The effectiveness of low-dose versus high-dose 99mTc MIBI protocols for radioguided surgery in patients with primary hyperparathyroidism.

Abstract:

OBJECTIVE:The aim of this study was to compare the efficacy of low-dose and high-dose (99m)Tc methoxy isobutyl isonitrile (MIBI) protocols in intraoperative localization of parathyroid adenomas by means of a gamma probe in patients with primary hyperparathyroidism (PHPT). PATIENTS AND METHODS:The study included 62 patients with PHPT who were divided into two groups. Group 1 consisted of 32 patients who were injected with a low dose (1 mCi) of (99m)Tc MIBI in the surgical suite 10 min before incision. Group 2 included 30 patients who were intravenously administered a high dose (15 mCi) of (99m)Tc MIBI 2 h before surgery. With the aid of a gamma probe, intraoperative localization of parathyroid adenomas was performed in both groups of patients who underwent minimally invasive parathyroidectomy. All lesions thought to be parathyroid adenomas were excised and subsequently evaluated histopathologically. RESULTS:All parathyroid adenomas in both groups were localized and excised by means of an intraoperative gamma probe. The sensitivity, specificity, and accuracy of low-dose and high-dose (99m)Tc MIBI protocols in the intraoperative localization of adenomas in patients with PHPT were 100%. CONCLUSION:In the light of these findings, we conclude that low-dose (99m)Tc MIBI may be preferred to intraoperative identification of parathyroid adenomas by means of a gamma probe in PHPT patients because it appears to be as effective as high-dose (99m)Tc MIBI. Moreover, the low-dose protocol does not have the disadvantages of high-dose protocol.

journal_name

Nucl Med Commun

authors

Gencoglu EA,Aras M,Moray G,Aktas A

doi

10.1097/MNM.0000000000000056

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

398-404

issue

4

eissn

0143-3636

issn

1473-5628

journal_volume

35

pub_type

杂志文章
  • 99mTc-depreotide tumour uptake in patients with non-Hodgkin's lymphoma.

    abstract:BACKGROUND:99mTc-depreotide (NeoTect) is a synthetic somatostatin analogue, which binds to somatostatin receptor (SSTR) subtypes 2, 3 and 5. Imaging patients with non-Hodgkin's lymphoma (NHL) using the somatostatin analogue In-pentetreotide (Octreoscan) has demonstrated the feasibility of identifying lymphoma sites wit...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.mnm.0000126628.01919.f9

    authors: Bushnell DL,Menda Y,Madsen MT,Link BK,Kahn D,Truhlar SM,Juweid M,Shannon M,Murguia JS

    更新日期:2004-08-01 00:00:00

  • Scintigraphic imaging of breast cancer: a review.

    abstract::Scintimammography is a recently verified technique that will expand the use of nuclear medicine to a new group of patients in whom scintigraphic imaging has not been widely used. If performed correctly, and in certain groups of patients, it delivers a sensitivity as high as X-ray mammography or magnetic resonance imag...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/00006231-199708000-00003

    authors: Buscombe JR,Cwikla JB,Thakrar DS,Hilson AJ

    更新日期:1997-08-01 00:00:00

  • A review of pediatric neuroendocrine tumors, their detection, and treatment by radioisotopes.

    abstract::Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring >90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5-2% of hypertensive children. Gastroenteropancreatic NETs can occ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001305

    authors: Haddad T,Fard-Esfahani A,Vali R

    更新日期:2021-01-01 00:00:00

  • Stunning phenomenon after a radioactive iodine- ¹³¹I diagnostic whole-body scan: Is it really a point of clinical consideration?

    abstract:PURPOSE:Stunning of thyroid remnants after diagnostic scanning (Dx-WBS) using radioactive iodine- (¹³¹I) may limit the efficacy of I therapy. We aimed to evaluate this assumption in a prospectively designed study. METHODS:Forty patients who underwent thyroidectomy for differentiated thyroid carcinoma were studied and ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e328362ad63

    authors: Amin A,Amin M,Badwey A

    更新日期:2013-08-01 00:00:00

  • Ga-68 DOTATATE PET/CT and F-18 FDG PET/CT in the evaluation of low and intermediate versus high-grade neuroendocrine tumors.

    abstract:OBJECTIVE:We investigated the role of Ga-68 DOTATATE PET/CT in comparison to F-18 FDG PET/CT in patients with low and intermediate versus high-grade neuroendocrine tumors (NETs). METHODS:We identified 81 patients who underwent Ga-68 DOTATATE PET/CT at our institution between May 2017 and December 2018 and met inclusio...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001255

    authors: You H,Kandathil A,Beg M,De Blanche L,Kazmi S,Subramaniam RM

    更新日期:2020-10-01 00:00:00

  • Normal bone and soft tissue distribution of fluorine-18-sodium fluoride and artifacts on 18F-NaF PET/CT bone scan: a pictorial review.

    abstract::Fluorine-18-sodium fluoride (F-NaF) PET/CT is a relatively new and high-resolution bone imaging modality. Since the use of F-NaF PET/CT has been increasing, it is important to accurately assess the images and be aware of normal distribution and major artifacts. In this pictorial review article, we will describe the no...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0000000000000720

    authors: Sarikaya I,Elgazzar AH,Sarikaya A,Alfeeli M

    更新日期:2017-10-01 00:00:00

  • Effect of administered activity on precision in the assessment of renal function using gamma camera renography.

    abstract::Split and total renal function are commonly assessed from time-activity curves obtained from gamma camera renography with 99Tcm-diethylenetriamine pentaacetate (99Tcm-DTPA) and 99Tcm-mercaptoacetyl-triglycine (99Tcm-MAG3). The impact of the statistical noise associated with these curves on the total precision in split...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199704000-00174

    authors: Moonen M,Jacobsson L

    更新日期:1997-04-01 00:00:00

  • Mediastinal intraoperative radioisotope sentinel lymph node mapping in non-small-cell lung cancer.

    abstract:BACKGROUND:Lymph node metastases are significant prognostic factors in localized non-small-cell lung cancer (NSCLC). Nodal micrometastases may not be detected using current histological methods. AIM:To determine the accuracy and role of sentinel lymph nodes (SLNs) in patients with NSCLC. METHODS:Intraoperative techne...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.mnm.0000169381.99894.2f

    authors: Atinkaya C,Ozlem Küçük N,Koparal H,Aras G,Sak SD,Ozdemir N

    更新日期:2005-08-01 00:00:00

  • Influence of statistical noise on the determination of the single kidney 99Tcm-DTPA clearance.

    abstract::Single kidney clearance can be obtained using the 99Tcm-DTPA complex and the scintillation camera. In order to evaluate the influence of statistical noise on the determination of the clearance, several non-noisy curves were constructed, simulating renal, background and precordial curves. Poisson noise was added to the...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198508000-00008

    authors: Piepsz A,Dobbeleir A,Ham HR

    更新日期:1985-08-01 00:00:00

  • The effects of informational intervention on state anxiety and satisfaction in patients undergoing bone scan.

    abstract::The aim of the study was to identify the most beneficial mode, in terms of anxiety reduction, of giving patients information prior to them undergoing a bone scan. (Research has identified the scan procedure as having a demonstrative effect on anxiety.) Additionally, satisfaction with the adequacy of the information wa...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199411000-00011

    authors: Leckie J

    更新日期:1994-11-01 00:00:00

  • Failure of washout following gustatory stimulation in Warthin's tumour.

    abstract::Scintigraphically, Warthin's tumour usually demonstrates increased tracer uptake compared to normal adjacent salivary tissue. A case is presented in which tumour uptake is no greater than the normal adjacent gland. Gustatory stimulation results in failure of tumour tracer washout, and this finding rather than 'hot' sa...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198806000-00007

    authors: Blue PW

    更新日期:1988-06-01 00:00:00

  • The role of IDA scintigraphy in the follow-up of liver disease in patients with cystic fibrosis.

    abstract::The main aim of this study was to investigate the role of N-(2,4,6 trimethyl-3-bromophenylcarbamoylmethyl) iminodiacetic acid (IDA; Mebrofenin) scintigraphy in follow-up assessments of the biliary system in patients with cystic fibrosis associated liver disease. Fourteen patients from a study published in 1996 were re...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200207000-00012

    authors: Foster JA,Ramsden WH,Conway SP,Taylor JM,Etherington C

    更新日期:2002-07-01 00:00:00

  • Various imaging modalities for the detection of salivary gland lesions: the advantages of 201Tl SPET.

    abstract::The aim of this study was to compare dual-isotope (99Tc(m) and 201Tl) SPET imaging with computed tomography (CT) and magnetic resonance imaging (MRI) in the differentiation of various lesions of the major salivary glands. Twenty-two patients underwent dual-isotope SPET imaging, of whom 12 also had CT and 15 also had a...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200003000-00012

    authors: Arbab AS,Koizumi K,Toyama K,Nambu A,Ichikawa T,Arai T,Araki T

    更新日期:2000-03-01 00:00:00

  • Deficiencies in product labelling instructions and quality control directions for 99mTc radiopharmaceuticals.

    abstract:OBJECTIVE:The aim of the study was to identify deficiencies in product labelling instructions for reconstitution and in the quality control directions detailed in the technical leaflets (TLs) or summary product characteristic (SPC) sheets of commonly used technetium labelling cold kits. MATERIALS AND METHODS:The recon...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000030

    authors: Buroni FE,Lodola L,Persico MG,Aprile C

    更新日期:2014-02-01 00:00:00

  • A 99Tcm-labelled leukotriene B4 receptor antagonist for scintigraphic detection of infection in rabbits.

    abstract::In a search for a rapid and accurate imaging agent for scintigraphic detection of infection and inflammation, an LTB4 receptor antagonist, 99Tcm-RP517, which contains the hydrazino nicotinamide moiety, has been developed recently. To study the in vivo behaviour of 99Tcm-RP517, rabbits with Escherichia coli infection w...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200011000-00010

    authors: Brouwers AH,Laverman P,Boerman OC,Oyen WJ,Barrett JA,Harris TD,Edwards DS,Corstens FH

    更新日期:2000-11-01 00:00:00

  • Follow-up of patients with superior vena cava syndrome by functional analysis of radionuclide venography.

    abstract::In addition to imaging, radionuclide venography can be used for studying haemodynamic changes in superior vena cava syndrome (SVCS) by using the indices of transit time (TT), time of half peak count (TH) and peak count ratio (PC ratio). The objective of this study was to examine the utility of applying these indices, ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199805000-00003

    authors: Mahmud AM,Teshima T,Isawa T,Miki M,Horikoshi M,Yanagimachi T,Nukiwa T

    更新日期:1998-05-01 00:00:00

  • Left ventricular ejection fraction determined with the nuclear stethoscope, gamma camera and contrast ventriculography.

    abstract::Left ventricular ejection fractions (EF) were measured with a nuclear stethoscope (NSt, beat-to-beat and ECG gated summation method) and contrast ventriculography (VG) immediately following one another (IFOA) (r X 0.96 and 0.95, respectively, n = 13). NSt and ECG gated gamma camera (MUGA) recordings IFOA were compared...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198605000-00003

    authors: Lund O,Rasmussen K,Jensen FT,Hansen HH

    更新日期:1986-05-01 00:00:00

  • Totally automatic definition of renal regions of interest from 99mTc-MAG3 renograms: validation in patients with normal kidneys and in patients with suspected renal obstruction.

    abstract:INTRODUCTION:An image-processing algorithm (AUTOROI) has been developed to totally automatically (or with manual assistance) detect whole-kidney contours and generate renal regions of interest (ROI) for the extraction of the quantitative measurements used in the interpretation of Tc-mercaptoacetyltriglycine (Tc-MAG3) r...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3283362aa3

    authors: Garcia EV,Folks R,Pak S,Taylor A

    更新日期:2010-05-01 00:00:00

  • Relationship of alveolar permeability and lung inflammation in patients with active diffuse infiltrative lung disease detected by 99Tcm-DTPA radioaerosol inhalation lung scintigraphy and quantitative 67Ga lung scans.

    abstract::The alveolar permeability (AP) in 21 patients with active diffuse infiltrative lung disease (ILD) was measured by 99Tcm-diethylenetriaminapentaacetate (DTPA) radioaerosol inhalation lung scintigraphy. The degree of AP damage in ILD was presented as the slope (% min-1) of the time-activity curve from the dynamic lung i...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199410000-00012

    authors: Kao CH,Lin HT,Yu SL,Wang SJ,Yeh SH

    更新日期:1994-10-01 00:00:00

  • A technique for lung ventilation-perfusion SPECT in neonates and infants.

    abstract:BACKGROUND:Single photon emission tomography (SPECT) of the lung is a well-established non-invasive technique for quantitative assessment of regional lung ventilation and perfusion distribution in children and in adults. However, its application in neonates as well as infants has been scarce because of several practica...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3282f25905

    authors: Sánchez-Crespo A,Rohdin M,Carlsson C,Bergström SE,Larsson SA,Jacobsson H,Lindahl S,Jonsson B

    更新日期:2008-02-01 00:00:00

  • A novel liver function evaluation system using radiopharmacokinetic modeling of technetium-99m-DTPA-galactosyl human serum albumin.

    abstract:BACKGROUND:A new kinetic model of technetium-99m-labeled diethylenetriaminepentaacetic acid-galactosyl human serum albumin (Tc-GSA) was developed to show the speed of asialoglycoprotein receptor-mediated endocytosis. MATERIALS AND METHODS:Ten healthy volunteers and 17 patients with liver cirrhosis were intravenously i...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e328362e7c7

    authors: Du S,Mao Y,Tong J,Li F,Che L,Li S,Yang H,Ba J,Hu N,Xing H,Lu X,Sang X,Zhang X,Wang X,Zhong S

    更新日期:2013-09-01 00:00:00

  • Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin?

    abstract:OBJECTIVE:The clearance rate of inhaled 99mTc-sestamibi from the lungs of healthy nonsmoking individuals is much slower than would be expected from its physical properties. The clearance rate is even slower in healthy cigarette smokers. As 99mTc-sestamibi is a substrate for P-glycoprotein (P-gp), pulmonary P-gp may be ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e32832b9a2d

    authors: Cheow HK,Ruparelia P,Shankar S,Szczepura KR,Ballinger JR,Hartman NG,Chilvers ER,Peters AM

    更新日期:2009-08-01 00:00:00

  • Detection of norepinephrine distribution in rats with adrenal medulla autotransplants using 125I-meta-iodobenzyl guanidine.

    abstract::The viability of autologous adrenal medullary transplants was evaluated using 125I-meta-iodobenzyl guanidine (MIBG), an adrenal medullary scanning agent. Bilateral cavities in the caudate nuclei were made stereotaxically in Wistar rats. One week later, the left adrenal medulla was resected by microsurgery, followed by...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199409000-00015

    authors: Shinoda M,Suzuki Y,Oi S,Tsugane R,Sato O

    更新日期:1994-09-01 00:00:00

  • Should the presence of other diseases exclude subjects as controls in studies of gallbladder response to cholecystokinin octapeptide (sincalide)? Scintigraphic results in patients with malignancies but no known gallbladder disease.

    abstract::Findings of hepatobiliary scintigraphy with intravenous cholecystokinin octapeptide (sincalide) were examined in 26 asymptomatic patients with various malignancies but no known pre-existing gallbladder disease, and normal hepatobiliary and gallbladder morphology on sonography. The maximum gallbladder ejection fraction...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199606000-00010

    authors: Jacobson AF,Teefey SA

    更新日期:1996-06-01 00:00:00

  • Effects of 99mTc-MIBI and 99mTc-MDP administration on dual-energy X-ray absorptiometry bone mineral density measurements.

    abstract:OBJECTIVE:Nuclear medicine procedures are often performed in close-time proximity to bone densitometry studies. The purpose of this study was to determine the effects of Tc-hexakis-2-methoxyisobutyl isonitrile (MIBI) and Tc-methylene diphosphonate (MDP) on the accuracy of bone mineral density (BMD) measurements perform...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e328329fc4c

    authors: Gumuser G,Parlak Y,Topal G,Aras F,Ruksen E,Sayit E

    更新日期:2009-06-01 00:00:00

  • Formulation and characterization of lutetium-177-labeled stannous (tin) colloid for radiosynovectomy.

    abstract:OBJECTIVE:Easy large-scale production, easy availability, cost-effectiveness, long half-life, and favorable radiation characteristics have made lutetium-177 (Lu) a preferred radionuclide for use in therapy. Lutetium-177-labeled stannous (Lu-Sn) colloid particles were formulated for application in radiosynovectomy, foll...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000684

    authors: Arora G,Singh M,Jha P,Tripathy S,Bal C,Mukherjee A,Shamim SA

    更新日期:2017-07-01 00:00:00

  • (99m)Tc-E-selectin binding peptide for imaging acute osteomyelitis in a novel rat model.

    abstract:INTRODUCTION:In the present study, (99m)Tc-radiolabelled E-selectin binding peptide ((99m)Tc-IMP-178) was investigated for its potential to image acute pyogenic osteomyelitis in a new animal model. Intraindividual comparisons were performed using an irrelevant peptide ((99m)Tc-IMP-100) to demonstrate specificity. METH...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200109000-00010

    authors: Gratz S,Béhé M,Boerman OC,Kunze E,Schulz H,Eiffert H,O'Reilly T,Behr TM,Angerstein C,Nebendahl K,Kauer F,Becker W

    更新日期:2001-09-01 00:00:00

  • The gamma camera as an absolute measurement device: determination of glomerular filtration rate in 99mTc-DTPA renography using a dual head gamma camera.

    abstract:AIM:The aim of this study was to design a general nuclear medicine method for fast, accurate and direct determination of the clearance of a radioactive indicator provided that all uptake compartments of the radioactive indicator could be included in the field of view of the gamma camera. METHODS:The data material for ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200410000-00006

    authors: Carlsen O

    更新日期:2004-10-01 00:00:00

  • Differentiating dural metastases from meningioma: role of 68Ga DOTA-NOC PET/CT.

    abstract:OBJECTIVE:To assess the ability of Ga DOTA-NOC PET/computed tomography (CT) to differentiate dural metastases from meningioma. PATIENTS AND METHODS:Patients who underwent a Ga DOTA-NOC PET/CT for differentiating meningiomas from dural metastases were included in the study. A visual score was assigned to the dural lesi...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001155

    authors: Purandare NC,Puranik A,Shah S,Agrawal A,Gupta T,Moiyadi A,Shetty P,Shridhar E,Patil V,Rangarajan V

    更新日期:2020-04-01 00:00:00

  • Functional nuclear medicine imaging of medullary thyroid cancer.

    abstract::Medullary thyroid cancer (MTC) originates from parafollicular C cells of the thyroid and accounts for 3-12% of all thyroid cancers. As opposed to other types of dedifferentiated thyroid tumours, MTC cells are highly functional, producing and secreting high amounts of calcitonin and carcinoembryonic antigen. As parafol...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0b013e32830f4af2

    authors: Bozkurt MF,Uğur O,Banti E,Grassetto G,Rubello D

    更新日期:2008-11-01 00:00:00