A complex extracellular sphingomyelinase of Pseudomonas aeruginosa inhibits angiogenesis by selective cytotoxicity to endothelial cells.

abstract：:Sepsis is a frequent complication in critical illness. The mechanisms that are involved in initiation and propagation of the disease are not well understood. Scavenger receptor A (SRA) is a membrane receptor that binds multiple polyanions such as oxidized LDL and endotoxin. Recent studies suggest that SRA acts as a pa...

journal_title：PLoS pathogens

authors： Ozment TR,Ha T,Breuel KF,Ford TR,Ferguson DA,Kalbfleisch J,Schweitzer JB,Kelley JL,Li C,Williams DL

更新日期：2012-01-01 00:00:00

abstract：:Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs. Unusually potent nAb titers developed in 2 of 8 rabbits immunized with virus-like particles (VLPs) expressing trimers (trimer...

journal_title：PLoS pathogens

authors： Crooks ET,Tong T,Chakrabarti B,Narayan K,Georgiev IS,Menis S,Huang X,Kulp D,Osawa K,Muranaka J,Stewart-Jones G,Destefano J,O'Dell S,LaBranche C,Robinson JE,Montefiori DC,McKee K,Du SX,Doria-Rose N,Kwong PD,Mascola

更新日期：2015-05-29 00:00:00

abstract：:Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate...

journal_title：PLoS pathogens

authors： Liang J,Sagum CA,Bedford MT,Sidhu SS,Sudol M,Han Z,Harty RN

更新日期：2017-01-11 00:00:00

abstract：:Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant strains continue to emerge, underscoring the need for additional novel mechanism inhibitors that will offer expanded therapeutic options in the clinic. We report a new class of small molecule antiretroviral compounds that di...

journal_title：PLoS pathogens

authors： Blair WS,Pickford C,Irving SL,Brown DG,Anderson M,Bazin R,Cao J,Ciaramella G,Isaacson J,Jackson L,Hunt R,Kjerrstrom A,Nieman JA,Patick AK,Perros M,Scott AD,Whitby K,Wu H,Butler SL

更新日期：2010-12-09 00:00:00

abstract：:Human noroviruses (huNoV) are the most frequent cause of non-bacterial acute gastroenteritis worldwide, particularly genogroup II genotype 4 (GII.4) variants. The viral nonstructural (NS) proteins encoded by the ORF1 polyprotein induce vesical clusters harboring the viral replication sites. Little is known so far abou...

journal_title：PLoS pathogens

authors： Doerflinger SY,Cortese M,Romero-Brey I,Menne Z,Tubiana T,Schenk C,White PA,Bartenschlager R,Bressanelli S,Hansman GS,Lohmann V

更新日期：2017-10-27 00:00:00

abstract：:The survival and persistence of Mycobacterium tuberculosis depends on its capacity to manipulate multiple host defense pathways, including the ability to actively inhibit the death by apoptosis of infected host cells. The genetic basis for this anti-apoptotic activity and its implication for mycobacterial virulence ha...

journal_title：PLoS pathogens

authors： Velmurugan K,Chen B,Miller JL,Azogue S,Gurses S,Hsu T,Glickman M,Jacobs WR Jr,Porcelli SA,Briken V

更新日期：2007-07-01 00:00:00

abstract：:The opa genes of the Gram negative bacterium Neisseria meningitidis encode Opacity-associated outer membrane proteins whose role is to promote adhesion to the human host tissue during colonisation and invasion. Each meningococcus contains 3-4 opa loci, each of which may be occupied by one of a large number of alleles....

journal_title：PLoS pathogens

authors： Callaghan MJ,Buckee CO,Jolley KA,Kriz P,Maiden MC,Gupta S

更新日期：2008-03-14 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an RNA virus in the Family Paramyxoviridae. Here, the activities performed by the RSV polymerase when it encounters the viral antigenomic promoter were examined. RSV RNA synthesis was reconstituted in vitro using recombinant, isolated polymerase and an RNA oligonucleotide template ...

journal_title：PLoS pathogens

authors： Noton SL,Deflubé LR,Tremaglio CZ,Fearns R

更新日期：2012-01-01 00:00:00

abstract：:The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that s...

journal_title：PLoS pathogens

authors： Anderson A,Laurenson-Schafer H,Partridge FA,Hodgkin J,McMullan R

更新日期：2013-01-01 00:00:00

abstract：:The obligate intracellular, gram-negative bacterium Chlamydophila pneumoniae (Cpn) has impact as a human pathogen. Little is known about changes in the Cpn transcriptome during its biphasic developmental cycle (the acute infection) and persistence. The latter stage has been linked to chronic diseases. To analyze Cpn C...

journal_title：PLoS pathogens

authors： Mäurer AP,Mehlitz A,Mollenkopf HJ,Meyer TF

更新日期：2007-06-01 00:00:00

abstract：:Rapid reprogramming of the macrophage activation phenotype is considered important in the defense against consecutive infection with diverse infectious agents. However, in the setting of persistent, chronic infection the functional importance of macrophage-intrinsic adaptation to changing environments vs. recruitment ...

journal_title：PLoS pathogens

authors： Rückerl D,Campbell SM,Duncan S,Sutherland TE,Jenkins SJ,Hewitson JP,Barr TA,Jackson-Jones LH,Maizels RM,Allen JE

更新日期：2017-03-23 00:00:00

abstract：:Poxviruses subvert the host immune response by producing immunomodulatory proteins, including a complement regulatory protein. Ectromelia virus provides a mouse model for smallpox where the virus and the host's immune response have co-evolved. Using this model, our study investigated the role of the complement system ...

journal_title：PLoS pathogens

authors： Moulton EA,Atkinson JP,Buller RM

更新日期：2008-12-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cassette of the cell wall integrity (CWI) pathway is primarily responsible for orchestrating changes of cell wall. However, functions of this cassette in other cellular processes are not well understood. Here, we found that the Botrytis cinerea mutant of MAPK kinase (BcMkk1)...

journal_title：PLoS pathogens

authors： Yin Y,Wu S,Chui C,Ma T,Jiang H,Hahn M,Ma Z

更新日期：2018-09-13 00:00:00

abstract：:Caspase-dependent cleavage of antigens associated with apoptotic cells plays a prominent role in the generation of CD8⁺ T cell responses in various infectious diseases. We found that the emergence of a large population of autoreactive CD8⁺ T effector cells specific for apoptotic T cell-associated self-epitopes exceeds...

journal_title：PLoS pathogens

authors： Franceschini D,Del Porto P,Piconese S,Trella E,Accapezzato D,Paroli M,Morrone S,Piccolella E,Spada E,Mele A,Sidney J,Sette A,Barnaba V

更新日期：2012-01-01 00:00:00

abstract：:We have identified from the mutualistic grass endophyte Epichloë festucae a non-ribosomal peptide synthetase gene (sidN) encoding a siderophore synthetase. The enzymatic product of SidN is shown to be a novel extracellular siderophore designated as epichloënin A, related to ferrirubin from the ferrichrome family. Targ...

journal_title：PLoS pathogens

authors： Johnson LJ,Koulman A,Christensen M,Lane GA,Fraser K,Forester N,Johnson RD,Bryan GT,Rasmussen S

更新日期：2013-01-01 00:00:00

abstract：:Intracellular Toll-like receptors (TLRs) expressed by dendritic cells recognize nucleic acids derived from pathogens and play an important role in the immune responses against the influenza virus (IAV), a single-stranded RNA sensed by different receptors including TLR7. However, the importance of TLR7 processing in th...

journal_title：PLoS pathogens

authors： Maschalidi S,Hässler S,Blanc F,Sepulveda FE,Tohme M,Chignard M,van Endert P,Si-Tahar M,Descamps D,Manoury B

更新日期：2012-01-01 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT) is a SM that interferes with the function and recruitment of innate i...

journal_title：PLoS pathogens

authors： Ries LNA,Pardeshi L,Dong Z,Tan K,Steenwyk JL,Colabardini AC,Ferreira Filho JA,de Castro PA,Silva LP,Preite NW,Almeida F,de Assis LJ,Dos Santos RAC,Bowyer P,Bromley M,Owens RA,Doyle S,Demasi M,Hernández DCR,Netto LES

更新日期：2020-07-15 00:00:00

abstract：:The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires thro...

journal_title：PLoS pathogens

authors： Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ

更新日期：2014-01-01 00:00:00

abstract：:SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been proposed recently. Here, w...

journal_title：PLoS pathogens

authors： Arnold LH,Groom HC,Kunzelmann S,Schwefel D,Caswell SJ,Ordonez P,Mann MC,Rueschenbaum S,Goldstone DC,Pennell S,Howell SA,Stoye JP,Webb M,Taylor IA,Bishop KN

更新日期：2015-10-02 00:00:00

abstract：:Since mucosal surfaces may be simultaneously colonized by multiple species, the success of an organism may be determined by its ability to compete with co-inhabitants of its niche. To explore the contribution of host factors to polymicrobial competition, a murine model was used to study the initiation of colonization ...

journal_title：PLoS pathogens

authors： Lysenko ES,Ratner AJ,Nelson AL,Weiser JN

更新日期：2005-09-01 00:00:00

abstract：:Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells in LN of cART-suppre...

journal_title：PLoS pathogens

authors： Pino M,Paganini S,Deleage C,Padhan K,Harper JL,King CT,Micci L,Cervasi B,Mudd JC,Gill KP,Jean SM,Easley K,Silvestri G,Estes JD,Petrovas C,Lederman MM,Paiardini M

更新日期：2019-10-18 00:00:00

abstract：:We report the identification of a novel polyomavirus present in respiratory secretions from human patients with symptoms of acute respiratory tract infection. The virus was initially detected in a nasopharyngeal aspirate from a 3-year-old child from Australia diagnosed with pneumonia. A random library was generated fr...

journal_title：PLoS pathogens

authors： Gaynor AM,Nissen MD,Whiley DM,Mackay IM,Lambert SB,Wu G,Brennan DC,Storch GA,Sloots TP,Wang D

更新日期：2007-05-04 00:00:00

abstract：:Species-dependent variation in proteins that aid or limit virus replication determines the ability of lentiviruses to jump between host species. Identifying and overcoming these differences facilitates the development of animal models for HIV-1, including models based on chimeric SIVs that express HIV-1 envelope (Env)...

journal_title：PLoS pathogens

authors： Del Prete GQ,Keele BF,Fode J,Thummar K,Swanstrom AE,Rodriguez A,Raymond A,Estes JD,LaBranche CC,Montefiori DC,KewalRamani VN,Lifson JD,Bieniasz PD,Hatziioannou T

更新日期：2017-09-25 00:00:00

abstract：:We have investigated to what extent natural transformation acting on free DNA substrates can facilitate transfer of mobile elements including transposons, integrons and/or gene cassettes between bacterial species. Naturally transformable cells of Acinetobacter baylyi were exposed to DNA from integron-carrying strains ...

journal_title：PLoS pathogens

authors： Domingues S,Harms K,Fricke WF,Johnsen PJ,da Silva GJ,Nielsen KM

更新日期：2012-01-01 00:00:00

abstract：:Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro. Circulating and antigen-stimulated concentrations of these inflammatory mediators...

journal_title：PLoS pathogens

authors： Coussens AK,Wilkinson RJ,Nikolayevskyy V,Elkington PT,Hanifa Y,Islam K,Timms PM,Bothamley GH,Claxton AP,Packe GE,Darmalingam M,Davidson RN,Milburn HJ,Baker LV,Barker RD,Drobniewski FA,Mein CA,Bhaw-Rosun L,Nuamah RA,

更新日期：2013-01-01 00:00:00

abstract：:Cellular immune responses require the generation and recruitment of diverse blood cell types that recognize and kill pathogens. In Drosophila melanogaster larvae, immune-inducible lamellocytes participate in recognizing and killing parasitoid wasp eggs. However, the sequence of events required for lamellocyte generati...

journal_title：PLoS pathogens

authors： Anderl I,Vesala L,Ihalainen TO,Vanha-Aho LM,Andó I,Rämet M,Hultmark D

更新日期：2016-07-14 00:00:00

abstract：:Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies. While natural killer (NK) cells can directly contribute to the control of viral replication, whet...

journal_title：PLoS pathogens

authors： Robbins SH,Bessou G,Cornillon A,Zucchini N,Rupp B,Ruzsics Z,Sacher T,Tomasello E,Vivier E,Koszinowski UH,Dalod M

更新日期：2007-08-24 00:00:00

abstract：:Phosphorylated derivatives of phosphatidylinositol (PIPs) are key membrane lipid residues involved in clathrin-mediated endocytosis (CME). CME relies on PIP species PI(4,5)P2 to mark endocytic sites at the plasma membrane (PM) associated to clathrin-coated vesicle (CCV) formation. The highly diverged parasitic protist...

journal_title：PLoS pathogens

authors： Cernikova L,Faso C,Hehl AB

更新日期：2020-02-24 00:00:00

abstract：:Many viruses express factors that reduce host gene expression through widespread degradation of cellular mRNA. An example of this class of proteins is the mRNA-targeting endoribonuclease SOX from the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV). Previous studies indicated that cleavage of messenger...

journal_title：PLoS pathogens

authors： Gaglia MM,Rycroft CH,Glaunsinger BA

更新日期：2015-12-08 00:00:00

abstract：:The life long relationship between herpes simplex virus and its host hinges on the ability of the virus to aggressively replicate in epithelial cells at the site of infection and transport into the nervous system through axons innervating the infection site. Interaction between the virus and the sensory neuron represe...

journal_title：PLoS pathogens

authors： Sawtell NM,Thompson RL

更新日期：2016-09-08 00:00:00