(99m)Tc-dextran scintigraphy to detect disease activity in patients with rheumatoid arthritis.

Abstract:

AIM:To test the applicability of Tc-dextran joint scintigraphy in the assessment of disease activity in patients with rheumatoid arthritis (RA), and to compare it with the clinical disease activity scores and laboratory parameters. METHODS:Twenty-seven patients with RA were investigated using Tc-dextran joint scintigraphy. The images were evaluated semi-quantitatively and the regional uptakes of the radiopharmaceutical were calculated for the knee, wrist and ankle joints. The clinical and laboratory parameters were collected and fully analysed. An articular Ritchie index (a tender joint score), the number of swollen joints (Sw), the number of tender joints, the morning stiffness (h), the total Ritchie articular index (R), the visual analogue scale (VAS) and the Disease Activity Score (DAS) were determined for all patients. RESULTS:Compared with controls, patients with RA had significantly higher regional Tc-dextran uptake in the knee, wrist and ankle joints (P=0.001). The regional Tc-dextran uptake showed no correlation with the patient's age, gender, duration of disease, number of swollen joints (Sw), number of tender joints, morning stiffness (h), VAS, total Ritchie articular index and DAS, or any laboratory parameters. There was a significant correlation between the regional Tc-dextran uptake for individual joints and the articular Ritchie index of the right and left wrist (r=0.42, P=0.03; r=0.45, P=0.02), right and left knee (r=0.66, P<0.0001; r=0.80, P<0.0001) and right and left ankle (r=0.47, P=0.014; r=0.76, P<0.0001), respectively. CONCLUSIONS:This study demonstrates that Tc-dextran scintigraphy is a sensitive method to detect active joint inflammation and could be useful in the management of patients with RA.

journal_name

Nucl Med Commun

authors

Kaya M,Tuna H,Fatih Firat M,Tuna F,Seren G,Necmi Yigitbasi O

doi

10.1097/01.mnm.0000126632.32413.2e

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

597-601

issue

6

eissn

0143-3636

issn

1473-5628

pii

00006231-200406000-00011

journal_volume

25

pub_type

临床试验,杂志文章
  • Failure of washout following gustatory stimulation in Warthin's tumour.

    abstract::Scintigraphically, Warthin's tumour usually demonstrates increased tracer uptake compared to normal adjacent salivary tissue. A case is presented in which tumour uptake is no greater than the normal adjacent gland. Gustatory stimulation results in failure of tumour tracer washout, and this finding rather than 'hot' sa...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198806000-00007

    authors: Blue PW

    更新日期:1988-06-01 00:00:00

  • Bone marrow scintigraphy in small cell carcinoma of the lung.

    abstract::A comparative study of bone marrow scintigraphy using 99Tcm-nanocolloid, conventional bone scintigraphy and bone marrow biopsy were performed in 35 patients with histologically proven small cell carcinoma of the lung to determine whether bone marrow scintigraphy has a role in the early detection of bone marrow metasta...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199401000-00006

    authors: Li DJ,Maughan TS,Miles KA,Wraight EP

    更新日期:1994-01-01 00:00:00

  • Wipe tests to assess 99Tcm surface contamination: effects of surface type, swab type and chemical form.

    abstract::The efficacy of wipe tests for assessing 99Tcm surface contamination was measured. Four types of surface were contaminated with four radiopharmaceuticals and wiped using four types of swab. The fraction of activity removed was measured by direct monitoring for each combination of surface, pharmaceutical and swab. The ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199102000-00005

    authors: Scott LE,Gibson CJ

    更新日期:1991-02-01 00:00:00

  • Background in 99Tcm DTPA renography evaluated by the impact of its components on individual kidney glomerular filtration rate.

    abstract::Following injection for renography, 99Tcm-labelled diethylenetriamine-pentacetic acid (DTPA) rapidly enters the extravascular space. Background therefore comprises two components, a falling intravascular signal and an extravascular signal which initially rises. We estimated the relative magnitudes of these two compone...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198808000-00003

    authors: Peters AM,Gordon I,Evans K,Todd-Pokropek A

    更新日期:1988-08-01 00:00:00

  • Intravenous administration of morphine sulfate in hepatobiliary imaging for acute cholecystitis: a review of clinical efficacy.

    abstract::Morphine sulfate has been used by several investigators in the cholescintigraphic diagnosis of acute cholecystitis. A review of the available literature indicates that morphine sulfate significantly reduces the total time required for the hepatobiliary examination, while retaining both high sensitivity (98.8%) and spe...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/00006231-198803000-00005

    authors: Vasquez TE,Rimkus DS,Pretorius HT,Greenspan G

    更新日期:1988-03-01 00:00:00

  • A routine method for using sodium iodide to stabilize sodium pertechnetate [99Tcm] dispensed for the preparation of 99Tcm-exametazime.

    abstract::When preparing 99Tcm-exametazime, it is important to use sodium 99Tcm-pertechnetate that is less than 2 h old. The addition of sodium iodide (NaI) to 99Tcm-pertechnetate is known to extend this time to 6 h. This paper describes a technique for implementing this in routine practice. Sterile kits consisting of 440 micro...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199205000-00003

    authors: Millar AM

    更新日期:1992-05-01 00:00:00

  • 201T1 and 99Tcm-J001X macrophage scintigraphy: two radionuclide imaging techniques for the surveillance of acute localized radiation over-exposures.

    abstract::The therapeutic or surgical management of acute localized irradiation is very complicated due to the delayed occurrence of ionizing radiation effects. There is a great need for non-invasive imaging techniques to delineate healthy from exposed tissues. Such a technique should be of value considering that spread of dama...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:

    authors: Perin F,Pittet JC,Hoffschir D,Daburon F,Normier G,Le Pape A

    更新日期:1995-07-01 00:00:00

  • Performance of two new solid-phase ligand assays for TSH using monoclonal antibodies.

    abstract::Three ligand assays for TSH using monoclonal antibodies, an IRMA, an ELISA and a DELFIA were compared with a standard DAB RIA technique. The IRMA proved to be superior in respect to sensitivity, precision, reproducibility and practicality. The highest sensitivity yet, was achieved by DELFIA. IRMA, ELISA and DELFIA are...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198504000-00003

    authors: Böttger I,Pabst HW,Senekowitsch R,Kriegel H

    更新日期:1985-04-01 00:00:00

  • Role of SUV(max) obtained by 18F-FDG PET/CT in patients with a solitary pancreatic lesion: predicting malignant potential and proliferation.

    abstract:OBJECTIVES:Maximum standardized uptake value (SUV(max)) is a marker of tumor glucose metabolism detected by [(18)F]-fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (PET/CT) and reflects tumor aggressiveness. The aim of the study was to evaluate the value of SUV(max) in differentiating benign from malignant solit...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328360668a

    authors: Hu SL,Yang ZY,Zhou ZR,Yu XJ,Ping B,Zhang YJ

    更新日期:2013-06-01 00:00:00

  • The value of syringe shields in a nuclear medicine department.

    abstract::The radiation dose to the pulp of both index fingers has been measured in a radiopharmacy supplying 11 000 patient doses a year, in a hospital dispensary (4500 doses a year) and in its injection area. Tungsten syringe shields were used for one week and not used during the other week. In the radiopharmacy and the dispe...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198508000-00004

    authors: Harding LK,Hesslewood S,Ghose SK,Thomson WH

    更新日期:1985-08-01 00:00:00

  • Fluorine-18 fluorodeoxyglucose avid thyroid incidentalomas on PET/CT scan in cancer patients: how sinister are they?

    abstract:OBJECTIVE:To evaluate the prevalence of malignancy in incidental thyroidal uptake on PET with fluorine-18 deoxyglucose integrated with computed tomography (F-FDG PET/CT) in Pakistani cancer patients and to assess the role of standardized uptake value (SUV) in deciding which lesions to investigate further. METHOD:We re...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000557

    authors: Hassan A,Riaz S,Zafar W

    更新日期:2016-10-01 00:00:00

  • Phagocytosis and dynamic RES scintigraphy: an evaluation of commercial colloids in rats.

    abstract::Reticuloendothelial system (RES) phagocytic function or capacity can be measured by clearance studies with test substances. This study in the rat examines three commercially available 99Tcm-labelled test substances, and different methods of calculating RES capacity. Albures size 500 nm and sulphur colloid size 600 nm ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198705000-00004

    authors: Holmberg SB,Hafström L,Jacobsson L

    更新日期:1987-05-01 00:00:00

  • Scintigraphic evaluation of renoprotective effects of coenzyme Q10 in a rat renal ischemia-reperfusion injury.

    abstract:PURPOSE:Renal ischemia-reperfusion injury (RIRI) may occur secondary to several reasons leading to renal failure. Coenzyme-Q10 (CoQ10) is a well-known antioxidant. However, the effects CoQ10 against RIRI have not been evaluated. Our aim was to evaluate protective effects of CoQ10 to renal ischemia-reperfusion by bioche...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001070

    authors: Akbulut A,Keseroglu BB,Koca G,Yuceturk CN,Ozgur BC,Surer H,Ogus E,Yumuşak N,Karakaya J,Korkmaz M

    更新日期:2019-10-01 00:00:00

  • Recovery of renal retention function by differentiating the Patlak-Rutland plot.

    abstract:INTRODUCTION:It has been suggested that renal retention function can be estimated by differentiation of the Patlak-Rutland plot. AIM:To evaluate the error resulting from this method. METHODS:A total of 5800 renograms were generated by convolving real input functions with artificial retention functions. Ten bi-exponen...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200405000-00012

    authors: Kuyvenhoven JD,Ham HR,Piepsz A

    更新日期:2004-05-01 00:00:00

  • Uptake of 123I-5-iodo-2-thiouracil, a possible radiopharmaceutical for noninvasive detection of ocular melanoma, in melanotic and amelanotic melanomas in hamsters.

    abstract::The uptake of 123I-5-iodo-2-thiouracil in melanotic and amelanotic melanoma implanted in Syrian golden hamsters was studied. A selective accumulation was found in the tumours. Uptake of 123ITU in melanotic melanomas was 4 to 5 times the uptake in amelanotic ones. For both tumours high ratios of tumours versus non-tumo...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198510000-00007

    authors: Franken NA,Van Langevelde A,Journée-De Korver JG,Bakker CN,Feitsma RI,Van Delft JL,Oosterhuis JA,Pauwels EK

    更新日期:1985-10-01 00:00:00

  • 18F-FEAU as a radiotracer for herpes simplex virus thymidine kinase gene expression: in-vitro comparison with other PET tracers.

    abstract:OBJECTIVE:The herpes simplex virus thymidine kinase (HSVtk) gene has frequently been applied as a reporter gene for monitoring transgene expression in animal models. In clinical gene therapy protocols, however, extremely low expression levels of the transferred gene are generally observed. Consequently, sensitive and s...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/01.mnm.0000186609.12895.20

    authors: Buursma AR,Rutgers V,Hospers GA,Mulder NH,Vaalburg W,de Vries EF

    更新日期:2006-01-01 00:00:00

  • Burden of metastatic bone disease measured on 18F-NaF PET/computed tomography studies as a prognostic indicator in patients with medullary thyroid cancer.

    abstract:PURPOSE:The aim of the study was to assess the association between the burden of metastatic bone disease measured on F-NaF PET/computed tomography (CT) studies and the overall survival (OS) of patients with medullary thyroid cancer (MTC). METHODS:We retrospectively analyzed 31 patients with MTC who performed 18F-NaF P...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001175

    authors: Ueda CE,Duarte PS,de Castroneves LA,Flávio J,Marin G,Sado HN,Sapienza MT,Hoff AO,Buchpiguel CA

    更新日期:2020-05-01 00:00:00

  • Cerebral uptake and retention of 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO).

    abstract::A new radiopharmaceutical, 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO) is described. This agent displays considerable promise for imaging cerebral blood flow. In studies in rats and one human volunteer, 99Tcm-HM-PAO demonstrates good brain uptake, prolonged retention of activity in the brain, and slow regional...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198508000-00003

    authors: Holmes RA,Chaplin SB,Royston KG,Hoffman TJ,Volkert WA,Nowotnik DP,Canning LR,Cumming SA,Harrison RC,Higley B

    更新日期:1985-08-01 00:00:00

  • Quality of care: identification and quantification of the process of care among children undergoing nuclear medicine studies.

    abstract::The aim of this study was to define indices which could be used to assess the quality of care of children undergoing an examination requiring intravenous (i.v.) access in an integrated department of radiology and to see if these indices could be quantified. A prospective study of all patients requiring an i.v. injecti...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:

    authors: Sherazi Z,Gordon I

    更新日期:1996-05-01 00:00:00

  • Performance of a single crystal digital gamma camera for first pass cardiac studies.

    abstract::First pass radionuclide angiocardiography (FPRNA) has gained increasing interest because of the development of new 99Tcm-labelled perfusion agents and of new 191Os/191Irm generator systems. The aim of the study was to evaluate the performance capacities of a small field of view single crystal digital gamma camera for ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199101000-00004

    authors: Dobbeleir A,Franken PR,Ham HR,Brihaye C,Guillaume M,Knapp FF,Vandevivere J

    更新日期:1991-01-01 00:00:00

  • Phase I/II clinical trial of the humanized anti-EGF-r monoclonal antibody h-R3 labelled with 99mTc in patients with tumour of epithelial origin.

    abstract:AIM:To evaluate the biodistribution, internal radiation dosimetry and toxicity of the humanized MAb h-R3 labelled with Tc in humans. METHODS:Twenty-five patients with suspected epithelial-derived tumours were included in this study and divided into two groups: group I consisted of 10 patients who received 3 mg/1110 MB...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200512000-00002

    authors: Torres LA,Perera A,Batista JF,Hernández A,Crombet T,Ramos M,Neninger E,Pérez M,Sánchez EL,Romero S,Aguilar V,Coca MA,Iznaga-Escobar N

    更新日期:2005-12-01 00:00:00

  • Evaluation of renal function following treatment with extracorporeal shock wave lithotripsy (ESWL): the use of whole-kidney, parenchymal and pelvic transit times.

    abstract::The aim of this prospective study was to assess the efficacy of using whole-kidney, mean parenchymal and pelvic transit times to evaluate renal function following treatment with extracorporeal shock wave lithotripsy (ESWL). Fifteen patients were evaluated 24-48 h before and after ESWL therapy using 99Tcm-DTPA renal sc...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199802000-00010

    authors: Ilgin N,Iftehar SA,Vural G,Bozkirli I,Gokcora N

    更新日期:1998-02-01 00:00:00

  • Preoperative 18F-FDG PET/computed tomography predicts survival following resection for colorectal liver metastases.

    abstract:OBJECTIVE:The liver is the most frequent metastatic site from colorectal cancer and about 20% of these patients are treated by surgical resection. However, the 5-year disease-free survival (DFS) following resection is only about 25% and 5-year overall survival (OS) about 38%. The aim of the study was to evaluate the ab...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001235

    authors: Grut H,Stern NM,Dueland S,Labori KJ,Dormagen JB,Schulz A

    更新日期:2020-09-01 00:00:00

  • Development of a conversion program to make SIMIND-generated SPECT data interfile acceptable to Xeleris.

    abstract::The Monte Carlo code SIMIND is used in nuclear medicine for research purposes, and also for testing the validity of various applications. Conversion of a SIMIND-generated interfile (header and image data file) is required to process the simulated image data on a Xeleris workstation. Currently there is no conversion pr...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000393

    authors: Pandey AK,Kumar JP,Aheer D,Sharma A,Hasan B,Patel C,Bal CS,Kumar R

    更新日期:2015-12-01 00:00:00

  • Right ventricular thallium-201 visualization in hypertrophic cardiomyopathy.

    abstract::Fifty-six patients with hypertrophic cardiomyopathy who had echocardiography and cardiac catheterization were studied. Eleven (18%) of 56 patients had right ventricular (RV) thallium-201 visualization at resting scan. RV thallium-201 visualization was observed in the apex or lower half of the RV free wall, which was q...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:

    authors: Nishimura T,Uehara T,Hayashida K,Nagata S

    更新日期:1988-01-01 00:00:00

  • Specifying dual-detector gamma cameras and associated computer systems.

    abstract::Increasingly, dual-detector gamma cameras are being purchased as replacements for single-headed cameras. The improvement in sensitivity offered by a dual-detector device can be used in several ways: to shorten acquisition times, to improve signal-to-noise ratios, or to reduce administered doses. This paper focuses on ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/00006231-199507000-00003

    authors: Tindale WB

    更新日期:1995-07-01 00:00:00

  • Information for patients and staff concerning nuclear medicine.

    abstract::Providing information to patients and staff is an important part of the practice of nuclear medicine. To assist in improving the standard of communications, guidance has been prepared covering the content, style and presentation of letters and leaflets for patients and for medical and nursing staff. Examples are provi...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199204000-00159

    authors: Clarke SE,McKillop JH,Prescott MC,Williams ED

    更新日期:1992-04-01 00:00:00

  • A review of captopril renal scintigraphy and its effect on patient management.

    abstract::Renal artery stenosis is an important and potentially curable cause of hypertension. Captopril renography is now recognized to have a high sensitivity and specificity in its diagnosis. Ultimately, however, the result is of little benefit if it does not lead to a change in patient management. To assess how patient mana...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199707000-00006

    authors: Ramsay D,Belton I,Finlay D

    更新日期:1997-07-01 00:00:00

  • Normal bone and soft tissue distribution of fluorine-18-sodium fluoride and artifacts on 18F-NaF PET/CT bone scan: a pictorial review.

    abstract::Fluorine-18-sodium fluoride (F-NaF) PET/CT is a relatively new and high-resolution bone imaging modality. Since the use of F-NaF PET/CT has been increasing, it is important to accurately assess the images and be aware of normal distribution and major artifacts. In this pictorial review article, we will describe the no...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0000000000000720

    authors: Sarikaya I,Elgazzar AH,Sarikaya A,Alfeeli M

    更新日期:2017-10-01 00:00:00

  • RET gene mutation analysis and long-term clinical outcomes of medullary thyroid cancer patients.

    abstract:OBJECTIVE:Medullary thyroid carcinoma is a rare, potentially aggressive tumour, with relatively worse prognosis than well-differentiated thyroid cancer. We evaluated the long-term outcomes and prognosis of medullary thyroid carcinoma patients at a single institution in India and compared outcomes based on results of RE...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001264

    authors: Prabhu M,Shakya S,Ballal S,Ahmed Shamim S,Bal C

    更新日期:2020-11-01 00:00:00