Wernicke's encephalopathy with cortical abnormalities: clinicoradiological features: report of 3 new cases and review of the literature.

Abstract:

OBJECTIVE:To investigate clinical and magnetic resonance imaging (MRI) features of Wernicke's encephalopathy with cortical abnormalities (WEc). METHODS:We retrospectively evaluated the clinical features and MRI findings in 3 cases of WEc in comparison with those of 7 previously reported cases. RESULTS:Besides the classical triad of ocular abnormalities, ataxia and global confusion, muscular weakness of all extremities was frequently recognized (5 of 6 evaluable cases; 83%). During the clinical courses, 2 patients (20%) died and 1 fell into a vegetative state. The cortical abnormalities were distributed in the frontal and parietal lobes, especially around the bilateral central sulcus, in all cases. In 1 case, the cortical abnormality was irreversible, and the abnormal lesion, similar to that seen in laminar necrosis, persisted. CONCLUSIONS:Bilateral frontal cortical abnormalities around the central sulcus and muscular weakness of all extremities might be the characteristic features of WEc.

journal_name

Eur Neurol

journal_title

European neurology

authors

Sakurai K,Sasaki S,Hara M,Yamawaki T,Shibamoto Y

doi

10.1159/000235596

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

274-80

issue

5

eissn

0014-3022

issn

1421-9913

pii

000235596

journal_volume

62

pub_type

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