Cooperativity between the 3' untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus.

abstract：:Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of Trypanosoma brucei, a parasite responsible for human African trypanosomiasis. Glucose enters many branches of metabolism beyond glycolysis, which has been w...

journal_title：PLoS pathogens

authors： Creek DJ,Mazet M,Achcar F,Anderson J,Kim DH,Kamour R,Morand P,Millerioux Y,Biran M,Kerkhoven EJ,Chokkathukalam A,Weidt SK,Burgess KE,Breitling R,Watson DG,Bringaud F,Barrett MP

更新日期：2015-03-16 00:00:00

abstract：:Nuclear factor of activated T cells 5 (NFAT5)/Tonicity enhancer binding protein (TonEBP) is a transcription factor induced by hypertonic stress in the kidney. However, the function of NFAT5 in other organs has rarely been studied, even though it is ubiquitously expressed. Indeed, although NFAT5 was reported to be crit...

journal_title：PLoS pathogens

authors： Qiu Y,Ye X,Zhang HM,Hanson P,Zhao G,Tong L,Xie R,Yang D

更新日期：2017-12-08 00:00:00

abstract：:To better understand the initiation of CD8(+) T cell responses during infection, the primary response to the intracellular parasite Toxoplasma gondii was characterized using 2-photon microscopy combined with an experimental system that allowed visualization of dendritic cells (DCs) and parasite specific CD8(+) T cells...

journal_title：PLoS pathogens

authors： John B,Harris TH,Tait ED,Wilson EH,Gregg B,Ng LG,Mrass P,Roos DS,Dzierszinski F,Weninger W,Hunter CA

更新日期：2009-07-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) requires the ESX1 specialized protein secretion system for virulence, for triggering cytosolic immune surveillance pathways, and for priming an optimal CD8+ T cell response. This suggests that ESX1 might act primarily by destabilizing the phagosomal membrane that surrounds the bacteriu...

journal_title：PLoS pathogens

authors： Garces A,Atmakuri K,Chase MR,Woodworth JS,Krastins B,Rothchild AC,Ramsdell TL,Lopez MF,Behar SM,Sarracino DA,Fortune SM

更新日期：2010-06-24 00:00:00

abstract：:The Pneumococcal serine-rich repeat protein (PsrP) is a pathogenicity island encoded adhesin that has been positively correlated with the ability of Streptococcus pneumoniae to cause invasive disease. Previous studies have shown that PsrP mediates bacterial attachment to Keratin 10 (K10) on the surface of lung cells t...

journal_title：PLoS pathogens

authors： Sanchez CJ,Shivshankar P,Stol K,Trakhtenbroit S,Sullam PM,Sauer K,Hermans PW,Orihuela CJ

更新日期：2010-08-12 00:00:00

abstract：:The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09 vaccination correlated with in-vivo antibody affinity maturation...

journal_title：PLoS pathogens

authors： Khurana S,Frasca D,Blomberg B,Golding H

更新日期：2012-09-01 00:00:00

abstract：:Astroviruses (AstVs) are positive sense, single-stranded RNA viruses transmitted to a wide range of hosts via the fecal-oral route. The number of AstV-infected animal hosts has rapidly expanded in recent years with many more likely to be discovered because of the advances in viral surveillance and next generation sequ...

journal_title：PLoS pathogens

authors： Karlsson EA,Small CT,Freiden P,Feeroz MM,Matsen FA 4th,San S,Hasan MK,Wang D,Jones-Engel L,Schultz-Cherry S

更新日期：2015-11-16 00:00:00

abstract：:Cellular immune responses require the generation and recruitment of diverse blood cell types that recognize and kill pathogens. In Drosophila melanogaster larvae, immune-inducible lamellocytes participate in recognizing and killing parasitoid wasp eggs. However, the sequence of events required for lamellocyte generati...

journal_title：PLoS pathogens

authors： Anderl I,Vesala L,Ihalainen TO,Vanha-Aho LM,Andó I,Rämet M,Hultmark D

更新日期：2016-07-14 00:00:00

abstract：:The Venus kinase receptor (VKR) is a single transmembrane molecule composed of an intracellular tyrosine kinase domain close to that of insulin receptor and an extracellular Venus Flytrap (VFT) structure similar to the ligand binding domain of many class C G protein coupled receptors. This receptor tyrosine kinase (RT...

journal_title：PLoS pathogens

authors： Vanderstraete M,Gouignard N,Cailliau K,Morel M,Hahnel S,Leutner S,Beckmann S,Grevelding CG,Dissous C

更新日期：2014-05-29 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) causes lifelong infection affecting between 50 and 90% of the global population. In addition to causing dermal lesions, HSV-1 is a leading cause of blindness resulting from recurrent corneal infection. Corneal disease is characterized by loss of corneal immunologic privilege and extensiv...

journal_title：PLoS pathogens

authors： Wuest T,Zheng M,Efstathiou S,Halford WP,Carr DJ

更新日期：2011-10-01 00:00:00

abstract：:The host response to mycobacterial infection depends on host and pathogen genetic factors. Recent studies in human populations suggest a strain specific genetic control of tuberculosis. To test for mycobacterial-strain specific genetic control of susceptibility to infection under highly controlled experimental conditi...

journal_title：PLoS pathogens

authors： Di Pietrantonio T,Hernandez C,Girard M,Verville A,Orlova M,Belley A,Behr MA,Loredo-Osti JC,Schurr E

更新日期：2010-10-28 00:00:00

abstract：:Foot-and-mouth disease (FMD) virus causes an acute vesicular disease of domesticated and wild ruminants and pigs. Identifying sources of FMD outbreaks is often confounded by incomplete epidemiological evidence and the numerous routes by which virus can spread (movements of infected animals or their products, contamina...

journal_title：PLoS pathogens

authors： Cottam EM,Wadsworth J,Shaw AE,Rowlands RJ,Goatley L,Maan S,Maan NS,Mertens PP,Ebert K,Li Y,Ryan ED,Juleff N,Ferris NP,Wilesmith JW,Haydon DT,King DP,Paton DJ,Knowles NJ

更新日期：2008-04-18 00:00:00

abstract：:Remodelling of the actin cytoskeleton in response to external stimuli is obligatory for many cellular processes in the amoebic cell. A rapid and local rearrangement of the actin cytoskeleton is required for the development of the cellular protrusions during phagocytosis, trogocytosis, migration, and invasion. Here, we...

journal_title：PLoS pathogens

authors： Tripathi A,Jain M,Chandra M,Parveen S,Yadav R,Collins BM,Maiti S,Datta S

更新日期：2020-05-04 00:00:00

abstract：:In this study, we investigated the significance of a conserved five-amino acid motif 'AELPR' in the C-terminal region of helper component-proteinase (HCPro) for potato virus A (PVA; genus Potyvirus) infection. This motif is a putative interaction site for WD40 domain-containing proteins, including VARICOSE (VCS). We a...

journal_title：PLoS pathogens

authors： De S,Pollari M,Varjosalo M,Mäkinen K

更新日期：2020-10-12 00:00:00

abstract：:MicroRNAs (miRNAs) suppress the transcriptional and post-transcriptional expression of genes in plants. Several miRNA families target genes encoding nucleotide-binding site-leucine-rich repeat (NB-LRR) plant innate immune receptors. The fungus Fusarium oxysporum f. sp. lycopersici causes vascular wilt disease in tomat...

journal_title：PLoS pathogens

authors： Ouyang S,Park G,Atamian HS,Han CS,Stajich JE,Kaloshian I,Borkovich KA

更新日期：2014-10-16 00:00:00

abstract：:In addition to modulating the function and stability of cellular mRNAs, microRNAs can profoundly affect the life cycles of viruses bearing sequence complementary targets, a finding recently exploited to ameliorate toxicities of vaccines and oncolytic viruses. To elucidate the mechanisms underlying microRNA-mediated an...

journal_title：PLoS pathogens

authors： Kelly EJ,Hadac EM,Cullen BR,Russell SJ

更新日期：2010-03-19 00:00:00

abstract：:Equine rhinitis A virus (ERAV) is closely related to foot-and-mouth disease virus (FMDV), belonging to the genus Aphthovirus of the Picornaviridae. How picornaviruses introduce their RNA genome into the cytoplasm of the host cell to initiate replication is unclear since they have no lipid envelope to facilitate fusion...

journal_title：PLoS pathogens

authors： Tuthill TJ,Harlos K,Walter TS,Knowles NJ,Groppelli E,Rowlands DJ,Stuart DI,Fry EE

更新日期：2009-10-01 00:00:00

abstract：:Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little is known about its possible wider regulatory role in this organism...

journal_title：PLoS pathogens

authors： De Majumdar S,Yu J,Fookes M,McAteer SP,Llobet E,Finn S,Spence S,Monahan A,Monaghan A,Kissenpfennig A,Ingram RJ,Bengoechea J,Gally DL,Fanning S,Elborn JS,Schneiders T

更新日期：2015-01-29 00:00:00

abstract：:The life long relationship between herpes simplex virus and its host hinges on the ability of the virus to aggressively replicate in epithelial cells at the site of infection and transport into the nervous system through axons innervating the infection site. Interaction between the virus and the sensory neuron represe...

journal_title：PLoS pathogens

authors： Sawtell NM,Thompson RL

更新日期：2016-09-08 00:00:00

abstract：:IFNγ signaling drives dendritic cells (DCs) to promote type I T cell (Th1) immunity. Here, we show that activation of DCs by IFNγ is equally crucial for the differentiation of a population of T-bet+ regulatory T (Treg) cells specialized to inhibit Th1 immune responses. Conditional deletion of IFNγ receptor in DCs but ...

journal_title：PLoS pathogens

authors： Lee HM,Fleige A,Forman R,Cho S,Khan AA,Lin LL,Nguyen DT,O'Hara-Hall A,Yin Z,Hunter CA,Muller W,Lu LF

更新日期：2015-02-06 00:00:00

abstract：:Although the importance of humoral immunity to malaria has been established, factors that control antibody production are poorly understood. Follicular helper T cells (Tfh cells) are pivotal for generating high-affinity, long-lived antibody responses. While it has been proposed that expansion of antigen-specific Tfh c...

journal_title：PLoS pathogens

authors： Figueiredo MM,Costa PAC,Diniz SQ,Henriques PM,Kano FS,Tada MS,Pereira DB,Soares IS,Martins-Filho OA,Jankovic D,Gazzinelli RT,Antonelli LRDV

更新日期：2017-07-10 00:00:00

abstract：:Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc. Prion diseases are invariably fatal and currently incurable, but oral drugs that can prolong incubation times in prion-infected mice have been developed. Here, we test...

journal_title：PLoS pathogens

authors： Burke CM,Mark KMK,Kun J,Beauchemin KS,Supattapone S

更新日期：2020-05-18 00:00:00

abstract：:B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (TFH) cells. We studied the effects of native heterodimeric IL-15 (hetIL-15) treatmen...

journal_title：PLoS pathogens

authors： Watson DC,Moysi E,Valentin A,Bergamaschi C,Devasundaram S,Fortis SP,Bear J,Chertova E,Bess J Jr,Sowder R,Venzon DJ,Deleage C,Estes JD,Lifson JD,Petrovas C,Felber BK,Pavlakis GN

更新日期：2018-02-23 00:00:00

abstract：:All pathogenesis and death associated with Plasmodium falciparum malaria is due to parasite-infected erythrocytes. Invasion of erythrocytes by P. falciparum merozoites requires specific interactions between host receptors and parasite ligands that are localized in apical organelles called micronemes. Here, we identify...

journal_title：PLoS pathogens

authors： Dawn A,Singh S,More KR,Siddiqui FA,Pachikara N,Ramdani G,Langsley G,Chitnis CE

更新日期：2014-12-18 00:00:00

abstract：:Mycobacterium tuberculosis is sensitive to nitric oxide generated by inducible nitric oxide synthase (iNOS). Consequently, to ensure its survival in macrophages, M. tuberculosis inhibits iNOS recruitment to its phagosome by an unknown mechanism. Here we report the mechanism underlying this process, whereby mycobacteri...

journal_title：PLoS pathogens

authors： Davis AS,Vergne I,Master SS,Kyei GB,Chua J,Deretic V

更新日期：2007-12-01 00:00:00

abstract：:We performed a quantitative analysis of the HLA restriction, antigen and epitope specificity of human pathogen specific responses in healthy individuals infected with M. tuberculosis (Mtb), in a South African cohort as a test case. The results estimate the breadth of T cell responses for the first time in the context ...

journal_title：PLoS pathogens

authors： Lindestam Arlehamn CS,McKinney DM,Carpenter C,Paul S,Rozot V,Makgotlho E,Gregg Y,van Rooyen M,Ernst JD,Hatherill M,Hanekom WA,Peters B,Scriba TJ,Sette A

更新日期：2016-07-13 00:00:00

abstract：:Previously, we demonstrated that Pseudomonas aeruginosa ExoT induces potent apoptosis in host epithelial cells in a manner that primarily depends on its ADP-ribosyltransferase domain (ADPRT) activity. However, the mechanism underlying ExoT/ADPRT-induced apoptosis remains undetermined. We now report that ExoT/ADPRT dis...

journal_title：PLoS pathogens

authors： Wood S,Goldufsky J,Shafikhani SH

更新日期：2015-05-28 00:00:00

abstract：:Human herpesviruses are antigenically rich agents that induce strong CD8+T cell responses in primary infection yet persist for life, continually challenging T cell memory through recurrent lytic replication and potentially influencing the spectrum of antigen-specific responses. Here we describe the first lytic proteom...

journal_title：PLoS pathogens

authors： Forrest C,Hislop AD,Rickinson AB,Zuo J

更新日期：2018-09-24 00:00:00

abstract：:Reverse transcriptase (RT) is the target for the majority of anti-HIV-1 drugs. As with all anti-AIDS treatments, continued success of RT inhibitors is persistently disrupted by the occurrence of resistance mutations. To explore latent resistance mechanisms potentially accessible to therapeutically challenged HIV-1 vir...

journal_title：PLoS pathogens

authors： Galilee M,Alian A

更新日期：2018-01-24 00:00:00

abstract：:Successful replication and transmission of large DNA viruses such as the cytomegaloviruses (CMV) family of viruses depends on the ability to interfere with multiple aspects of the host immune response. Apoptosis functions as a host innate defence mechanism against viral infection, and the capacity to interfere with th...

journal_title：PLoS pathogens

authors： Fleming P,Kvansakul M,Voigt V,Kile BT,Kluck RM,Huang DC,Degli-Esposti MA,Andoniou CE

更新日期：2013-02-01 00:00:00