The impact of PET/CT imaging performed in the early postoperative period on the management of breast cancer patients.

Abstract:

OBJECTIVES:The aim of the study was to evaluate the role of F-fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) in the early postoperative staging of breast cancer and to document (18)F-FDG PET/CT-based stage alterations and any subsequent impact on management. MATERIALS AND METHODS:Between January 2009 and June 2012, PET/CT images of patients with histopathologically proven breast cancer who underwent surgery with no previous chemotherapy or radiotherapy were retrospectively reviewed. Any stage alteration due to a change in nodal or metastatic status on PET/CT was noted. RESULTS:A total of 77 women (median age: 52 years; range: 26-87 years) were included. PET/CT revealed distant metastases that were previously undetected in 12 of the 77 women (15.6%). Of these women, one (8.3%) was diagnosed with stage I, four (33.3%) with stage II, and seven (58.4%) with stage III disease before the PET study. In two patients, lung lesions were diagnosed as metastases by conventional imaging methods, and in one patient the lesions were revealed to have a low probability for malignancy on PET/CT, and they were confirmed as benign on follow-up CT. Thus, changes in disease stage occurred in 15 of 77 (19.5%) patients following PET/CT. The disease was upstaged in 14 patients (18.2%) and downstaged in one (1.3%). CONCLUSION:The impact of (18)F-FDG PET/CT is highest in newly diagnosed stage III breast cancer because of the identification of previously undetected extra-axillary lymph nodes and distant metastases. Early postoperative (18)F-FDG PET/CT imaging may alter the staging and potentially contribute to the management of these patients.

journal_name

Nucl Med Commun

authors

Sen F,Akpinar AT,Ogur U,Duman G,Tamgac F,Alper E

doi

10.1097/MNM.0b013e328360d8ec

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

571-6

issue

6

eissn

0143-3636

issn

1473-5628

journal_volume

34

pub_type

杂志文章
  • 67Ga-9N3 uptake by xenografts of human melanotic melanoma in mice.

    abstract::Tumour uptake of the inert, neutral complex 67Ga-9N3 and the tumour:blood concentration ratio (1,4,7,triazacyclononane-1,4,7, triacetic acid) were measured in mice bearing xenografts of the human melanotic melanoma HX118. Between 1 and 4 h after the injection the tumour:blood ratio increased from 3.5 to 21 and the con...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199209000-00006

    authors: Harrison A,Walker CA,Pereira KA,Parker D,Royle L,Matthews RC,Craig AS

    更新日期:1992-09-01 00:00:00

  • In vivo evaluation of three different 99mTc-labelled radiopharmaceuticals for sentinel lymph node identification.

    abstract::This work was designed to compare sentinel lymph node (SLN) uptake of 99mTc-labelled human serum albumin colloid (99mTc-HSAC), 99mTc-labelled antimony sulphur colloid (99mTc-SC) and a 99mTc-labelled dextran 70 solution (99mTc-Dx) and their selectivity in the identification of this node in the right rear footpad (RRF) ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200105000-00006

    authors: Edreira MM,Colombo LL,Perez JH,Sajaroff EO,de Castiglia SG

    更新日期:2001-05-01 00:00:00

  • Diagnostic performance of a novel dedicated breast PET scanner with C-shaped ring detectors.

    abstract:BACKGROUND:A dedicated breast PET scanner with C-shaped detectors (C scanner) has been newly developed. The purpose of this study was to re-evaluate the diagnostic performance of high-resolution PET images with the new reconstruction conditions, obtained using this C scanner in breast cancer patients, and to compare th...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000661

    authors: Nakamoto R,Nakamoto Y,Ishimori T,Nishimatsu K,Miyake KK,Kanao S,Iima M,Toi M,Togashi K

    更新日期:2017-05-01 00:00:00

  • New possibilities in erythrocyte survival studies with the application of a Well-type germanium semiconductor detector.

    abstract::The application of a Well-type germanium semiconductor detector creates new possibilities in erythrocyte survival studies. Using 51Cr, the effective dose equivalent in a standard procedure can be reduced from approximately 780 to 2 microSv. The properties of the detector, namely, high efficiency and high energy resolu...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199105000-00010

    authors: De Vries RA,Oldenburg SJ,Thelosen T,De Bruin M,Poortman J,Van de Wiel A

    更新日期:1991-05-01 00:00:00

  • Acute effect of 3-(4-acetamido)-butyrril-lorazepam (DDS2700) on brain function assessed by PET at rest and during attentive tasks.

    abstract::The aim of this study was to assess, by positron emission tomography (PET), the effect on cerebral functional activity of a new lorazepam-gamma-aminobutyric acid (GABA) conjugate [3-(4-acetamido)-butyrril lorazepam (DDS2700)]. Ten healthy volunteers were studied by PET and [18F]fluoro-deoxy-D-glucose ([18F]FDG) under ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200104000-00008

    authors: Moresco RM,Tettamanti M,Gobbo C,Del Sole A,Ravasi L,Messa C,Paulesu E,Lucignani G,Perani D,Fazio F

    更新日期:2001-04-01 00:00:00

  • Correlation between serum 25-hydroxyvitamin D concentrations and regional cerebral blood flow in degenerative dementia.

    abstract:BACKGROUND:Chronic low serum vitamin D concentrations are common among the elderly. Recent studies have suggested that its metabolite, 25-hydroxyvitamin D (25-OHD), might be important for preserving cognitive functions through specific brain protective effects. However, this hypothesis is still under discussion. The ai...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32835674c4

    authors: Farid K,Volpe-Gillot L,Petras S,Plou C,Caillat-Vigneron N,Blacher J

    更新日期:2012-10-01 00:00:00

  • Formulation and characterization of lutetium-177-labeled stannous (tin) colloid for radiosynovectomy.

    abstract:OBJECTIVE:Easy large-scale production, easy availability, cost-effectiveness, long half-life, and favorable radiation characteristics have made lutetium-177 (Lu) a preferred radionuclide for use in therapy. Lutetium-177-labeled stannous (Lu-Sn) colloid particles were formulated for application in radiosynovectomy, foll...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000684

    authors: Arora G,Singh M,Jha P,Tripathy S,Bal C,Mukherjee A,Shamim SA

    更新日期:2017-07-01 00:00:00

  • The role of fluorine-18 fluorodeoxyglucose PET in prognosis evaluation for stem cell transplantation of lymphoma: a systematic review and meta-analysis.

    abstract::The role of fluorine-18 fluorodeoxyglucose PET (F-FDG PET) in prognostic evaluation of pre-stem cell transplantation (SCT) and post-SCT is still uncertain. A systematic review and meta-analysis were carried out to detect the prognostic power of F-FDG PET. 'PubMed', EMBASE, and Springer were searched for relevant artic...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MNM.0000000000000468

    authors: Wang C,Li P,Wu S,Lu J,Liu Q,Luo H,Song S

    更新日期:2016-04-01 00:00:00

  • The clinical usefulness of the fingers-to-palm ratio in different hand microcirculatory abnormalities.

    abstract::A non-invasive nuclear medicine technique was developed to screen patients with painful hands so as to separate patients with a normal from those with an abnormal microcirculation of the hands in different clinical conditions. Such a technique is important, as the other methods available are either subjective or rathe...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200007000-00010

    authors: Galuska L,Garai I,Csiki Z,Varga J,Bodolay E,Bajnok L

    更新日期:2000-07-01 00:00:00

  • Bone lesion detection with carrier-added 99mTc-EDTMP in comparison with 99mTc-DPD.

    abstract::An increased uptake of bone-seeking radiopharmaceuticals into malignant bone lesions could further improve the diagnostic accuracy of routine bone scanning. The tracers used in clinical routine for bone scanning are methylene-diphosphonate (MDP), dicarboxypropane-diphosphonate (DPD) and ethylenediaminetetramethylene-p...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200404000-00008

    authors: Fueger BJ,Mitterhauser M,Wadsak W,Ofluoglu S,Traub T,Karanikas G,Dudczak R,Pirich C

    更新日期:2004-04-01 00:00:00

  • Radioimmunolocalization and selective delivery of radiation in a rat model system: comparison of intact and fragmented antibody.

    abstract::Monoclonal antibody (MoAb) fragments are known to have advantages over intact immunoglobulins for radioimmunoscintigraphy. It is less clear whether they are as effective in the delivery of radioimmunotherapy. The imaging and dosimetric properties of an intact MoAb, K-1-21, reactive against human kappa light chains (LC...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:

    authors: Walker KZ,Seymour-Munn K,Towson JE,Axiak SM,Raison RL,Bautovitch GJ,Morris J,Basten A

    更新日期:1988-07-01 00:00:00

  • Somatostatin and somatostatin analogues in medullary thyroid carcinoma.

    abstract::Medullary thyroid carcinoma (MTC) is a neuroendocrine tumour characterized by the production and secretion of calcitonin. MTC tumours may express functional somatostatin receptors (hSSTR). A significant proportion of hSSTR receptor-positive MTC tumours, including metastatic disease, may be visualized in vivo through 1...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199609000-00013

    authors: O'Byrne KJ,O'Hare N,Sweeney E,Freyne PJ,Cullen MJ

    更新日期:1996-09-01 00:00:00

  • How has the management of medullary thyroid carcinoma changed with the advent of 18F-FDG and non-18F-FDG PET radiopharmaceuticals.

    abstract::Medullary thyroid cancer (MTC) arises from parafollicular C cells and is an elusive tumor to image. It occurs as a sporadic neoplasm in 70-80% of cases and is hereditary in 20-30% because of germline mutations of the rearranged during transfection proto-oncogene. Successful disease management relies on accurate stagin...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0b013e3283529bf7

    authors: Wong KK,Laird AM,Moubayed A,Chondrogiannis S,Marzola MC,Evangelista L,Gross MD,Rubello D

    更新日期:2012-07-01 00:00:00

  • Changes in septal regional ejection fraction early and late following coronary artery bypass grafting in patients without postoperative myocardial infarction.

    abstract::Changes in regional ejection fraction (rEF) of the interventricular septum following coronary artery bypass graft (CABG) surgery were examined using first-pass radionuclide ventriculography (RNVG) in patients without objective evidence of postoperative myocardial infarction (MI). One hundred and one patients had pre- ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:

    authors: Jacobson AF,Tow DE,Lapsley D,Khuri S

    更新日期:1992-10-01 00:00:00

  • Dual-time 18F-FDG PET/CT for the detection of liver metastases in breast cancer.

    abstract:OBJECTIVE:The aim was to investigate the diagnostic potential of dual-time-point F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in patients with breast cancer with known or suspected liver metastases and to assess its clinical value on clinical management. PATIENTS AND METHODS:A t...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000918

    authors: Annovazzi A,Rea S,Vici P,Fabi A,Sciuto R

    更新日期:2018-12-01 00:00:00

  • Stress-only myocardial perfusion scintigraphy: a prospective study on the accuracy and observer agreement with quantitative coronary angiography as the gold standard.

    abstract:OBJECTIVE:Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. PATIENTS AND METHODS:A total of 109 patients with typical angina and no previous coronary artery di...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0000000000000739

    authors: Ejlersen JA,May O,Mortensen J,Nielsen GL,Lauridsen JF,Allan J

    更新日期:2017-11-01 00:00:00

  • Incidental detection of apical hypertrophic cardiomyopathy by myocardial perfusion imaging.

    abstract:BACKGROUND:Echocardiography plays a central role in the diagnosis of hypertrophic cardiomyopathy (HCM). However, apical involvement of HCM may be missed because of foreshortening and inadequate clinical suspicion. These patients may be referred for single-photon emission computed tomography imaging. METHODS:We present...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328334fc41

    authors: Irwin RB,Arumugam P,Khattar RS

    更新日期:2010-04-01 00:00:00

  • Can administration of metoclopramide reduce artefacts related to abdominal activity in myocardial perfusion SPECT?

    abstract:OBJECTIVES:Myocardial perfusion SPECT is frequently affected by artefacts related to abdominal activity. Metoclopramide has been suggested to relieve this, but two previous studies have shown conflicting results. METHODS:Ninety-five patients received 10 mg metoclopramide orally after injection of 99mTc-tetrofosmin for...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.mnm.0000243368.73141.61

    authors: Grüning T,Brogsitter C,Khonsari M,Jones IW,Nevin SM,Burchert W

    更新日期:2006-12-01 00:00:00

  • Role of SUV(max) obtained by 18F-FDG PET/CT in patients with a solitary pancreatic lesion: predicting malignant potential and proliferation.

    abstract:OBJECTIVES:Maximum standardized uptake value (SUV(max)) is a marker of tumor glucose metabolism detected by [(18)F]-fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (PET/CT) and reflects tumor aggressiveness. The aim of the study was to evaluate the value of SUV(max) in differentiating benign from malignant solit...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328360668a

    authors: Hu SL,Yang ZY,Zhou ZR,Yu XJ,Ping B,Zhang YJ

    更新日期:2013-06-01 00:00:00

  • Importance of 18F-FDG PET/CT to select patients with nonresectable colorectal liver metastases for liver transplantation.

    abstract:OBJECTIVE:The aim of this study was to evaluate fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT for the selection of patients with nonresectable colorectal liver metastases (NCLM) for liver transplantation (LT). In the secondary cancer study, we reported an improved 5-year overall survival in patients treated with LT for...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000843

    authors: Grut H,Revheim ME,Line PD,Dueland S

    更新日期:2018-07-01 00:00:00

  • Detection of CBF deficits in neuropsychiatric disorders by an expert system: a 99Tcm-HMPAO brain SPET study using automated image registration.

    abstract::The aims of this study were to develop an objective method for assessing rCBF deficits using a statistical image analysis protocol and to validate its effective use in clinical practice. 99Tcm-HMPAO brain SPET images were acquired for 40 normal subjects, 10 patients with Alzheimer's disease and 10 patients with depres...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199901000-00006

    authors: Imran MB,Kawashima R,Sato K,Kinomura S,Ono S,Qureshy A,Fukuda H

    更新日期:1999-01-01 00:00:00

  • Assessment of glioma viability by estimating 201Tl SPET tumour uptake volume.

    abstract::The aim of this study was to develop a quantitative method to assess viable tumour based on post-operative 201Tl single photon emission tomography (SPET). We studied 15 patients with histologically defined highly malignant gliomas in the post-operative phase before initiation of adjuvant treatment. A 201Tl index was c...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199909000-00010

    authors: Källén K,Geijer B,Andersson AM,Holtås S,Ryding E,Rosén I

    更新日期:1999-09-01 00:00:00

  • The impact of Ga-68 DOTATATE PET/CT imaging on management of patients with paragangliomas.

    abstract:OBJECTIVE:Paragangliomas are rare tumours of neural crest origin that express high levels of somatostatin receptor. Ga-68 DOTATATE PET/CT is a widely accepted method for imaging of neuroendocrine tumours. This study was performed to review a Ga-68 DOTATATE PET/CT patient database and to establish the impact of the moda...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001130

    authors: Skoura E,Priftakis D,Novruzov F,Caplin ME,Gnanasegaran G,Navalkissoor S,Bomanji J

    更新日期:2020-02-01 00:00:00

  • Enhanced uptake of 99Tcm-MDP in skeletal metastases from prostate cancer following initiation of hormone treatment: potential for increasing delivery of therapeutic agents.

    abstract::Following androgen ablation therapy, skeletal metastases from prostate cancer appear in some instances to show an increase in 99Tcm-methylene diphosphonate (99Tcm-MDP) uptake. Such a phenomenon could represent a mechanism to increase delivery of bone-seeking therapeutic agents to skeletal metastatic sites. The aim of ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199910000-00002

    authors: Bushnell DL,Madsen M,Kahn D,Nathan M,Williams RD

    更新日期:1999-10-01 00:00:00

  • Does renal damage occur after the administration of 32P for palliation of pain from skeletal metastases?

    abstract::In normal adults, the maintenance of phosphate balance involves the reabsorption of 85-90% of filtered phosphate by the proximal tubule. At a glomerular filtration rate (GFR) of 125 ml min-1 and a plasma phosphate concentration of 1.3 mmol l-1, the filtered phosphate is approximately 235 mmol day-1. Following intraven...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199807000-00011

    authors: Nair N,Mahadeo DS,Patel R

    更新日期:1998-07-01 00:00:00

  • Clinical relevance of 18F-FDG-negative osteoblastic metastatic bone lesions noted on PET/CT in breast cancer patients.

    abstract:PURPOSE:Our study aims to assess the clinical relevance of fluorine-18 fluorodeoxyglucose (F-FDG) negative osteoblastic metastatic bone lesions noted on PET/computed tomography (CT) in breast cancer patients. PATIENTS AND METHODS:The medical records of breast cancer patients were reviewed retrospectively from January ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000481

    authors: Al-Muqbel KM,Yaghan RJ,Al-Omari MH,Rousan LA,Dagher NM,Al Bashir S

    更新日期:2016-06-01 00:00:00

  • Estimation of patient attenuation factor for iodine-131 based on direct dose rate measurements from radioiodine therapy patients.

    abstract::The aim of the study was to measure the actual dose at 1 m from the patients per unit activity with the aim of providing a more accurate prediction of the dose levels around radioiodine patients in the hospital, as well as to compare our results with the literature. In this work the demonstration of a patient body tis...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000223

    authors: Soliman K,Alenezi A

    更新日期:2015-02-01 00:00:00

  • Pretargeted gamma imaging of murine metastatic melanoma lung lesions with bispecific antibody and radiolabeled polymer drug conjugates.

    abstract:INTRODUCTION:Bispecific monoclonal antibodies (bsMAbs) have been developed as a pretargeting tool to reduce background activity, thereby increasing target to background (T : B) ratios. To enhance visualization of small lesions in vivo, we have used the pretargeting approach of bsMAb and negatively charged polymers radi...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32834af77b

    authors: Gada KS,Patil V,Panwar R,Majewski S,Tekabe Y,Khaw BA

    更新日期:2011-12-01 00:00:00

  • Removal of the internal mammary sentinel node in breast cancer.

    abstract:OBJECTIVE:The aim of the study was to determine the evolution of patients with internal mammary chain (IMC) drainage whether the IMC-sentinel lymph node (IMC-SLN) was biopsied or not, as well as to determine the clinical implications of the biopsy of the IMC-SLN (IMC-SLNB) in patients with breast cancer and IMC drainag...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328330addf

    authors: Domènech-Vilardell A,Bajén MT,Benítez AM,Ricart Y,Mora J,Rodríguez-Bel L,García-Tejedor A,Climent J,López-Ojeda A,Urruticoechea A,Martín-Comín J

    更新日期:2009-12-01 00:00:00

  • Performance of two new solid-phase ligand assays for TSH using monoclonal antibodies.

    abstract::Three ligand assays for TSH using monoclonal antibodies, an IRMA, an ELISA and a DELFIA were compared with a standard DAB RIA technique. The IRMA proved to be superior in respect to sensitivity, precision, reproducibility and practicality. The highest sensitivity yet, was achieved by DELFIA. IRMA, ELISA and DELFIA are...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198504000-00003

    authors: Böttger I,Pabst HW,Senekowitsch R,Kriegel H

    更新日期:1985-04-01 00:00:00