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Validation of the CT iterative reconstruction technique for low-dose CT attenuation correction for improving the quality of PET images in an obesity-simulating body phantom and clinical study.

Abstract：

OBJECTIVE:The aim of this study was to validate the efficacy of computed tomography (CT) iterative reconstruction (CT-IR) for low-dose CT attenuation correction in terms of the estimation of attenuation coefficient and quality of PET images. MATERIALS AND METHODS:We used normal and obesity-simulating body phantoms. PET images were reconstructed using two attenuation correction maps obtained using filtered back projection (CT-FBP) and CT-IR. The CT numbers, attenuation coefficients, contrast-to-noise ratio (CNR10 mm), and coefficient of variation were evaluated. Fifty-two consecutive patients who underwent F-FDG PET/CT with low-dose CT scans were selected for the clinical study. Clinical PET images were reconstructed using CT-FBP and CT-IR, and the effects of CT-IR were examined according to the maximum standardized uptake value (SUVmax), contrast-to-noise ratio in the tumor (CNRtumor), and signal-to-noise ratio in the liver (SNRliver). RESULTS:The CT number on the CT-IR was significantly lower than that of CT-FBP in the obesity-simulating body phantom. The decrease in attenuation coefficients obtained using CT-IR was smaller than that obtained using CT-FBP. The CNR10 mm and coefficient of variation obtained using CT-IR were superior to those obtained using CT-FBP. The SUVmax was not significantly different between the CT-FBP and CT-IR. Although the difference in the SNRliver between the CT-FBP and CT-IR was not significant, the CNRtumor of the CT-IR was significantly higher than that obtained using CT-FBP in obese patients. CONCLUSION:We demonstrated that CT-IR improved the estimation of the attenuation coefficient and provided significant improvement in the CNR of the clinical PET images.

journal_name

Nucl Med Commun

journal_title

Nuclear medicine communications

authors

Matsutomo N,Nagaki A,Sasaki M

doi

10.1097/MNM.0000000000000326

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

839-47

issue

eissn

0143-3636

issn

1473-5628

journal_volume

pub_type

杂志文章

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Validation of the CT iterative reconstruction technique for low-dose CT attenuation correction for improving the quality of PET images in an obesity-simulating body phantom and clinical study.