Somatostatin and somatostatin analogues in medullary thyroid carcinoma.

Abstract:

:Medullary thyroid carcinoma (MTC) is a neuroendocrine tumour characterized by the production and secretion of calcitonin. MTC tumours may express functional somatostatin receptors (hSSTR). A significant proportion of hSSTR receptor-positive MTC tumours, including metastatic disease, may be visualized in vivo through 111In-pentetreotide scintigraphy. Four patients with recurrent/metastatic disease, who had previously been assessed with 111In-anti-CEA monoclonal antibody fragment [F(ab')2] imaging, were evaluated. 111In-pentetreotide scintigraphy localized all known disease sites. Furthermore, mediastinal disease was detected in one patient with negative conventional, and 111In-anti-CEA F(ab')2 imaging studies. The detection of somatostatin within the tumour (2 patients), or negative octreotide challenges (2 patients), did not affect the outcome of 111In-pentetreotide scintigraphy. In conclusion, 111In-pentetreotide scintigraphy appears at least as effective as 111In-anti-CEA F(ab')2 imaging and should be considered in the diagnostic evaluation of MTC, particularly in the setting of recurrent/metastatic disease not detected by conventional means.

journal_name

Nucl Med Commun

authors

O'Byrne KJ,O'Hare N,Sweeney E,Freyne PJ,Cullen MJ

doi

10.1097/00006231-199609000-00013

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

810-6

issue

9

eissn

0143-3636

issn

1473-5628

journal_volume

17

pub_type

杂志文章
  • Effects of extracellular Na+ and Ca2+ ions and Ca2+ channel modulators on the cell-associated activity of 99mTc-MIBI and 99mTc-tetrofosmin in tumour cells.

    abstract::Our aim was to determine whether the Ca2+ ion or cell membrane Ca2+ and Na+/Ca2+ ion transport systems are involved in maintaining the cell-associated activity of technetium-99m-hexakis-methoxy-isobutyl-isonitrile (99mTc-MIBI) and technetium-99m-ethylene-bis[bis(2-ethoxyethyl)phosphin] (99mTc-tetrofosmin) in tumour ce...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200302000-00008

    authors: Arbab AS,Ueki J,Koizumi K,Araki T

    更新日期:2003-02-01 00:00:00

  • A dual-isotope method for studying protein kinetics in pleural effusions in humans.

    abstract::A method is described for studying protein kinetics in pleural effusions in humans. In 15 patients with pleural effusions from a variety of causes, protein inflow was monitored by measuring the rate of appearance in the effusion of the plasma protein transferrin, radiolabelled in vivo by intravenous injection of 113In...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199206000-00043

    authors: Smith MJ,Joseph J,Flatman WD,Basran GS

    更新日期:1992-06-01 00:00:00

  • Evaluation of the (14)C-urea breath test using indigenously produced (14)C-urea capsules and a modified technique for trapping exhaled breath: a pilot study.

    abstract::The carbon urea breath test ((14)C-UBT) is a noninvasive technique used to detect Helicobacter pylori infection in patients presenting with dyspeptic symptoms. The present study was undertaken to determine the efficacy of indigenously produced (14)C-UBT capsules by the Board of Radiation and Isotope Technology, India....

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000043

    authors: Tiwari BP,Nistala S,Patil SP,Kalgutkar DP,Jaychandran N,Chander H,Basu S

    更新日期:2014-03-01 00:00:00

  • 201Tl myocardial perfusion SPET: adenosine alone or combined with dynamic exercise.

    abstract::201Tl myocardial perfusion single photon emission tomography (SPET) with pharmacological coronary vasodilatation using adenosine is now often used in the investigation of a patient with ischaemic heart disease (IHD). In this study, we present data from two groups of patients. Group A (n = 40) experienced 201Tl SPET wi...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199408000-00003

    authors: Mahmood S,Gupta NK,Gunning M,Bomanji JB,Jarritt PH,Ell PJ

    更新日期:1994-08-01 00:00:00

  • 99Tcm-MIBI single photon emission tomography (SPET) for detecting myocardial ischaemia and necrosis in patients with significant coronary artery disease.

    abstract::The ability of 99Tcm-methoxyisobutylisonitrile (MIBI) single photon emission tomography (SPET) to detect myocardial ischaemia and necrosis was assessed in 56 patients (45 male, 11 female, aged 55 +/- 5 years), with clinically recognized ischaemic heart disease (IHD). All underwent coronary angiography (CA) and left ve...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199212000-00004

    authors: Sciammarella MG,Fragasso G,Gerundini P,Maffioli L,Cappelletti A,Margonato A,Savi A,Chierchia S

    更新日期:1992-12-01 00:00:00

  • A retrospective study comparing contrast-enhanced computed tomography with 18F-FDG-PET/CT in the early follow-up of patients with retroperitoneal sarcomas.

    abstract:OBJECTIVE:To compare 18-fluorine-labeled 2-deoxy-2-fluoro-D-glucose PET/computed tomography ((18)F-FDG-PET/CT) with contrast enhancement computed tomography (CECT) in the early follow-up of patients who had undergone treatment for primitive retroperitoneal sarcomas (RS). METHODS:This is a retrospective study on 24 pat...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32835ae545

    authors: Niccoli-Asabella A,Altini C,Notaristefano A,Merenda N,Altieri ML,Stabile-Ianora AA,Fanelli M,Rubini G

    更新日期:2013-01-01 00:00:00

  • Radionuclide synovectomy in haemophilic joints.

    abstract::Chronic synovitis often occurs in people with haemophilia. Untreated chronic haemophilic synovitis affects the metabolism of chondrocytes, thus leading to haemophilic arthropathy. A recently introduced therapeutic protocol includes radiation synovectomy (RS), a safe and cost-effective therapeutic method, which has giv...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0b013e32835ed50c

    authors: Teyssler P,Kolostova K,Bobek V

    更新日期:2013-04-01 00:00:00

  • A new method for the radiochemical purity measurement of ¹¹¹In-pentetreotide.

    abstract:OBJECTIVES AND METHODS:The recommended method for the measurement of radiochemical purity (RCP) of ¹¹¹In-labelled pentetreotide is thin-layer chromatography with a silica gel as the stationary phase and a 0.1 N sodium citrate solution (pH 5) as the mobile phase. According to the supplier's instructions, the mobile phas...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32834a7003

    authors: Salgado-Garcia C,Montoza-Aguado M,Luna-Alcaide AB,Segovia-Gonzalez MM,de Mora ES,Lopez-Martin J,Ramos-Font C,Jimenez-Heffernan A

    更新日期:2011-12-01 00:00:00

  • Utility of 18F-FDG uptake in various regions of Waldeyer's ring to differentiate benign from malignant lesions in the midline roof of the nasopharynx.

    abstract:PURPOSE:Lymphoid hyperplasia is not uncommon in the midline roof of the nasopharynx. Most nasopharyngeal carcinoma patients present with primary tumors in the midline of the nasopharynx. The aim of this study was to evaluate the efficacy of 2-[fluorine-18] fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/computed tomography (C...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0000000000000141

    authors: Chen YK,Wang SC,Cheng RH,Yeh CL,Tsui CC,Chia-Hung K

    更新日期:2014-09-01 00:00:00

  • Adrenal scintigraphy in Cushing's syndrome caused by bilateral hyperplasia, adenoma or carcinoma.

    abstract::The results of scintigraphy in 29 patients with Cushing's syndrome were evaluated. It was possible to separate bilateral hyperplasia from unilateral abnormality. In cases of unilateral abnormality correct localization of the tumour was accomplished and it was possible to visualize adrenocortical carcinoma. The many ad...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198501000-00005

    authors: Lindberg S,Ernest I,Fjälling M,Holmdahl C

    更新日期:1985-01-01 00:00:00

  • Impact of fluorodeoxyglucose PET on the management of esophageal cancer.

    abstract::Esophageal cancer is the third most common malignancy of the alimentary tract. The incidence of esophageal cancer has steadily increased over the past three decades. Almost all therapeutic modalities for esophageal cancer are associated with a considerable mortality and morbidity. Consequently, there has been growing ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0b013e32831af204

    authors: Salavati A,Basu S,Heidari P,Alavi A

    更新日期:2009-02-01 00:00:00

  • Detection of metastatic bone lesions in patients with prostate carcinoma: 99Tcm-monoclonal antibody imaging.

    abstract::Bone scintigraphy has been shown to be sensitive in determining bone involvement in patients with malignancy, but it does not allow the assessment of bone marrow lesions in early disease. The aim of this study was to detect bone marrow invasion using 99Tcm-labelled monoclonal antigranulocyte antibody (AgMoAb) in patie...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199710000-00013

    authors: Kiraç S,Duman Y,Cüreklibatur I,Yüksel D,Nazli O,Günaydin G,Taner M

    更新日期:1997-10-01 00:00:00

  • Relationship between various parameters derived from 123I-labelled beta-methyl-branched fatty acid whole-body scintigraphy and left ventricular ejection fraction in patients with ischaemic heart disease.

    abstract::Heart uptake and clearance of 123I-15-(p-iodophenyl)-3(R,S)-methyl- pentadecanoic acid (BMIPP) by whole-body scintigraphy in relation to left ventricular ejection fraction (LVEF) was evaluated in 34 patients with ischaemic heart disease. At 45 and 210 min after injection, anterior whole-body images were obtained. In e...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199409000-00004

    authors: Matsunari I,Saga T,Taki J,Akashi Y,Wakasugi T,Hirai JI,Aoyama T,Matoba M,Nishikawa T,Ichiyanagi K

    更新日期:1994-09-01 00:00:00

  • 99mTcN complexes of tert-butyl dithiocarbamate and methoxyisobutyl dithiocarbamate as myocardial and brain imaging agents.

    abstract:OBJECTIVE:Two ligands viz. tert-butyl dithiocarbamate (TBDTC) and methoxyisobutyl dithiocarbamate (MIBDTC), which are analogous to the tert-butyl isonitrile (TBI) and sestamibi (MIBI) ligands, were synthesized and labelled with the [99mTcN] core to evaluate their potential as myocardial agents. As these complexes have ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/01.mnm.0000183793.51474.2f

    authors: Mathur A,Mallia MB,Subramanian S,Banerjee S,Kothari K,Dhotare B,Sarma HD,Venkatesh M

    更新日期:2005-11-01 00:00:00

  • Prediction of lymph node metastasis by PET/CT metabolic parameters in patients with esophageal squamous cell carcinoma.

    abstract:OBJECTIVE:The aim of this study was to investigate the capability of F-FDG PET/computed tomography (CT)-related metabolic parameters to predict lymph node metastasis (LNM) and occult lymph node metastasis (OLNM) in patients with esophageal squamous cell carcinoma (ESCC). METHODS:Totally 84 patients undergoing curative...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001050

    authors: Xu M,Wang L,Ouyang M,Lin J,Wang L,Zheng X,Miao S,Tang K

    更新日期:2019-09-01 00:00:00

  • Contribution of ¹¹¹In-pentetreotide SPECT/CT imaging to conventional somatostatin receptor scintigraphy in the detection of neuroendocrine tumours.

    abstract:AIM:The aim of the study was to assess the contribution of 111In-pentetreotide single-photon emission computed tomography/computed tomography (SPECT/CT) imaging to conventional somatostatin receptor scintigraphy (SRS) in terms of lesion characterization and localization in the detection of neuroendocrine tumours (NETs)...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000239

    authors: Sainz-Esteban A,Olmos R,González-Sagrado M,González ML,Ruiz MÁ,García-Talavera P,Gamazo C,Villanueva JG,Cobo A,de Luis D

    更新日期:2015-03-01 00:00:00

  • In vivo kinetics of 123I-labelled insulin: studies in normal subjects and patients with diabetes mellitus.

    abstract::Radioactive tracer techniques using 131I- and 125I-insulin have been applied to study insulin metabolism. A simple method to label human insulin with 123I to a high specific activity is described. We have used this radiotracer to study insulin kinetics in vivo in normal subjects and in two groups of diabetic patients....

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198710000-00003

    authors: Sinclair AJ,Signore A,Bomanji J,Britton KE,Pozzilli P,Gale EA

    更新日期:1987-10-01 00:00:00

  • Significant correlation between cerebral hypoperfusion and neuropsychological assessment scores of patients with mild cognitive impairment.

    abstract:PURPOSE:The regions of significant correlation between cerebral hypoperfusion and neuropsychological assessment scores were evaluated using (99m)Tc-HMPAO SPECT in patients with mild cognitive impairment (MCI) on the basis of its three subtypes, namely, single-domain amnestic MCI (aMCI-s), multiple-domain amnestic MCI (...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32835587f8

    authors: Yoon HJ,Park KW,Jeong YJ,Kang DY

    更新日期:2012-08-01 00:00:00

  • 99Tcm-glutathione for imaging inflammatory lesions.

    abstract::The purpose of this study was to demonstrate the accumulation of 99Tcm-glutathione (GSH) in experimental abscesses. The biodistribution of 99Tcm-GSH was determined in mice with turpentine-induced abscesses in comparison with 99Tcm-human immunoglobulin (HIG) at 1, 3, 6 and 24 h. Arthritis was induced by intra-articular...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199407000-00007

    authors: Ercan MT,Unlenen E,Aktaş A

    更新日期:1994-07-01 00:00:00

  • Preparation of radioactive praseodymium oxide as a multifunctional agent in nuclear medicine: expanding the horizons of cancer therapy using nanosized neodymium oxide.

    abstract:OBJECTIVE:Many studies have attempted to assess the significance of the use of the β(-)particle emitter praseodymium-142 ((142)Pr) in cancer treatment. As praseodymium oxide (Pr(2)O(3)) powder is not water soluble, it was dissolved in HCl solution and the resultant solution had to be pH adjusted to be in an injectable ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32835aa7bd

    authors: Bakht MK,Sadeghi M,Ahmadi SJ,Sadjadi SS,Tenreiro C

    更新日期:2013-01-01 00:00:00

  • A method for attenuation and scatter correction of brain SPECT based on computed tomography images.

    abstract::A method for attenuation and scatter correction of brain single photon emission computed tomography (SPECT) is described where computed tomography (CT) images of the brain are used for the calculation of attenuation maps. The method is evaluated for the substance 99mTc hexamethylpropylene amine oxime. A transmission d...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200304000-00011

    authors: Larsson A,Johansson L,Sundström T,Ahlström KR

    更新日期:2003-04-01 00:00:00

  • Fluorine-18 fluorodeoxyglucose avid thyroid incidentalomas on PET/CT scan in cancer patients: how sinister are they?

    abstract:OBJECTIVE:To evaluate the prevalence of malignancy in incidental thyroidal uptake on PET with fluorine-18 deoxyglucose integrated with computed tomography (F-FDG PET/CT) in Pakistani cancer patients and to assess the role of standardized uptake value (SUV) in deciding which lesions to investigate further. METHOD:We re...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000557

    authors: Hassan A,Riaz S,Zafar W

    更新日期:2016-10-01 00:00:00

  • A meta-analysis of scintimammography: an evidence-based approach to its clinical utility.

    abstract:BACKGROUND:Scintimammography using (99m)Tc-labelled isonitriles, sestamibi and tetrofosmin, has become a mature technique in the adjunctive setting for the diagnosis of primary breast cancer. To establish an evidence base for its use, clinically, a meta-analysis was performed on both single-site and multi-centre trials...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/00006231-200607000-00007

    authors: Hussain R,Buscombe JR

    更新日期:2006-07-01 00:00:00

  • Criteria for the use of monoclonal antibodies, legislation and ethical considerations.

    abstract::The criteria governing the in vivo use of monoclonal antibodies in humans are based upon a number of legal requirements with respect to radiation hygiene, pharmaceutical legislation, radiopharmaceutical legislation and regulations with respect to products arising from biotechnology. This in itself has led to a complic...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199308000-00005

    authors: Cox PH

    更新日期:1993-08-01 00:00:00

  • Radiation dose rates from paediatric patients undergoing 99Tcm investigations.

    abstract::Infants or children undergoing nuclear medicine investigations may subsequently come into close contact with nurses or parents responsible for their care. In order to estimate the radiation dose to these individuals, and to formulate appropriate recommendations, dose rates were measured at distances of 0.1, 0.5 and 1....

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:

    authors: Mountford PJ,O'Doherty MJ,Harding LK,Thomson WH,Carter NJ,Bray D,Paul C,Batchelor S

    更新日期:1991-08-01 00:00:00

  • Technetium-99m-dimercaptosuccinic acid renal scintigraphy and single photon emission computed tomography/computed tomography in patients with sickle cell disease.

    abstract:PURPOSE:Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomograp...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0000000000001086

    authors: Ramos CD,Onusic DM,Brunetto SQ,Amorim BJ,Souza TF,Saad STO,Lima MDCL

    更新日期:2019-11-01 00:00:00

  • A comparison of 18F-FDG gamma camera PET, mammography and ultrasonography in demonstrating primary disease in locally advanced breast cancer.

    abstract:BACKGROUND:Positron emission tomography (PET) imaging using [18F]fluorodeoxyglucose (18F-FDG) is recognized to have a major role in oncological imaging. Over recent years there has been a steady increase in the use of gamma camera PET (GCPET) systems as these are less expensive than dedicated PET scanners and facilitat...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.mnm.0000130239.76326.ca

    authors: Marshall C,Mustafa S,Wheatley DC,Eremin JE,El-Sheemy M,Jibril JA,Eremin O,Griffiths PA

    更新日期:2004-07-01 00:00:00

  • Assessment of left ventricular volume and ejection fraction: comparison of QGS and MBGS analyses of ECG-gated myocardial perfusion SPECT imaging.

    abstract:OBJECTIVES:The purpose of this study was to compare quantitative ECG-gated single-photon emission computed tomography (SPECT) (QGS) and model-based ECG-gated single-photon emission computed tomography (MBGS) for determination of end-diastolic cardiac volume (EDV), end-systolic cardiac volume (ESV), and left ventricular...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3283294d19

    authors: Khorsand A,Gyöngyösi M,Graf S,Zamini S,Schuster E,Sochor H,Porenta G

    更新日期:2009-04-01 00:00:00

  • Incidental detection of apical hypertrophic cardiomyopathy by myocardial perfusion imaging.

    abstract:BACKGROUND:Echocardiography plays a central role in the diagnosis of hypertrophic cardiomyopathy (HCM). However, apical involvement of HCM may be missed because of foreshortening and inadequate clinical suspicion. These patients may be referred for single-photon emission computed tomography imaging. METHODS:We present...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328334fc41

    authors: Irwin RB,Arumugam P,Khattar RS

    更新日期:2010-04-01 00:00:00

  • Uptake of 2-[18F]fluoro-2-deoxy-D-glucose in uterine leiomyoma: imaging of four patients by coincidence positron emission tomography.

    abstract::Uterine leiomyomas, benign tumours of the human uterus, are the most common uterine neoplasm and are composed of smooth muscle with varying amounts of fibrous connective tissue. As a functional imaging modality, 2-[F]fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography can be used to obtain information about ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200409000-00012

    authors: Ak I,Ozalp S,Yalçin OT,Zor E,Vardareli E

    更新日期:2004-09-01 00:00:00