Abstract:
:Pentavalent 99Tcm-dimercaptosuccinic acid (99Tcm-(V)DMSA) has an established role in imaging medullary thyroid carcinoma. There have been case reports of uptake in bone metastases. Our aims were to compare 99Tcm-(V)DMSA with 99Tcm-hydroxymethylene diphosphonate (99Tcm-HDP) in bone metastases, to assess its value in imaging of bone metastases, and to assess the prospects of the beta-emitting analogues 186/188Re-(V)DMSA as palliative agents for painful bone metastases. Ten patients confirmed by a 99Tcm-HDP bone scan to have bone metastases secondary to carcinoma of the prostate, lung or breast were injected with 99Tcm-(V)DMSA (600 MBq). Whole-body scans acquired at 3 and 24 h were compared with the 99Tcm-HDP bone scans. 99Tcm-(V)DMSA showed high soft tissue background, kidney retention and avid uptake in most bone metastases: 86% of bone lesions identified on bone scans were detected with 99Tcm-(V)DMSA. The lesion-to-normal ratios were comparable to or lower than those for 99Tcm-HDP at 3 h, but increased by 24 h. Instances of abnormal uptake in liver, primary lung tumour, lymph nodes and pleural effusion were observed. We conclude that 99Tcm-(V)DMSA is a tracer for bone metastases (with lower sensitivity than 99Tcm-HDP) and soft tissue tumours. If 186/188Re-(V)DMSA behave similarly, they may find use in therapy for soft tissue tumours and bony metastases.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Lam AS,Kettle AG,O'Doherty MJ,Coakley AJ,Barrington SF,Blower PJdoi
10.1097/00006231-199710000-00003subject
Has Abstractpub_date
1997-10-01 00:00:00pages
907-14issue
10eissn
0143-3636issn
1473-5628journal_volume
18pub_type
临床试验,杂志文章abstract::The investigation of left ventricular contractile reserve usually requires the determination of left ventricular volume, but its measurement with radionuclide angiography is difficult. The aim of this study was to determine left ventricular volume directly during exercise by the simultaneous measurement of peak exerci...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199612000-00007
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate the diagnostic value of fluorodeoxyglucose-18 (FDG)-PET/computed tomography (CT) and MRI parameters in determining the molecular subtypes of invasive breast cancer. METHODS:Data from 55 primary invasive breast cancer masses in 51 female patients who underwent pre-treat...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001220
更新日期:2020-08-01 00:00:00
abstract::Our aim was to determine whether the Ca2+ ion or cell membrane Ca2+ and Na+/Ca2+ ion transport systems are involved in maintaining the cell-associated activity of technetium-99m-hexakis-methoxy-isobutyl-isonitrile (99mTc-MIBI) and technetium-99m-ethylene-bis[bis(2-ethoxyethyl)phosphin] (99mTc-tetrofosmin) in tumour ce...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200302000-00008
更新日期:2003-02-01 00:00:00
abstract::While 18F-FDG labelling of monocytes would allow in vivo trafficking with positron emission tomography (PET), present methods suffer from poor retention of radioactivity. We investigated the feasibility of utilizing insulin for improved [18F]fluorodeoxyglucose (18F-FDG) labelling. Separated human monocytes and lymphoc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200206000-00007
更新日期:2002-06-01 00:00:00
abstract::A new radiopharmaceutical, 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO) is described. This agent displays considerable promise for imaging cerebral blood flow. In studies in rats and one human volunteer, 99Tcm-HM-PAO demonstrates good brain uptake, prolonged retention of activity in the brain, and slow regional...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198508000-00003
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:Single photon emission tomography (SPECT) of the lung is a well-established non-invasive technique for quantitative assessment of regional lung ventilation and perfusion distribution in children and in adults. However, its application in neonates as well as infants has been scarce because of several practica...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f25905
更新日期:2008-02-01 00:00:00
abstract::Published values of tissue weighting factors for adolescents and children derived from the life-span study of the atomic bomb survivors have been used to calculate the effective dose to patients aged 1, 5, 10 and 15 years undergoing a common paediatric procedure requiring one of the following radiopharmaceuticals: 99T...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199906000-00012
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. PATIENTS AND METHODS:A total of 109 patients with typical angina and no previous coronary artery di...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000739
更新日期:2017-11-01 00:00:00
abstract:AIM:This study was carried out to compare the efficacy of Y, Lu, and combination of both radiotracers (tandem) peptide receptor radionuclide therapy (PRRT) in patients with inoperable and metastatic neuroendocrine tumors. MATERIALS AND METHODS:Systematic searches of PubMed and SciVerse Scopus databases were performed ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,meta分析
doi:10.1097/MNM.0000000000000758
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:Respiratory complications are common after arthroplasty, with pulmonary thromboembolic disease (PTE) and fat emboli being the most serious. A scintigraphic study was designed to assess the occurrence of both diseases. A prospective tomographic study of perfusion was performed within 24 h of arthroplasty. D...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200111000-00011
更新日期:2001-11-01 00:00:00
abstract::Captopril renography is used for the non-invasive diagnosis of renovascular hypertension, but suffers from the drawbacks of lower sensitivity and false-positive tests due to a fall in blood pressure. Aspirin renography has been proposed as a useful test for evaluation of unilateral renal artery stenoses of moderate de...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200004000-00006
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:There is evidence that the status of human papilloma virus subtype 16 (HPV-p16) alters the prognosis of patients with oropharyngeal squamous cell cancer (OSCC). We sought to establish whether there is a relationship between HPV-p16 status and 18F-FDG uptake in the prognosis of OSCC. MATERIALS AND METHODS:Patie...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000208
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Upon diagnosis, distant metastases are encountered in 21-50% of neuroendocrine tumours (NETs). However, few systemic treatment options are available for the well-differentiated NETs in the metastatic stage. Lu-DOTATATE is one of the most effective treatments in this limited patient group. We retrospectively inv...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000874
更新日期:2018-08-01 00:00:00
abstract::Monoclonal antibody (MoAb) fragments are known to have advantages over intact immunoglobulins for radioimmunoscintigraphy. It is less clear whether they are as effective in the delivery of radioimmunotherapy. The imaging and dosimetric properties of an intact MoAb, K-1-21, reactive against human kappa light chains (LC...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Echocardiography plays a central role in the diagnosis of hypertrophic cardiomyopathy (HCM). However, apical involvement of HCM may be missed because of foreshortening and inadequate clinical suspicion. These patients may be referred for single-photon emission computed tomography imaging. METHODS:We present...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328334fc41
更新日期:2010-04-01 00:00:00
abstract::The standard nuclear medicine textbooks describe the pyramidal lobe of the thyroid as arising from the upper part of the thyroid lobes. Anatomy and surgical texts however describe it as a thyroglossal tract remnant and state that it arises from the isthmus. Review of 150 thyroid scintigrams confirms that on scintigrap...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198403000-00006
更新日期:1984-03-01 00:00:00
abstract::The aims of this study were to establish the percentage of metastatic renal cell carcinoma (RCC) lesions detected by radioimmunoscintigraphy (RIS) with the chimeric monoclonal antibody 131I-cG250 versus positron emission tomography (PET) with 18F-labelled deoxyglucose ([18F]FDG), and to evaluate the use of these radio...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200203000-00005
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:N staging is a key factor when considering the choice of treatment for non-small-lung cancer. It is possible that there is a correlation between N2 metastasis and some risk factors. The objective of the present study was to evaluate associations between several risk factors and N(2) metastasis using univaria...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000144
更新日期:2014-09-01 00:00:00
abstract::This work was designed to compare sentinel lymph node (SLN) uptake of 99mTc-labelled human serum albumin colloid (99mTc-HSAC), 99mTc-labelled antimony sulphur colloid (99mTc-SC) and a 99mTc-labelled dextran 70 solution (99mTc-Dx) and their selectivity in the identification of this node in the right rear footpad (RRF) ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200105000-00006
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Clinical studies in women using technetium-99m (Tc)-Bombesin have shown successful radionuclide imaging of breast tumours overexpressing gastrin-releasing peptide receptors (GRPRs). Recent studies have demonstrated that most breast tumours overexpress folate receptors (FRα). AIM:The aim of this work was to ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000460
更新日期:2016-04-01 00:00:00
abstract::Micturating renograms often need to be carried out on children, with whom difficulty may be experienced in synchronizing onset of micturition with camera and computer acquisition. A flow detection system has been developed which will automate these acquisitions, resulting in far fewer false starts or lost studies. The...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198709000-00003
更新日期:1987-09-01 00:00:00
abstract::Three ligand assays for TSH using monoclonal antibodies, an IRMA, an ELISA and a DELFIA were compared with a standard DAB RIA technique. The IRMA proved to be superior in respect to sensitivity, precision, reproducibility and practicality. The highest sensitivity yet, was achieved by DELFIA. IRMA, ELISA and DELFIA are...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198504000-00003
更新日期:1985-04-01 00:00:00
abstract::Reticuloendothelial system (RES) phagocytic function or capacity can be measured by clearance studies with test substances. This study in the rat examines three commercially available 99Tcm-labelled test substances, and different methods of calculating RES capacity. Albures size 500 nm and sulphur colloid size 600 nm ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198705000-00004
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT for the selection of patients with nonresectable colorectal liver metastases (NCLM) for liver transplantation (LT). In the secondary cancer study, we reported an improved 5-year overall survival in patients treated with LT for...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000843
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motio...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000539
更新日期:2016-09-01 00:00:00
abstract::Fifty-six patients with hypertrophic cardiomyopathy who had echocardiography and cardiac catheterization were studied. Eleven (18%) of 56 patients had right ventricular (RV) thallium-201 visualization at resting scan. RV thallium-201 visualization was observed in the apex or lower half of the RV free wall, which was q...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring >90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5-2% of hypertensive children. Gastroenteropancreatic NETs can occ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001305
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the diagnostic value of 2-(fluorine-18)-fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/CT in comparison with MRI for the detection of recurrent ovarian cancer. METHODS:Forty-seven patients with suspected ovarian cancer recurrence after total ablative or cytoreductive surgery, ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32834fc5bf
更新日期:2012-05-01 00:00:00
abstract::The advent of PET instrumentation signaled the beginning of a new perspective in nuclear medicine diagnostic imaging. PET systems rely on several corrections that must be applied in order to establish accurate and reliable quantification. The inherent properties of PET detector architecture and the crystals themselves...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0b013e328365ac1e
更新日期:2013-11-01 00:00:00
abstract::To study the accuracy of renal function quantification with 99Tcm-DMSA we compared DMSA renal uptake and creatinine clearance in 16 cases of children with single kidney. The age of the patients ranged from two months to fourteen years. Creatinine clearance was normalized to 1.73 m2. DMSA uptake was measured 7 h after ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198511000-00009
更新日期:1985-11-01 00:00:00