Abstract：
:Reticuloendothelial system (RES) phagocytic function or capacity can be measured by clearance studies with test substances. This study in the rat examines three commercially available 99Tcm-labelled test substances, and different methods of calculating RES capacity. Albures size 500 nm and sulphur colloid size 600 nm used for liver scintigraphic imaging and Nanocoll size 50 nm used for bone-marrow scintigraphic imaging were tested. The rats were examined under a gamma camera and the uptake by the liver, clearance from the heart and clearance from blood samples were recorded. Different amounts of substances were tested. The final uptake in different organs was recorded after the animals were sacrificed. Colloid size and stability were tested with a polycarbonate filter. (Nanocoll was found to have at least 10 times smaller colloid diameter, leading to a thousand times more particles per milligram). RES function was calculated as the uptake rate or clearance rate, k. In a logarithmic plot, the relationship between uptake or clearance and time was found to be linear between 90 and 300s and calculations of k in this interval are recommended. k-values selected from blood sample curves were 11 +/- 5 S.E.M. lower than those calculated from heart clearance curves or liver uptake curves. Increasing amounts of Nanocoll caused a decrease in uptake rate k. Albures and sulphur colloid could not be given in amounts that caused any change in k. Only Nanocoll could be given in sufficiently large amounts (above the critical dose) to challenge RES and avoid complete extraction from the circulation during first passage through RE organs. Nanocoll seems suitable for use in tests of RES function and the optimal amount was 0.03 mg per rat (0.6 X 10(12) particles).
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Holmberg SB,Hafström L,Jacobsson Ldoi
10.1097/00006231-198705000-00004subject
Has Abstractpub_date
1987-05-01 00:00:00pages
335-46issue
5eissn
0143-3636issn
1473-5628journal_volume
8pub_type
杂志文章abstract：OBJECTIVE:To assess standardized uptake value (SUV) measurement uncertainty (MU) of lung cancer lesions with uptake greater than mediastinum but less than or equal to the liver and that of the mediastinum blood pool, and to compare lesion SUV with mediastinum SUV by assessing MU of their ratio. PATIENTS AND METHODS:Dy...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000677
更新日期：2017-06-01 00:00:00
abstract：:The alveolar permeability (AP) in 21 patients with active diffuse infiltrative lung disease (ILD) was measured by 99Tcm-diethylenetriaminapentaacetate (DTPA) radioaerosol inhalation lung scintigraphy. The degree of AP damage in ILD was presented as the slope (% min-1) of the time-activity curve from the dynamic lung i...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199410000-00012
更新日期：1994-10-01 00:00:00
abstract：AIM:To test the applicability of Tc-dextran joint scintigraphy in the assessment of disease activity in patients with rheumatoid arthritis (RA), and to compare it with the clinical disease activity scores and laboratory parameters. METHODS:Twenty-seven patients with RA were investigated using Tc-dextran joint scintigr...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/01.mnm.0000126632.32413.2e
更新日期：2004-06-01 00:00:00
abstract：:The use of 111In-labelled granulocyte scintigraphy is recognized as a reliable method for detecting osteomyelitis and has similar sensitivity and significantly increased specificity compared to bone scintigraphy and 67Ga studies. Recent published work using pure granulocytes labelled with 111In tropolonate to detect o...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-198810000-00007
更新日期：1988-10-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to compare the efficacy of low-dose and high-dose (99m)Tc methoxy isobutyl isonitrile (MIBI) protocols in intraoperative localization of parathyroid adenomas by means of a gamma probe in patients with primary hyperparathyroidism (PHPT). PATIENTS AND METHODS:The study included 62 pat...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000056
更新日期：2014-04-01 00:00:00
abstract：:We studied 20 patients aged 46-69 years (mean 57 years) undergoing long-term haemodialysis (HD) and 20 age- and sex-matched controls with single photon emission tomography (SPET) and 99Tcm-hexamethyl-propyleneamine-oxime to look for regional abnormalities in cerebral blood flow (CBF) and their relation to cognitive dy...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199607000-00011
更新日期：1996-07-01 00:00:00
abstract：:We have assessed the usefulness of a radionuclide dilution method for estimation of ascitic fluid volume. 99Tc(m) macroaggregated albumin (10 MBq) was injected into the peritoneal fluid. Multiple samples were taken using a trocath peritoneal dialysis catheter over a 4-h period. Blood samples were taken at the same tim...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/00006231-200012000-00009
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to evaluate the accuracy of the sequential multiphase and dual-tracer (SMADT) technique utilizing technetium-99m pertechnetate (99mTcO4) and dynamic technetium-99m-2-methoxyisobutylisonitrile (99mTc-MIBI) with single-photon emission computed tomography/computed tomography (SPECT/CT) f...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000215
更新日期：2015-01-01 00:00:00
abstract：:21 patients with Wolff-Parkinson-White (WPW) syndrome were investigated through radionuclide imaging and body surface mapping. Ventricular preexcitation was localized by display of identical phase ventricular regions (phase display). In 79% of the cases radioisotope and body surface mapping methods have identical resu...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-198607000-00004
更新日期：1986-07-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000856
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:Brain metastases are common in lung cancer. Whole-body 2-deoxy-2-[fluorine-18]fluoro-D-glucose ([F]FDG) PET/computed tomography (CT) is used for general staging, but MRI is the best modality for characterizing brain abnormalities. We aimed to determine whether PET/CT is suitable for selecting patients for MRI...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000371
更新日期：2015-11-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199906000-00012
更新日期：1999-06-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0b013e32835ae545
更新日期：2013-01-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000001005
更新日期：2019-06-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000001205
更新日期：2020-07-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000232
更新日期：2015-02-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000025
更新日期：2014-02-01 00:00:00
abstract：AIM:The aim of this study was to design a general nuclear medicine method for fast, accurate and direct determination of the clearance of a radioactive indicator provided that all uptake compartments of the radioactive indicator could be included in the field of view of the gamma camera. METHODS:The data material for ...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
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更新日期：2004-10-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
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更新日期：2013-08-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199808000-00006
更新日期：1998-08-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
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更新日期：2015-04-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000731
更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-02-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000660
更新日期：2017-05-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
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journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：OBJECTIVES:As PET has become a standard of treatment in patients with cancer, publications of oncologic PET have grown sharply. We aimed to organize the data of meta-analyses of oncologic PET and assess the quality of studies. MATERIALS AND METHODS:The inclusion criteria were studies that meta-analyzed to combine the ...
journal_title：Nuclear medicine communications
pub_type： 杂志文章,meta分析
doi：10.1097/MNM.0000000000000908
更新日期：2018-12-01 00:00:00
