Béliveau C,Cusson M,Gyapay G,Drezen JM

更新日期：2010-05-27 00:00:00