Abstract:
OBJECTIVE:To compare 18-fluorine-labeled 2-deoxy-2-fluoro-D-glucose PET/computed tomography ((18)F-FDG-PET/CT) with contrast enhancement computed tomography (CECT) in the early follow-up of patients who had undergone treatment for primitive retroperitoneal sarcomas (RS). METHODS:This is a retrospective study on 24 patients who underwent (18)F-FDG-PET/CT and CECT within 2 years after therapy for RS. (18)F-FDG-PET/CT and CECT results were compared with results of histological examination and clinical-instrumental follow-up. We calculated the sensitivity and specificity of CECT and (18)F-FDG-PET/CT for retroperitoneal recurrences and compared them with results of the McNemar test. Negative predictive values (NPVs) and positive predictive values (PPVs) were calculated and the positive percentage agreement and negative percentage agreement were evaluated. RESULTS:The sensitivity and specificity of (18)F-FDG-PET/CT were 66.7 and 100% and those for CECT were 58.3 and 50%, respectively. For (18)F-FDG-PET/CT, PPV was 100% [95% confidence interval (CI): 67-100%] and NPV was 75% (95% CI: 58-75%); for CECT, PPV was 54% (95% CI: 33-73%) and NPV was 55% (95% CI: 30-78%). Positive percentage agreement and negative percentage agreement were, respectively, 38 and 72% for retroperitoneal lesions, 42.8 and 100% for liposarcomas, 40 and 50% for leiomyosarcomas, 14.2 and 94% for abdominal lymph nodes, and 16.6 and 100% for lung metastasis. Neither technique gave reliable results for liver metastasis. CONCLUSION:Our data show that (18)F-FDG-PET/CT has a higher overall specificity compared with CECT in identifying areas of recurrence, demonstrating its validity for early whole-body detection of lesions. In our hands (18)F-FDG-PET/CT seems to be a good tool in the early follow-up of patients experiencing recurrence of RS.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Niccoli-Asabella A,Altini C,Notaristefano A,Merenda N,Altieri ML,Stabile-Ianora AA,Fanelli M,Rubini Gdoi
10.1097/MNM.0b013e32835ae545subject
Has Abstractpub_date
2013-01-01 00:00:00pages
32-9issue
1eissn
0143-3636issn
1473-5628journal_volume
34pub_type
杂志文章abstract::Heart uptake and clearance of 123I-15-(p-iodophenyl)-3(R,S)-methyl- pentadecanoic acid (BMIPP) by whole-body scintigraphy in relation to left ventricular ejection fraction (LVEF) was evaluated in 34 patients with ischaemic heart disease. At 45 and 210 min after injection, anterior whole-body images were obtained. In e...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-199409000-00004
更新日期:1994-09-01 00:00:00
abstract::An analysis of lymphocyte subsets was performed in 24 patients with surgically verified unresectable hepatocellular carcinoma (HCC). In all cases, the hepatic artery was cannulated and ligated and a single dose of 131I-Hepama-1 monoclonal antibody (MAb) was infused through a hepatic artery catheter. Blood samples were...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-199505000-00010
更新日期:1995-05-01 00:00:00
abstract::Cystic fibrosis patients require pancreatic enzyme supplements to aid food digestion. It is suspected that incorrect delivery of this enzyme may result in both significant malabsorption and the development of strictures in the proximal colon caused by the high-dose supplement reaching this region before the food. Inve...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199808000-00006
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:This study investigated dopamine transporter blockade in the rat striatum after treatment with various doses of methylphenidate using a high-resolution small animal SPECT ('TierSPECT') and I-FP-CIT. METHODS:I-FP-CIT was administered intravenously 1 h after intraperitoneal injection of methylphenidate (3 mg.k...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328014a0df
更新日期:2007-03-01 00:00:00
abstract::The aim of this study was to compare the sensitivity and specificity of morphine-augmented hepatobiliary scintigraphy (MA-HBS) with that of conventional hepatobiliary scintigraphy (C-HBS) for acute cholecystitis. The results of most MA-HBS studies cannot be compared with C-HBS estimates, since articles describing C-HB...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199512000-00013
更新日期:1995-12-01 00:00:00
abstract::Planar scintimammography with 99Tcm-sestamibi (99Tcm-MIBI) has been shown to be useful in diagnosing breast carcinoma. The aim of this study was to compare single photon emission tomography (SPET) and planar imaging for scintimammography with 99Tcm-MIBI in the detection of primary breast cancer and axillary lymph node...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::Should one correct for extrathyroidal neck radioactivity ('neck background') when interpreting perchlorate discharge test results? A new background correction method was developed using a linear probe. 123I produces photon peaks at two energy levels: 159 keV (gamma-rays) and 28 keV (X-rays), with an attenuation of 15 ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199211000-00013
更新日期:1992-11-01 00:00:00
abstract::The technique of 99Tcm-labelled red cell scintigraphy as a means of detecting rebleeding was investigated in 33 patients with bleeding peptic ulcers. Scintigrams were performed twice during the 24 h period succeeding diagnostic endoscopy. There was scintigraphic evidence of rebleeding in 23 patients but this was clini...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198509000-00003
更新日期:1985-09-01 00:00:00
abstract::During measurements of the extrinsic spatial resolution of a gamma camera, it was noted that there was a variation with the position in the field of view. The problem was traced to the collimator, and this was confirmed by inspection of the parallel hole structure. Removal of the cover showed that the lead foil honeyc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200009000-00012
更新日期:2000-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the clinical role of technetium-99m pertechnetate (Tc-99m) imaging in thyroidectomized differentiated thyroid cancer patients immediately before radioiodine-131 (I-131) treatment (Tx). PATIENT AND METHODS:Eighty-six consecutive post-total-thyroidectomy patients (15 men, 71...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000426
更新日期:2016-02-01 00:00:00
abstract::The aim of this study was to compare the extent and severity of wall motion abnormalities, perfusion and glucose metabolism, in recent myocardial infarction in patients with and without revascularization. Forty-nine patients were studied (82% men; mean age 58 years) by using echocardiography, 201Tl single photon emiss...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200311000-00006
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:To investigate whether the number of fluorodeoxyglucose (FDG)-avid focal lesions and the presence of extramedullary disease (EMD) on F-FDG PET/computed tomography (PET/CT) can predict the outcomes of newly diagnosed symptomatic multiple myeloma patients. METHODS:We performed a meta-analysis to research the pro...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001242
更新日期:2020-06-23 00:00:00
abstract:OBJECTIVES:Radioiodine ablation of thyroid tissue remains the cornerstone of treatment for patients with differentiated thyroid carcinoma after thyroidectomy. Selecting an optimal dose of radioiodine for successful ablation is a continuous challenge in these patients. METHODS:We compared the treatment response of 341 ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,随机对照试验
doi:10.1097/MNM.0b013e32834e306a
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:In studies of the distribution of lung function, the image quality of lung single photon emission computed tomography (SPECT) is important and one factor influencing it is the reconstruction algorithm. AIM:To systematically evaluate ordered subsets expectation maximization (OSEM) and compare it with filtere...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f1acac
更新日期:2007-12-01 00:00:00
abstract::Captopril renography is used for the non-invasive diagnosis of renovascular hypertension, but suffers from the drawbacks of lower sensitivity and false-positive tests due to a fall in blood pressure. Aspirin renography has been proposed as a useful test for evaluation of unilateral renal artery stenoses of moderate de...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200004000-00006
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. PATIENTS AND METHODS:A total of 109 patients with typical angina and no previous coronary artery di...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000739
更新日期:2017-11-01 00:00:00
abstract:AIM:To report our data concerning the changes in post-stress and at-rest left ventricular ejection fraction and ventricular volumes in patients with thallium gated SPECT. METHODS:Post-stress and at-rest thallium gated SPECT was performed in 629 consecutive patients; left ventricular ejection fraction (LVEF), left vent...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/01.mnm.0000167648.29853.93
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:Simulated data from the recent Institute of Physics and Engineering in Medicine audit of quantitative cerebral perfusion were used to optimize the parameters of eigenimage analysis, a method for computer-aided detection. METHODS:Twenty normal images provided by the audit were registered to the International ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32832cc273
更新日期:2009-09-01 00:00:00
abstract::The purpose of this study was to validate different scintigraphic approaches for assessing acute myocardial infarctions. 201Tl, 99Tcm pyrophosphate (PPi) and combined 201Tl/99Tcm PPi tomograms were evaluated in 115 consecutive patients, in 85 of whom clinical examination revealed acute myocardial infarction. The overa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199009000-00005
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abstract:BACKGROUND:To prevent salivary dysfunction in thyroid cancer patients who have undergone radioiodine ablation, massaging the parotid gland (PG) is presumed to be helpful for the removal of radioiodine. The purpose of this study was to evaluate the effect of PG massage in the removal of radioiodine from the PG. METHODS...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,随机对照试验
doi:10.1097/MNM.0000000000000176
更新日期:2014-11-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32834508b3
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:Our study aims to assess the clinical relevance of fluorine-18 fluorodeoxyglucose (F-FDG) negative osteoblastic metastatic bone lesions noted on PET/computed tomography (CT) in breast cancer patients. PATIENTS AND METHODS:The medical records of breast cancer patients were reviewed retrospectively from January ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000481
更新日期:2016-06-01 00:00:00
abstract::In a search for a rapid and accurate imaging agent for scintigraphic detection of infection and inflammation, an LTB4 receptor antagonist, 99Tcm-RP517, which contains the hydrazino nicotinamide moiety, has been developed recently. To study the in vivo behaviour of 99Tcm-RP517, rabbits with Escherichia coli infection w...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200011000-00010
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the usefulness of (123)I-iomazenil (IMZ) single photon emission computed tomography (SPECT) for the pre-surgical identification of epileptogenic areas in patients with temporal lobe epilepsy and to compare the results with those of (123)I-IMP SPECT and (18)Fluorodeoxyglu...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/01.mnm.0000243380.79872.32
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Echocardiography plays a central role in the diagnosis of hypertrophic cardiomyopathy (HCM). However, apical involvement of HCM may be missed because of foreshortening and inadequate clinical suspicion. These patients may be referred for single-photon emission computed tomography imaging. METHODS:We present...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328334fc41
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Paragangliomas are rare tumours of neural crest origin that express high levels of somatostatin receptor. Ga-68 DOTATATE PET/CT is a widely accepted method for imaging of neuroendocrine tumours. This study was performed to review a Ga-68 DOTATATE PET/CT patient database and to establish the impact of the moda...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001130
更新日期:2020-02-01 00:00:00
abstract::The aim of this study was to describe and evaluate an approach for improving radiopharmaceutical supply chain safety by implementing bar code technology. We first evaluated the current situation of our radiopharmaceutical supply chain and, by means of the ALARM protocol, analysed two dispensing errors that occurred in...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000177
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:This study aimed to assess the efficacy of fluorine-18 fluorodeoxyglucose (F-FDG)-PET for predicting overall survival (OS) and disease-free survival (DFS) in oesophageal cancer patients after definitive chemoradiotherapy (CRT) and prognostic importance of metabolic response detected by post-treatment PET at ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000594
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the incremental value of technetium-99m-methyl diphosphonate (Tc-MDP) single-photon emission computed tomography/computed tomography (SPECT/CT) over Tc-MDP two-phase bone scan (TPBS) in the assessment of the patients with pain following knee arthroplasty. PATIENTS AND ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000825
更新日期:2018-05-01 00:00:00
abstract::Measurements were made of the concentration of radioactivity in the breast milk of two patients: one following 100 MBq (2.7 mCi) 99Tcm-pertechnetate administration, and the other following administration of 550 MBq (15 mCi) 99Tcm-glucoheptonate. The fractional activity concentrations in the former case were about two ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198710000-00011
更新日期:1987-10-01 00:00:00