Bone lesion detection with carrier-added 99mTc-EDTMP in comparison with 99mTc-DPD.

Abstract:

:An increased uptake of bone-seeking radiopharmaceuticals into malignant bone lesions could further improve the diagnostic accuracy of routine bone scanning. The tracers used in clinical routine for bone scanning are methylene-diphosphonate (MDP), dicarboxypropane-diphosphonate (DPD) and ethylenediaminetetramethylene-phosphonate (EDTMP). MDP and DPD are usually labelled with 99mTc for diagnostic use, whereas EDTMP is labelled with 153Sm for therapeutic purposes. This study aimed to compare, for the first time, bone scanning with an improved preparation of 99mTc-EDTMP (by the addition of rhenium) (carrier-added) with 99mTc-DPD. Twenty malignant bone lesions were investigated in 10 patients. The ratios of bone lesion to soft tissue (BL/ST) and of bone lesion to normal bone (BL/NB) were compared 3 h after the injection of either compound. Quantitative analysis demonstrated a significant (P<0.05) difference in BL/ST ratio in favour of 99mTc-DPD. The BL/NB ratio was not significantly different. Visual image analysis resulted in a clinically comparable interpretation of imaging studies with the use of 99mTc-DPD and carrier-added 99mTc-EDTMP. These preliminary data support the concept of carrier addition to increase bone uptake by the modification of the complex structure of 99mTc-EDTMP. However, any advantage over conventional 99mTc-based tracers for bone scintigraphy in clinical use needs to be demonstrated in controlled trials.

journal_name

Nucl Med Commun

authors

Fueger BJ,Mitterhauser M,Wadsak W,Ofluoglu S,Traub T,Karanikas G,Dudczak R,Pirich C

doi

10.1097/00006231-200404000-00008

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

361-5

issue

4

eissn

0143-3636

issn

1473-5628

pii

00006231-200404000-00008

journal_volume

25

pub_type

杂志文章
  • 201T1 and 99Tcm-J001X macrophage scintigraphy: two radionuclide imaging techniques for the surveillance of acute localized radiation over-exposures.

    abstract::The therapeutic or surgical management of acute localized irradiation is very complicated due to the delayed occurrence of ionizing radiation effects. There is a great need for non-invasive imaging techniques to delineate healthy from exposed tissues. Such a technique should be of value considering that spread of dama...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:

    authors: Perin F,Pittet JC,Hoffschir D,Daburon F,Normier G,Le Pape A

    更新日期:1995-07-01 00:00:00

  • Optimized robust plasma sampling for glomerular filtration rate studies.

    abstract::In the presence of abnormal fluid collection (e.g. ascites), the measurement of glomerular filtration rate (GFR) based on a small number (1-4) of plasma samples fails. This study investigated how a few samples will allow adequate characterization of plasma clearance to give a robust and accurate GFR measurement. A tot...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328356fb6d

    authors: Murray AW,Gannon MA,Barnfield MC,Waller ML

    更新日期:2012-09-01 00:00:00

  • Prospective evaluation of the negative predictive value of V/Q SPECT using 99mTc-Technegas.

    abstract:OBJECTIVE:To verify the negative predictive value of pulmonary ventilation/perfusion scintigraphy with single photon emission computed tomography (V/Q SPECT) in ruling out pulmonary thromboembolism. METHODS:V/Q SPECT using 99mTc-Technegas was performed on 584 patients to rule out pulmonary thromboembolism between Octo...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e32827a8e99

    authors: Leblanc M,Leveillée F,Turcotte E

    更新日期:2007-08-01 00:00:00

  • Quantifying public radiation exposure related to lutetium-177 octreotate therapy for the development of a safe outpatient treatment protocol.

    abstract:OBJECTIVES:Radionuclide therapies, including treatment of neuroendocrine tumors with lutetium-177 (Lu-177) octreotate, often involve hospital admission to minimize radiation exposure to the public. Overnight admission due to Lu-177 octreotate therapy incurs additional cost for the hospital and is an inconvenience for t...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000232

    authors: Olmstead C,Cruz K,Stodilka R,Zabel P,Wolfson R

    更新日期:2015-02-01 00:00:00

  • Molecular PET and PET/CT imaging of tumour cell proliferation using F-18 fluoro-L-thymidine: a comprehensive evaluation.

    abstract::Positron emission tomography (PET) using F-18 fluoro-3'-deoxy-3-L-fluorothymidine (FLT) offers noninvasive assessment of cell proliferation in vivo. The most important application refers to the evaluation of tumour proliferative activity, representing a key feature of malignancy. Most data to date suggest that FLT is ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0b013e32832ee93b

    authors: Barwick T,Bencherif B,Mountz JM,Avril N

    更新日期:2009-12-01 00:00:00

  • 99Tcm-MAG3: a sensitive indicator for evaluating perfusion and rejection of renal transplants.

    abstract::Radionuclide renography has a role in evaluating perfusion of transplanted kidneys. In the course of rejection, cortical perfusion decreases before urinary excretion changes. Based on the facts that 99Tcm-MAG3 has different pharmacokinetics and shows a higher kidney-to-background count ratio than 99Tcm-DTPA, we postul...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:

    authors: Oriuchi N,Miyamoto K,Hoshino K,Imai J,Takahashi Y,Sakai S,Shimada A,Endo K

    更新日期:1997-05-01 00:00:00

  • Ga-68 DOTATATE PET/CT and F-18 FDG PET/CT in the evaluation of low and intermediate versus high-grade neuroendocrine tumors.

    abstract:OBJECTIVE:We investigated the role of Ga-68 DOTATATE PET/CT in comparison to F-18 FDG PET/CT in patients with low and intermediate versus high-grade neuroendocrine tumors (NETs). METHODS:We identified 81 patients who underwent Ga-68 DOTATATE PET/CT at our institution between May 2017 and December 2018 and met inclusio...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001255

    authors: You H,Kandathil A,Beg M,De Blanche L,Kazmi S,Subramaniam RM

    更新日期:2020-10-01 00:00:00

  • Fever of unknown origin, infection of subcutaneous devices, brain abscesses and endocarditis.

    abstract::The term 'fever of unknown origin' includes a wide range of conditions that often remain undiagnosed. The possibility of an infection must be promptly diagnosed in order to begin appropriate therapy. Imaging with radiopharmaceuticals, computed tomography, magnetic resonance imaging and ultrasound are the most commonly...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/00006231-200603000-00003

    authors: Cascini GL,De Palma D,Matteucci F,Biggi A,Rambaldi PF,Signore A,Mansi L

    更新日期:2006-03-01 00:00:00

  • The differential ratio. A method for describing blood flow in renal transplants.

    abstract::The blood flow in renal transplants can be represented by (1) a K/A ratio, the ratio of the slopes of the ascending part of the renal perfusion curve and the arterial curve, (2) a perfusion index, the ratio of a part of the area under the first-pass arterial curve and renal curve, and (3) a height ratio, the ratio of ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199011000-00006

    authors: Groothedde RT,Koppejan LJ,Heidendal GK,Hasman A

    更新日期:1990-11-01 00:00:00

  • In-vivo quantification of dose-dependent dopamine transporter blockade in the rat striatum with small animal SPECT.

    abstract:OBJECTIVE:This study investigated dopamine transporter blockade in the rat striatum after treatment with various doses of methylphenidate using a high-resolution small animal SPECT ('TierSPECT') and I-FP-CIT. METHODS:I-FP-CIT was administered intravenously 1 h after intraperitoneal injection of methylphenidate (3 mg.k...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328014a0df

    authors: Nikolaus S,Antke C,Beu M,Kley K,Larisch R,Wirrwar A,Müller HW

    更新日期:2007-03-01 00:00:00

  • The feasibility of 225Ac as a source of alpha-particles in radioimmunotherapy.

    abstract::This paper proposes the utilization of 225Ac for the alpha-radioimmunotherapy of cancer. The isotope decays with a radioactive half-life of 10 days into a cascade of short-lived alpha- and beta-emitting isotopes. In addition, when indicated by the pharmacokinetic requirements of particular clinical applications, 213Bi...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199302000-00009

    authors: Geerlings MW,Kaspersen FM,Apostolidis C,van der Hout R

    更新日期:1993-02-01 00:00:00

  • The gamma camera as an absolute measurement device: determination of glomerular filtration rate in 99mTc-DTPA renography using a dual head gamma camera.

    abstract:AIM:The aim of this study was to design a general nuclear medicine method for fast, accurate and direct determination of the clearance of a radioactive indicator provided that all uptake compartments of the radioactive indicator could be included in the field of view of the gamma camera. METHODS:The data material for ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200410000-00006

    authors: Carlsen O

    更新日期:2004-10-01 00:00:00

  • The effects of informational intervention on state anxiety and satisfaction in patients undergoing bone scan.

    abstract::The aim of the study was to identify the most beneficial mode, in terms of anxiety reduction, of giving patients information prior to them undergoing a bone scan. (Research has identified the scan procedure as having a demonstrative effect on anxiety.) Additionally, satisfaction with the adequacy of the information wa...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199411000-00011

    authors: Leckie J

    更新日期:1994-11-01 00:00:00

  • SPET-generated colour-coded polar maps to quantify 99Tcm-MIBI and 123I-BMIPP uptake in chronically dysfunctional myocardium: comparison with coronary anatomy and wall motion.

    abstract::The combined use of 123I-BMIPP and 99Tcm-MIBI SPET imaging has been proposed as an alternative to PET for the non-invasive detection of jeopardized myocardium after a myocardial infarction, a mismatch accurately indicating jeopardized but still viable tissue. In this paper, a new quantitative approach is described, ex...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199712000-00005

    authors: Hambÿe AS,Dobbeleir A,Franken PR

    更新日期:1997-12-01 00:00:00

  • Role of SUV(max) obtained by 18F-FDG PET/CT in patients with a solitary pancreatic lesion: predicting malignant potential and proliferation.

    abstract:OBJECTIVES:Maximum standardized uptake value (SUV(max)) is a marker of tumor glucose metabolism detected by [(18)F]-fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (PET/CT) and reflects tumor aggressiveness. The aim of the study was to evaluate the value of SUV(max) in differentiating benign from malignant solit...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328360668a

    authors: Hu SL,Yang ZY,Zhou ZR,Yu XJ,Ping B,Zhang YJ

    更新日期:2013-06-01 00:00:00

  • Radiolabeling RGD peptide and preliminary biodistribution evaluation in mice bearing S180 tumors.

    abstract:OBJECTIVE:To prepare the rhenium-188 (188Re)-arginine-glycine-aspartic acid (RGD) peptide in a convenient manner and to evaluate its potential as an agent for alphavbeta3 integrin receptor-positive tumors. METHODS:Radiolabeled RGD was obtained by conjugating the His group at the end of peptide with fac-[188Re(H2O)3(CO...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3283334e48

    authors: Ma Y,Yu J,Han Y,Shen H,Li Z,Zhou W,Yin D

    更新日期:2010-02-01 00:00:00

  • Comparison between low and high radioactive iodine (131I) reablation dose in patients with papillary thyroid cancer.

    abstract:AIM:The aim of this study was to assess ablation outcome after a second ablation dose and compare the ablation rate after low and high reablation doses of iodine-131 ((131)I) after failure of the first ablation with 3700 MBq. PATIENTS AND METHODS:The study included 81 patients with papillary thyroid cancer; they faile...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000233

    authors: M El-Refaei S,W Yassin S,Salman K,Al Munshy T,Al-Ezzi M,M Al-Sayed Y,Abd Elkareem Husseni M

    更新日期:2015-02-01 00:00:00

  • A retrospective study comparing contrast-enhanced computed tomography with 18F-FDG-PET/CT in the early follow-up of patients with retroperitoneal sarcomas.

    abstract:OBJECTIVE:To compare 18-fluorine-labeled 2-deoxy-2-fluoro-D-glucose PET/computed tomography ((18)F-FDG-PET/CT) with contrast enhancement computed tomography (CECT) in the early follow-up of patients who had undergone treatment for primitive retroperitoneal sarcomas (RS). METHODS:This is a retrospective study on 24 pat...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32835ae545

    authors: Niccoli-Asabella A,Altini C,Notaristefano A,Merenda N,Altieri ML,Stabile-Ianora AA,Fanelli M,Rubini G

    更新日期:2013-01-01 00:00:00

  • Osteoblastic and hyperostotic craniofacial lesion detected by 99mTc-labeled methylene diphosphonate bone scintigraphy and single-photon emission computed tomography/computed tomography: a pictorial essay.

    abstract::99mTc-bisphophonates bone scan, planar and single-photon emission computed tomography/computed tomography (SPECT/CT) modalities, is a commonly used technique that provides high sensitivity and specificity for detection of osseous metastases. However, besides bone metastases, SPECT/CT provides an accurate evaluation of...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001318

    authors: Ju H,Paycha F

    更新日期:2021-02-01 00:00:00

  • Pre-surgical identification of epileptogenic areas in temporal lobe epilepsy by 123I-iomazenil SPECT: a comparison with IMP SPECT and FDG PET.

    abstract:OBJECTIVES:The aim of this study was to evaluate the usefulness of (123)I-iomazenil (IMZ) single photon emission computed tomography (SPECT) for the pre-surgical identification of epileptogenic areas in patients with temporal lobe epilepsy and to compare the results with those of (123)I-IMP SPECT and (18)Fluorodeoxyglu...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/01.mnm.0000243380.79872.32

    authors: Kaneko K,Sasaki M,Morioka T,Koga H,Abe K,Sawamoto H,Ohya N,Yoshiura T,Mihara F,Honda H

    更新日期:2006-11-01 00:00:00

  • Audit of nuclear medicine scientific and technical standards.

    abstract::The British Nuclear Medicine Society has developed a process for the service-specific organizational audit of nuclear medicine departments. This process identified the need for a scheme suitable for the audit of the scientific and technical standards of a department providing such a service. This document has evolved ...

    journal_title:Nuclear medicine communications

    pub_type: 指南,杂志文章,实务指引

    doi:10.1097/01.mnm.0000135041.46837.ca

    authors: Jarritt PH,Perkins AC,Woods SD,British Nuclear Medicine Society.

    更新日期:2004-08-01 00:00:00

  • Optimizing an 18F-NaF and 18F-FDG cocktail for PET assessment of metastatic castration-resistant prostate cancer.

    abstract:BACKGROUND:PET/computed tomography (CT) imaging with the sodium-(F)-fluoride/2-(F)-fluoro-2-deoxy-D-glucose (F-NaF/F-FDG) cocktail has been proposed for patients with osseous metastases. This work aimed to optimize the cocktail composition for patients with metastatic castration-resistant prostate cancer (mCRPC). MATE...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000383

    authors: Simoncic U,Perlman S,Liu G,Jeraj R

    更新日期:2015-12-01 00:00:00

  • Validation of the CT iterative reconstruction technique for low-dose CT attenuation correction for improving the quality of PET images in an obesity-simulating body phantom and clinical study.

    abstract:OBJECTIVE:The aim of this study was to validate the efficacy of computed tomography (CT) iterative reconstruction (CT-IR) for low-dose CT attenuation correction in terms of the estimation of attenuation coefficient and quality of PET images. MATERIALS AND METHODS:We used normal and obesity-simulating body phantoms. PE...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000326

    authors: Matsutomo N,Nagaki A,Sasaki M

    更新日期:2015-08-01 00:00:00

  • Various imaging modalities for the detection of salivary gland lesions: the advantages of 201Tl SPET.

    abstract::The aim of this study was to compare dual-isotope (99Tc(m) and 201Tl) SPET imaging with computed tomography (CT) and magnetic resonance imaging (MRI) in the differentiation of various lesions of the major salivary glands. Twenty-two patients underwent dual-isotope SPET imaging, of whom 12 also had CT and 15 also had a...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200003000-00012

    authors: Arbab AS,Koizumi K,Toyama K,Nambu A,Ichikawa T,Arai T,Araki T

    更新日期:2000-03-01 00:00:00

  • Mediastinal intraoperative radioisotope sentinel lymph node mapping in non-small-cell lung cancer.

    abstract:BACKGROUND:Lymph node metastases are significant prognostic factors in localized non-small-cell lung cancer (NSCLC). Nodal micrometastases may not be detected using current histological methods. AIM:To determine the accuracy and role of sentinel lymph nodes (SLNs) in patients with NSCLC. METHODS:Intraoperative techne...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.mnm.0000169381.99894.2f

    authors: Atinkaya C,Ozlem Küçük N,Koparal H,Aras G,Sak SD,Ozdemir N

    更新日期:2005-08-01 00:00:00

  • Totally automatic definition of renal regions of interest from 99mTc-MAG3 renograms: validation in patients with normal kidneys and in patients with suspected renal obstruction.

    abstract:INTRODUCTION:An image-processing algorithm (AUTOROI) has been developed to totally automatically (or with manual assistance) detect whole-kidney contours and generate renal regions of interest (ROI) for the extraction of the quantitative measurements used in the interpretation of Tc-mercaptoacetyltriglycine (Tc-MAG3) r...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3283362aa3

    authors: Garcia EV,Folks R,Pak S,Taylor A

    更新日期:2010-05-01 00:00:00

  • Cerebral uptake and retention of 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO).

    abstract::A new radiopharmaceutical, 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO) is described. This agent displays considerable promise for imaging cerebral blood flow. In studies in rats and one human volunteer, 99Tcm-HM-PAO demonstrates good brain uptake, prolonged retention of activity in the brain, and slow regional...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198508000-00003

    authors: Holmes RA,Chaplin SB,Royston KG,Hoffman TJ,Volkert WA,Nowotnik DP,Canning LR,Cumming SA,Harrison RC,Higley B

    更新日期:1985-08-01 00:00:00

  • The role of IDA scintigraphy in the follow-up of liver disease in patients with cystic fibrosis.

    abstract::The main aim of this study was to investigate the role of N-(2,4,6 trimethyl-3-bromophenylcarbamoylmethyl) iminodiacetic acid (IDA; Mebrofenin) scintigraphy in follow-up assessments of the biliary system in patients with cystic fibrosis associated liver disease. Fourteen patients from a study published in 1996 were re...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200207000-00012

    authors: Foster JA,Ramsden WH,Conway SP,Taylor JM,Etherington C

    更新日期:2002-07-01 00:00:00

  • Prospective evaluation of qualitative and quantitative ¹⁸F-FDG PET-CT parameters for predicting survival in recurrent carcinoma of the cervix.

    abstract:OBJECTIVE:The aim of this study was to evaluate the prognostic significance of qualitative and quantitative F-fluorodeoxyglucose (F-FDG) PET-computed tomography (PET-CT) parameters in patients with recurrent cervical carcinoma. METHODS:Twenty-six patients (age: 44 ± 10.1 years) with histologically proven recurrent car...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e3283622f0d

    authors: Maharjan S,Sharma P,Patel CD,Sharma DN,Dhull VS,Jain SK,Thulkar S,Malhotra A,Kumar R

    更新日期:2013-08-01 00:00:00

  • Comparison of 123I-MIBG SPECT-CT and 18F-DOPA PET-CT in the evaluation of patients with known or suspected recurrent paraganglioma.

    abstract:OBJECTIVES:Detection of recurrent disease is essential for treatment planning in patients with paraganglioma. The aim of this study was to compare 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy [whole-body and single-photon emission computed tomography (SPECT) computed tomography (CT) scanning] and fluorine-18-L...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328345a340

    authors: Rufini V,Treglia G,Castaldi P,Perotti G,Calcagni ML,Corsello SM,Galli G,Fanti S,Giordano A

    更新日期:2011-07-01 00:00:00