Abstract:
:A significant number of patients with primary hyperparathyroidism have negative preoperative 201Tl/99Tcm subtraction localization scans. In this study an attempt was made to improve scan localization by creating a period of relative hypocalcaemia and increased parathyroid hormone (PTH) secretion before scanning. Six patients with primary hyperparathyroidism were studied (mean serum calcium 2.80 mmol l-1; range 2.70-2.95). All had had a negative standard 201Tl/99Tcm scan carried out within the 6 months prior to this study. Patients were commenced on an intravenous infusion of the calcium chelating agent trisodium edetate at a dose of 24 mg kg-1 h-1 given in 500 ml 0.9% saline over 90 min. Immediately thereafter a 201Tl/99Tcm scan was carried out in the usual way. Three patients showed areas of discordant thallium uptake consistent with the presence of a parathyroid adenoma. Two of these patients had surgery and an adenoma was found at the site corresponding to the scan appearances. It would appear that creating relative hypocalcaemia and increasing PTH secretion may allow increased thallium uptake, possibly secondary to the increased cellular metabolic activity, and thus creating a positive scan.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Gallacher SJ,Fraser WD,Logue FC,Boyle IT,Gray HW,McKillop JHdoi
10.1097/00006231-199109000-00005subject
Has Abstractpub_date
1991-09-01 00:00:00pages
793-7issue
9eissn
0143-3636issn
1473-5628journal_volume
12pub_type
杂志文章abstract::Since 99Tcm-DTPA is diffusible and not significantly protein bound in plasma, it rapidly enters the extravascular space following injection. Therefore, during the first few minutes of the DTPA renogram, the period on which the measurements of individual kidney glomerular filtration rate and differential function are b...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198812000-00006
更新日期:1988-12-01 00:00:00
abstract::Lymphoscintigraphy for sentinel node (SN) detection has been studied extensively in melanoma and breast cancer. In head and neck squamous cell carcinoma (HNSCC), however, experience in this field is relatively meagre. The purpose of this study was to document and evaluate lymphoscintigraphic findings in HNSCC patients...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200306000-00006
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motio...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000539
更新日期:2016-09-01 00:00:00
abstract::Recombinant human thyrotropin (rhTSH) has been evaluated in 38 patients with differentiated thyroid cancer. The patients had all been treated previously by operation and 31 had received radioiodine 131I. The patients continued to take thyroid hormone and changed to a low iodine diet for 14 days before and throughout t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200006000-00004
更新日期:2000-06-01 00:00:00
abstract::Radically operated tumour patients (gastrointestinal cancer, n = 10; lung cancer, n = 10) were subjected to continuous prospective monitoring of the serum level of tissue polypeptide antigen (TPA) prior to surgical treatment as well as during the subsequent year. The following observations were made: Immediately after...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198602000-00007
更新日期:1986-02-01 00:00:00
abstract::The physical considerations of using dual isotope brain SPECT imaging to monitor blood flow changes during cognitive activation studies were investigated. These factors included field uniformity, spatial resolution and crosstalk. Serial dual isotope single photon emission computed tomographic (SPECT) studies of a test...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199305000-00008
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to assess the influence of different normalization procedures on relative changes in standardized uptake values (SUV) of F-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for the assessment of chemotherapy response in patients with colorectal carcinoma ...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e32832bdc80
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:Detection of recurrent disease is essential for treatment planning in patients with paraganglioma. The aim of this study was to compare 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy [whole-body and single-photon emission computed tomography (SPECT) computed tomography (CT) scanning] and fluorine-18-L...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328345a340
更新日期:2011-07-01 00:00:00
abstract::Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring >90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5-2% of hypertensive children. Gastroenteropancreatic NETs can occ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001305
更新日期:2021-01-01 00:00:00
abstract::The purpose of this study was to validate different scintigraphic approaches for assessing acute myocardial infarctions. 201Tl, 99Tcm pyrophosphate (PPi) and combined 201Tl/99Tcm PPi tomograms were evaluated in 115 consecutive patients, in 85 of whom clinical examination revealed acute myocardial infarction. The overa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199009000-00005
更新日期:1990-09-01 00:00:00
abstract::The aim of this prospective study was to assess the efficacy of using whole-kidney, mean parenchymal and pelvic transit times to evaluate renal function following treatment with extracorporeal shock wave lithotripsy (ESWL). Fifteen patients were evaluated 24-48 h before and after ESWL therapy using 99Tcm-DTPA renal sc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199802000-00010
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVES:Concurrent inflammation or anemia at the time of PET/computed tomography (CT) could be one of several causes of diffuse splenic (18)F-fluorodeoxyglucose ((18)F-FDG) uptake. In this study, we focused on cytokines to investigate interactions during this phenomenon and clarify the significance of splenic (18)F-...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e3283595cac
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Our study aims to assess the clinical relevance of fluorine-18 fluorodeoxyglucose (F-FDG) negative osteoblastic metastatic bone lesions noted on PET/computed tomography (CT) in breast cancer patients. PATIENTS AND METHODS:The medical records of breast cancer patients were reviewed retrospectively from January ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000481
更新日期:2016-06-01 00:00:00
abstract::Pentavalent 99Tcm-dimercaptosuccinic acid (99Tcm-(V)DMSA) has an established role in imaging medullary thyroid carcinoma. There have been case reports of uptake in bone metastases. Our aims were to compare 99Tcm-(V)DMSA with 99Tcm-hydroxymethylene diphosphonate (99Tcm-HDP) in bone metastases, to assess its value in im...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-199710000-00003
更新日期:1997-10-01 00:00:00
abstract::In order to compare visual interpretation of inflammation detected by leukocyte scintigraphy with that of different computer-aided quantification methods, 34 patients (25 with ulcerative colitis and 9 with endoscopically verified non-inflamed colonic mucosa), were investigated using 99Tcm-hexamethylpropyleneamine oxim...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199504000-00161
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:A lack of response to cardiac resynchronization therapy (CRT) has been reported in 20-40% of heart failure patients with left ventricular (LV) dyssynchrony who underwent treatment based on the established guidelines. The study aimed to investigate the relationship between (99m)Tc-tetrofosmin ((99m)Tc-TF) myoc...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000150
更新日期:2014-09-01 00:00:00
abstract::Thirty patients with aortic valve incompetence and 21 control subjects were examined by M-mode echocardiography at rest and radionuclide ventriculography during submaximal handgrip exercise. The patients had greater left ventricular dimensions and end-systolic wall stress values but peak systolic wall stress values di...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199004000-00004
更新日期:1990-04-01 00:00:00
abstract::The viability of autologous adrenal medullary transplants was evaluated using 125I-meta-iodobenzyl guanidine (MIBG), an adrenal medullary scanning agent. Bilateral cavities in the caudate nuclei were made stereotaxically in Wistar rats. One week later, the left adrenal medulla was resected by microsurgery, followed by...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199409000-00015
更新日期:1994-09-01 00:00:00
abstract::Fractionation of 99Tcm-exametazime enables several patients doses to be prepared from one vial. To overcome the disadvantages of storage at -70 degrees C, storage at higher temperatures was investigated with replacement of stannous ions before use. Kits were fractionated using a nitrogen-purged 0.9% w/v sodium chlorid...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199903000-00013
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:In our study, tumor heterogeneity was evaluated using the parameters skewness and kurtosis on pretreatment Ga-68 DOTA-TATE PET/CT to assess therapy responses of lesions in patients with gastroenteropancreatic neuroendocrine tumors (GEP NETs) treated with peptide receptor radionuclide therapy (PRRT). METHOD:We ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001231
更新日期:2020-10-01 00:00:00
abstract::At present, it is difficult to distinguish between bacterial infections and sterile inflammatory processes using radiopharmaceuticals. This is so for a variety of reasons, including binding to bacteria with low affinity (e.g. infection) and binding to a specific micro-organism (e.g. radiolabelled monoclonal antibodies...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-199812000-00002
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:The determination of lesion boundaries on FDG PET is difficult due to the point-spread blurring and unknown uptake of activity within a lesion. Standard threshold-based methods for volumetric quantification on PET usually neglect any size dependence and are biased by dependence on the signal-to-background ra...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e328155d154
更新日期:2007-06-01 00:00:00
abstract::Following injection for renography, 99Tcm-labelled diethylenetriamine-pentacetic acid (DTPA) rapidly enters the extravascular space. Background therefore comprises two components, a falling intravascular signal and an extravascular signal which initially rises. We estimated the relative magnitudes of these two compone...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198808000-00003
更新日期:1988-08-01 00:00:00
abstract::We investigated a simple and reliable method for the preparation of 99Tcm-dimercaptosuccinic acid (99Tcm(V)-DMSA) without the addition of oxygen. The effect of pH, amount of reducing agent, and oxygen addition in the synthesis of 99Tcm(V)-DMSA were evaluated. At pH 9, we obtained a radiochemical yield of 95% +/- 1.2% ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200106000-00002
更新日期:2001-06-01 00:00:00
abstract:PURPOSE:The goal of this study was to assess global cerebral glucose uptake in subjects with known cardiovascular risk factors by employing a quantitative F-fluorodeoxyglucose-PET/computed tomography (FDG-PET/CT) technique. We hypothesized that at-risk subjects would demonstrate decreased global brain glucose uptake co...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001349
更新日期:2020-12-14 00:00:00
abstract::To evaluate the clinical utility of 123I-labelled 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (123I-BMIPP), myocardial scintigraphy using 123I-BMIPP was performed in 13 patients with hypertrophic cardiomyopathy (HCM), and the findings were compared with those of 201Tl. The uptake of each tracer was scored visual...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199406000-00008
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVES:As PET has become a standard of treatment in patients with cancer, publications of oncologic PET have grown sharply. We aimed to organize the data of meta-analyses of oncologic PET and assess the quality of studies. MATERIALS AND METHODS:The inclusion criteria were studies that meta-analyzed to combine the ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,meta分析
doi:10.1097/MNM.0000000000000908
更新日期:2018-12-01 00:00:00
abstract::N-isopropyl-p-I-123-iodoamphetamine (123I-IMP) is extracted by the brain in proportion to regional blood flow. It is particularly useful in the clinical assessment of various pathological conditions related to altered cerebral flow. Moreover, it has been reported that 123I-IMP is avidly incorporated into melanin and m...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199602000-00010
更新日期:1996-02-01 00:00:00
abstract::The aim of this study was to look for regional cerebral blood flow (rCBF) abnormalities in patients with a recent diagnosis of pseudotumour cerebri (PTC) and to compare 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) cerebral single photon emission tomographic (SPET) findings with those of X-ray computed tomograph...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199608000-00009
更新日期:1996-08-01 00:00:00
abstract::The main aim of this study was to investigate the role of N-(2,4,6 trimethyl-3-bromophenylcarbamoylmethyl) iminodiacetic acid (IDA; Mebrofenin) scintigraphy in follow-up assessments of the biliary system in patients with cystic fibrosis associated liver disease. Fourteen patients from a study published in 1996 were re...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200207000-00012
更新日期:2002-07-01 00:00:00