Abstract:
:We investigated a simple and reliable method for the preparation of 99Tcm-dimercaptosuccinic acid (99Tcm(V)-DMSA) without the addition of oxygen. The effect of pH, amount of reducing agent, and oxygen addition in the synthesis of 99Tcm(V)-DMSA were evaluated. At pH 9, we obtained a radiochemical yield of 95% +/- 1.2% within 10 min and a high stability until 7 h, with 92% +/- 1.5% radiochemical purity. However, at a pH lower than 9, the radiochemical yield was below 90% within 10 min, and a longer reaction time was needed to obtain a radiochemical yield above 90%. The addition of oxygen did not have an additional effect on the radiochemical yield or its stability at pH 9, whereas it increased the radiochemical yield of 99Tcm-(V)-DMSA at pH 7. It was noted that the smaller the amount of reducing agent used, the higher was the radiochemical yield obtained at pH 7. However, at pH 9, the radiochemical yield was not dependent on the amount of reducing agent. In conclusion, the synthesis of 99Tcm(V)-DMSA was more dependent on the pH of the reaction mixture than on the amount of reducing agent or the addition of oxygen. The adjustment of pH 9 was the easiest and most effective method for the synthesis of 99Tcm(V)-DMSA using a commercial kit for 99Tcm(III)-DMSA.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Oh SJ,Ha HJ,Moon DH,Ryu JS,Lee HKdoi
10.1097/00006231-200106000-00002keywords:
subject
Has Abstractpub_date
2001-06-01 00:00:00pages
613-6issue
6eissn
0143-3636issn
1473-5628journal_volume
22pub_type
杂志文章abstract::A new radiopharmaceutical for hepatobiliary scanning, 99Tcm Iodida, which has significant advantages in patients with high bilirubinaemia, was used to assess biliary tract complications in 30 consecutive liver transplant patients. There was adequate hepatic extraction and excretion for diagnostic imaging even in patie...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199011000-00005
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to determine the fraction of administered activity that was excreted and retained by a small cohort of patients who each received treatment with radium-223 dichloride (Ra). Ra is an α-emitting radionuclide that has been approved for use in the treatment of bone metastases that are sec...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000783
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Nuclear medicine procedures are often performed in close-time proximity to bone densitometry studies. The purpose of this study was to determine the effects of Tc-hexakis-2-methoxyisobutyl isonitrile (MIBI) and Tc-methylene diphosphonate (MDP) on the accuracy of bone mineral density (BMD) measurements perform...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e328329fc4c
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to evaluate the role of F-fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) in the early postoperative staging of breast cancer and to document (18)F-FDG PET/CT-based stage alterations and any subsequent impact on management. MATERIALS AND METHODS:Between January 2009 and ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328360d8ec
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:A lack of response to cardiac resynchronization therapy (CRT) has been reported in 20-40% of heart failure patients with left ventricular (LV) dyssynchrony who underwent treatment based on the established guidelines. The study aimed to investigate the relationship between (99m)Tc-tetrofosmin ((99m)Tc-TF) myoc...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000150
更新日期:2014-09-01 00:00:00
abstract::This paper proposes the utilization of 225Ac for the alpha-radioimmunotherapy of cancer. The isotope decays with a radioactive half-life of 10 days into a cascade of short-lived alpha- and beta-emitting isotopes. In addition, when indicated by the pharmacokinetic requirements of particular clinical applications, 213Bi...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199302000-00009
更新日期:1993-02-01 00:00:00
abstract::The efficacy of wipe tests for assessing 99Tcm surface contamination was measured. Four types of surface were contaminated with four radiopharmaceuticals and wiped using four types of swab. The fraction of activity removed was measured by direct monitoring for each combination of surface, pharmaceutical and swab. The ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199102000-00005
更新日期:1991-02-01 00:00:00
abstract::Heart uptake and clearance of 123I-15-(p-iodophenyl)-3(R,S)-methyl- pentadecanoic acid (BMIPP) by whole-body scintigraphy in relation to left ventricular ejection fraction (LVEF) was evaluated in 34 patients with ischaemic heart disease. At 45 and 210 min after injection, anterior whole-body images were obtained. In e...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-199409000-00004
更新日期:1994-09-01 00:00:00
abstract::(99m)Tc dimercaptosuccinic acid (DMSA) renal scans can provide accurate diagnosis of acute pyelonephritis, its sequelae (renal scars) and differential renal function (DRF). The purposes of this retrospective study were (1) to assess the relationship between DRF obtained during acute pyelonephritis and at follow-up, an...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200210000-00011
更新日期:2002-10-01 00:00:00
abstract::The purpose of this study was to validate different scintigraphic approaches for assessing acute myocardial infarctions. 201Tl, 99Tcm pyrophosphate (PPi) and combined 201Tl/99Tcm PPi tomograms were evaluated in 115 consecutive patients, in 85 of whom clinical examination revealed acute myocardial infarction. The overa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199009000-00005
更新日期:1990-09-01 00:00:00
abstract::A non-invasive nuclear medicine technique was developed to screen patients with painful hands so as to separate patients with a normal from those with an abnormal microcirculation of the hands in different clinical conditions. Such a technique is important, as the other methods available are either subjective or rathe...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200007000-00010
更新日期:2000-07-01 00:00:00
abstract::To evaluate the clinical utility of 123I-labelled 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (123I-BMIPP), myocardial scintigraphy using 123I-BMIPP was performed in 13 patients with hypertrophic cardiomyopathy (HCM), and the findings were compared with those of 201Tl. The uptake of each tracer was scored visual...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199406000-00008
更新日期:1994-06-01 00:00:00
abstract::Polyphosphonate ligands labelled with radioisotopes decaying by moderate energy beta emission have shown utility as palliative agents for painful bone metastasis. 177Lu (T(1/2)=6.71 d, Ebetamax=497 keV) has radionuclidic properties suitable for use in palliative therapy of bone metastasis. 177Lu was produced at a high...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200201000-00011
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:We investigated the localization pattern of a novel imaging agent, (99m)Tc-labelled glucosamine (ECDG), in a variety of rheumatic conditions. MATERIALS AND METHODS:Sixteen patients were recruited into the study, with either active rheumatoid arthritis or osteoarthritis. (99m)Tc-ECDG was prepared in-house an...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000096
更新日期:2014-06-01 00:00:00
abstract::Renal artery stenosis is an important and potentially curable cause of hypertension. Captopril renography is now recognized to have a high sensitivity and specificity in its diagnosis. Ultimately, however, the result is of little benefit if it does not lead to a change in patient management. To assess how patient mana...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199707000-00006
更新日期:1997-07-01 00:00:00
abstract::The ability of 99Tcm-methoxyisobutylisonitrile (MIBI) single photon emission tomography (SPET) to detect myocardial ischaemia and necrosis was assessed in 56 patients (45 male, 11 female, aged 55 +/- 5 years), with clinically recognized ischaemic heart disease (IHD). All underwent coronary angiography (CA) and left ve...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199212000-00004
更新日期:1992-12-01 00:00:00
abstract::Fever of unknown origin is defined as a temperature above 39.0 degrees C together with a white blood cell count > or = 15,000 mm-3, the duration of fever exceeding 2 weeks and a correct diagnosis not being obtained in the first week of hospitalization. In neonates and infants with fever of unknown origin, the localiza...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199811000-00003
更新日期:1998-11-01 00:00:00
abstract::A miniature, non-imaging caesium iodide nuclear probe optically coupled to a photodiode (the 'Cardioscint') has been developed which, in conjunction with a modified personal computer, is capable of continuous on-line monitoring of left ventricular function and ST-segment level at the bedside. The purpose of this study...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199205000-00004
更新日期:1992-05-01 00:00:00
abstract::The time course of thyroglobulin (Tg) was monitored in patients with differentiated thyroid carcinoma after ablative therapy (thyroidectomy + 131I-treatment) with particular respect to endogeneous antibodies (Tg-ABs). In 232 patients (196 without Tg-ABs, 36 with Tg-ABs at the time of treatment) a sensitivity of 88% (a...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198405000-00003
更新日期:1984-05-01 00:00:00
abstract:INTRODUCTION:PET/computed tomography (CT) using fluorine-18 fluorodeoxyglucose (F-FDG) has been used in the diagnosis of recurrence and metastases of differentiated thyroid cancer (DTC) in cases of negative whole-body scan (WBS) despite elevated concentrations of stimulated thyroglobulin (Tg). AIM:To assess the utilit...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000563
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Extramammary Paget's disease (EMPD) is rare, and limited data have been reported on the utilization of fluorine-18 fluorodeoxyglucose PET/computed tomography ((18)F-FDG PET/CT) in this disease. The aim of this study is to evaluate the role of (18)F-FDG PET/CT in the diagnosis and staging of EMPD. MATERIALS AND...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000340
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:This radiotherapy planning study evaluated tumour delineation using both optimally respiratory gated and nongated fluorine-18 fluorodeoxyglucose-PET (F-FDG-PET). METHODS:For 22 non-small-cell lung tumours, both scans were used to create the nongated and gated (g) gross tumour volumes (GTVg) together with the...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000409
更新日期:2016-01-01 00:00:00
abstract::First-pass radionuclide angiography, for the evaluation of ventricular function during peak physiological stress, requires the use of a low-energy point source for correction of motion artifacts. A design for the construction of a refillable 125I point source is presented. ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199201000-00009
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:Radionuclide therapies, including treatment of neuroendocrine tumors with lutetium-177 (Lu-177) octreotate, often involve hospital admission to minimize radiation exposure to the public. Overnight admission due to Lu-177 octreotate therapy incurs additional cost for the hospital and is an inconvenience for t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000232
更新日期:2015-02-01 00:00:00
abstract::The influence of zooming on centre-of-rotation (COR) of the rotating camera-based SPECT system and on the resolution of tomographic images was investigated. COR values were measured as a function of zoom factor varying from x1.0 to x3.0. Measurements were performed using two SPECT systems collimated with three collima...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198701000-00002
更新日期:1987-01-01 00:00:00
abstract::A general method is presented for fitting experimental data to arbitrary linear compartmental models, based on readily available public domain software. The model is defined by input data so that the same program can be used for different compartmental models. Its use is exemplified by application to the four-compartm...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200108000-00009
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the diagnostic value of function volume/morphological volume ratio calculated from ventilation/perfusion single-photon emission computed tomography/computed tomography in distinguishing the lungs with bronchiolitis obliterans syndrome (BOS) from the lungs without this syndrome after lung transplan...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001021
更新日期:2019-07-01 00:00:00
abstract::Scintimammography is a recently verified technique that will expand the use of nuclear medicine to a new group of patients in whom scintigraphic imaging has not been widely used. If performed correctly, and in certain groups of patients, it delivers a sensitivity as high as X-ray mammography or magnetic resonance imag...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-199708000-00003
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Congenital obstructive renal disease often requires a decision early in the child's life on whether or not surgery is required. Differential renal function (DRF) calculated from the renogram provides important information for the correct decision in this process. A recent publication cast doubt as to the rel...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f20e1f
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare the sensitivity of single-photon emission computed tomography/computed tomography (SPECT/CT) using 99mTc-sestamibi (MIBI) with that of PET/CT using 11C-methionine (MET) for localization of parathyroid adenomas/hyperplasia in primary hyperparathyroidism. MATERIALS AND ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000216
更新日期:2015-01-01 00:00:00