Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells.

abstract：:Many broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1) were shown effective in animal models, and are currently evaluated in clinical trials. However, use of these antibodies in humans is hampered by the rapid emergence of resistant viruses. Here we show that soft-randomizatio...

journal_title：PLoS pathogens

authors： Otsuka Y,Schmitt K,Quinlan BD,Gardner MR,Alfant B,Reich A,Farzan M,Choe H

更新日期：2018-08-20 00:00:00

abstract：:HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contain an incomplete spherical shell where Gag is arranged with the N-term...

journal_title：PLoS pathogens

authors： de Marco A,Müller B,Glass B,Riches JD,Kräusslich HG,Briggs JA

更新日期：2010-11-24 00:00:00

abstract：:Bdellovibrio bacteriovorus is a Delta-proteobacterium that oscillates between free-living growth and predation on Gram-negative bacteria including important pathogens of man, animals and plants. After entering the prey periplasm, killing the prey and replicating inside the prey bdelloplast, several motile B. bacteriov...

journal_title：PLoS pathogens

authors： Hobley L,Fung RK,Lambert C,Harris MA,Dabhi JM,King SS,Basford SM,Uchida K,Till R,Ahmad R,Aizawa S,Gomelsky M,Sockett RE

更新日期：2012-02-01 00:00:00

abstract：:IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in transcriptional regulation, also functions as an innate immune response DNA sensor and induces the IL-1β and antiviral type-1 interferon-β (IFN-β) cytokines. We have shown that IFI16, in association with BRCA1, functions as a se...

journal_title：PLoS pathogens

authors： Iqbal J,Ansari MA,Kumar B,Dutta D,Roy A,Chikoti L,Pisano G,Dutta S,Vahedi S,Veettil MV,Chandran B

更新日期：2016-10-20 00:00:00

abstract：:Two billion people are latently infected with Mycobacterium tuberculosis (Mtb). Mtb-infected macrophages are likely to be sequestered inside the hypoxic environments of the granuloma and differentiate into lipid-loaded macrophages that contain triacylglycerol (TAG)-filled lipid droplets which may provide a fatty acid-...

journal_title：PLoS pathogens

authors： Daniel J,Maamar H,Deb C,Sirakova TD,Kolattukudy PE

更新日期：2011-06-01 00:00:00

abstract：:Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation characterized by the influx of myeloid cells and production of proinflammatory cytokines including interferons (IFNs). It is unclear, however, how the immune system clears the virus without causing lethal immunopathology. Here,...

journal_title：PLoS pathogens

authors： Stifter SA,Bhattacharyya N,Pillay R,Flórido M,Triccas JA,Britton WJ,Feng CG

更新日期：2016-01-05 00:00:00

abstract：:A defect in the PKA1 gene encoding the catalytic subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase A (PKA) is known to reduce capsule size and attenuate virulence in the fungal pathogen Cryptococcus neoformans. Conversely, loss of the PKA regulatory subunit encoded by pkr1 results in overpro...

journal_title：PLoS pathogens

authors： Hu G,Steen BR,Lian T,Sham AP,Tam N,Tangen KL,Kronstad JW

更新日期：2007-03-01 00:00:00

abstract：:Hepatitis B virus (HBV) core protein (HBc) contains an N-terminal domain (NTD, assembly domain) and a C-terminal domain (CTD), which are linked by a flexible linker region. HBc plays multiple essential roles in viral replication, including capsid assembly, packaging of the viral pregenomic RNA (pgRNA) into nucleocapsi...

journal_title：PLoS pathogens

authors： Liu K,Luckenbaugh L,Ning X,Xi J,Hu J

更新日期：2018-05-21 00:00:00

abstract：:Plant parasitic nematodes (PPNs) seriously threaten global food security. Conventionally an integrated approach to PPN management has relied heavily on carbamate, organophosphate and fumigant nematicides which are now being withdrawn over environmental health and safety concerns. This progressive withdrawal has left a...

journal_title：PLoS pathogens

authors： Warnock ND,Wilson L,Patten C,Fleming CC,Maule AG,Dalzell JJ

更新日期：2017-02-27 00:00:00

abstract：:One of the hallmarks of adaptive immunity is the development of a long-term pathogen specific memory response. While persistent memory T cells certainly impact the immune response during a secondary challenge, their role in unrelated infections is less clear. To address this issue, we utilized lymphocytic choriomening...

journal_title：PLoS pathogens

authors： Crosby EJ,Goldschmidt MH,Wherry EJ,Scott P

更新日期：2014-02-27 00:00:00

abstract：:Cells of the immune system are derived from hematopoietic stem cells (HSCs) residing in the bone marrow. HSCs become activated in response to stress, such as acute infections, which adapt the bone marrow output to the needs of the immune response. However, the impact of infection-adapted HSC activation and differentia...

journal_title：PLoS pathogens

authors： Abidin BM,Hammami A,Stäger S,Heinonen KM

更新日期：2017-08-07 00:00:00

abstract：:Host genetic variation modifying HIV-1 acquisition risk can inform development of HIV-1 prevention strategies. However, associations between rare or intermediate-frequency variants and HIV-1 acquisition are not well studied. We tested for the association between variation in genic regions and extreme HIV-1 acquisition...

journal_title：PLoS pathogens

authors： Mackelprang RD,Bamshad MJ,Chong JX,Hou X,Buckingham KJ,Shively K,deBruyn G,Mugo NR,Mullins JI,McElrath MJ,Baeten JM,Celum C,Emond MJ,Lingappa JR,Partners in Prevention HSV\/HIV Transmission Study and the Partners PrEP Study T

更新日期：2017-11-06 00:00:00

abstract：:Herpesviruses persist indefinitely in their host through complex and poorly defined interactions that mediate latent, chronic or productive states of infection. Human cytomegalovirus (CMV or HCMV), a ubiquitous β-herpesvirus, coordinates the expression of two viral genes, UL135 and UL138, which have opposing roles in ...

journal_title：PLoS pathogens

authors： Buehler J,Zeltzer S,Reitsma J,Petrucelli A,Umashankar M,Rak M,Zagallo P,Schroeder J,Terhune S,Goodrum F

更新日期：2016-05-24 00:00:00

abstract：:Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leishmania and related trypanosomatids, which lack catalase and selenium-glutathione peroxidases, the discovery of this family of enzymes provided the molecular basis for peroxide removal in these organisms. In this report ...

journal_title：PLoS pathogens

authors： Castro H,Teixeira F,Romao S,Santos M,Cruz T,Flórido M,Appelberg R,Oliveira P,Ferreira-da-Silva F,Tomás AM

更新日期：2011-10-01 00:00:00

abstract：:The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (T4SS) VirB, which is thought to translocate effector proteins that mo...

journal_title：PLoS pathogens

authors： Myeni S,Child R,Ng TW,Kupko JJ 3rd,Wehrly TD,Porcella SF,Knodler LA,Celli J

更新日期：2013-01-01 00:00:00

abstract：:Malaria, caused by the apicomplexan parasite Plasmodium, still represents a major threat to human health and welfare and leads to about one million human deaths annually. Plasmodium is a rapidly multiplying unicellular organism undergoing a complex developmental cycle in man and mosquito - a life style that requires r...

journal_title：PLoS pathogens

authors： Kehr S,Sturm N,Rahlfs S,Przyborski JM,Becker K

更新日期：2010-12-23 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

journal_title：PLoS pathogens

authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

更新日期：2019-07-15 00:00:00

abstract：:The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell-mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number of important features of the immune system that relate directly to the...

journal_title：PLoS pathogens

authors： Chen CY,Huang D,Wang RC,Shen L,Zeng G,Yao S,Shen Y,Halliday L,Fortman J,McAllister M,Estep J,Hunt R,Vasconcelos D,Du G,Porcelli SA,Larsen MH,Jacobs WR Jr,Haynes BF,Letvin NL,Chen ZW

更新日期：2009-04-01 00:00:00

abstract：:Replication of viroids, small non-protein-coding plant pathogenic RNAs, entails reiterative transcription of their incoming single-stranded circular genomes, to which the (+) polarity is arbitrarily assigned, cleavage of the oligomeric strands of one or both polarities to unit-length, and ligation to circular RNAs. Wh...

journal_title：PLoS pathogens

authors： Gas ME,Hernández C,Flores R,Daròs JA

更新日期：2007-11-01 00:00:00

abstract：:Amebiasis is caused by the protozoan parasite Entamoeba histolytica (Eh), a potentially fatal disease occurring mainly in developing countries. How Eh interacts with innate host factors in the gut is poorly understood. Eh resides and feed in/on the outer colonic mucus layer and thus share an ecological niche with indi...

journal_title：PLoS pathogens

authors： Leon-Coria A,Kumar M,Moreau F,Chadee K

更新日期：2018-11-30 00:00:00

abstract：:Peptides presentation to T cells by MHC class II molecules is of importance in initiation of immune response to a pathogen. The level of MHC II expression directly influences T lymphocyte activation and is often targeted by various viruses. Kaposi's sarcoma-associated herpesvirus (KSHV) encoded LANA is known to evade ...

journal_title：PLoS pathogens

authors： Cai Q,Banerjee S,Cervini A,Lu J,Hislop AD,Dzeng R,Robertson ES

更新日期：2013-10-01 00:00:00

abstract：:During blood stage Plasmodium falciparum infection, merozoites invade uninfected erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand binding events. Understanding each element in this process increases the potential to block the parasite's life cycle via drugs or vaccines. To i...

journal_title：PLoS pathogens

authors： Weiss GE,Gilson PR,Taechalertpaisarn T,Tham WH,de Jong NW,Harvey KL,Fowkes FJ,Barlow PN,Rayner JC,Wright GJ,Cowman AF,Crabb BS

更新日期：2015-02-27 00:00:00

abstract：:Plasmodium falciparum malaria kills over 500,000 children every year and has been a scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum parasites, the human genome is imprinted with polymorphisms that not only confer innate resistance to falciparum malaria, but also cause hemoglobino...

journal_title：PLoS pathogens

authors： Taylor SM,Cerami C,Fairhurst RM

更新日期：2013-01-01 00:00:00

abstract：:Although the intracellular bacterium Listeria monocytogenes has an established predilection for disseminated infection during pregnancy that often results in spontaneous abortion or stillbirth, the specific host-pathogen interaction that dictates these disastrous complications remain incompletely defined. Herein, we d...

journal_title：PLoS pathogens

authors： Rowe JH,Ertelt JM,Xin L,Way SS

更新日期：2012-01-01 00:00:00

abstract：:Marburg virus (family Filoviridae) causes sporadic outbreaks of severe hemorrhagic disease in sub-Saharan Africa. Bats have been implicated as likely natural reservoir hosts based most recently on an investigation of cases among miners infected in 2007 at the Kitaka mine, Uganda, which contained a large population of ...

journal_title：PLoS pathogens

authors： Amman BR,Carroll SA,Reed ZD,Sealy TK,Balinandi S,Swanepoel R,Kemp A,Erickson BR,Comer JA,Campbell S,Cannon DL,Khristova ML,Atimnedi P,Paddock CD,Crockett RJ,Flietstra TD,Warfield KL,Unfer R,Katongole-Mbidde E,Downin

更新日期：2012-01-01 00:00:00

abstract：:The factors that govern the development of tuberculosis disease are incompletely understood. We hypothesized that some strains of Mycobacterium tuberculosis (M. tuberculosis) are more capable of causing disseminated disease than others and may be associated with polymorphisms in host genes responsible for the innate i...

journal_title：PLoS pathogens

authors： Caws M,Thwaites G,Dunstan S,Hawn TR,Lan NT,Thuong NT,Stepniewska K,Huyen MN,Bang ND,Loc TH,Gagneux S,van Soolingen D,Kremer K,van der Sande M,Small P,Anh PT,Chinh NT,Quy HT,Duyen NT,Tho DQ,Hieu NT,Torok E,Hien

更新日期：2008-03-28 00:00:00

abstract：:Reverse transcriptase (RT) is the target for the majority of anti-HIV-1 drugs. As with all anti-AIDS treatments, continued success of RT inhibitors is persistently disrupted by the occurrence of resistance mutations. To explore latent resistance mechanisms potentially accessible to therapeutically challenged HIV-1 vir...

journal_title：PLoS pathogens

authors： Galilee M,Alian A

更新日期：2018-01-24 00:00:00

abstract：:We have characterized a novel pleiotropic role for CymR, the master regulator of cysteine metabolism. We show here that CymR plays an important role both in stress response and virulence of Staphylococcus aureus. Genes involved in detoxification processes, including oxidative stress response and metal ion homeostasis,...

journal_title：PLoS pathogens

authors： Soutourina O,Dubrac S,Poupel O,Msadek T,Martin-Verstraete I

更新日期：2010-05-13 00:00:00

abstract：:The African sleeping sickness parasite Trypanosoma brucei evades the host immune system through antigenic variation of its variant surface glycoprotein (VSG) coat. Although the T. brucei genome contains ∼1500 VSGs, only one VSG is expressed at a time from one of about 15 subtelomeric VSG expression sites (ESs). For an...

journal_title：PLoS pathogens

authors： Povelones ML,Gluenz E,Dembek M,Gull K,Rudenko G

更新日期：2012-01-01 00:00:00

abstract：:Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 and MASP-2, the two key activator proteases of the complement lec...

journal_title：PLoS pathogens

authors： Nagy ZA,Szakács D,Boros E,Héja D,Vígh E,Sándor N,Józsi M,Oroszlán G,Dobó J,Gál P,Pál G

更新日期：2019-12-20 00:00:00