Immobility in the sedentary plant-parasitic nematode H. glycines is associated with remodeling of neuromuscular tissue.

abstract：:Open reading frame (ORF) 45 of Kaposi's sarcoma-associated herpesvirus (KSHV) is a tegument protein. A genetic analysis with a null mutant suggested a possible role for this protein in the events leading to viral egress. In this study, ORF45 was found to interact with KIF3A, a kinesin-2 motor protein that transports c...

journal_title：PLoS pathogens

authors： Sathish N,Zhu FX,Yuan Y

更新日期：2009-03-01 00:00:00

abstract：:All gammaherpesviruses encode a major glycoprotein homologous to the Epstein-Barr virus gp350. These glycoproteins are often involved in cell binding, and some provide neutralization targets. However, the capacity of gammaherpesviruses for long-term transmission from immune hosts implies that in vivo neutralization is...

journal_title：PLoS pathogens

authors： Machiels B,Lété C,Guillaume A,Mast J,Stevenson PG,Vanderplasschen A,Gillet L

更新日期：2011-11-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection induces an atypical CD8 T cell response, termed inflationary, that is characterised by accumulation and maintenance of high numbers of effector memory like cells in circulation and peripheral tissues-a feature being successfully harnessed for vaccine purposes. Although stability of this...

journal_title：PLoS pathogens

authors： Baumann NS,Torti N,Welten SPM,Barnstorf I,Borsa M,Pallmer K,Oduro JD,Cicin-Sain L,Ikuta K,Ludewig B,Oxenius A

更新日期：2018-04-13 00:00:00

abstract：:During infection Neisseria meningitidis (Nm) encounters multiple environments within the host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the importance of invasion into the bloodstream in the meningococcal disease process, little is known about how Nm adapts to permit survival a...

journal_title：PLoS pathogens

authors： Echenique-Rivera H,Muzzi A,Del Tordello E,Seib KL,Francois P,Rappuoli R,Pizza M,Serruto D

更新日期：2011-05-01 00:00:00

abstract：:Host genetic variation modifying HIV-1 acquisition risk can inform development of HIV-1 prevention strategies. However, associations between rare or intermediate-frequency variants and HIV-1 acquisition are not well studied. We tested for the association between variation in genic regions and extreme HIV-1 acquisition...

journal_title：PLoS pathogens

authors： Mackelprang RD,Bamshad MJ,Chong JX,Hou X,Buckingham KJ,Shively K,deBruyn G,Mugo NR,Mullins JI,McElrath MJ,Baeten JM,Celum C,Emond MJ,Lingappa JR,Partners in Prevention HSV\/HIV Transmission Study and the Partners PrEP Study T

更新日期：2017-11-06 00:00:00

abstract：:Human T Lymphotropic virus (HTLV) infection can persist in individuals resulting, at least in part, from viral escape of the innate immunity, including inhibition of type I interferon response in infected T-cells. Plasmacytoid dendritic cells (pDCs) are known to bypass viral escape by their robust type I interferon pr...

journal_title：PLoS pathogens

authors： Assil S,Futsch N,Décembre E,Alais S,Gessain A,Cosset FL,Mahieux R,Dreux M,Dutartre H

更新日期：2019-02-28 00:00:00

abstract：:Poliomyelitis has nearly been eradicated through the efforts of the World Health Organization's Global Eradication Initiative raising questions on containment of the virus after it has been eliminated in the wild. Most manufacture of inactivated polio vaccines currently requires the growth of large amounts of highly v...

journal_title：PLoS pathogens

authors： Knowlson S,Burlison J,Giles E,Fox H,Macadam AJ,Minor PD

更新日期：2015-12-31 00:00:00

abstract：:The COVID-19 pandemic highlights the substantial public health, economic, and societal consequences of virus spillover from a wildlife reservoir. Widespread human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also presents a new set of challenges when considering viral spillover from peo...

journal_title：PLoS pathogens

authors： Olival KJ,Cryan PM,Amman BR,Baric RS,Blehert DS,Brook CE,Calisher CH,Castle KT,Coleman JTH,Daszak P,Epstein JH,Field H,Frick WF,Gilbert AT,Hayman DTS,Ip HS,Karesh WB,Johnson CK,Kading RC,Kingston T,Lorch JM,Mend

更新日期：2020-09-03 00:00:00

abstract：:As humans age, they experience a progressive loss of thymic function and a corresponding shift in the makeup of the circulating CD8+ T cell population from naïve to memory phenotype. These alterations are believed to result in impaired CD8+ T cell responses in older individuals; however, evidence that these global cha...

journal_title：PLoS pathogens

authors： Lelic A,Verschoor CP,Ventresca M,Parsons R,Evelegh C,Bowdish D,Betts MR,Loeb MB,Bramson JL

更新日期：2012-01-01 00:00:00

abstract：:Innate immune cells shape the host response to microbial pathogens. Here we elucidate critical differences in the molecular response of macrophages vs. dendritic cells (DCs) to Histoplasma capsulatum, an intracellular fungal pathogen of humans. It has long been known that macrophages are permissive for Histoplasma gro...

journal_title：PLoS pathogens

authors： Van Prooyen N,Henderson CA,Hocking Murray D,Sil A

更新日期：2016-07-26 00:00:00

abstract：:Human bocavirus 1 (HBoV1) belongs to the genus Bocaparvovirus of the Parvoviridae family, and is an emerging human pathogenic respiratory virus. In vitro, HBoV1 infects well-differentiated/polarized primary human airway epithelium (HAE) cultured at an air-liquid interface (HAE-ALI). Although it is well known that auto...

journal_title：PLoS pathogens

authors： Deng X,Yan Z,Cheng F,Engelhardt JF,Qiu J

更新日期：2016-01-14 00:00:00

abstract：:Our appreciation for the extent of Epstein Barr virus (EBV) transcriptome complexity continues to grow through findings of EBV encoded microRNAs, new long non-coding RNAs as well as the more recent discovery of over a hundred new polyadenylated lytic transcripts. Here we report an additional layer to the EBV transcrip...

journal_title：PLoS pathogens

authors： Ungerleider N,Concha M,Lin Z,Roberts C,Wang X,Cao S,Baddoo M,Moss WN,Yu Y,Seddon M,Lehman T,Tibbetts S,Renne R,Dong Y,Flemington EK

更新日期：2018-08-06 00:00:00

abstract：:Critical aspects of HIV-1 infection occur in mucosal tissues, particularly in the gut, which contains large numbers of HIV-1 target cells that are depleted early in infection. We used electron tomography (ET) to image HIV-1 in gut-associated lymphoid tissue (GALT) of HIV-1-infected humanized mice, the first three-dime...

journal_title：PLoS pathogens

authors： Ladinsky MS,Kieffer C,Olson G,Deruaz M,Vrbanac V,Tager AM,Kwon DS,Bjorkman PJ

更新日期：2014-01-30 00:00:00

abstract：:Unlike the pandemic form of HIV-1 (group M), group O viruses are endemic in west central Africa, especially in Cameroon. However, little is known about group O's genetic evolution, and why this highly divergent lineage has not become pandemic. Using a unique and large set of group O sequences from samples collected fr...

journal_title：PLoS pathogens

authors： Leoz M,Feyertag F,Kfutwah A,Mauclère P,Lachenal G,Damond F,De Oliveira F,Lemée V,Simon F,Robertson DL,Plantier JC

更新日期：2015-08-04 00:00:00

abstract：:Metalloproteases (MPs) have demonstrated roles in immune modulation. In some cases, these enzymes are produced by parasites to influence host immune responses such that parasite infection is facilitated. One of the best examples of parasite-mediated immune modulation is the matrix metalloprotease (MMP) leishmanolysin ...

journal_title：PLoS pathogens

authors： Hambrook JR,Kaboré AL,Pila EA,Hanington PC

更新日期：2018-10-29 00:00:00

abstract：:The Pseudomonas syringae acetyltransferase HopZ1a is delivered into host cells by the type III secretion system to promote bacterial growth. However, in the model plant host Arabidopsis thaliana, HopZ1a activity results in an effector-triggered immune response (ETI) that limits bacterial proliferation. HopZ1a-triggere...

journal_title：PLoS pathogens

authors： Bastedo DP,Khan M,Martel A,Seto D,Kireeva I,Zhang J,Masud W,Millar D,Lee JY,Lee AH,Gong Y,Santos-Severino A,Guttman DS,Desveaux D

更新日期：2019-07-03 00:00:00

abstract：:The high environmental adaptability of bacteria is contingent upon their ability to sense changes in their surroundings. Bacterial pathogen entry into host poses an abrupt and dramatic environmental change, during which successful pathogens gauge multiple parameters that signal host localization. The facultative human...

journal_title：PLoS pathogens

authors： Haber A,Friedman S,Lobel L,Burg-Golani T,Sigal N,Rose J,Livnat-Levanon N,Lewinson O,Herskovits AA

更新日期：2017-01-23 00:00:00

abstract：:RIG-I-Like Receptors (RLRs) sense cytosolic viral RNA to transiently activate type I IFN production. Here, we report that a type I IFN inducible DExD/H helicase, DDX24, exerts a negative-regulatory effect on RLR function. Expression of DDX24 specifically suppressed RLR activity, while DDX24 loss, which caused embryoni...

journal_title：PLoS pathogens

authors： Ma Z,Moore R,Xu X,Barber GN

更新日期：2013-10-01 00:00:00

abstract：:In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory neurons. In humans, local opioids and opioid peptides significantly...

journal_title：PLoS pathogens

authors： Rittner HL,Hackel D,Voigt P,Mousa S,Stolz A,Labuz D,Schäfer M,Schaefer M,Stein C,Brack A

更新日期：2009-04-01 00:00:00

abstract：:Yersinia utilizes a sophisticated type III secretion system to enhance its chances of survival and to overcome the host immune system. SmpB (small protein B) and SsrA (small stable RNA A) are components of a unique bacterial translational control system that help maintain the bacterial translational machinery in a ful...

journal_title：PLoS pathogens

authors： Okan NA,Bliska JB,Karzai AW

更新日期：2006-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1002924.]. ...

journal_title：PLoS pathogens

authors： Grard G,Fair JN,Lee D,Slikas E,Steffen I,Muyembe JJ,Sittler T,Veeraraghavan N,Ruby JG,Wang C,Makuwa M,Mulembakani P,Tesh RB,Mazet J,Rimoin AW,Taylor T,Schneider BS,Simmons G,Delwart E,Wolfe ND,Chiu CY,Leroy EM

更新日期：2017-09-07 00:00:00

abstract：:Kaposi's sarcoma (KS) lesions are complex mixtures of KS-associated herpesvirus (KSHV)-infected spindle and inflammatory cells. In order to survive the host immune responses, KSHV encodes a number of immunomodulatory proteins, including the E3 ubiquitin ligase K5. In exploring the role of this viral protein in monocyt...

journal_title：PLoS pathogens

authors： Karki R,Lang SM,Means RE

更新日期：2011-04-01 00:00:00

abstract：:The obligate intracellular, gram-negative bacterium Chlamydophila pneumoniae (Cpn) has impact as a human pathogen. Little is known about changes in the Cpn transcriptome during its biphasic developmental cycle (the acute infection) and persistence. The latter stage has been linked to chronic diseases. To analyze Cpn C...

journal_title：PLoS pathogens

authors： Mäurer AP,Mehlitz A,Mollenkopf HJ,Meyer TF

更新日期：2007-06-01 00:00:00

abstract：:Exosomes are secreted cellular vesicles that can induce specific CD4(+) T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic a...

journal_title：PLoS pathogens

authors： Izquierdo-Useros N,Naranjo-Gómez M,Erkizia I,Puertas MC,Borràs FE,Blanco J,Martinez-Picado J

更新日期：2010-03-26 00:00:00

abstract：:Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8(+) T cell responses in a context of chronic inflammation and antigen persistence, since it is characterized by chronic infection in the spleen and CD8(+) T cells are required for the development of protective immunity. However, antigen...

journal_title：PLoS pathogens

authors： Joshi T,Rodriguez S,Perovic V,Cockburn IA,Stäger S

更新日期：2009-05-01 00:00:00

abstract：:The primary role of cytoplasmic viral RNA-dependent RNA polymerase (RdRp) is viral genome replication in the cellular cytoplasm. However, picornaviral RdRp denoted 3D polymerase (3D(pol)) also enters the host nucleus, where its function remains unclear. In this study, we describe a novel mechanism of viral attack in w...

journal_title：PLoS pathogens

authors： Liu YC,Kuo RL,Lin JY,Huang PN,Huang Y,Liu H,Arnold JJ,Chen SJ,Wang RY,Cameron CE,Shih SR

更新日期：2014-06-26 00:00:00

abstract：:Human noroviruses (huNoV) are the most frequent cause of non-bacterial acute gastroenteritis worldwide, particularly genogroup II genotype 4 (GII.4) variants. The viral nonstructural (NS) proteins encoded by the ORF1 polyprotein induce vesical clusters harboring the viral replication sites. Little is known so far abou...

journal_title：PLoS pathogens

authors： Doerflinger SY,Cortese M,Romero-Brey I,Menne Z,Tubiana T,Schenk C,White PA,Bartenschlager R,Bressanelli S,Hansman GS,Lohmann V

更新日期：2017-10-27 00:00:00

abstract：:Apicomplexans are obligate intracellular parasites that actively penetrate their host cells to create an intracellular niche for replication. Commitment to invasion is thought to be mediated by the rhoptries, specialized apical secretory organelles that inject a protein complex into the host cell to form a tight-junct...

journal_title：PLoS pathogens

authors： Beck JR,Fung C,Straub KW,Coppens I,Vashisht AA,Wohlschlegel JA,Bradley PJ

更新日期：2013-02-01 00:00:00

abstract：:Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate...

journal_title：PLoS pathogens

authors： Liang J,Sagum CA,Bedford MT,Sidhu SS,Sudol M,Han Z,Harty RN

更新日期：2017-01-11 00:00:00

abstract：:CD4(+) T cell loss is central to HIV pathogenesis. In the initial weeks post-infection, the great majority of dying cells are uninfected CD4(+) T cells. We previously showed that the 3S motif of HIV-1 gp41 induces surface expression of NKp44L, a cellular ligand for an activating NK receptor, on uninfected bystander CD...

journal_title：PLoS pathogens

authors： Fausther-Bovendo H,Vieillard V,Sagan S,Bismuth G,Debré P

更新日期：2010-07-01 00:00:00